KEGG   ENZYME: 3.5.99.7Help
Entry
EC 3.5.99.7                 Enzyme                                 

Name
1-aminocyclopropane-1-carboxylate deaminase;
1-aminocyclopropane-1-carboxylate endolyase (deaminating);
ACC deaminase;
1-aminocyclopropane carboxylic acid deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3 (overall reaction) [RN:R00997];
(1a) 1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate;
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
H2O [CPD:C00001];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate
Product
2-oxobutanoate [CPD:C00109];
NH3 [CPD:C00014];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate (spontaneous)
Comment
A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.
History
EC 3.5.99.7 created 1981 as EC 4.1.99.4, transferred 2002 to EC 3.5.99.7, modified 2014
Pathway
Propanoate metabolism
Orthology
K01505  
1-aminocyclopropane-1-carboxylate deaminase
Genes
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
ANI: 
AFM: 
AOR: 
AOR_1_662114(AO090701000360) AOR_1_906134(AO090102000551)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
ABE: 
TVE: 
ZTR: 
SPO: 
CNE: 
CNB: 
MPR: 
SCM: 
PIF: 
DDA: 
DDC: 
DDD: 
DZE: 
PAO: 
PAU: 
PAP: 
PAG: 
PDK: 
PPU: 
PPG: 
PPW: 
PPUU: 
PST: 
PSB: 
PSP: 
PFL: 
PFO: 
PFS: 
PFE: 
PEN: 
PMY: 
PSA: 
PBA: 
PSK: 
CJA: 
ABC: 
ABN: 
ABB: 
SFR: 
SAZ: 
SHN: 
CPS: 
PHA: 
PSHAa2700(dcyD)
PAT: 
PSM: 
SDE: 
AMC: 
ALT: 
GAG: 
PIN: 
TTU: 
LPN: 
LPF: 
LPP: 
LPC: 
LPA: 
lpa_02014(rimM)
MMT: 
MAH: 
FTH: 
HCH: 
MMW: 
AHA: 
ASA: 
ASA_3948(acdS)
OCE: 
RSO: 
RS05576(RSp0646)
RSL: 
RSN: 
RSM: 
RSE: 
RPI: 
RPF: 
REH: 
CNC: 
BMA: 
BMV: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPZ: 
BPQ: 
BPK: 
BTE: 
BTD: 
BVI: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BAM: 
BAC: 
BMU: 
BMJ: 
BCT: 
BXE: 
BPH: 
BPY: 
BGL: 
BUG: 
BGE: 
BGF: 
BGD: 
BYI: 
BUK: 
BPX: 
BUO: 
AXY: 
AXO: 
AXN: 
POL: 
AAV: 
AJS: 
DIA: 
AAA: 
ACK: 
VAP: 
VPE: 
VPD: 
MPT: 
HSE: 
CFU: 
CJE: 
CJJ: 
CJR: 
CFF: 
CCV: 
CHA: 
MLO: 
MCI: 
MOP: 
MAM: 
SMK: 
SMQ: 
SMX: 
SMEG: 
SMD: 
ARA: 
AVI: 
REL: 
RLE: 
pRL100087(acdS)
RTR: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
S23_05660(acaS)
AOL: 
AZC: 
SNO: 
MRD: 
MET: 
MNO: 
GOH: 
AMV: 
GXY: 
AZL: 
ALI: 
TMO: 
TMO_c0455(acdS)
MSM: 
MSG: 
MAB: 
MABB: 
MMV: 
SCO: 
SCO5247(2SC7G11.09c)
SMA: 
SGR: 
SCB: 
SVL: 
SVE: 
SDV: 
SALB: 
MPH: 
KFL: 
NDA: 
FRI: 
FAL: 
NML: 
MMAR: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
PDX: 
AMI: 
SESP: 
BN6_16700(acdS)
AMS: 
ACTN: 
AFS: 
CAI: 
SNA: 
LIL: 
LIC: 
LBJ: 
LBL: 
ANA: 
NPU: 
AVA: 
NAZ: 
CPI: 
PSN: 
SHG: 
HHY: 
CHU: 
CHU_3479(yedO)
RSI: 
MTT: 
GFO: 
FJO: 
FPS: 
FP1206(acdS)
FBR: 
COC: 
ZPR: 
RAN: 
RAI: 
CAO: 
CLY: 
WVI: 
KDI: 
LAN: 
MRS: 
FBA: 
FTE: 
MRB: 
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYS: 
THA: 
 » show all
Taxonomy
Reference
1
  Authors
Honma, M. and Shimomura, T.
  Title
Metabolism of 1-aminocyclopropane-1-carboxylic acid.
  Journal
Agric. Biol. Chem. 42 (1978) 1825-1831.
Reference
2  [PMID:10938279]
  Authors
Yao M, Ose T, Sugimoto H, Horiuchi A, Nakagawa A, Wakatsuki S, Yokoi D, Murakami T, Honma M, Tanaka I.
  Title
Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus.
  Journal
J. Biol. Chem. 275 (2000) 34557-65.
  Organism
Hansenula saturnus
  Sequence
[up:Q7M523]
Reference
3  [PMID:21244019]
  Authors
Thibodeaux CJ, Liu HW
  Title
Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.
  Journal
Biochemistry. 50 (2011) 1950-62.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
69553-48-6

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