KEGG   ENZYME: 3.6.3.1Help
Entry
EC 3.6.3.1                  Enzyme                                 
Name
phospholipid-translocating ATPase;
Mg2+-ATPase;
flippase;
aminophospholipid-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (phospholipid-flipping)
Reaction(IUBMB)
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2] [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
phospholipid [side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
phospholipid [side 2]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase').
Orthology
K01530  
phospholipid-translocating ATPase
K14802  
phospholipid-transporting ATPase
Genes
HSA: 
10079(ATP9A) 10396(ATP8A1) 148229(ATP8B3) 23200(ATP11B) 23250(ATP11A) 286410(ATP11C) 374868(ATP9B) 51761(ATP8A2) 5205(ATP8B1) 57194(ATP10A) 57198(ATP8B2) 57205(ATP10D) 79895(ATP8B4)
PTR: 
452677(ATP11A) 453268(ATP10A) 453422(ATP8B4) 455439(ATP8B1) 455484(ATP9B) 458341(ATP9A) 461189(ATP8A1) 461351(ATP10D) 465889(ATP11C) 467238(ATP8A2) 468652(ATP8B3) 469505(ATP8B2) 471016(ATP11B)
PPS: 
100967766(ATP8B4) 100972951(ATP8B2) 100973832(ATP8B1) 100975459(ATP8B3) 100977979(ATP10A) 100978328(ATP9B) 100979822(ATP10D) 100981064(ATP9A) 100985769(ATP11A) 100986009(ATP8A2) 100989463(ATP8A1) 100994939(ATP11B) 100995604(ATP11C)
GGO: 
101126258 101126969 101127464 101129100(ATP8B2) 101130545(ATP11C) 101130730(ATP8B4) 101133046(ATP8B3) 101133383(ATP10A) 101135145(ATP11A) 101138062(ATP10D) 101139526(ATP11B) 101142751(ATP8B1) 101147224(ATP9B)
PON: 
100171619(ATP8B4) 100435833(ATP9B) 100440505(ATP10A) 100441755(ATP8B3) 100446676(ATP8A1) 100448675(ATP11C) 100450195(ATP8B1) 100451934 100453547(ATP10D) 100460078(ATP8B2) 100461085(ATP11B)
MCC: 
695802(ATP11C) 695994(ATP8B1) 697957(ATP9B) 702630(ATP8A1) 704458(ATP10D) 708453(ATP11B) 709311(ATP8A2) 710250(ATP9A) 711435(ATP10A) 712589(ATP11A) 716570(ATP8B4) 716652(ATP8B2) 721348(ATP8B3)
MMU: 
11980(Atp8a1) 11981(Atp9a) 11982(Atp10a) 231287(Atp10d) 241633(Atp8b4) 320940(Atp11c) 50769(Atp8a2) 50770(Atp11a) 50771(Atp9b) 54667(Atp8b2) 54670(Atp8b1) 67331(Atp8b3) 76295(Atp11b)
RNO: 
289615(Atp8a1) 291411(Atp9b) 291555(Atp8b1) 299616(Atp8b3) 306600(Atp11a) 311396(Atp8b4) 317599(Atp11c) 360932(Atp10d) 361929(Atp11b) 365266(Atp10a) 685152 691889 84011(Atp9a)
CFA: 
100687016(ATP8A2) 476190(ATP8B1) 476992(ATP11A) 477265(ATP9A) 478644(ATP11B) 481066(ATP11C) 482134(ATP10D) 483926(ATP9B) 486036(ATP8A2) 487549(ATP8B4) 488691(ATP10A) 490447(ATP8B2) 607976(ATP8A1) 612245(ATP8B3)
AML: 
100464545(ATP9A) 100465107(ATP11B) 100465593(ATP8A1) 100465614 100466989(ATP11C) 100468066 100469171 100471522(ATP8B2) 100473489(ATP8B4) 100477848(ATP8A2) 100481501(ATP8B1) 100483547(ATP11A) 100483624
FCA: 
