| Entry |
|
|---|
| Name |
oxaloacetate decarboxylase;
oxaloacetate beta-decarboxylase;
oxalacetic acid decarboxylase;
oxalate beta-decarboxylase;
oxaloacetate carboxy-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
|---|
| Sysname |
oxaloacetate carboxy-lyase (pyruvate-forming) |
|---|
| Reaction(IUBMB) |
oxaloacetate = pyruvate + CO2 [RN:R00217] |
|---|
| Reaction(KEGG) |
R00217;
(other) R00471 R00995
 |
|---|
| Substrate |
oxaloacetate [CPD:C00036] |
|---|
| Product |
pyruvate [CPD:C00022];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Manganese [CPD:C00034];
Biotin [CPD:C00120];
Sodium [CPD:C01330] |
|---|
| Inhibitor |
Acetyl-CoA [CPD:C00024] |
|---|
| Comment |
The enzyme from Klebsiella aerogenes is a biotinyl protein and also
decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is
accompanied by the extrusion of two sodium ions from cells. Some
animal enzymes require Mn2+. |
|---|
| Pathway |
PATH: ec00330 Arginine and proline metabolism
PATH: ec00620 Pyruvate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01571 oxaloacetate decarboxylase, alpha subunit
KO: K01572 oxaloacetate decarboxylase, beta subunit
KO: K01573 oxaloacetate decarboxylase, gamma subunit |
|---|
| Genes |
EFE: EFER_0028(oadB) EFER_0029(oadA) EFER_0030(oadG) EFER_3127
STY: STY0063(oadB) STY0064(oadA) STY0065(oadG) STY3531(oadB)
STY3532(oadA) STY3533(oadG)
STT: t0056(oadB) t0057(oadA) t0058(oadG) t3266(oadB) t3267(oadA)
t3268(oadG)
SPT: SPA0055(oadB) SPA0056(oadA) SPA0057(oadG) SPA3218(oadB)
SPA3219(oadA) SPA3220(oadG)
SEK: SSPA0051 SSPA0052(oadA) SSPA0054 SSPA3005 SSPA3007(oadG)
SPQ: SPAB_00065 SPAB_00066 SPAB_00067 SPAB_02755 SPAB_02756
SPAB_04177 SPAB_04178 SPAB_04179
SEI: SPC_0058(oadB) SPC_0059(oadA) SPC_0060(oadG) SPC_0762(oadG)
SPC_0763(oadA) SPC_0764(oadB) SPC_3421(oadB) SPC_3422(oadA)
SPC_3423(oadG)
SEC: SC0048(oadB) SC0049(oadA) SC0050(oag3) SC0764(oadG)
SC0765(oadA) SC0766(oadB) SC3289(oadB) SC3290(oadA)
SC3291(oadG)
SEH: SeHA_C0058 SeHA_C0059(oadA) SeHA_C0060 SeHA_C0893 SeHA_C0895
SeHA_C3649 SeHA_C3651
SEE: SNSL254_A0059 SNSL254_A0060(oadA) SNSL254_A0061 SNSL254_A0830
SNSL254_A3614 SNSL254_A3615(oadA) SNSL254_A3616
SEW: SeSA_A0060 SeSA_A0061(oadA) SeSA_A0062 SeSA_A3543
SeSA_A3544(oadA) SeSA_A3545
SEA: SeAg_B0061 SeAg_B0062(oadA) SeAg_B0063 SeAg_B0802 SeAg_B0804
SeAg_B3542 SeAg_B3543(oadA) SeAg_B3544
SED: SeD_A0059 SeD_A0060(oadA) SeD_A0061 SeD_A0861 SeD_A0862(oadA)
