KEGG   ENZYME: 4.1.1.15Help
Entry
EC 4.1.1.15                 Enzyme                                 
Name glutamate decarboxylase;
L-glutamic acid decarboxylase;
L-glutamic decarboxylase;
cysteic acid decarboxylase;
L-glutamate alpha-decarboxylase;
aspartate 1-decarboxylase;
aspartic alpha-decarboxylase;
L-aspartate-alpha-decarboxylase;
gamma-glutamate decarboxylase;
L-glutamate 1-carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
Reaction(IUBMB) L-glutamate = 4-aminobutanoate + CO2 [RN:R00261]
Reaction(KEGG) R00261;
(other) R00489 R01682 R02466
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Substrate L-glutamate [CPD:C00025]
Product 4-aminobutanoate [CPD:C00334];
CO2 [CPD:C00011]
Cofactor Pyridoxal phosphate [CPD:C00018]
Comment A pyridoxal-phosphate protein. The brain enzyme also acts on
L-cysteate, 3-sulfino-L-alanine and L-aspartate.
Pathway PATH: ec00250  Alanine, aspartate and glutamate metabolism
PATH: ec00410  beta-Alanine metabolism
PATH: ec00430  Taurine and hypotaurine metabolism
PATH: ec00650  Butanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01580  glutamate decarboxylase
Genes HSA: 2571(GAD1) 2572(GAD2)
PTR: 466026(GAD2) 468557(GAD1)
MCC: 613029(GAD2) 613030(GAD1)
MMU: 14415(Gad1) 14417(Gad2)
RNO: 24379(Gad1) 24380(Gad2)
CFA: 478794(GAD1) 487107(GAD2)
BTA: 512459(GAD2) 517552(GAD1)
SSC: 396928(GAD1) 396929(GAD2)
ECB: 100052860 100055419
MDO: 100017915 100019319
OAA: 100075098 100077642
GGA: 395395(GAD2) 395743(GAD1)
TGU: 778442(GAD1) 778447(GAD1)
XLA: 378551(gad1-A)
XTR: 100145511
DRE: 378441(gad1)
BFO: BRAFLDRAFT_59477
CIN: 448951(gad)
SPU: 579659
DME: Dmel_CG14994(Gad1) Dmel_CG7811(b)
DPO: Dpse_GA13411(Dpse_Gad1) Dpse_GA20603
DAN: Dana_GF24407
AGA: AgaP_AGAP005866
AAG: AaeL_AAEL011981
AME: 408432
TCA: 663315
API: 100164132
CEL: Y37D8A.23(unc-25)
CBR: CBG15755
ATH: AT2G02000(GAD3) AT3G17760(GAD5) AT5G17330(GAD)
POP: POPTR_648236
OSA: 4332184(Os03g0236200) 4333932(Os03g0720300)
     4335973(Os04g0447400) 4335977(Os04g0447800)
     4345787(Os08g0465800)
PPP: PHYPADRAFT_105373
OLU: OSTLU_36228
CME: CMF072C
SCE: YMR250W(GAD1)
KLA: KLLA0C14432g
PIC: PICST_40180(DCE1) PICST_55334(GAD2) PICST_87778(DPL1)
YLI: YALI0F08415g
NCR: NCU06803
MGR: MGG_02378 MGG_02817
FGR: FG01572.1
ANI: AN5447.2
AFM: AFUA_3G11120 AFUA_6G13490 AFUA_8G06020
AOR: AO090003000666 AO090005000539 AO090103000342
ANG: An02g06860 An08g08840 An15g04770
NFI: NFIA_059440
CNE: CNH03700
UMA: UM02125.1
DDI: DDB_0231439(gadB) DDB_0231446(gadA)
TET: TTHERM_00289080
ECO: b1493(gadB) b3517(gadA)
ECJ: JW1488(gadB) JW3485(gadA)
ECD: ECDH10B_1624(gadB) ECDH10B_3694(gadA)
EBW: BWG_1314(gadB) BWG_3206(gadA)
ECE: Z2215(gadB) Z4930(gadA)
ECS: ECs2098 ECs4397
ECF: ECH74115_2106(gadA) ECH74115_4879(gadB)
ETW: ECSP_1978(gadB) ECSP_4507(gadA)
ECG: E2348C_1620(gadB) E2348C_3759(gadA)
ECC: c1922(gadB) c4328(gadA)
ECI: UTI89_C1707(gadB) UTI89_C4049(gadA)
ECP: ECP_1489 ECP_3616
ECV: APECO1_2931(gadB) APECO1_621(gadA)
ECW: EcE24377A_1682(gadB) EcE24377A_4005(gadA)
ECX: EcHS_A1578(gadB) EcHS_A3720(gadA)
ECM: EcSMS35_1680(gadA) EcSMS35_3820(gadB)
ECY: ECSE_1583 ECSE_3786
ECL: EcolC_0200 EcolC_2164
ECK: EC55989_1625(gadB) EC55989_3962(gadA)
ECQ: ECED1_1639(gadB) ECED1_4195(gadA)
ECR: ECIAI1_1503(gadB) ECIAI1_3667(gadA)
ECT: ECIAI39_1758(gadB) ECIAI39_4020(gadA)
ECZ: ECS88_1581(gadB) ECS88_3930(gadA)
EUM: ECUMN_1747(gadB) ECUMN_4018(gadA)
ELF: LF82_0785(gadA) LF82_0786(gadB)
EBL: B21_01464(gadB) B21_03318(gadA)
EBD: ECBD_0222 ECBD_2146