101080270(ATP9A) 101084112(ATP8B4) 101085594(ATP8A2) 101085949(ATP8B2) 101091868(ATP8A1) 101093440(ATP10A) 101097392(ATP10D) 101097781(ATP11A) 101099184(ATP8B3) 101099649(ATP11B) 101099786(ATP11C) 101101003(ATP8B1) 101101004(ATP9B)
BTA: 
100137953(ATP8B4) 317692(ATP8A1) 508723(ATP8A2) 510301(ATP9B) 512547(ATP11A) 516579 529689(ATP11C) 536495(ATP10D) 536660 541187(ATP8B1) 614392(ATP11B) 785713(ATP8B2)
SSC: 
100136901(ATP9A) 100153006(ATP8B1) 100154720(ATP8B4) 100154901 100513137(ATP8B3) 100515393(ATP8A1) 100517341(ATP8B2) 100520087(ATP10D) 100523658(ATP11C) 100624673 100625134(ATP8A2) 100738314
ECB: 
100052707(ATP9A) 100054112(ATP8B1) 100055432(ATP11C) 100059537(ATP8A2) 100061624(ATP10D) 100062211(ATP10A) 100062902(ATP8A1) 100065346 100066562 100066940(ATP11A) 100069998(ATP8B4) 100146926(ATP8B3)
MDO: 
100012603(ATP11C) 100016294(ATP8B1) 100018023(ATP8B3) 100019520(ATP10D) 100020493(ATP8B2) 100020627(ATP8A1) 100022587(ATP11A) 100022728(ATP9A) 100023022 100024643(ATP8A2) 100616715 100617055 100618061(ATP8B4)
SHR: 
100915222(ATP8B3) 100917108(ATP8A1) 100917244 100918632(ATP11B) 100921779(ATP11A) 100921902(ATP11C) 100922437(ATP8B1) 100924402(ATP8B2) 100926891(ATP9B) 100927847 100932995(ATP8B4) 100934378(ATP10D)
OAA: 
100073923 100074214(ATP10B) 100075863(ATP8B3) 100077977(ATP9A) 100078463 100078594(ATP11C) 100079760(ATP8B1) 100081427 100084825(ATP11A) 100089451(ATP8A1)
GGA: 
418685(ATP10A) 418749(ATP11A) 418936(ATP8A2) 419345(ATP9A) 420817(ATP9B) 422254(ATP11C) 422768(ATP10D) 422776(ATP8A1) 424964(ATP11B) 428328(ATP8B3) 770035(ATP8B2)
MGP: 
100538381(ATP11C) 100539283 100541990(ATP9A) 100542612 100545574(ATP10D) 100545930 100546259 100547261(ATP8A1) 100547912(ATP8B3) 100550069(ATP11A)
TGU: 
100219227(ATP11B) 100219240(ATP8B2) 100220565(ATP8A2) 100220790(ATP8B1) 100220889(ATP11A) 100223014 100223812(ATP10A) 100224155(ATP9B) 100228586(ATP8A1) 100228886(ATP10D) 100229226(ATP9A)
ACS: 
100553567 100554182 100556007 100556669(atp8b2) 100556728(atp10d) 100557766(atp8b1) 100558859(atp11a) 100559061 100562936 100564127(atp8a1)
XLA: 
380518(atp11c)
XTR: 
100145017(atp8b4) 100485769(atp11a) 100490666 100494528 100497381 100498300(atp11c) 394841(atp9a) 594952(atp8b1) 733571(atp8a1)
DRE: 
100148342(atp8b1) 100330943(atp8a2) 368385(atp11c) 559291 562925(atp11a) 563932(atp10a) 567172 568160(atp9b) 571658(atp10d)
TRU: 
101062591 101063382 101065186 101065715 101066624 101067743 101068743 101069381 101069525 101069669 101075533
OLA: 
101159740 101161426 101162251 101163741 101163914 101165629 101165817 101166536 101173537 101173888
BFO: 
BRAFLDRAFT_69708 BRAFLDRAFT_85520 BRAFLDRAFT_85893 BRAFLDRAFT_94829
CIN: 
100179108 100179447 100186331(atp10a) 100186827(atp8a1)
SPU: 
580898(ATP11B) 581778 590738 594696 764069
DME: 
Dmel_CG14741 Dmel_CG31729 Dmel_CG33298 Dmel_CG42321
DPO: 
Dpse_GA13214 Dpse_GA16426 Dpse_GA24969 Dpse_GA25312
DAN: 
Dana_GF11187 Dana_GF22754 Dana_GF23110
