| Entry |
|
|---|
| Name |
2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
HOHPDA hydrolase |
|---|
| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
 |
|---|
| Sysname |
2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase |
|---|
| Reaction(IUBMB) |
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate +
2-oxopent-4-enoate [RN:R02606] |
|---|
| Reaction(KEGG) |
R02606;
(other) R05359 R05360 R05361
 |
|---|
| Substrate |
2,6-dioxo-6-phenylhexa-3-enoate [CPD:C01273];
H2O [CPD:C00001] |
|---|
| Product |
benzoate [CPD:C00180];
2-oxopent-4-enoate [CPD:C00596] |
|---|
| Comment |
Cleaves the products from biphenol, 3-isopropylcatechol and
3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol
1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the
breakdown of biphenyl-related compounds by Pseudomonas sp. |
|---|
| Pathway |
PATH: ec00621 Biphenyl degradation
PATH: ec00628 Fluorene degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K10222 2,6-dioxo-6-phenylhexa-3-enoate hydrolase |
|---|
| Genes |
REH: H16_B0600(bphD)
BXE: Bxe_C1186(bphD)
PNA: Pnap_4141
RHA: RHA1_ro10136(bphD1)
 |
|---|
| Structures |
PDB: 1C4X 1J1I 2OG1 2VF2 2WUD 2WUE 2WUF 2WUG |
|---|
Reference
Authors
Title
Journal
|
1
Omori, T., Sugimura, K., Ishigooka, H. and Minoda, Y.
Purification and some properties of a
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme
from Pseudomonas cruciviae S93 B1 involved in the degradation of
biphenyl.
Agric. Biol. Chem. 50 (1986) 931-937. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.7.1.8
IUBMB Enzyme Nomenclature: 3.7.1.8
ExPASy - ENZYME nomenclature database: 3.7.1.8
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.8
BRENDA, the Enzyme Database: 3.7.1.8
CAS: 102925-38-2 |
|---|
