| Entry |
|
|---|
| Name |
H+/K+-exchanging ATPase;
H+-K+-ATPase;
H,K-ATPase;
(K+ + H+)-ATPase |
|---|
| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of
substances
 |
|---|
| Sysname |
ATP phosphohydrolase (H+/K+-exchanging) |
|---|
| Reaction(IUBMB) |
ATP + H2O + H+in + K+out = ADP + phosphate + H+out + K+in
[RN:R00086] |
|---|
| Reaction(KEGG) |
R00086
 |
|---|
| Substrate |
ATP [CPD:C00002];
H2O [CPD:C00001];
H+ [CPD:C00080];
K+ [CPD:C00238] |
|---|
| Product |
ADP [CPD:C00008];
phosphate [CPD:C00009];
H+ [CPD:C00080];
K+ [CPD:C00238] |
|---|
| Cofactor |
H+ [CPD:C00080];
Potassium [CPD:C00238] |
|---|
| Comment |
A P-type ATPase that undergoes covalent phosphorylation during the
transport cycle. A gastric mucosal enzyme that catalyses the efflux
of one H+ and the influx of one K+ per ATP hydrolysed. |
|---|
| Pathway |
PATH: ec00190 Oxidative phosphorylation |
|---|
| Orthology |
KO: K01541 H+/K+-exchanging ATPase
KO: K01542 H+/K+-exchanging ATPase alpha polypeptide
KO: K01543 H+/K+-exchanging ATPase beta polypeptide
KO: K01544 non-gastric H+/K+-exchanging ATPase |
|---|
| Genes |
HSA: 479(ATP12A) 495(ATP4A) 496(ATP4B)
PTR: 452489(ATP12A) 738405(ATP4B)
MCC: 698222(ATP4B) 718753(ATP4A) 721488
MMU: 11944(Atp4a) 11945(Atp4b) 192113(Atp12a)
RNO: 171028(Atp12a) 24216(Atp4a) 24217(Atp4b)
CFA: 403820(ATP12A) 404020(ATP4B) 431686(ATP4A)
BTA: 521163(ATP4A) 530703(ATP12A) 614308(ATP4B)
SSC: 397131(ATP4B) 397552(ATP4A)
ECB: 100052912 100069135
MDO: 100013166 100016220 100022970 100022999 100023029
OAA: 100092554
GGA: 386581(ATP4B) 419743(RCJMB04_25f22)
TGU: 100230086
XLA: 379283(atp12ab) 379459 380512(atp12aa)
XTR: 448282(atp4b)
PIC: PICST_60178(PMR2)
CAL: CaO19.4328(CCC2)
AFM: AFUA_5G00730
SPN: SP_2101
SPD: SPD_1927
SPR: spr1911(ctpC)
SPV: SPH_2289
MMA: MM_0910
SSO: SSO2896
 |
|---|
| Structures |
PDB: 1IWC 1IWF 3IXZ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5682852]
Sachs G, Collier RH, Shoemaker RL, Hirschowitz BI.
The energy source for gastric H+ secretion.
Biochim. Biophys. Acta. 162 (1968) 210-9.
frog |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2552824]
Hersey SJ, Perez A, Matheravidathu S, Sachs G.
Gastric H+-K+-ATPase in situ: evidence for compartmentalization.
Am. J. Physiol. 257 (1989) G539-47.
Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:2158765]
Rabon EC, Reuben MA.
The mechanism and structure of the gastric H,K-ATPase.
Annu. Rev. Physiol. 52 (1990) 321-44. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.6.3.10
IUBMB Enzyme Nomenclature: 3.6.3.10
ExPASy - ENZYME nomenclature database: 3.6.3.10
BRENDA, the Enzyme Database: 3.6.3.10 |
|---|