DER: 
Dere_GG22494 Dere_GG23838 Dere_GG25354
DPE: 
Dper_GL10402 Dper_GL26178
DSE: 
Dsec_GM10404 Dsec_GM20281
DSI: 
Dsim_GD25762
DWI: 
Dwil_GK10743 Dwil_GK14835
DYA: 
Dyak_GE13364 Dyak_GE18642
DGR: 
Dgri_GH23120 Dgri_GH25099
DMO: 
Dmoj_GI17208 Dmoj_GI18942
DVI: 
Dvir_GJ17966 Dvir_GJ21316
AGA: 
AgaP_AGAP002644 AgaP_AGAP008184 AgaP_AGAP010026 AgaP_AGAP011483
AAG: 
AaeL_AAEL000767 AaeL_AAEL004981 AaeL_AAEL007689
CQU: 
CpipJ_CPIJ006230 CpipJ_CPIJ006290 CpipJ_CPIJ006431 CpipJ_CPIJ008924
AME: 
409192 413138 413328 552074
NVI: 
100115599(NV17459) 100115967(NV50397) 100120212(NV16662) 100121956(NV14640)
TCA: 
655986(Atp9b) 663307
API: 
100167224
PHU: 
Phum_PHUM041040 Phum_PHUM204310
ISC: 
IscW_ISCW009949
CEL: 
CELE_F02C9.3(tat-6) CELE_F36H2.1(tat-5) CELE_Y49E10.11(tat-1)
CBR: 
CBG11664(Cbr-tat-2) CBG11754(Cbr-tat-1) CBG16933(Cbr-tat-5) CBG18322(Cbr-tat-3)
BMY: 
Bm1_02170 Bm1_27560 Bm1_41570
TSP: 
Tsp_03493 Tsp_05177 Tsp_07506 Tsp_10481
SMM: 
Smp_091650 Smp_104500 Smp_163820 Smp_181230
NVE: 
NEMVE_v1g10129 NEMVE_v1g106065 NEMVE_v1g115237 NEMVE_v1g50157
HMG: 
100198383 100198433 100209479 100210424
TAD: 
TRIADDRAFT_23045 TRIADDRAFT_25047 TRIADDRAFT_55823 TRIADDRAFT_56098
AQU: 
100632419 100633776(Atp8b2) 100640697
ATH: 
AT1G13210(ACA.l) AT1G17500 AT1G26130 AT1G54280 AT1G59820(ALA3) AT1G68710 AT1G72700 AT3G13900 AT3G25610 AT3G27870 AT5G44240(ALA2)
ALY: 
ARALYDRAFT_356659 ARALYDRAFT_474559 ARALYDRAFT_475328 ARALYDRAFT_889156
GMX: 
100778710 100784621 100786505 100787473 100792942 100815547 100819559
MTR: 
MTR_2g099690 MTR_8g062150
CSV: 
101207069
RCU: 
RCOM_0654980 RCOM_0699240 RCOM_1095380 RCOM_1173290 RCOM_1464220
POP: 
POPTR_230718 POPTR_299001 POPTR_421641 POPTR_592804 POPTR_741584 POPTR_751108 POPTR_797847 POPTR_803861
VVI: 
100247431 100249823 100250575 100252404 100256123 100259356 100264484 100264967
OSA: 
4324268 4332752 4337521 4341328 4348609 4350436
DOSA: 
Os06t0565900-01(Os06g0565900)
BDI: 
100837629 100838453 100846736
SBI: 
SORBI_01g022190(SORBIDRAFT_01g022190) SORBI_01g036200(SORBIDRAFT_01g036200) SORBI_10g014640(SORBIDRAFT_10g014640) SORBI_10g022370(SORBIDRAFT_10g022370)
SMO: 
SELMODRAFT_113552 SELMODRAFT_168751
PPP: 
PHYPADRAFT_165384 PHYPADRAFT_168461 PHYPADRAFT_189702
CRE: 
CHLREDRAFT_190292(ALA2) CHLREDRAFT_193025(ALA3)
VCN: 
VOLCADRAFT_104891 VOLCADRAFT_95397
OLU: 
OSTLU_49740
OTA: 
Ot06g03680
CME: 
CMR306C CMS375C
SCE: 
YAL026C(DRS2) YDR093W(DNF2) YER166W(DNF1) YIL048W(NEO1) YMR162C(DNF3)
AGO: 
AGOS_ADL079C AGOS_ADR350W AGOS_AFL191W AGOS_AGR120C
ERC: 
Ecym_5071
KLA: 
KLLA0A04015g KLLA0C08393g KLLA0C17644g KLLA0E01651g
LTH: 
KLTH0D02156g
PPA: 
PAS_chr1-4_0233 PAS_chr2-1_0057 PAS_chr2-1_0756 PAS_chr2-1_0807 PAS_chr4_0662
VPO: 
Kpol_1009p21 Kpol_1033p9 Kpol_1040p10
ZRO: 
ZYRO0D05170g
CGR: 
CAGL0G06270g CAGL0H04477g CAGL0L00715g CAGL0L11814g
