KEGG   ENZYME: 3.6.3.9Help
Entry
EC 3.6.3.9                  Enzyme                                 
Name
Na+/K+-exchanging ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
Orthology
K01539  
sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 
476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 
456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 
100968564(ATP1A2) 100968910(ATP1A4) 100992562(ATP1A1)
GGO: 
101132606(ATP1A2) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 
100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
MCC: 
706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MMU: 
11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 
24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CFA: 
403992(ATP1A1) 488636(ATP1A2) 488637(ATP1A4) 612463(ATP1A3)
AML: 
FCA: 
101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4)
BTA: 
282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
SSC: 
100157711(ATP1A4) 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
ECB: 
100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
MDO: 
100010919 100029759(ATP1A2)
SHR: 
100914130 100922123(ATP1A3) 100928210
GGA: 
396467(ATP1A3) 396468(ATP1A2) 396530(ATP1A1)
MGP: 
100303690(ATP1A1)
ACS: 
100564542
XLA: 
380132(atp1a3) 398583(atp1a1-b) 398752(atp1a2) 399285(atp1a1-a)
XTR: 
100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 
64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1) 64616(atp1a1b)
TRU: 
101065136 101066343
OLA: 
101156309 101161996 101168472
BFO: 
BRAFLDRAFT_57104
CIN: 
100175029
SPU: 
404637
DME: 
Dmel_CG3701 Dmel_CG5670(Atpalpha)
DPO: 
Dpse_GA17624 Dpse_GA19046
DAN: 
Dana_GF13018 Dana_GF17998
DER: 
Dere_GG21788 Dere_GG24266
DPE: 
Dper_GL16920 Dper_GL24291
DSE: 
Dsec_GM15055
DSI: 
Dsim_GD19388
DWI: 
Dwil_GK11950 Dwil_GK17901
DYA: 
Dyak_GE11863 Dyak_GE25699
DGR: 
Dgri_GH20530 Dgri_GH21713
DMO: 
Dmoj_GI10755 Dmoj_GI18976
DVI: 
Dvir_GJ10697 Dvir_GJ22439
AGA: 
AgaP_AGAP002858
AAG: 
AaeL_AAEL012062
CQU: 
CpipJ_CPIJ005966
NVI: 
100122763(NV13508)
TCA: 
663833
API: 
100167886
PHU: 
Phum_PHUM336910 Phum_PHUM361900
ISC: 
IscW_ISCW002538
CEL: 
CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2)
CBR: 
CBG01656 CBG09434(Cbr-eat-6)
BMY: 
Bm1_51740
TSP: 
Tsp_04833
SMM: 
Smp_015020(SNaK1)
NVE: 
NEMVE_v1g186331 NEMVE_v1g245490
HMG: 
100209869(atp1a3)
TAD: 
TRIADDRAFT_63163
AQU: 
100634317
ZMA: 
100382948
CRE: 
CHLREDRAFT_187139
VCN: 
VOLCADRAFT_78789
OLU: 
OSTLU_48492
OTA: 
Ot01g00900
PIC: 
PICST_60178(PMR2)
PAN: 
PODANSg1282 PODANSg8259
TTT: 
THITE_125028 THITE_2118086
MGR: 
MGG_10027
FGR: 
FG04512.1
NHE: 
NECHADRAFT_103674 NECHADRAFT_71444
VAL: 
VDBG_02452
SSL: 
SS1G_00628
BFU: 
BC1G_04401 BC1G_06532
NFI: 
NFIA_025530 NFIA_041430
AFM: 
AFUA_7G04570
AOR: 
AOR_1_264174(AO090005000141)
ANG: 
ANI_1_1014084(An09g00930)
AFV: 
AFLA_073840 AFLA_125660
ACT: 
ACLA_004560 ACLA_006260
PCS: 
Pc21g08760
PBL: 
PAAG_04243
ABE: 
ARB_01038 ARB_06970
TVE: 
TRV_00354 TRV_02788
PNO: 
SNOG_00706
PTE: 
PTT_00480
ZTR: 
MYCGRDRAFT_70478
LBC: 
LACBIDRAFT_186573 LACBIDRAFT_232929
PGR: 
PGTG_03133
MBR: 
MONBRDRAFT_35405
NGR: 
NAEGRDRAFT_258 NAEGRDRAFT_30663
DPP: 
DICPUDRAFT_47441 DICPUDRAFT_90846
TET: 
TTHERM_00049030 TTHERM_00061570 TTHERM_00245100 TTHERM_00268190 TTHERM_00355800 TTHERM_00365390 TTHERM_00365450 TTHERM_00420900 TTHERM_00643550 TTHERM_00700900 TTHERM_00989440 TTHERM_01149330 TTHERM_01150350
PTM: 
GSPATT00000481001 GSPATT00015953001 GSPATT00030416001 GSPATT00032952001 PTMB.66
GLA: 
GL50803_96670
PIF: 
PITG_14384
TCX: 
Tcr_1065
DAR: 
Daro_1851
GUR: 
Gura_3300
GEO: 
Geob_1849
PCA: 
Pcar_2279
SAT: 
SYN_02485
MAC: 
MA4378
MBA: 
Mbar_A1053
MMA: 
MM_1069
MMAZ: 
MmTuc01_1100
MBU: 
Mbur_0431
MZH: 
Mzhil_1847
MPY: 
Mpsy_0778
 » show all
Taxonomy
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim. Biophys. Acta. 23 (1957) 394-401.
  Organism
Carcinus maenas
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J. Biol. Chem. 240 (1965) 1437-45.
  Organism
Cavia porcellus
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS. Lett. 268 (1990) 314-24.
Other DBs
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IUBMB Enzyme Nomenclature: 
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BRENDA, the Enzyme Database: 
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