KEGG   ENZYME: 3.6.3.1Help
Entry
EC 3.6.3.1                  Enzyme                                 

Name
phospholipid-translocating ATPase;
Mg2+-ATPase;
flippase;
aminophospholipid-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (phospholipid-flipping)
Reaction(IUBMB)
ATP + H2O + phospholipid[side 1] = ADP + phosphate + phospholipid[side 2] [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
phospholipid[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
phospholipid[side 2]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase').
Orthology
K01530  
phospholipid-translocating ATPase
K14802  
phospholipid-transporting ATPase
Genes
HSA: 
10079(ATP9A) 10396(ATP8A1) 148229(ATP8B3) 23200(ATP11B) 23250(ATP11A) 286410(ATP11C) 374868(ATP9B) 51761(ATP8A2) 5205(ATP8B1) 57194(ATP10A) 57198(ATP8B2) 57205(ATP10D) 79895(ATP8B4)
PTR: 
452677(ATP11A) 453268(ATP10A) 453422(ATP8B4) 455439(ATP8B1) 455484(ATP9B) 458341(ATP9A) 461189(ATP8A1) 461351(ATP10D) 465889(ATP11C) 467238(ATP8A2) 468652(ATP8B3) 469505(ATP8B2) 471016(ATP11B)
PPS: 
100967766(ATP8B4) 100972951(ATP8B2) 100973832(ATP8B1) 100975459(ATP8B3) 100977979(ATP10A) 100978328(ATP9B) 100979822(ATP10D) 100981064(ATP9A) 100985769(ATP11A) 100986009(ATP8A2) 100989463(ATP8A1) 100994939(ATP11B) 100995604(ATP11C)
GGO: 
101126258 101126969 101127464 101129100(ATP8B2) 101130545(ATP11C) 101130730(ATP8B4) 101133046(ATP8B3) 101133383(ATP10A) 101135145(ATP11A) 101138062(ATP10D) 101139526(ATP11B) 101142751(ATP8B1) 101147224(ATP9B)
PON: 
100171619(ATP8B4) 100435833(ATP9B) 100440505(ATP10A) 100441755(ATP8B3) 100446676(ATP8A1) 100448675(ATP11C) 100450195(ATP8B1) 100451934 100453547(ATP10D) 100460078(ATP8B2) 100461085(ATP11B)
MCC: 
695802(ATP11C) 695994(ATP8B1) 697957(ATP9B) 702630(ATP8A1) 704458(ATP10D) 708453(ATP11B) 709311(ATP8A2) 710250(ATP9A) 711435(ATP10A) 712589(ATP11A) 716570(ATP8B4) 716652(ATP8B2) 721348(ATP8B3)
MCF: 
101925402 102114806(ATP11A) 102116390(ATP11C) 102118254(ATP8B2) 102127028(ATP10A) 102127268(ATP10D) 102132865(ATP8B3) 102137184(ATP9B) 102138350(ATP8B1) 102139274(ATP8B4) 102139473(ATP9A) 102145170(ATP8A1) 102145479(ATP8A2)
MMU: 
11980(Atp8a1) 11981(Atp9a) 11982(Atp10a) 231287(Atp10d) 241633(Atp8b4) 320940(Atp11c) 50769(Atp8a2) 50770(Atp11a) 50771(Atp9b) 54667(Atp8b2) 54670(Atp8b1) 67331(Atp8b3) 76295(Atp11b)
RNO: 
289615(Atp8a1) 291411(Atp9b) 291555(Atp8b1) 299616(Atp8b3) 306600(Atp11a) 311396(Atp8b4) 317599(Atp11c) 360932(Atp10d) 361929(Atp11b) 365266(Atp10a) 685152 691889 84011(Atp9a)
CGE: 
100751265(Atp8b2) 100755398(Atp10d) 100756336(Atp11c) 100756975(Atp8a1) 100757984 100759968 100761170(Atp11a) 100763292(Atp8b1) 100763581(Atp8a2) 100765138(Atp9b) 100774607(Atp10a)
HGL: 
101699526(Atp9b) 101710735(Atp11a) 101712888(Atp8b4) 101715035(Atp8b1) 101716149(Atp10d) 101721324(Atp11c) 101721413(Atp9a) 101721856 101721978(Atp8a2) 101723336(Atp8b3) 101723838(Atp8b2) 101725306(Atp11b) 101725406(Atp8a1)
TUP: 
102469376(ATP11A) 102475250(ATP8B4) 102484095(ATP8B1) 102485526(ATP8B2) 102490800(ATP8B3) 102491504(ATP10D) 102493301(ATP9A) 102494521(ATP8A1) 102495181(ATP10A) 102496769(ATP8A2) 102497224(ATP11B)
CFA: 
100687016(ATP8A2) 476190(ATP8B1) 476992(ATP11A) 477265(ATP9A) 478644(ATP11B) 481066(ATP11C) 482134(ATP10D) 483926(ATP9B) 486036 487549(ATP8B4) 488691(ATP10A) 490447(ATP8B2) 607976(ATP8A1) 612245(ATP8B3)
