| Entry |
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| Name |
kynureninase
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
L-kynurenine hydrolase
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| Reaction(IUBMB) |
L-kynurenine + H2O = anthranilate + L-alanine [RN: R00987]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines.
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| Pathway |
| Tryptophan metabolism | | Metabolic pathways |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | CME: | | SCE: | | AGO: | | ERC: | | LTH: | | PPA: | | VPO: | | ZRO: | | TPF: | | TDL: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | CNE: | | CNB: | | CGI: | | PPL: | | LBC: | | CCI: | | SCM: | | UMA: | | PGR: | | MBR: | | NGR: | | DDI: | | DPP: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PFL: | | PFS: | | PFC: | | ACD: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | SWD: | | ILO: | | PAT: | | PSM: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | GAG: | | GNI: | | GPS: | | NHL: | | HEL: | | KKO: | | PSE: | | RSO: | | RSC: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BPT: | | BAV: | | AXY: | | AKA: | | POL: | | PNA: | | AAV: | | DIA: | | AAA: | | ACK: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | RTA: | | CFU: | | TIN: | | THI: | | RGE: | | LIP: | | LIR: | | ADE: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | MLO: | | MCI: | | MOP: | | MAM: | | ARA: | | RTR: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | AOL: | | CAK: | | SIL: | | SIT: | | RSP: | | RSH: | | RSQ: | | RSK: | | RCP: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | PSF: | | PGA: | | PGL: | | OAT: | | OAR: | | MMR: | | SAL: | | SWI: | | ELI: | | RCE: | | AZL: | | ALI: | | PGV: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BCL: | | BPF: | | BMQ: | | BMD: | | OIH: | | GTN: | | HHD: | | ESI: | | EAT: | | EAN: | | BBE: | | SIV: | | AOE: | | SAY: | | SAP: | | NBR: | | RHA: | | RER: | | ROP: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | CMI: | | CMS: | | CMC: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KSE: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | SRO: | | FRI: | | NML: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | AYM: | | CPM: | | CCA: | | CFE: | | ABA: | | ACA: | | ACM: | | SUS: | | CTM: | | SRM: | | CPI: | | NKO: | | SCN: | | HHY: | | SGN: | | CMR: | | BBD: | | EVI: | | CHU: | | SLI: | | RSI: | | FLI: | | EOL: | | FAE: | | MTT: | | GFO: | | FJO: | | FPS: | | FBR: | | FCO: | | FIN: | | RBI: | | ZPR: | | CAT: | | FBC: | | CAO: | | CLY: | | KDI: | | LAN: | | ZGA: | | MRS: | | ASL: | | PTQ: | | NDO: | | POM: | | FTE: | | OHO: | | GAU: | | TLI: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | CAP: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | TRA: | | MRB: | | MSV: | | HAL: | | HSL: | | HVO: | | HME: | | HBO: | | HRU: | | HAH: | |
» show all
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| Reference |
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| Authors |
JAKOBY WB, BONNER DM. |
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| Title |
Kynureninase from Neurospora: purification and properties. |
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| Journal |
J. Biol. Chem. 205 (1953) 699-707. |
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| Organism |
Neurospora crassa [GN: ncr] |
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| Reference |
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| Authors |
JAKOBY WB, BONNER DM. |
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| Title |
Kynureninase from Neurospora: interaction of enzyme with substrates, coenzyme, and amines. |
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| Journal |
J. Biol. Chem. 205 (1953) 709-15. |
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| Organism |
Neurospora crassa [GN: ncr] |
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| Reference |
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| Authors |
KNOX WE. |
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| Title |
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. |
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| Journal |
Biochem. J. 53 (1953) 379-85. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
4 |
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| Authors |
Wiss, O. and Weber, F. |
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| Title |
Die Reindarstellung der Kynureninase. |
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| Journal |
Hoppe-Seyler's Z. Physiol. Chem. 304 (1956) 232-240. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9024-78-6 |
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