SeD_A3711 SeD_A3713
SEG: SG0057 SG0058 SG0059 SG0744(oadG2) SG3243
SET: SEN0055 SEN0056 SEN0057 SEN0711(dcoC) SEN3184 SEN3185 SEN3186
STM: STM0054 STM0055 STM0056 STM0766(dcoC) STM0768(dcoB)
STM3351(oadB) STM3352(oadA) STM3353(oadG)
KPN: KPN_00030(dcoB) KPN_00031 KPN_00032(dcoC) KPN_00765 KPN_00766
KPN_03637
KPE: KPK_0483(oadG_2) KPK_0484(oadA_2) KPK_0485(oadB_2)
KPK_4718(oadA_1)
KPU: KP1_4950(oadB) KP1_4952(oadA) KP1_4953(oadC)
HDU: HD0782(oadB) HD0783(oadA) HD0784(oadG)
HSO: HS_0201(oadG) HS_0202(oadA) HS_0203(oadB)
HSM: HSM_0069 HSM_0070 HSM_0071
PMU: PM1421 PM1422 PM1423
MSU: MS0038(oadB) MS0039(oadA) MS0040(oadG)
APL: APL_1375(oadG) APL_1376(oadA) APL_1377(oadB)
APJ: APJL_1393 APJL_1394(oadA) APJL_1395(oadB)
APA: APP7_1426 APP7_1427 APP7_1428
ASU: Asuc_0301 Asuc_0302 Asuc_0303
AAP: NT05HA_0821 NT05HA_0822 NT05HA_0823
AAT: D11S_1379 D11S_1380 D11S_1381
VCH: VC0549 VC0550 VC0551 VC0792 VC0793m(oadA-2) VC0794
VCO: VC0395_A0084 VC0395_A0085(oadA-1) VC0395_A0086(oadB-1)
VC0395_A0319(oadB-2) VC0395_A0320(oadA-2) VC0395_A0321
VCM: VCM66_0507 VCM66_0508(oadA-1) VCM66_0509(oadB-1)
VCM66_0750(oadB-2) VCM66_0751(oadA-2) VCM66_0752
VCJ: VCD_001054 VCD_001055 VCD_001056 VCD_003531 VCD_003532
VCD_003533
VVU: VV1_1600 VV1_1601 VV1_1602
VVY: VV2798 VV2799 VV2800
VPA: VP2543 VP2544 VP2545
VHA: VIBHAR_03490 VIBHAR_03491 VIBHAR_03492
VSP: VS_2568 VS_2569 VS_2570
VEX: VEA_002524 VEA_002525 VEA_002526
VFI: VF_0539(oadA) VF_0540(oadB) VF_2592(oadC)
VFM: VFMJ11_0550 VFMJ11_0551(oadA) VFMJ11_0552
VSA: VSAL_I0638 VSAL_I0639 VSAL_I0640
PPR: PBPRA2298 PBPRA2299 PBPRA3050 PBPRA3051 PBPRA3052
PAU: PA14_71720(oadA)
PAP: PSPA7_6223(oadA)
PAG: PLES_58301
PPU: PP_5346(oadA)
PPF: Pput_5255
PPG: PputGB1_5395
PPW: PputW619_5124
PST: PSPTO_5510(oadA)
PSB: Psyr_5060
PSP: PSPPH_5142(oadA)
PFL: PFL_6157(oadA)
PFO: Pfl01_5639
PFS: PFLU6070(oadA)
PEN: PSEEN5495(oadA)
PMY: Pmen_2892 Pmen_2893 Pmen_2894
PSA: PST_1377 PST_1378
CJA: CJA_2756 CJA_2757(oadA) CJA_2758
AVN: Avin_02060(pycB)
SFR: Sfri_1065 Sfri_1066 Sfri_1067
SAZ: Sama_1051 Sama_1052 Sama_1053
SBL: Sbal_1024 Sbal_1025 Sbal_1026
SBM: Shew185_1091 Shew185_1092 Shew185_1093
SBN: Sbal195_1125 Sbal195_1126 Sbal195_1127
SBP: Sbal223_3265 Sbal223_3266 Sbal223_3267
SLO: Shew_1219 Shew_1220 Shew_1221
SPC: Sputcn32_1029 Sputcn32_1030 Sputcn32_1031
SSE: Ssed_1320 Ssed_1321 Ssed_1322
SPL: Spea_1198 Spea_1199 Spea_1200