AML: 
100464545(ATP9A) 100465107(ATP11B) 100465593(ATP8A1) 100465614 100466989(ATP11C) 100468066 100469171 100471522(ATP8B2) 100473489(ATP8B4) 100477848(ATP8A2) 100481501(ATP8B1) 100483547(ATP11A) 100483624
FCA: 
101080270(ATP9A) 101084112(ATP8B4) 101085594(ATP8A2) 101085949(ATP8B2) 101091868(ATP8A1) 101093440(ATP10A) 101097392(ATP10D) 101097781(ATP11A) 101099184(ATP8B3) 101099649(ATP11B) 101099786(ATP11C) 101101003(ATP8B1) 101101004(ATP9B)
BTA: 
100137953(ATP8B4) 317692(ATP8A1) 508723(ATP8A2) 510301(ATP9B) 510723(ATP10A) 512547(ATP11A) 516579(ATP9A) 529689(ATP11C) 536495(ATP10D) 536660 541187(ATP8B1) 614392(ATP11B) 785713(ATP8B2)
BOM: 
102267112(ATP8B1) 102273088(ATP8A1) 102274109(ATP11A) 102275579(ATP8B3) 102277314(ATP9A) 102277904 102283091(ATP11B) 102283926(ATP10A) 102284238(ATP11C) 102285765(ATP9B) 102286964(ATP8B2) 102287691(ATP8B4) 102288181(ATP10D)
PHD: 
102315710(ATP9B) 102316657(ATP8A1) 102317048(ATP10A) 102323992(ATP8B4) 102324376(ATP8B3) 102326120(ATP11A) 102334126(ATP11B) 102336225(ATP10D) 102341726(ATP8B1) 102342622(ATP8B2) 102342862(ATP8A2) 102344655(ATP11C)
CHX: 
102169281(ATP8B3) 102169720(ATP8B1) 102173860(ATP11A) 102175139(ATP9A) 102175374(ATP11C) 102176951(ATP8A1) 102177243(ATP8B4) 102178344(ATP10D) 102180093(ATP8B2) 102188453(ATP9B) 102190912(ATP11B) 102191462(ATP10A) 102191532(ATP8A2)
SSC: 
100136901(ATP9A) 100153006(ATP8B1) 100154720(ATP8B4) 100154901(ATP9B) 100158162(ATP10A) 100513137(ATP8B3) 100515393(ATP8A1) 100517341(ATP8B2) 100520087(ATP10D) 100523658(ATP11C) 100624673 100625134(ATP8A2) 100738314
CFR: 
102506116 102506670(ATP8B3) 102511701(ATP11C) 102513418(ATP8B1) 102514562(ATP11B) 102514997(ATP10D) 102516878(ATP9A) 102516996(ATP8A1) 102517778(ATP8B4) 102518000(ATP9B) 102518370(ATP10A) 102522523(ATP8B2) 102522954(ATP11A)
ECB: 
100052707(ATP9A) 100054112(ATP8B1) 100055432(ATP11C) 100059537(ATP8A2) 100061624(ATP10D) 100062211(ATP10A) 100062902(ATP8A1) 100065346(ATP9B) 100066562(ATP11B) 100066940(ATP11A) 100069998(ATP8B4) 100146926(ATP8B3) 100629225(ATP8B2)
MYB: 
102241136(ATP8B2) 102242688(ATP8A1) 102245482(ATP9B) 102246310(ATP8B4) 102246538(ATP9A) 102251532(ATP10D) 102252418(ATP8B1) 102253439(ATP11B) 102260200(ATP8B3) 102261343(ATP11C) 102263207(ATP8A2) 102263392(ATP11A)
MDO: 
100012603(ATP11C) 100016294(ATP8B1) 100018023(ATP8B3) 100019520(ATP10D) 100020493(ATP8B2) 100020627(ATP8A1) 100022587(ATP11A) 100022728(ATP9A) 100023022 100024643(ATP8A2) 100616715 100617055 100618061(ATP8B4)
SHR: 
100915222(ATP8B3) 100917108(ATP8A1) 100917244 100918632(ATP11B) 100921779(ATP11A) 100921902(ATP11C) 100922437(ATP8B1) 100924402(ATP8B2) 100926891(ATP9B) 100927847 100932995(ATP8B4) 100934378(ATP10D)
OAA: 
100073923 100074214(ATP10B) 100075863(ATP8B3) 100077977(ATP9A) 100078463 100078594(ATP11C) 100079760(ATP8B1) 100081427 100084825(ATP11A) 100089451(ATP8A1)
GGA: 
418685(ATP10A) 418749(ATP11A) 418936(ATP8A2) 419345(ATP9A) 420817(ATP9B) 422254(ATP11C) 422768(ATP10D) 422776(ATP8A1) 424964(ATP11B) 426857(ATP8B1) 428328(ATP8B3) 770035(ATP8B2)
MGP: 
TGU: 
100219227(ATP11B) 100219240(ATP8B2) 100220565(ATP8A2) 100220790(ATP8B1) 100220889(ATP11A) 100223014 100223812(ATP10A) 100224155(ATP9B) 100228586(ATP8A1) 100228886(ATP10D) 100229226(ATP9A)
FAB: 
