KEGG   ENZYME: 4.1.1.22Help
Entry
EC 4.1.1.22                 Enzyme                                 
Name histidine decarboxylase;
L-histidine decarboxylase;
L-histidine carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname L-histidine carboxy-lyase (histamine-forming)
Reaction(IUBMB) L-histidine = histamine + CO2 [RN:R01167]
Reaction(KEGG) R01167
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Substrate L-histidine [CPD:C00135]
Product histamine [CPD:C00388];
CO2 [CPD:C00011]
Cofactor Pyridoxal phosphate [CPD:C00018];
Pyruvate [CPD:C00022]
Comment A pyridoxal-phosphate protein (in animal tissues). The bacterial
enzyme has a pyruvoyl residue as prosthetic group.
Pathway PATH: ec00340  Histidine metabolism
PATH: ec01065  Biosynthesis of alkaloids derived from histidine and
               purine
PATH: ec01100  Metabolic pathways
Orthology KO: K01590  histidine decarboxylase
Genes HSA: 3067(HDC)
PTR: 453425(HDC)
MCC: 715287(HDC)
MMU: 15186(Hdc)
RNO: 24443(Hdc)
CFA: 487551(HDC)
BTA: 515950(HDC)
SSC: 100156724
ECB: 100069939
MDO: 100031203
OAA: 100075371
GGA: 415454(HDC)
TGU: 100229258
DRE: 793609(hdc)
BFO: BRAFLDRAFT_234140
SPU: 548615(HDC)
DME: Dmel_CG3454(Hdc)
DPO: Dpse_GA17460
DAN: Dana_GF12784
DER: Dere_GG24151
DPE: Dper_GL11582
DSE: Dsec_GM21194
DSI: Dsim_GD10721
DYA: Dyak_GE19346
DGR: Dgri_GH21773
DMO: Dmoj_GI19320
AGA: AgaP_AGAP009001
CQU: CpipJ_CPIJ009897
AME: 408587
NVI: 100119434
TCA: 664593
ISC: IscW_ISCW012649
ATH: AT1G43710
POP: POPTR_559359 POPTR_816223
RCU: RCOM_1170790
VVI: 100258141
OSA: 4329593(Os02g0541300)
SBI: SORBI_04g022140(SORBIDRAFT_04g022140)
PPP: PHYPADRAFT_203066 PHYPADRAFT_208586
CRE: CHLREDRAFT_40158(SDC1)
PTI: PHATRDRAFT_2217
TPS: THAPSDRAFT_14389(HDC)
PAY: PAU_02211(hdc)
DDA: Dd703_0354
DDC: Dd586_3787
DZE: Dd1591_0272
VVU: VV2_1425
VHA: VIBHAR_02100
PEN: PSEEN2506(pmsA)
ACB: A1S_2379
ABY: ABAYE1098(hdc)
ABC: ACICU_02576(basG)
ABN: AB57_2808
ABB: ABBFA_001064
SWD: Swoo_0827
MCA: MCA2307
FTU: FTT_0664c(hdc)
FTF: FTF0664c(hdc)
FTW: FTW_1064
FTL: FTL_0938
FTH: FTH_0917(hdc)
FTA: FTA_0986
FTM: FTM_1194(hdc)
FTN: FTN_1019(hdc)
MMW: Mmwyl1_1637
ASA: ASA_4380(hdc)
SUN: SUN_0880
MLO: mlr6209
LRE: Lreu_1832
LRF: LAR_1717
CPE: CPE0390(dchS)
CPF: CPF_0378
CPR: CPR_0373
CTC: CTC01478
CTH: Cthe_3028
ELE: Elen_2499
GVI: gll2219
NPU: Npun_F1479
AMR: AM1_6060(hdc)
Taxonomy
Structures PDB: 1HQ6  1IBT  1IBU  1IBV  1IBW  1PYA  
Reference
  Authors
  Title

  Journal
 1  [PMID:16747851]
Epps HM
Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine
decarboxylase from Cl. welchii Type A.
Biochem. J. 39 (1945) 42-6.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:5681461]
Riley WD, Snell EE.
Histidine decarboxylase of Lactobacillus 30a. IV. The presence of
covalently bound pyruvate as the prosthetic group.
Biochemistry. 7 (1968) 3520-8.
Lactobacillus sp.
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:5216347]
Rosenthaler J, Guirard BM, Chang GW, Snell EE.
Purification and properties of histidine decarboxylase from
Lactobacillus 30a.
Proc. Natl. Acad. Sci. U. S. A. 54 (1965) 152-8.
Lactobacillus sp.
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.22
IUBMB Enzyme Nomenclature: 4.1.1.22
ExPASy - ENZYME nomenclature database: 4.1.1.22
BRENDA, the Enzyme Database: 4.1.1.22
CAS: 9024-61-7
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