KEGG   ENZYME: 3.7.1.2Help
Entry
EC 3.7.1.2                  Enzyme                                 
Name fumarylacetoacetase;
beta-diketonase;
fumarylacetoacetate hydrolase
Class Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname 4-fumarylacetoacetate fumarylhydrolase
Reaction(IUBMB) 4-fumarylacetoacetate + H2O = acetoacetate + fumarate [RN:R01364]
Reaction(KEGG) R01364
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Substrate 4-fumarylacetoacetate [CPD:C01061];
H2O [CPD:C00001]
Product acetoacetate [CPD:C00164];
fumarate [CPD:C00122]
Comment Also acts on other 3,5- and 2,4-dioxo acids.
Pathway PATH: ec00350  Tyrosine metabolism
PATH: ec00643  Styrene degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K01555  fumarylacetoacetase
Genes HSA: 2184(FAH)
PTR: 467738(FAH)
MCC: 712716(FAH)
MMU: 14085(Fah)
RNO: 29383(Fah)
CFA: 610140(FAH)
BTA: 508724(FAH)
SSC: 100152004
ECB: 100049804
MDO: 100013682
OAA: 100083425
GGA: 415482(FAH)
TGU: 100225499
XLA: 380150(fah)
XTR: 100135385
DRE: 322372(fah)
BFO: BRAFLDRAFT_281736
SPU: 582493
DME: Dmel_CG14993(Faa)
DPO: Dpse_GA13410
DAN: Dana_GF24408
DER: Dere_GG14224
DPE: Dper_GL16789
DSE: Dsec_GM14018
DSI: Dsim_GD13297
DYA: Dyak_GE20652
DGR: Dgri_GH17004
DMO: Dmoj_GI11418
AGA: AgaP_AGAP005865
AAG: AaeL_AAEL011973
CQU: CpipJ_CPIJ018102
AME: 552210
NVI: 100117860
TCA: 663294
ISC: IscW_ISCW020196
CEL: K10C2.4(fumarylacetoacetase)
CBR: CBG05065
NVE: NEMVE_v1g241460
HMG: 100212015
TAD: TRIADDRAFT_49733
ATH: AT1G12050
POP: POPTR_652386
RCU: RCOM_0670030
OSA: 4328618(Os02g0196800)
ZMA: 100192485 100192910
PPP: PHYPADRAFT_137922 PHYPADRAFT_190260
CRE: CHLREDRAFT_122609
CME: CMQ154C
NCR: NCU05537
PAN: PODANSg2765
MGR: MGG_00317
FGR: FG02851.1 FG06449.1
ANI: AN1896.2
AFM: AFUA_2G04230
AOR: AO090003000211
ANG: An11g02170
AFV: AFLA_036080
PCS: Pc12g09030
NFI: NFIA_081020
CIM: CIMG_01313
URE: UREG_01239
SSL: SS1G_06879
BFU: BC1G_14722
UMA: UM01423.1
MBR: MONBRDRAFT_34985
DDI: DDB_0231609(fah)
TET: TTHERM_00044990
PTM: GSPATT00029655001
PTI: PHATRDRAFT_50281
TPS: THAPSDRAFT_33724
PAE: PA2008(fahA)
PAU: PA14_38530(fahA)
PAP: PSPA7_3281(fahA)
PAG: PLES_33151(fahA)
PPU: PP_4620
PPF: Pput_4480
PPG: PputGB1_4604
PPW: PputW619_0818
PST: PSPTO_3550(fahA)
PSB: Psyr_3325
PSP: PSPPH_3245(fahA)
PFL: PFL_0968(fahA)
PFO: Pfl01_0911
PFS: PFLU1026
PEN: PSEEN4611(fah)
AVN: Avin_50190(fahA)
PCR: Pcryo_1558
PRW: PsycPRwf_1038
ACI: ACIAD3577 ACIAD3578
ACB: A1S_3414
ABM: ABSDF3593(hmgB)
ABY: ABAYE0068(hmgB)
ABC: ACICU_03610
ABN: AB57_3867(fahA)
ABB: ABBFA_000069(fahA)
PHA: PSHAa2169(fah)
PAT: Patl_1123
MMW: Mmwyl1_2735
RSO: RS01759(RSp0690)
RPI: Rpic_4535
RPF: Rpic12D_3463
REU: Reut_A1794 Reut_B3924
REH: H16_B1670(fahA)
RME: Rmet_4375
CTI: RALTA_B0413 RALTA_B1480(fahA)
