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Entry
EC 3.6.1.59                 Enzyme                                 

Name
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;
DcpS;
m7GpppX pyrophosphatase;
m7GpppN m7GMP phosphohydrolase;
m7GpppX diphosphatase;
m7G5'ppp5'N m7GMP phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Reaction(KEGG)
(other) R04368
Show
Substrate
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD:C02339];
H2O [CPD:C00001]
Product
N7-methylguanosine 5'-phosphate;
5'-diphospho-[mRNA] [CPD:C02100]
Comment
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].
History
EC 3.6.1.59 created 2012, modified 2013
Orthology
K12584  
m7GpppX diphosphatase
Genes
HSA: 
28960(DCPS)
PTR: 
451655(DCPS)
PPS: 
100974902(DCPS)
GGO: 
101145375(DCPS)
PON: 
100441593(DCPS)
NLE: 
100601639(DCPS)
MCC: 
MCF: 
102120410(DCPS)
CJC: 
100410129(DCPS)
MMU: 
69305(Dcps)
RNO: 
266605(Dcps)
CGE: 
100761162(Dcps)
NGI: 
103735398(Dcps)
HGL: 
101715664(Dcps)
OCU: 
TUP: 
102484523(DCPS)
CFA: 
609536(DCPS)
AML: 
UMR: 
103660653(DCPS)
FCA: 
101088950(DCPS)
PTG: 
102969848(DCPS)
BTA: 
282640(DCPS)
BOM: 
102278216(DCPS)
PHD: 
102317093(DCPS)
CHX: 
102190586(DCPS)
OAS: 
101114475(DCPS)
SSC: 
396689(DCPS)
CFR: 
102519944(DCPS)
BACU: 
103009141(DCPS)
LVE: 
103078579(DCPS)
ECB: 
100064530(DCPS)
MYB: 
102251721(DCPS)
MYD: 
102774242(DCPS)
PALE: 
102879340(DCPS)
MDO: 
100019554(DCPS)
SHR: 
100935301(DCPS)
OAA: 
GGA: 
419716(DCPS)
MGP: 
APLA: 
101792448(DCPS)
TGU: 
100217679(DCPS)
FAB: 
101821090(DCPS)
PHI: 
102102643(DCPS)
FPG: 
101910550(DCPS)
FCH: 
102047627(DCPS)
ASN: 
102384846(DCPS)
AMJ: 
102564856(DCPS)
PSS: 
102454492(DCPS)
CMY: 
102947472(DCPS)
ACS: 
100567351(dcps)
PBI: 
103066095(DCPS)
XLA: 
394400(dcps)
XTR: 
100216298(dcps)
DRE: 
402850(dcps)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180338(dcps)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
552284(GB18766)
NVI: 
TCA: 
BMOR: 
API: 
100163679(Dcps)
PHU: 
ISC: 
CEL: 
CBR: 
CBG12933(Cbr-dcs-1)
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
OLU: 
BPG: 
MIS: 
MPP: 
CSL: 
SCE: 
YLR270W(DCS1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0D02700(NCAS0D02700) NCAS_0F00320(NCAS0F00320)
NDI: 
NDAI_0I02210(NDAI0I02210) NDAI_0K02850(NDAI0K02850)
TPF: 
TPHA_0F02580(TPHA0F02580) TPHA_0K01170(TPHA0K01170)
TBL: 
TBLA_0A09660(TBLA0A09660) TBLA_0G00540(TBLA0G00540)
TDL: 
TDEL_0G04070(TDEL0G04070)
KAF: 
KAFR_0A05030(KAFR0A05030) KAFR_0G02510(KAFR0G02510)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.6901(DCS1) CaO19_6901(CaJ7_0135)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
VAL: 
ELA: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_1208164(AO090001000669)
ANG: 
ANI_1_3306024(An02g13910)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT114139(AGABI1DRAFT_114139)
ABV: 
AGABI2DRAFT193987(AGABI2DRAFT_193987)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
ECU: 
EIN: 
EHE: 
NCE: 
EHI: 
EHI_169590(223.t00003)
EDI: 
ACAN: 
PTM: 
TPS: 
PIF: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:16963086]
  Authors
Malys N, McCarthy JE
  Title
Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
  Journal
J. Mol. Biol. 363 (2006) 370-82.
  Sequence
[sce:YLR270W]
Reference
2  [PMID:18441014]
  Authors
Liu SW, Rajagopal V, Patel SS, Kiledjian M
  Title
Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.
  Journal
J. Biol. Chem. 283 (2008) 16427-36.
Reference
3  [PMID:12198172]
  Authors
Liu H, Rodgers ND, Jiao X, Kiledjian M
  Title
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
  Journal
EMBO. J. 21 (2002) 4699-708.
  Sequence
[hsa:28960] [sce:YLR270W]
Reference
4  [PMID:14523240]
  Authors
van Dijk E, Le Hir H, Seraphin B
  Title
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12081-6.
  Sequence
[hsa:28960] [sce:YLR270W]
Reference
5  [PMID:15769464]
  Authors
Chen N, Walsh MA, Liu Y, Parker R, Song H
  Title
Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
  Journal
J. Mol. Biol. 347 (2005) 707-18.
  Sequence
[hsa:28960]
Reference
6  [PMID:15383679]
  Authors
Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE
  Title
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and  characterization of C. elegans scavenger DcpS.
  Journal
RNA. 10 (2004) 1609-24.
  Sequence
Reference
7  [PMID:22985415]
  Authors
Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E
  Title
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
  Journal
Biochemistry. 51 (2012) 8003-13.
  Sequence
[up:D3K0N9] [cel:CELE_Y113G7A.9] [hsa:28960] [sce:YLR270W]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system