KEGG   ENZYME: 3.6.3.9Help
Entry
EC 3.6.3.9                  Enzyme                                 

Name
Na+/K+-exchanging ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
History
EC 3.6.3.9 created 1984 as EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001
Orthology
K01539  
sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 
476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 
456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 
100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 
101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 
100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 
100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 
706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 
102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CJC: 
100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
MMU: 
11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 
24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 
100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
HGL: 
101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
TUP: 
102475448(ATP1A3) 102483255(ATP1A4) 102483989 102483994(ATP1A1)
CFA: 
403992(ATP1A1) 488636(ATP1A2) 488637(ATP1A4) 612463(ATP1A3)
AML: 
UMR: 
103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
FCA: 
101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785(ATP1A2)
PTG: 
BTA: 
282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 
102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
PHD: 
102341310(ATP1A1) 102343479(ATP1A2) 102343841(ATP1A4) 102344375(ATP1A3)
CHX: 
102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 
101103751(ATP1A3) 101118148(ATP1A2) 101118398(ATP1A4) 443381(ATP1A1)
SSC: 
100157711(ATP1A4) 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 
102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
BACU: 
102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 
103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
ECB: 
100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
MYB: 
102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 
102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770178 102770472(ATP1A1)
PALE: 
102884868(ATP1A4) 102885125(ATP1A2) 102888359(ATP1A1) 102893697(ATP1A3)
MDO: 
100010919(ATP1A1) 100029759(ATP1A2)
SHR: 
GGA: 
396467(ATP1A3) 396468(ATP1A2) 396530(ATP1A1)
MGP: 
100303690(ATP1A1)
APLA: 
TGU: 
100190719(ATP1A1)
FAB: 
PHI: 
FPG: 
101914787(ATP1A1) 101915017(ATP1A2)
FCH: 
102050259(ATP1A1) 102059303(ATP1A2)
CLV: 
102092496(ATP1A1) 102093141(ATP1A2)
ASN: 
102371189(ATP1A2) 102372830(ATP1A1) 102376674(ATP1A3)
AMJ: 
102566197(ATP1A2) 102567591(ATP1A1) 102575084(ATP1A3)
PSS: 
102460622(ATP1A1) 102462326(ATP1A2)
CMY: 
102936217(ATP1A1) 102938341(ATP1A2) 102943620
ACS: 
PBI: 
103051176(ATP1A2) 103054113(ATP1A1) 103058247(ATP1A3) 103063371
XLA: 
380132(atp1a3) 398583(atp1a1-b) 398752(atp1a2) 399285(atp1a1-a)
XTR: 
100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 
64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2)
CBR: 
CBG01656 CBG09434(Cbr-eat-6)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
Smp_015020(SNaK1)
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
CVR: 
CCP: 
PIC: 
CTEN: 
PAN: 
TTT: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
AFM: 
AOR: 
AOR_1_264174(AO090005000141)
ANG: 
ANI_1_1014084(An09g00930)
AFV: 
ACT: 
NFI: 
PCS: 
PBL: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CPUT: 
SLA: 
PFP: 
PGR: 
MLR: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
TET: 
PTM: 
PIF: 
NGR: 
GLA: 
TCX: 
DAR: 
GUR: 
GEO: 
PCA: 
SAT: 
MAC: 
MBA: 
MMA: 
MMAZ: 
MBU: 
MZH: 
MPY: 
 » show all
Taxonomy
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim. Biophys. Acta. 23 (1957) 394-401.
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J. Biol. Chem. 240 (1965) 1437-45.
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS. Lett. 268 (1990) 314-24.
Other DBs
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