KEGG   ENZYME: 4.1.1.25Help
Entry
EC 4.1.1.25                 Enzyme                                 
Name tyrosine decarboxylase;
L-tyrosine decarboxylase;
L-(-)-tyrosine apodecarboxylase;
L-tyrosine carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname L-tyrosine carboxy-lyase (tyramine-forming)
Reaction(IUBMB) L-tyrosine = tyramine + CO2 [RN:R00736]
Reaction(KEGG) R00736;
(other) R02080
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Substrate L-tyrosine [CPD:C00082]
Product tyramine [CPD:C00483];
CO2 [CPD:C00011]
Cofactor Pyridoxal phosphate [CPD:C00018]
Comment A pyridoxal-phosphate protein. The bacterial enzyme also acts on
3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
Pathway PATH: ec00350  Tyrosine metabolism
PATH: ec00950  Isoquinoline alkaloid biosynthesis
PATH: ec01063  Biosynthesis of alkaloids derived from shikimate
               pathway
PATH: ec01100  Metabolic pathways
Orthology KO: K01592  tyrosine decarboxylase
Genes ATH: AT4G28680
GBE: GbCGDNIH1_0718
MJA: MJ0050
MMP: MMP0131
MMQ: MmarC5_1547
MMZ: MmarC7_1130
MAE: Maeo_1008
MVN: Mevan_1136
MAC: MA0006
MBA: Mbar_A0977
MMA: MM_1317
MBU: Mbur_1732
MTP: Mthe_1636
MHU: Mhun_2611
MLA: Mlab_1545
MEM: Memar_1848
MBN: Mboo_2166
MPL: Mpal_2080
MTH: MTH1116
MST: Msp_0329(mfnA)
MSI: Msm_0987
MKA: MK1500
AFU: AF2004
HAL: VNG0327G(gadD)
HSL: OE1498R(mfnA)
HMA: rrnAC1798(gadD)
NPH: NP1194A(gadD)
HLA: Hlac_0591
PTO: PTO0150
PHO: PH0937
PAB: PAB1578
PFU: PF1159
TKO: TK1814
TGA: TGAM_2137(mfnA)
TSI: TSIB_0460
RCI: RCIX1543(mfnA)
APE: APE_0020.1
SMR: Smar_1292
HBU: Hbut_0224
Taxonomy
Structures PDB: 3F9T  
Reference
  Authors
  Title
  Journal
 1
McGilvery, R.W. and Cohen, P.P.
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
J. Biol. Chem. 174 (1948) 813-816.
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.25
IUBMB Enzyme Nomenclature: 4.1.1.25
ExPASy - ENZYME nomenclature database: 4.1.1.25
BRENDA, the Enzyme Database: 4.1.1.25
CAS: 9002-09-9
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