KEGG   ENZYME: 3.6.3.10Help
Entry
EC 3.6.3.10                 Enzyme                                 
Name
H+/K+-exchanging ATPase;
H+-K+-ATPase;
H,K-ATPase;
(K+ + H+)-ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (H+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + H+in + K+out = ADP + phosphate + H+out + K+in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
H+ [CPD:C00080];
K+ [CPD:C00238]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
H+ [CPD:C00080];
K+ [CPD:C00238]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.
Pathway
Oxidative phosphorylation
Orthology
K01541  
H+/K+-exchanging ATPase
K01542  
H+/K+-exchanging ATPase alpha polypeptide
K01543  
H+/K+-exchanging ATPase beta polypeptide
K01544  
non-gastric H+/K+-exchanging ATPase
Genes
HSA: 
479(ATP12A) 495(ATP4A) 496(ATP4B)
PTR: 
452489(ATP12A) 738405(ATP4B) 747915(ATP4A)
PPS: 
100979788(ATP12A) 100980523(ATP4A) 100991047(ATP4B)
GGO: 
101138827(ATP4A) 101141471(ATP4B) 101142592(ATP12A)
PON: 
100435235(ATP4A) 100459814(ATP4B)
MCC: 
MMU: 
11944(Atp4a) 11945(Atp4b) 192113(Atp12a)
RNO: 
171028(Atp12a) 24216(Atp4a) 24217(Atp4b)
CFA: 
403820(ATP12A) 404020(ATP4B) 431686(ATP4A)
AML: 
FCA: 
101091583(ATP12A) 101092078(ATP4B) 101100771(ATP4A)
BTA: 
521163(ATP4A) 530703(ATP12A) 614308(ATP4B)
SSC: 
100521921(ATP12A) 397131(ATP4B) 397552(ATP4A)
ECB: 
100052912(ATP12A) 100069135 100147108
MDO: 
100013166 100016220 100022970(ATP12A) 100022999 100023029
SHR: 
100914456 100914816(ATP4B) 100926385(ATP4A)
OAA: 
100092554
GGA: 
386581(ATP4B) 419743(ATP12A)
MGP: 
100548075 100550873
TGU: 
100219097 100230086 100230444(ATP4B)
ACS: 
100560046 100563553
XLA: 
379283(atp12a-b) 379459(atp4b) 380512(atp12a-a) 399450(atp4a) 733327
XTR: 
100488221 448282(atp4b) 594945(atp12a)
PIC: 
PICST_60178(PMR2)
AFM: 
AFUA_5G00730
CCI: 
CC1G_09151
SPN: 
SP_2101
SPD: 
SPD_1927
SPR: 
spr1911(ctpC)
SPV: 
SPH_2289
MMA: 
MM_0910
SSO: 
SSO2896
 » show all
Taxonomy
Reference
1  [PMID:5682852]
  Authors
Sachs G, Collier RH, Shoemaker RL, Hirschowitz BI.
  Title
The energy source for gastric H+ secretion.
  Journal
Biochim. Biophys. Acta. 162 (1968) 210-9.
  Organism
frog
Reference
2  [PMID:2552824]
  Authors
Hersey SJ, Perez A, Matheravidathu S, Sachs G.
  Title
Gastric H+-K+-ATPase in situ: evidence for compartmentalization.
  Journal
Am. J. Physiol. 257 (1989) G539-47.
  Organism
Oryctolagus cuniculus
Reference
3  [PMID:2158765]
  Authors
Rabon EC, Reuben MA.
  Title
The mechanism and structure of the gastric H,K-ATPase.
  Journal
Annu. Rev. Physiol. 52 (1990) 321-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system