KEGG   ENZYME: 3.7.1.9Help
Entry
EC 3.7.1.9                  Enzyme                                 

Name
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
2-hydroxymuconate-6-semialdehyde formylhydrolase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]
Reaction(KEGG)
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]
Comment
The enzyme is involved in the degradation of catechols.
History
EC 3.7.1.9 created 1990, modified 2013
Pathway
Benzoate degradation
Xylene degradation
Styrene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10216  
2-hydroxymuconate-semialdehyde hydrolase
Genes
PSC: 
MAD: 
HP15_4033(xylF)
RPI: 
RPF: 
REU: 
RME: 
BVI: 
BUR: 
AJS: 
VEI: 
CTT: 
ADN: 
ADK: 
MPT: 
LCH: 
AZO: 
azo1968(xylF)
DAR: 
TMZ: 
 » show all
Taxonomy
Reference
1  [PMID:4325686]
  Authors
Sala-Trepat JM, Evans WC.
  Title
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
  Journal
Eur. J. Biochem. 20 (1971) 400-13.
  Organism
Azotobacter sp.
Reference
2  [PMID:3481421]
  Authors
Harayama S, Rekik M, Wasserfallen A, Bairoch A.
  Title
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
  Journal
Mol. Gen. Genet. 210 (1987) 241-7.
  Organism
Escherichia coli [GN:eco]
Reference
3  [PMID:7890778]
  Authors
Diaz E, Timmis KN
  Title
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which  cleaves carbon-carbon bonds.
  Journal
J. Biol. Chem. 270 (1995) 6403-411.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
54004-61-4

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