101810545(ATP11C) 101810751(ATP11B) 101810902(ATP8B3) 101811109(ATP8A2) 101811423(ATP8B1) 101812034(ATP8A1) 101812745(ATP9B) 101814904(ATP9A) 101815983(ATP10D) 101816724(ATP10A) 101818211(ATP11A) 101821153(ATP8B2)
PHI: 
102101068(ATP10A) 102101248(ATP8B2) 102102103(ATP8B3) 102103842(ATP8A1) 102105284(ATP8A2) 102105351(ATP10D) 102108883(ATP9A) 102109610(ATP11C) 102111315(ATP11A) 102111642(ATP11B) 102113319(ATP9B) 102113467(ATP8B1)
APLA: 
101790964(ATP9A) 101791602(ATP11A) 101791790(ATP8B3) 101793669(ATP11B) 101794313(ATP9B) 101795223(ATP10A) 101796204 101796582 101799242(ATP11C) 101799384(ATP8A2) 101801741(ATP10D) 101802029(ATP8A1)
FPG: 
101910802 101911821(ATP8B3) 101913038(ATP9B) 101916078(ATP11B) 101917032(ATP11C) 101919027(ATP9A) 101919278(ATP10A) 101922803(ATP11A) 101923166(ATP10D) 101923260(ATP8B1) 101924039(ATP8A1) 101924949(ATP8B2)
FCH: 
102045913(ATP8B1) 102046707(ATP11A) 102047378(ATP9A) 102047521(ATP10A) 102048251(ATP11B) 102049838(ATP8A1) 102050149(ATP8B2) 102053221(ATP9B) 102053969(ATP8B3) 102054952(ATP11C) 102056359(ATP10D) 102056518(ATP8A2)
CLV: 
102083976(ATP8B3) 102086533(ATP11B) 102087502(ATP9A) 102090638(ATP10D) 102091646(ATP9B) 102094964(ATP11A) 102096479(ATP8A2) 102096539(ATP8B1) 102097439(ATP11C) 102097812(ATP10A) 102098463(ATP8A1)
ASN: 
102367742(ATP10A) 102373780(ATP11B) 102375504(ATP11A) 102376473(ATP8A1) 102377086(ATP8B1) 102377908(ATP8B2) 102379283(ATP8B3) 102380315(ATP10D) 102381830(ATP11C) 102382122(ATP9A) 102386600
PSS: 
102443448(ATP8A1) 102443594(ATP8B3) 102444118(ATP11A) 102446401(ATP10D) 102451838(ATP9B) 102452052(ATP8A2) 102453318(ATP10A) 102461705(ATP8B1) 102462311(ATP8B4) 102462934(ATP9A) 102463452(ATP11B) 102463788(ATP11C)
ACS: 
XLA: 
380518(atp11c)
XTR: 
100135380(atp11b) 100145017(atp8b4) 100485769(atp11a) 100490666(atp8b3) 100494528(atp10a) 100497381(atp9b) 100498300(atp11c) 101730757(atp8a2) 394841(atp9a) 594952(atp8b1) 733571(atp8a1)
DRE: 
100148342(atp8b1) 100329583 100330943(atp8a2) 100537096 368385(atp11c) 559291 562925(atp11a) 563932(atp10a) 567172(atp10a) 568160(atp9b) 571658(atp10d)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346182(ATP11C) 102347589(ATP11B) 102350555(ATP9B) 102351430(ATP11A) 102353398(ATP9A) 102353470(ATP8B4) 102354183 102354915(ATP8A2) 102355245(ATP10D) 102361071 102361964 102362406(ATP8B2) 102366329(ATP8B1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409192(GB10030) 413138(GB10456) 413328 552074(GB15437)
NVI: 
TCA: 
655986(Atp9b) 656757 658562(ATP8B2) 663307
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG11664(Cbr-tat-2) CBG11754(Cbr-tat-1) CBG16933(Cbr-tat-5) CBG18322(Cbr-tat-3)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s11630g(POPTRDRAFT_751108) POPTR_0001s34920g(POPTRDRAFT_797847) POPTR_0006s10970g(POPTRDRAFT_560995) POPTR_0008s01520g(POPTRDRAFT_765109) POPTR_0010s04910g(POPTRDRAFT_230718) POPTR_0010s25250g(POPTRDRAFT_725358) POPTR_0012s05450g(POPTRDRAFT_421641) POPTR_0017s04520g POPTR_299001 POPTR_592804 POPTR_741584
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0277600-00(Os01g0277600) Os03t0334700-01(Os03g0334700) Os05t0100600-01(Os05g0100600) Os06t0565900-01(Os06g0565900) Os10t0412000-01(Os10g0412000) Os11t0446500-00(Os11g0446500)
BDI: 
SBI: 
SORBI_01g022190(SORBIDRAFT_01g022190) SORBI_01g036200(SORBIDRAFT_01g036200) SORBI_01g036650(SORBIDRAFT_01g036650) SORBI_02g037875(SORBIDRAFT_02g037875) SORBI_03g011170(SORBIDRAFT_03g011170) SORBI_07g019240(SORBIDRAFT_07g019240) SORBI_09g000210(SORBIDRAFT_09g000210) SORBI_10g014640(SORBIDRAFT_10g014640) SORBI_10g022370(SORBIDRAFT_10g022370)
