KEGG   ENZYME: 3.7.1.8Help
Entry
EC 3.7.1.8                  Enzyme                                 

Name
2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
HOHPDA hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase
Reaction(IUBMB)
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate [RN:R02606]
Reaction(KEGG)
Substrate
2,6-dioxo-6-phenylhexa-3-enoate [CPD:C01273];
H2O [CPD:C00001]
Product
benzoate [CPD:C00180];
2-oxopent-4-enoate [CPD:C00596]
Comment
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
History
EC 3.7.1.8 created 1989
Pathway
Dioxin degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10222  
2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Genes
PSD: 
CYQ: 
CZA: 
BXE: 
Bxe_C1186(bphD)
PNA: 
ACK: 
Taxonomy
Reference
1
  Authors
Omori, T., Sugimura, K., Ishigooka, H. and Minoda, Y.
  Title
Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl.
  Journal
Agric. Biol. Chem. 50 (1986) 931-937.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
102925-38-2

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