EBR: ECB_01451(gadB) ECB_03365(gadA)
EFE: EFER_1575(gadB)
YEN: YE3693(gadA)
SFL: SF1734(gadB) SF3594(gadA)
SFX: S1867(gadB) S4173(gadA)
SFV: SFV_1730(gadB) SFV_3989(gadA)
SSN: SSON_1631(gadB) SSON_3569(gadA)
SBO: SBO_1563(gadB) SBO_3516(gadA)
SBC: SbBS512_E1756(gadB)
SDY: SDY_1615(gadB)
PMR: PMI1407(gadB)
EIC: NT01EI_0906
VCH: VC1149
VCO: VC0395_A0719
VCJ: VCD_003193
VVU: VV1_2824
VVY: VV1442
VPA: VP1237
VHA: VIBHAR_03063
VEX: VEA_003759
VFI: VF_0892 VF_1064(gadA)
VFM: VFMJ11_1137
VSA: VSAL_I1197(gadB)
PPR: PBPRA1498
SDN: Sden_2434
SAZ: Sama_1200
SPL: Spea_2953
SHN: Shewana3_2686
SHL: Shal_3043
SWD: Swoo_4739
ILO: IL2256(gadB)
CPS: CPS_1007
PHA: PSHAa2293
PAT: Patl_3931
MAQ: Maqu_3584
FTU: FTT_1722c(gad)
FTF: FTF1722c(gad)
FTW: FTW_0076
FTL: FTL_1862 FTL_1863
FTN: FTN_1701
FPH: Fphi_0903
HCH: HCH_00996
AHA: AHA_3494
ASA: ASA_0823
REU: Reut_A1624
RME: Rmet_0460 Rmet_1766
BXE: Bxe_A3826 Bxe_C0551
BBR: BB2658
BAV: BAV2797(gadA2)
GSU: GSU1707
GME: Gmet_1644
GLO: Glov_0959
PPD: Ppro_0931
DDS: Ddes_0045
DSA: Desal_3551
LIP: LI0261(gad)
DPS: DP0385
DOL: Dole_0831
DAT: HRM2_37530
SAT: SYN_00664
BME: BMEII0910 BMEII0911
BMF: BAB2_0865 BAB2_0866
BMC: BAbS19_II07990 BAbS19_II08000
BMT: BSUIS_B0344
BOV: BOV_A0309
BCA: BCE_2691
LMO: lmo0447 lmo2363 lmo2434
LMF: LMOf2365_2334(gadB) LMOf2365_2405(gadG)
LMH: LMHCC_0240
LIN: lin2463 lin2528
LWE: lwe2381(gadB)
LLA: L123581(gadB)
LLM: llmg_1179(gadB)
LPL: lp_3420(gadB)
LBR: LVIS_0079 LVIS_1847
CPE: CPE2058
CPF: CPF_2315
CPR: CPR_2029
CBO: CBO1917(gadA)
CBA: CLB_1854
CBH: CLC_1861
CBY: CLM_2134
CBL: CLK_1372
CBB: CLD_2710
CBF: CLI_1981
MTU: Rv3432c(gadB)
MTC: MT3538(gadB)
MRA: MRA_3473(gadB)
MTF: TBFG_13469
MBO: Mb3462c(gadB)
MBB: BCG_3498c(gadB)
MBT: JTY_3498(gadB)
MPA: MAP4257(gadB)
MAV: MAV_4373
MSM: MSMEG_1574
MUL: MUL_0878(gadB)
MVA: Mvan_1483
MGI: Mflv_4935
MAB: MAB_3740c
MMC: Mmcs_1145
MKM: Mkms_1162
MJL: Mjls_1172
MMI: MMAR_1118(gadB)
NFA: nfa35400
RHA: RHA1_ro06016(gadA)
RER: RER_35380
ROP: ROP_60750
SCO: SCO3416(gad)
SMA: SAV_3601(gadB1) SAV_4655(gadB2)
SGR: SGR_4077
AAU: AAur_3971
RSA: RSal33209_2078
FRA: Francci3_0181
FRE: Franean1_6904
FAL: FRAAL0380(gadB)
STP: Strop_4374
SAQ: Sare_2341
BTH: BT_2570
BFR: BF0454
BFS: BF0393(gadB)
BVU: BVU_3895
PDI: BDI_0821
MIN: Minf_0102(gadB)
AMU: Amuc_0372
SYN: sll1641(gad)
SYG: sync_0455
SYR: SynRCC307_1544(gadA)
MAR: MAE_41860
PMT: PMT0474(gadA)
PMF: P9303_18041
MAC: MA1949
MBA: Mbar_A2744
AFU: AF1323 AF2295
APE: APE_0412 APE_2267.1
PAS: Pars_1500
Taxonomy
Structures PDB: 1NWD  1PMM  1PMO  1XEY  2DGK  2DGL  2DGM  2OKJ  2OKK  3FZ6  
     3FZ7  3FZ8  3HBX  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:14081858]
AMBE L, SOHONIE K.
PURIFICATION AND PROPORTIES OF GLUTAMATE DECARBOXYLASE FROM FIELD
BEAN (DOLICHOS LABLAB).
Enzymologia. 26 (1963) 98-107.
Dolichos lablab
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4937550]
Nakano Y, Kitaoka S.
L-aspartate  -decarboxylase in a cell-free system from Escherichia
coli.
J. Biochem. (Tokyo). 70 (1971) 327-34.
Escherichia coli [GN:eco]
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:14841200]
ROBERTS E, FRANKEL S.
Further studies of glutamic acid decarboxylase in brain.
J. Biol. Chem. 190 (1951) 505-12.
Mus musculus [GN:mmu]
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.15
IUBMB Enzyme Nomenclature: 4.1.1.15
ExPASy - ENZYME nomenclature database: 4.1.1.15
BRENDA, the Enzyme Database: 4.1.1.15
CAS: 9024-58-2
DBGET integrated database retrieval system