KEGG   ENZYME: 3.6.3.49Help
Entry
EC 3.6.3.49                 Enzyme                                 

Name
channel-conductance-controlling ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (channel-conductance-controlling)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
History
EC 3.6.3.49 created 2000
Orthology
K05031  
cystic fibrosis transmembrane conductance regulator
Genes
HSA: 
1080(CFTR)
PTR: 
463674(CFTR)
PPS: 
100989405(CFTR)
GGO: 
101132066(CFTR)
PON: 
100137035(CFTR)
MCC: 
574346(CFTR)
MCF: 
102130331(CFTR)
MMU: 
12638(Cftr)
RNO: 
24255(Cftr)
CGE: 
100754506(Cftr)
HGL: 
101709472(Cftr)
TUP: 
102490714(CFTR)
CFA: 
492302(CFTR)
AML: 
FCA: 
492308(CFTR)
PTG: 
102956215(CFTR)
BTA: 
281067(CFTR)
BOM: 
PHD: 
102332344(CFTR)
CHX: 
102179446(CFTR)
SSC: 
403154(CFTR)
CFR: 
102505598(CFTR)
BACU: 
103004581(CFTR)
LVE: 
103088529(CFTR)
ECB: 
100071259(CFTR)
MYB: 
102257625(CFTR)
MYD: 
102773631(CFTR)
PALE: 
102884577(CFTR)
MDO: 
100014119(CFTR)
SHR: 
100919086(CFTR)
OAA: 
100078764(CFTR)
GGA: 
100049619(CFTR)
MGP: 
TGU: 
100222243(CFTR)
FAB: 
101809710(CFTR)
PHI: 
102114534(CFTR)
APLA: 
101803386(CFTR)
FPG: 
101921929(CFTR)
FCH: 
102050923(CFTR)
CLV: 
102089481(CFTR)
ASN: 
102369471(CFTR)
AMJ: 
102563163(CFTR)
PSS: 
102447829(CFTR)
CMY: 
102936252(CFTR)
ACS: 
PBI: 
103057487(CFTR)
XTR: 
100486085(cftr)
DRE: 
559080(cftr)
TRU: 
492310(cftr)
MZE: 
OLA: 
XMA: 
LCM: 
102346483(CFTR)
CMK: 
103179362(cftr)
 » show all
Taxonomy
Reference
1  [PMID:9147660]
  Authors
Chen M, Zhang JT.
  Title
Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes.
  Journal
Mol. Membr. Biol. 13 (1996) 33-40.
  Organism
Homo sapiens, Oryctolagus cuniculus
Reference
2  [PMID:9013845]
  Authors
Tusnady GE, Bakos E, Varadi A, Sarkadi B.
  Title
Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters.
  Journal
FEBS. Lett. 402 (1997) 1-3.
  Organism
Homo sapiens
Reference
3  [PMID:9922375]
  Authors
Sheppard DN, Welsh MJ.
  Title
Structure and function of the CFTR chloride channel.
  Journal
Physiol. Rev. 79 (1999) S23-45.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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