KEGG   ENZYME: 4.1.1.1Help
Entry
EC 4.1.1.1                  Enzyme                                 
Name pyruvate decarboxylase;
alpha-carboxylase;
pyruvic decarboxylase;
alpha-ketoacid carboxylase;
2-oxo-acid carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname 2-oxo-acid carboxy-lyase (aldehyde-forming)
Reaction(IUBMB) a 2-oxo acid = an aldehyde + CO2 [RN:R00636]
Reaction(KEGG) R00636 > R00224;
(other) R00014 R00755
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Substrate 2-oxo acid [CPD:C00161]
Product aldehyde [CPD:C00071];
CO2 [CPD:C00011]
Cofactor Thiamin diphosphate [CPD:C00068]
Comment A thiamine-diphosphate protein. Also catalyses acyloin formation.
Pathway PATH: ec00010  Glycolysis / Gluconeogenesis
PATH: ec01100  Metabolic pathways
Orthology KO: K01568  pyruvate decarboxylase
Genes ATH: AT4G33070 AT5G01320 AT5G01330(PDC3)
OSA: 4324066(Os01g0160100) 4339066(Os05g0469600)
     4339068(Os05g0469800)
SCE: YDL080C(THI3) YGR087C(PDC6) YLR044C(PDC1)
AGO: AGOS_AAL073W AGOS_ACL134C AGOS_ADR254W
KLA: KLLA0E16357g
DHA: DEHA0D18381g DEHA0G19525g
PIC: PICST_64926(PDC1) PICST_86443(PDC2)
VPO: Kpol_1010p48
CAL: CaO19.10395
CGR: CAGL0L06842g CAGL0M07920g
YLI: YALI0D10131g
SPO: SPAC13A11.06 SPAC186.09 SPAC1F8.07c SPAC3G9.11c
NCR: NCU02397
FGR: FG09834.1
ANI: AN4888.2
AFM: AFUA_3G11070 AFUA_5G14810 AFUA_6G00750
AOR: AO090003000661 AO090038000139
ANG: An01g01590 An02g06820 An09g01030 An13g03320
NFI: NFIA_066190
SSL: SS1G_10985
BFU: BC1G_11347
CNE: CNJ00950
CNB: CNBJ2540
LBC: LACBIDRAFT_188370
UMA: UM03994.1
ABY: ABAYE1030
ABC: ACICU_02656
ABN: AB57_2877
CAC: CA_P0025(pdc)
NPU: Npun_F2126
RCI: RCIX1497(pdc)
Taxonomy
Structures PDB: 1PVD  1PYD  1QPB  1VC3  1ZPD  2VBI  2VJY  2VK1  2VK4  2VK8  
     2W93  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:12980978]
SINGER TP, PENSKY J.
Isolation and properties of the carboxylase of wheat germ.
J. Biol. Chem. 196 (1952) 375-88.
Triticum aestivum
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.1
IUBMB Enzyme Nomenclature: 4.1.1.1
ExPASy - ENZYME nomenclature database: 4.1.1.1
BRENDA, the Enzyme Database: 4.1.1.1
CAS: 9001-04-1
DBGET integrated database retrieval system