KEGG   ENZYME: 3.7.1.3Help
Entry
EC 3.7.1.3                  Enzyme                                 
Name kynureninase
Class Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname L-kynurenine hydrolase
Reaction(IUBMB) L-kynurenine + H2O = anthranilate + L-alanine [RN:R00987]
Reaction(KEGG) R00987;
(other) R02668 R03936
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Substrate L-kynurenine [CPD:C00328];
H2O [CPD:C00001]
Product anthranilate [CPD:C00108];
L-alanine [CPD:C00041]
Cofactor Pyridoxal phosphate [CPD:C00018]
Comment A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine
and some other (3-arylcarbonyl)-alanines.
Pathway PATH: ec00380  Tryptophan metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01556  kynureninase
Genes HSA: 8942(KYNU)
PTR: 459641(KYNU)
MCC: 719227
MMU: 70789(Kynu)
RNO: 116682(Kynu)
CFA: 483907(KYNU)
BTA: 520327(KYNU)
ECB: 100057449
MDO: 100017601
OAA: 100085483
GGA: 424302(KYNU)
TGU: 100226180
DRE: 572053
BFO: BRAFLDRAFT_283826
CIN: 100176031
SPU: 580378
ISC: IscW_ISCW005441 IscW_ISCW012597
CEL: C15H9.7(kynureninase)
CBR: CBG14833
BMY: Bm1_17865
SMM: Smp_023470
NVE: NEMVE_v1g235255
HMG: 100205580
TAD: TRIADDRAFT_28018
CME: CMF128C
SCE: YLR231C(BNA5)
AGO: AGOS_AGL098W
LTH: KLTH0F08052g
DHA: DEHA0G14949g
PIC: PICST_55542(BNA5)
PPA: PAS_chr3_1194
VPO: Kpol_1029p21
LEL: LELG_00640
ZRO: ZYRO0C04708g
CAL: CaO19.394
CTP: CTRG_03162
CDU: CD36_08000
YLI: YALI0B22902g
NCR: NCU09183
PAN: PODANSg2503 PODANSg5014
MGR: MGG_10969
FGR: FG04131.1 FG04829.1
ANI: AN1857.2 AN5952.2
AFM: AFUA_2G10360 AFUA_4G09840
AOR: AO090003001247 AO090011000602
ANG: An04g07200 An16g04630
AFV: AFLA_025850 AFLA_044260
PCS: Pc22g11870 Pc22g20570
NFI: NFIA_085760 NFIA_106210
CIM: CIMG_04357
URE: UREG_01602
SSL: SS1G_08223
BFU: BC1G_03468
CNE: CNC03980
CNB: CNBC3200
LBC: LACBIDRAFT_305901
UMA: UM04846.1
MBR: MONBRDRAFT_26773
DDI: DDB_0231361(kynU)
TBR: Tb09.160.0810
TCR: 503881.10
LMA: LmjF26.2240
LIF: LinJ26.2210
LBZ: LbrM26_V2.2160
XCC: XCC1553
XCB: XC_2681
XCA: xccb100_2707
XCV: XCV1642
XAC: XAC1601
XOO: XOO2428
XOM: XOO_2305
XOP: PXO_00758(kynU)
SML: Smlt3160
SMT: Smal_2598
PAE: PA2080(kynU)
PAU: PA14_37610
PAP: PSPA7_3208(kynU)
PAG: PLES_32411
PFL: PFL_0762(kynU)
PFS: PFLU5188
ACB: A1S_1957
ABM: ABSDF1703
ABY: ABAYE1599
ABC: ACICU_02077
ABN: AB57_2299(kynU)
ABB: ABBFA_001492(kynU)
SWD: Swoo_1405
ILO: IL2179
PAT: Patl_2921
AMC: MADE_02408
KKO: Kkor_0377
RSO: RSc0759
RPI: Rpic_0709
RPF: Rpic12D_0775
REU: Reut_A0808
REH: H16_A2815(kynU)
RME: Rmet_2650 Rmet_5192
CTI: RALTA_A2304
BMA: BMA0352
BMV: BMASAVP1_A0651(kynU)
BML: BMA10229_A2486(kynU)
BMN: BMA10247_0099(kynU)
BPS: BPSL0847
BPM: BURPS1710b_1054(kynU)
BPL: BURPS1106A_0896(kynU)
BPD: BURPS668_0893(kynU)
BPR: GBP346_A0820(kynU)
BTE: BTH_I0710(kynU)
BVI: Bcep1808_2700
BUR: Bcep18194_A5909 Bcep18194_C7639
BCN: Bcen_1967
BCH: Bcen2424_2578
BCM: Bcenmc03_2602
BCJ: BCAL2791
BAM: Bamb_2626
BAC: BamMC406_2497
BMU: Bmul_0719
BMJ: BMULJ_02541(kynU)
BXE: Bxe_A0734
BPH: Bphy_0507