ZMA: 
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YAL026C(DRS2) YDR093W(DNF2) YER166W(DNF1) YIL048W(NEO1) YMR162C(DNF3)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A03670(NCAS0A03670) NCAS_0A13450(NCAS0A13450) NCAS_0D00950(NCAS0D00950) NCAS_0F01710(NCAS0F01710)
NDI: 
NDAI_0A02590(NDAI0A02590) NDAI_0C06110(NDAI0C06110) NDAI_0H02560(NDAI0H02560) NDAI_0H03190(NDAI0H03190)
TPF: 
TPHA_0B03400(TPHA0B03400) TPHA_0C01120(TPHA0C01120) TPHA_0C04600(TPHA0C04600) TPHA_0H02720(TPHA0H02720) TPHA_0K00950(TPHA0K00950)
TBL: 
TBLA_0A04620(TBLA0A04620) TBLA_0B09370(TBLA0B09370) TBLA_0F03810(TBLA0F03810) TBLA_0J01460(TBLA0J01460)
TDL: 
TDEL_0A01330(TDEL0A01330) TDEL_0G02790(TDEL0G02790) TDEL_0H02100(TDEL0H02100) TDEL_0H03790(TDEL0H03790)
KAF: 
KAFR_0B02510(KAFR0B02510) KAFR_0B04880(KAFR0B04880) KAFR_0I01860(KAFR0I01860) KAFR_0K00630(KAFR0K00630)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1364054(AO090011000813) AOR_1_152094(AO090120000088) AOR_1_2132154(AO090003001200) AOR_1_278114(AO090701000148)
ANG: 
ANI_1_1060104(An12g08790) ANI_1_2000184(An04g06840) ANI_1_558104(An12g04500)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_049640(21.t00048) EHI_096620(6.t00057) EHI_140130(8.t00012) EHI_141350(309.t00009) EHI_168260(191.t00016)
EDI: 
ACAN: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_III007600(17.m07665) BBOV_IV001830(21.m02975) BBOV_IV003630(21.m02979)
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
PHATRDRAFT_52368(ATPase-P4)
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb11.02.0850 Tb927.4.1510(Tb04.2L9.780) Tb927.6.3550(Tb06.2N9.170)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:8136700]
  Authors
Morris MB, Auland ME, Xu YH, Roufogalis BD.
  Title
Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane.
  Journal
Biochem. Mol. Biol. Int. 31 (1993) 823-32.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:8839453]
  Authors
Vermeulen WP, Briede JJ, Roelofsen B.
  Title
Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity.
  Journal
Mol. Membr. Biol. 13 (1996) 95-102.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:9099684]
  Authors
Suzuki H, Kamakura M, Morii M, Takeguchi N.
  Title
The phospholipid flippase activity of gastric vesicles.
  Journal
J. Biol. Chem. 272 (1997) 10429-34.
  Organism
Mus musculus [GN:mmu]
Reference
4  [PMID:7971987]
  Authors
Auland ME, Roufogalis BD, Devaux PF, Zachowski A.
  Title
Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 10938-42.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:16452632]
  Authors
Alder-Baerens N, Lisman Q, Luong L, Pomorski T, Holthuis JC
  Title
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles.
  Journal
Mol. Biol. Cell. 17 (2006) 1632-42.
Reference
6  [PMID:20053675]
  Authors
Lopez-Marques RL, Poulsen LR, Hanisch S, Meffert K, Buch-Pedersen MJ, Jakobsen MK, Pomorski TG, Palmgren MG
  Title
Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA alpha-subunit.
  Journal
Mol. Biol. Cell. 21 (2010) 791-801.
  Organism
Arabidopsis thaliana [GN:ath]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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