KEGG   ENZYME: 4.1.1.18Help
Entry
EC 4.1.1.18                 Enzyme                                 
Name lysine decarboxylase;
L-lysine carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname L-lysine carboxy-lyase (cadaverine-forming)
Reaction(IUBMB) L-lysine = cadaverine + CO2 [RN:R00462]
Reaction(KEGG) R00462
Show
Substrate L-lysine [CPD:C00047]
Product cadaverine [CPD:C01672];
CO2 [CPD:C00011]
Cofactor Pyridoxal phosphate [CPD:C00018]
Comment A pyridoxal-phosphate protein. Also acts on 5-hydroxy-L-lysine.
Pathway PATH: ec00310  Lysine degradation
PATH: ec00960  Tropane, piperidine and pyridine alkaloid
               biosynthesis
PATH: ec01064  Biosynthesis of alkaloids derived from ornithine,
               lysine and nicotinic acid
PATH: ec01100  Metabolic pathways
Orthology KO: K01582  lysine decarboxylase
Genes PFA: PFD0285c
ECO: b0186(ldcC) b4131(cadA)
ECJ: JW0181(ldcC) JW4092(cadA)
ECD: ECDH10B_0166(ldcC) ECDH10B_4324(cadA)
EBW: BWG_0178(ldcC) BWG_3845(cadA)
ECE: Z0198(ldcC) Z5734(cadA)
ECS: ECs0188 ECs5113
ECF: ECH74115_0196(ldcC1) ECH74115_5647(ldcC2)
ETW: ECSP_0185(ldcC) ECSP_5231(cadA)
ECG: E2348C_0191(ldcC) E2348C_4458(cadA)
ECC: c0224(ldcC) c5140(cadA)
ECI: UTI89_C0201(ldcC) UTI89_C4728(cadA)
ECP: ECP_0194 ECP_0327 ECP_4375
ECV: APECO1_1801(ldcC) APECO1_2322(cadA)
ECW: EcE24377A_0190(ldcC) EcE24377A_4686
ECX: EcHS_A0188(ldcC1) EcHS_A4372(ldcC2)
ECM: EcSMS35_0197(ldcC1) EcSMS35_4600(ldcC2)
ECY: ECSE_0185 ECSE_4431
ECL: EcolC_3474 EcolC_3896
ECK: EC55989_0180(ldcC) EC55989_4624(cadA)
ECQ: ECED1_0192(ldcC) ECED1_4867(cadA)
ECR: ECIAI1_0186(ldcC) ECIAI1_4364(cadA)
ECT: ECIAI39_0189(ldcC) ECIAI39_4560(cadA)
ECZ: ECS88_0197(ldcC) ECS88_4635(cadA)
EUM: ECUMN_0183(ldcC) ECUMN_4665(cadA)
ELF: LF82_0254(cadA) LF82_1172(ldcC)
EBL: B21_00183(ldcC) B21_03964(cadA)
EBD: ECBD_3433 ECBD_3899
EBR: ECB_00184(ldcC) ECB_04002(cadA)
EFE: EFER_0209(ldcC) EFER_1900(cadA)
STY: STY0259(ldcC) STY2806(cadA)
STT: t0236(ldcC) t0297(cadA)
SPT: SPA0241(ldcC) SPA0307(cadA)
SEK: SSPA0233 SSPA0290
SPQ: SPAB_00299 SPAB_00369
SEI: SPC_0250(ldcC) SPC_1091(cadA)
SEC: SC0234(ldcC) SC2554(cadA)
SEH: SeHA_C0272 SeHA_C2822
SEE: SNSL254_A0256 SNSL254_A2760
SEW: SeSA_A0261 SeSA_A2801
SEA: SeAg_B0275 SeAg_B2718
SED: SeD_A0256(ldcC) SeD_A2935
SEG: SG0238(ldcC) SG2596(cadA)
SET: SEN0241(ldcC) SEN2539(cadA)
SES: SARI_00317 SARI_02768
STM: STM0234(ldcC) STM2559(cadA)
YEN: YE3267(ldcC)
SFL: SF0176(ldcC)
SFX: S0179(ldcC)
SFV: SFV_0169(ldcC)
SSN: SSON_0199(ldcC)
SBC: SbBS512_E0179(ldcC1)
ETA: ETA_09070(cadA)
ENT: Ent638_0724
ESA: ESA_03153
KPN: KPN_00199(ldcC) KPN_00500(cadA)
KPE: KPK_4092 KPK_4534(ldcC)
KPU: KP1_1043(ldcC) KP1_1410(cadA)
