KEGG   ENZYME: 3.8.1.6Help
Entry
EC 3.8.1.6                  Enzyme                                 

Name
4-chlorobenzoate dehalogenase;
halobenzoate dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
4-chlorobenzoate chlorohydrolase
Reaction(IUBMB)
4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride [RN:R01307]
Reaction(KEGG)
Substrate
4-chlorobenzoate [CPD:C02370];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
chloride [CPD:C00698]
Comment
Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate---CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase).
History
EC 3.8.1.6 created 1989, modified 1999
Reference
1  [PMID:6497878]
  Authors
Muller R, Thiele J, Klages U, Lingens F.
  Title
Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3.
  Journal
Biochem. Biophys. Res. Commun. 124 (1984) 178-82.
  Organism
Pseudomonas sp.
Reference
2  [PMID:18889931]
  Authors
HEPPEL LA, PORTERFIELD VT
  Title
Enzymatic dehalogenation of certain brominated and chlorinated compounds.
  Journal
J. Biol. Chem. 176 (1948) 763-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94047-11-7

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