KEGG   ENZYME: 3.6.1.6Help
Entry
EC 3.6.1.6                  Enzyme                                 
Name nucleoside-diphosphatase;
thiaminpyrophosphatase;
UDPase;
inosine diphosphatase;
adenosine diphosphatase;
IDPase;
ADPase;
adenosinepyrophosphatase;
guanosine diphosphatase;
guanosine 5'-diphosphatase;
inosine 5'-diphosphatase;
uridine diphosphatase;
uridine 5'-diphosphatase;
nucleoside diphosphate phosphatase;
type B nucleoside diphosphatase;
GDPase;
CDPase;
nucleoside 5'-diphosphatase;
type L nucleoside diphosphatase;
NDPase;
nucleoside diphosphate phosphohydrolase
Class Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname nucleoside-diphosphate phosphohydrolase
Reaction(IUBMB) a nucleoside diphosphate + H2O = a nucleotide + phosphate
[RN:R00329]
Reaction(KEGG) R00329 > R00155 R00328 R00961
Show
Substrate nucleoside diphosphate [CPD:C00454];
H2O [CPD:C00001]
Product nucleotide [CPD:C00215];
phosphate [CPD:C00009]
Comment Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate
Pathway PATH: ec00230  Purine metabolism
PATH: ec00240  Pyrimidine metabolism
Orthology KO: K01511  ectonucleoside triphosphate diphosphohydrolase 5/6
KO: K12304  soluble calcium-activated nucleotidase 1
KO: K12305  ectonucleoside triphosphate diphosphohydrolase 4
Genes HSA: 124583(CANT1) 955(ENTPD6) 957(ENTPD5) 9583(ENTPD4)
PTR: 453027(ENTPD5) 458146(ENTPD6) 464056(ENTPD4) 468345(CANT1)
MCC: 698503(ENTPD5) 705663(ENTPD6) 710935 717197(ENTPD4)
MMU: 12497(Entpd6) 12499(Entpd5) 67464(Entpd4) 76025(Cant1)
RNO: 246272(Cant1) 314312(Entpd5) 361063(Entpd4) 85260(Entpd6)
CFA: 480384(ENTPD5) 485564(ENTPD6) 486117(ENTPD4) 608038(CANT1)
BTA: 508097(ENTPD6) 518086(CANT1) 531411(ENTPD4) 533096(ENTPD5)
SSC: 100154506 100155254
ECB: 100053982 100056466 100057043(ENTPD6) 100057405(CANT1)
MDO: 100021277 100024118 100026552 100033226
OAA: 100075558 100088014
GGA: 419531(ENTPD4) 423343(ENTPD5) 430103(CANT1)
TGU: 100220000 100224923
XLA: 379060(MGC52693) 495422(entpd4) 734187
XTR: 394537(cant1) 677731(entpd4)
DRE: 406558(cant1a) 436692 445201(cant1b) 550560(entpd6) 556849
BFO: BRAFLDRAFT_57510
CIN: 100181727
SPU: 580175 587808
DME: Dmel_CG5276
DPO: Dpse_GA18779
DAN: Dana_GF16866
DER: Dere_GG18156
DPE: Dper_GL12374
DSE: Dsec_GM23945
DSI: Dsim_GD18755
DYA: Dyak_GE26097
DGR: Dgri_GH17322
DMO: Dmoj_GI10286
AGA: AgaP_AGAP001217
AAG: AaeL_AAEL006659
CQU: CpipJ_CPIJ006723
AME: 550987
NVI: 100120729
TCA: 662718
API: 100163150
ISC: IscW_ISCW018254
CEL: F08C6.6(apy-1) K08H10.4(uda-1) R07E4.4(mig-23) ZK563.7
CBR: CBG11542 CBG14198 CBG14784 CBG16731
BMY: Bm1_34420
NVE: NEMVE_v1g175561
HMG: 100202807
TAD: TRIADDRAFT_21256 TRIADDRAFT_32564
CME: CMQ456C
MBR: MONBRDRAFT_28836
EHI: EHI_053610 EHI_104590 EHI_112890
EDI: EDI_058390 EDI_125320 EDI_305410
PFA: PF14_0297
CPV: cgd6_1570
CHO: Chro.60194
TBR: Tb927.7.1930
PTI: PHATRDRAFT_14301
TPS: THAPSDRAFT_31247
Taxonomy
Structures PDB: 2H2N  2H2U  3EXM  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:14389272]
GIBSON DM, AYENGAR P, SANADI DR.
A phosphatase specific for nucleoside diphosphates.
Biochim. Biophys. Acta. 16 (1955) 536-8.
Sus scofa [GN:ssc]
Reference
  Authors
  Title
  Journal
 2
Horecker, B.L., Hurwitz, J. and Heppel, L.A.
The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate.
J. Am. Chem. Soc. 79 (1957) 701-702.
Other DBs ExplorEnz - The Enzyme Database: 3.6.1.6
IUBMB Enzyme Nomenclature: 3.6.1.6
ExPASy - ENZYME nomenclature database: 3.6.1.6
BRENDA, the Enzyme Database: 3.6.1.6
CAS: 9027-69-4
DBGET integrated database retrieval system