NCS: 
NCAS_0F01710(NCAS0F01710)
NDI: 
NDAI_0H02560(NDAI0H02560)
TPF: 
TPHA_0H02720(TPHA0H02720)
TBL: 
TBLA_0A04620(TBLA0A04620)
TDL: 
TDEL_0H03790(TDEL0H03790)
KAF: 
KAFR_0K00630(KAFR0K00630)
DHA: 
DEHA2D07348g DEHA2D13332g DEHA2F02750g DEHA2G21340g
PIC: 
PICST_33561(DRS2) PICST_52414(NEO1) PICST_81178(DNF2) PICST_85147(DNF1)
PGU: 
PGUG_01130 PGUG_02248
LEL: 
LELG_01810 LELG_02095 LELG_03042 LELG_03729 LELG_04566
CAL: 
CaO19.14070(DRS2) CaO19.2680 CaO19.323 CaO19.6778(DRS2) CaO19.783(NEO1) CaO19.7955 CaO19.8405(NEO1) CaO19.8547(DNF2) CaO19.932(DNF2)
CTP: 
CTRG_05626
CDU: 
CD36_87150
COT: 
CORT_0C00180
YLI: 
YALI0C00495g YALI0E34551g YALI0F01122g
CLU: 
CLUG_05270
NCR: 
NCU00352 NCU03818 NCU07443
SMP: 
SMAC_06469
PAN: 
PODANSg4419 PODANSg4879 PODANSg8460 PODANSg8809
TTT: 
THITE_2119421
MTM: 
MYCTH_2304292
MGR: 
MGG_04066 MGG_12922
FGR: 
FG05149.1 FG06743.1 FG08595.1 FG09020.1
NHE: 
NECHADRAFT_39061
VAL: 
VDBG_08912
SSL: 
SS1G_08813 SS1G_09007 SS1G_11636 SS1G_11637
BFU: 
BC1G_09245 BC1G_10682 BC1G_10952 BC1G_15074
ANI: 
AN2011.2 AN6112.2 AN6614.2 AN8672.2
NFI: 
NFIA_084430
AFM: 
AFUA_2G08850 AFUA_4G10210 AFUA_6G02070 AFUA_6G03950
AOR: 
AOR_1_1364054(AO090011000813) AOR_1_152094(AO090120000088) AOR_1_2132154(AO090003001200) AOR_1_278114(AO090701000148)
ANG: 
ANI_1_1060104(An12g08790) ANI_1_2000184(An04g06840) ANI_1_558104(An12g04500)
AFV: 
AFLA_026240 AFLA_046150 AFLA_056080 AFLA_090860
ACT: 
ACLA_080690
PCS: 
Pc13g03700 Pc20g13010 Pc22g12730 Pc22g24380
CIM: 
CIMG_00808
CPW: 
CPC735_012780 CPC735_015090 CPC735_024460 CPC735_054960
PBL: 
PAAG_07970
URE: 
UREG_00777 UREG_03314 UREG_03553 UREG_04515
ABE: 
ARB_04946
TVE: 
TRV_07132
PNO: 
SNOG_13018
PTE: 
PTT_08728
ZTR: 
MYCGRDRAFT_99706
TML: 
GSTUM_00002118001 GSTUM_00012189001
SPO: 
SPAC24B11.12c SPAC4F10.16c SPAC6C3.06c SPAC821.13c SPBC887.12
CNE: 
CNA03720 CND03980 CNH03470 CNN01890
CNB: 
CNBA3510
CGI: 
CGB_A3440W
PPL: 
POSPLDRAFT_25855 POSPLDRAFT_28725 POSPLDRAFT_92916
LBC: 
LACBIDRAFT_189016
MPR: 
MPER_02882 MPER_06588 MPER_09506 MPER_09870 MPER_11247
CCI: 
CC1G_01594 CC1G_02009 CC1G_07338
SCM: 
SCHCODRAFT_236043 SCHCODRAFT_60553 SCHCODRAFT_83428
UMA: 
UM02436.1 UM03293.1 UM04394.1
MGL: 
MGL_1395 MGL_3263 MGL_3828
PGR: 
PGTG_06808
ECU: 
ECU06_0930 ECU09_1440
EIN: 
Eint_060860
EHE: 
EHEL_060880
NCE: 
NCER_100998 NCER_101354
MBR: 
MONBRDRAFT_23245 MONBRDRAFT_26477 MONBRDRAFT_32498 MONBRDRAFT_8524
NGR: 
NAEGRDRAFT_31746 NAEGRDRAFT_38509 NAEGRDRAFT_44754 NAEGRDRAFT_83357
DDI: 
DDB_G0269380 DDB_G0270870(atp9b) DDB_G0282959
DPP: 
DICPUDRAFT_46686 DICPUDRAFT_48870
EHI: 
EHI_049640(21.t00048) EHI_096620(6.t00057) EHI_140130(8.t00012) EHI_141350(309.t00009) EHI_168260(191.t00016)
EDI: 
EDI_025160 EDI_043500 EDI_167540 EDI_252620
PFA: 
PFL0950c(ATPase2) PFL1125w
PYO: 
PY01853 PY06483
PKN: 