BPY: Bphyt_1473 Bphyt_3228
BGL: bglu_1g29390
BPE: BP0553
BPA: BPP0242
BBR: BB0246
BPT: Bpet4463(kynU)
BAV: BAV0201
POL: Bpro_3589
PNA: Pnap_3019
AAV: Aave_1156
DAC: Daci_2164
DIA: Dtpsy_2439
VAP: Vapar_1448
CTT: CtCNB1_3652
LIP: LI0415
ADE: Adeh_3164
ACP: A2cp1_3355
ANK: AnaeK_3281
MXA: MXAN_0917(kynU)
SCL: sce1905 sce3005
MLO: mll0621
ARA: Arad_8495(kynU)
BJA: blr4159
BRA: BRADO1528
BBT: BBta_6512
CAK: Caul_5245
SIL: SPO2824(kynU)
SIT: TM1040_2225
RSP: RSP_0242
RSH: Rsph17029_1885
RSQ: Rsph17025_1584
RSK: RSKD131_1566
JAN: Jann_2085
RDE: RD1_3643(kynU)
PDE: Pden_2620
DSH: Dshi_1230
MMR: Mmar10_1471
SAL: Sala_1389
SWI: Swit_0679
ELI: ELI_14150
RCE: RC1_2772(kynU)
BAN: BA2753(kynU)
BAR: GBAA2753(kynU)
BAA: BA_3279
BAT: BAS2567
BAH: BAMEG_1842(kynU)
BAI: BAA_2817(kynU)
BCE: BC2759
BCA: BCE_2787(kynU)
BCZ: BCZK2488(kynU)
BCR: BCAH187_A2808(kynU)
BCB: BCB4264_A2766(kynU)
BCU: BCAH820_2761(kynU)
BCG: BCG9842_B2526(kynU)
BCQ: BCQ_2600(kynU)
BCX: BCA_2837(kynU)
BCY: Bcer98_1903
BTK: BT9727_2523(kynU)
BTL: BALH_2478(kynU)
BWE: BcerKBAB4_2559
BCL: ABC0651
OIH: OB0756
GTN: GTNG_3166
ESI: Exig_0182
EAT: EAT1b_1503
BBE: BBR47_16300
AOE: Clos_2733
RHA: RHA1_ro01800
RER: RER_54640
ROP: ROP_14740
SCO: SCO3645(SCH10.23c)
SMA: SAV_4527
SGR: SGR_3413
CMI: CMM_0492
CMS: CMS_0247
ART: Arth_1432
AAU: AAur_2057
ACH: Achl_1437
RSA: RSal33209_2068
KSE: Ksed_02180
NCA: Noca_3396
TFU: Tfu_0922
SRO: Sros_6950 Sros_9107
NML: Namu_0589
KRA: Krad_1865
SEN: SACE_0279 SACE_4057
AMI: Amir_0265 Amir_2025
STP: Strop_3530
SAQ: Sare_3905
CAI: Caci_1353 Caci_3511
CCA: CCA00568(kynU)
CFE: CF0434(kynU)
ABA: Acid345_0680
ACA: ACP_0174
SUS: Acid_2875
CHU: CHU_3381(iscS)
CPI: Cpin_1147
GFO: GFO_2720
FJO: Fjoh_0506
FPS: FP2215(kynU)
RBI: RB2501_02490
GAU: GAU_3277(kynU)
RRS: RoseRS_4470
RCA: Rcas_0822
CAU: Caur_1258
CAG: Cagg_2100
CHL: Chy400_1378
DRA: DR_A0338
DGE: Dgeo_1534
DDR: Deide_2p01450
HAL: VNG0915G(hakA)
HSL: OE2332F(hakA)
Taxonomy
Structures PDB: 1QZ9  2HZP  3E9K  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13129248]
JAKOBY WB, BONNER DM.
Kynureninase from Neurospora: purification and properties.
J. Biol. Chem. 205 (1953) 699-707.
Neurospora crassa [GN:ncr]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13129249]
JAKOBY WB, BONNER DM.
Kynureninase from Neurospora: interaction of enzyme with substrates,
coenzyme, and amines.
J. Biol. Chem. 205 (1953) 709-15.
Neurospora crassa [GN:ncr]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:13032082]
KNOX WE.
The relation of liver kynureninase to tryptophan metabolism in
pyridoxine deficiency.
Biochem. J. 53 (1953) 379-85.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title
  Journal
 4
Wiss, O. and Weber, F.
Die Reindarstellung der Kynureninase.
Hoppe-Seyler's Z. Physiol. Chem. 304 (1956) 232-240.
Other DBs ExplorEnz - The Enzyme Database: 3.7.1.3
IUBMB Enzyme Nomenclature: 3.7.1.3
ExPASy - ENZYME nomenclature database: 3.7.1.3
BRENDA, the Enzyme Database: 3.7.1.3
CAS: 9024-78-6
DBGET integrated database retrieval system