BMA: BMA2055(fahA)
BMV: BMASAVP1_A0857(fahA)
BML: BMA10229_A2689(fahA)
BMN: BMA10247_1920(fahA)
BPS: BPSL2738
BPM: BURPS1710b_3227(fahA)
BPL: BURPS1106A_3212(fahA)
BPD: BURPS668_3173(fahA)
BPR: GBP346_A3352(fahA)
BTE: BTH_I1398(fahA)
BVI: Bcep1808_0758
BUR: Bcep18194_A3914 Bcep18194_C7461
BCN: Bcen_0338 Bcen_5612
BCH: Bcen2424_0821 Bcen2424_5976
BCM: Bcenmc03_0790
BCJ: BCAL3183
BAM: Bamb_0702
BAC: BamMC406_0719
BMU: Bmul_2562
BMJ: BMULJ_00676(fah)
BXE: Bxe_A2724 Bxe_A3899 Bxe_B2528 Bxe_C0995
BPH: Bphy_2434
BPY: Bphyt_0781 Bphyt_2380
BGL: bglu_2g18610
BPE: BP3135(fahA)
BPA: BPP0806(fahA)
BBR: BB0891(fahA)
BPT: Bpet4017(fahA)
BAV: BAV0527(fah)
POL: Bpro_2996
PNA: Pnap_1118
AAV: Aave_0256
DAC: Daci_2036
VAP: Vapar_0100 Vapar_0287
CTT: CtCNB1_3782
LCH: Lcho_0432 Lcho_0709 Lcho_2044 Lcho_4303
BJA: bll0342(fah)
BRA: BRADO6964(fahA)
BBT: BBta_0567(fahA)
RPA: RPA4670(fahA)
RPB: RPB_0909
RPC: RPC_0892
RPD: RPD_1020
RPE: RPE_0913
RPT: Rpal_5151
NHA: Nham_0926
XAU: Xaut_3332
MET: M446_2533
MPO: Mpop_1045
MNO: Mnod_1192
CAK: Caul_0412
SIL: SPO0685(hmgB)
SIT: TM1040_2622
JAN: Jann_1436
RDE: RD1_3653(fahA)
PDE: Pden_3548
DSH: Dshi_3811
NAR: Saro_2463
SWI: Swit_3863
ACR: Acry_1081
MAB: MAB_0888c
NFA: nfa53050
RHA: RHA1_ro02309
RER: RER_47200
ROP: ROP_20210
SCO: SCO4580(SCD16A.03)
SMA: SAV_4858(fahA)
SGR: SGR_2967
KSE: Ksed_10630
NCA: Noca_0655
TCU: Tcur_0706
SRO: Sros_8847
FRE: Franean1_3789
NML: Namu_0529
SEN: SACE_0136(fahA) SACE_3942(fahA)
SVI: Svir_07020
AMI: Amir_0090
STP: Strop_4256
SAQ: Sare_4686
CAI: Caci_1686
AFO: Afer_0803
ABA: Acid345_2007
ACA: ACP_0315(fahA)
SUS: Acid_6516
SRU: SRU_2360(fahA)
DFE: Dfer_2109
GFO: GFO_2263
FJO: Fjoh_3411
FPS: FP0680(fahA)
FBA: FIC_00442
RBI: RB2501_15884
GAU: GAU_0438
CAU: Caur_2512
CAG: Cagg_3806
CHL: Chy400_2710
HAU: Haur_4887
Taxonomy
Structures PDB: 1HYO  1QCN  1QCO  1QQJ  2HZY  
Reference
  Authors
  Title

  Journal
 1  [PMID:18117010]
CONNORS WM, STOTZ E
The purification and properties of a triacetic acid-hydrolyzing
enzyme.
J. Biol. Chem. 178 (1949) 881-90.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13319328]
EDWARDS SW, KNOX WE.
Homogentisate metabolism:  the isomerization of maleylacetoacetate
by an enzyme which requires glutathione.
J. Biol. Chem. 220 (1956) 79-91.
Bos taurus [GN:bta], Rattus norvegicus [GN:rno]
Reference
  Authors
  Title
  Journal
 3  [PMID:18880754]
MEISTER A, GREENSTEIN JP
Enzymatic hydrolysis of 2,4-diketo acids.
J. Biol. Chem. 175 (1948) 573-88.
Other DBs ExplorEnz - The Enzyme Database: 3.7.1.2
IUBMB Enzyme Nomenclature: 3.7.1.2
ExPASy - ENZYME nomenclature database: 3.7.1.2
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.2
BRENDA, the Enzyme Database: 3.7.1.2
CAS: 9032-59-1
DBGET integrated database retrieval system