PKH_143630 PKH_143990
TAN: 
TA04770 TA14990
TPV: 
TP02_0772 TP03_0479
BBO: 
BBOV_III007600(17.m07665) BBOV_IV001830(21.m02975) BBOV_IV003630(21.m02979)
CPV: 
cgd2_2400 cgd3_2730
CHO: 
Chro.20257 Chro.30311
TGO: 
TGME49_024190 TGME49_047690
TET: 
TTHERM_00123720 TTHERM_00158340 TTHERM_00294760 TTHERM_00316630 TTHERM_00325570 TTHERM_00372460 TTHERM_00429720 TTHERM_00449540 TTHERM_00474738 TTHERM_00715640 TTHERM_00797940 TTHERM_00797960 TTHERM_00797970 TTHERM_00923160 TTHERM_00977610 TTHERM_00977720 TTHERM_00994350 TTHERM_01123860 TTHERM_01156820 TTHERM_01156830 TTHERM_01166280 TTHERM_01359440
PTM: 
GSPATT00000395001 GSPATT00003702001 GSPATT00007622001 GSPATT00012819001 GSPATT00016583001 GSPATT00021132001 GSPATT00021561001 GSPATT00029621001 GSPATT00032129001 GSPATT00033417001 GSPATT00035083001 PTMB.138c
TBR: 
Tb11.02.0850 Tb927.4.1510(Tb04.2L9.780) Tb927.6.3550(Tb06.2N9.170)
TCR: 
503999.100 504057.11 506941.60 509591.60 510877.80 511511.60
LMA: 
LMJF_13_1530 LMJF_30_2260 LMJF_34_2630 LMJF_34_3220
LIF: 
LINJ_13_1590 LINJ_30_2270 LINJ_34_2460 LINJ_34_3000
LDO: 
LDBPK_131590
LMI: 
LMXM_13_1530
LBZ: 
LBRM_13_1380 LBRM_13_1400 LBRM_20_2190 LBRM_30_2210
GLA: 
GL50803_10019 GL50803_101810
TVA: 
TVAG_028590 TVAG_093660 TVAG_119100 TVAG_499250
PTI: 
PHATRDRAFT_52368(ATPase-P4)
TPS: 
THAPSDRAFT_26702
PIF: 
PITG_03291 PITG_13604 PITG_15267
 » show all
Taxonomy
Reference
1  [PMID:8136700]
  Authors
Morris MB, Auland ME, Xu YH, Roufogalis BD.
  Title
Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane.
  Journal
Biochem. Mol. Biol. Int. 31 (1993) 823-32.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:8839453]
  Authors
Vermeulen WP, Briede JJ, Roelofsen B.
  Title
Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity.
  Journal
Mol. Membr. Biol. 13 (1996) 95-102.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:9099684]
  Authors
Suzuki H, Kamakura M, Morii M, Takeguchi N.
  Title
The phospholipid flippase activity of gastric vesicles.
  Journal
J. Biol. Chem. 272 (1997) 10429-34.
  Organism
Mus musculus [GN:mmu]
Reference
4  [PMID:7971987]
  Authors
Auland ME, Roufogalis BD, Devaux PF, Zachowski A.
  Title
Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 10938-42.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:16452632]
  Authors
Alder-Baerens N, Lisman Q, Luong L, Pomorski T, Holthuis JC
  Title
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles.
  Journal
Mol. Biol. Cell. 17 (2006) 1632-42.
Reference
6  [PMID:20053675]
  Authors
Lopez-Marques RL, Poulsen LR, Hanisch S, Meffert K, Buch-Pedersen MJ, Jakobsen MK, Pomorski TG, Palmgren MG
  Title
Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA alpha-subunit.
  Journal
Mol. Biol. Cell. 21 (2010) 791-801.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system