CKO: CKO_03180
SPE: Spro_3767 Spro_3773
EIC: NT01EI_0291 NT01EI_0859 NT01EI_3413
HSO: HS_1007(cadA)
VCH: VC0281
VCO: VC0395_A2658(cadA)
VCM: VCM66_0266(cadA)
VCJ: VCD_001340
VVU: VV1_2060
VVY: VV2381
VPA: VP2890
VHA: VIBHAR_00205
VFI: VF_2057(cadA)
VFM: VFMJ11_2162
VSA: VSAL_I2491(cadA)
PPF: Pput_1725
PEN: PSEEN3557
PMY: Pmen_2068
PHA: PSHAa1094
SDE: Sde_2967
FTU: FTT_0406(cadA)
FTF: FTF0406(cadA)
FTW: FTW_1667(cadA)
FTL: FTL_0476
FTH: FTH_0474(cadA)
FTA: FTA_0502
FTN: FTN_0504
FPH: Fphi_0341
AHA: AHA_1192
ASA: ASA_3141(cadA)
CVI: CV_1992
BVI: Bcep1808_2516 Bcep1808_5440
BUR: Bcep18194_A5763 Bcep18194_B2074
BCN: Bcen_1821 Bcen_4356
BCH: Bcen2424_2432 Bcen2424_4010
BAM: Bamb_2479 Bamb_4345
PNU: Pnuc_0651
RFR: Rfer_2126
POL: Bpro_2415
PNA: Pnap_2020
AAV: Aave_3257
VEI: Veis_3498
MFA: Mfla_0915
BHA: BH2640(cad)
BAN: BA4172(cad-2)
BAR: GBAA4172(cad-2)
BAA: BA_4643
BAT: BAS3874
BAH: BAMEG_4215(speA)
BAI: BAA_4197(speA)
BCA: BCE_0027(cad) BCE_4009(cad)
BCZ: BCZK0025(cad) BCZK3722(cad)
BCQ: BCQ_3751(cad)
BCY: Bcer98_2664
BTK: BT9727_0025(cad) BT9727_3707(cad)
BTL: BALH_0025(cad) BALH_3588
BWE: BcerKBAB4_3788
BCL: ABC0049
OIH: OB0035
GKA: GK1065(cad)
GTN: GTNG_0022 GTNG_0929
GWC: GWCH70_0963
SAB: SAB0430
SAA: SAUSA300_0458
LWE: lwe2643
SPN: SP_0916
SPD: SPD_0809(cad)
SPR: spr0816(cad)
CAC: CAC2338
CPE: CPE0549(dclY)
CPF: CPF_0528
CPR: CPR_0514
CTC: CTC02271
SWO: Swol_1357
DSY: DSY0236
TTE: TTE0093(ldcC) TTE1027(ldcC2)
CHY: CHY_0049(cad)
MTA: Moth_2265
MPA: MAP2144
MAV: MAV_2031
NFA: nfa6850
SCO: SCO7311(SC5F8.21c)
SYN: sll1683(cad)
SYW: SYNW0944(cad)
SYC: syc0823_d(ldcC)
SYF: Synpcc7942_0707
SYG: sync_1022(cad)
SYR: SynRCC307_0782
SYX: SynWH7803_1540
TEL: tlr1866
CYT: cce_4417
GVI: gll3487
ANA: all4887
PMA: Pro1112(ldcC)
PMM: PMM1084(cad)
PMT: PMT1066(cad)
PMN: PMN2A_0665
PMB: A9601_11901(cad)
PMC: P9515_11741(cad)
PMF: P9303_09861(cad)
PMG: P9301_11911(cad)
PMH: P9215_12201(cad)
PME: NATL1_14971(cad)
MEM: Memar_1269
Taxonomy
Structures PDB: 1T35  2PLJ  2PLK  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:16747785]
Gale EF, Epps HM.
Studies on bacterial amino-acid decarboxylases: 1. l(+)-lysine
decarboxylase.
Biochem. J. 38 (1944) 232-42.
Escherichia coli [GN:eco], Bacterium cardaveris
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:5762458]
Soda K, Moriguchi M.
Crystalline lysine decarboxylase.
Biochem. Biophys. Res. Commun. 34 (1969) 34-9.
Escherichia coli [GN:eco], Bacterium cardaveris
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.18
IUBMB Enzyme Nomenclature: 4.1.1.18
ExPASy - ENZYME nomenclature database: 4.1.1.18
BRENDA, the Enzyme Database: 4.1.1.18
CAS: 9024-76-4
DBGET integrated database retrieval system