5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;
DcpS;
m7GpppX pyrophosphatase;
m7GpppN m7GMP phosphohydrolase;
m7GpppX diphosphatase;
m7G5'ppp5'N m7GMP phosphohydrolase

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase

a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]

R09878;
(other) R04368

5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA];
H2O [CPD:C00001]

The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].

1  [PMID:16963086]

Malys N, McCarthy JE

Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.

J. Mol. Biol. 363 (2006) 370-82.

2  [PMID:18441014]

Liu SW, Rajagopal V, Patel SS, Kiledjian M

Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.

J. Biol. Chem. 283 (2008) 16427-36.

3  [PMID:12198172]

Liu H, Rodgers ND, Jiao X, Kiledjian M

The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.

EMBO. J. 21 (2002) 4699-708.

4  [PMID:14523240]

van Dijk E, Le Hir H, Seraphin B

DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.

Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12081-6.

5  [PMID:15769464]

Chen N, Walsh MA, Liu Y, Parker R, Song H

Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

J. Mol. Biol. 347 (2005) 707-18.

6  [PMID:15383679]

Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE

Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and  characterization of C. elegans scavenger DcpS.

RNA. 10 (2004) 1609-24.

7  [PMID:22985415]

Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.

Biochemistry. 51 (2012) 8003-13.