SHE: Shewmr4_2985 Shewmr4_2986 Shewmr4_2987
SHM: Shewmr7_3067 Shewmr7_3068 Shewmr7_3069
SHN: Shewana3_3164 Shewana3_3165 Shewana3_3166
SHW: Sputw3181_3134 Sputw3181_3135 Sputw3181_3136
SHL: Shal_1235 Shal_1236 Shal_1237
SWD: Swoo_1741 Swoo_3335 Swoo_3336 Swoo_3337
SWP: swp_1378 swp_1379 swp_1380
ILO: IL1734(oadB) IL1735(oadA) IL1736(oadG)
CPS: CPS_1048(oadG) CPS_1049(oadA) CPS_1050(oadB)
PHA: PSHAa0538(oadG) PSHAa0539(oadA) PSHAa0540(oadB)
PAT: Patl_3011 Patl_3012
SDE: Sde_1305 Sde_1306 Sde_1307
MAQ: Maqu_0970 Maqu_0971 Maqu_0972
AMC: MADE_02840 MADE_02841 MADE_02842
PIN: Ping_3375 Ping_3376 Ping_3377
TTU: TERTU_2785 TERTU_2786(oadA) TERTU_2787
LPF: lpl0507(dcoA)
LPP: lpp0531(dcoA)
LPC: LPC_2878(dcoA)
MCA: MCA2479(oadB) MCA2480(oadA) MCA2481(oadC)
TGR: Tgr7_1916
HCH: HCH_05201 HCH_05202(oadA1) HCH_05203 HCH_06704(oadA2)
CSA: Csal_0692 Csal_0693 Csal_0694 Csal_1556
ABO: ABO_0843(oadG) ABO_0844(oadA) ABO_0845(oadB)
MMW: Mmwyl1_3622 Mmwyl1_3623 Mmwyl1_3624 Mmwyl1_3925
TAU: Tola_0400 Tola_0401 Tola_0402 Tola_1848
RMA: Rmag_0847 Rmag_0848 Rmag_0849
VOK: COSY_0772(oadB) COSY_0773(oadA)
KKO: Kkor_1244 Kkor_1245 Kkor_1246
TBD: Tbd_1556
MFA: Mfla_1512
MMB: Mmol_1150
MEI: Msip34_1393
APP: CAP2UW1_3917
HHE: HH1686(pycB)
WSU: WS0565
TDN: Suden_1258 Suden_1260
CJR: CJE1011
CJJ: CJJ81176_0940
CJU: C8J_0870
CJD: JJD26997_0881
CCO: CCC13826_1508
CLA: Cla_1197(pycB)
SDL: Sdel_0603 Sdel_0604 Sdel_0605
NIS: NIS_1302 NIS_1303 NIS_1304
SUN: SUN_1432 SUN_1433 SUN_1434
NAM: NAMH_1018 NAMH_1019 NAMH_1020
GLO: Glov_1820
GBM: Gbem_0334 Gbem_1454
GEO: Geob_0239
GEM: GM21_0316 GM21_2799
PPD: Ppro_0033 Ppro_3084
DSA: Desal_0778 Desal_0780
DPS: DP0687
DOL: Dole_0075 Dole_2282
DAL: Dalk_1191 Dalk_3782
DAT: HRM2_06280(oadB1) HRM2_31800(pcb) HRM2_38530(oadB2)
RRU: Rru_A1320
MGM: Mmc1_3195 Mmc1_3196 Mmc1_3197
SPY: SPy_1174 SPy_1191(oadA)
SPZ: M5005_Spy_0894(oadA2) M5005_Spy_0903(oadB)
M5005_Spy_0909(oadA1)
SPM: spyM18_1126 spyM18_1142(oadA)
SPG: SpyM3_0822 SpyM3_0836(oadA)
SPS: SPs1023 SPs1036
SPH: MGAS10270_Spy1008(oadA2) MGAS10270_Spy1017(oadB)
MGAS10270_Spy1023(oadA1)
SPI: MGAS10750_Spy1043(oadA2) MGAS10750_Spy1052(oadB)
MGAS10750_Spy1053 MGAS10750_Spy1059(oadA1)
SPJ: MGAS2096_Spy0967 MGAS2096_Spy0968(oadA1)
SPK: MGAS9429_Spy1011(oadA1)
SPF: SpyM50888 SpyM50903
SPA: M6_Spy0883 M6_Spy0898
SPB: M28_Spy0867(oadA2) M28_Spy0870 M28_Spy0876(oadB)
M28_Spy0882(oadA1)
SOZ: Spy49_0923 Spy49_0926 Spy49_0933 Spy49_0939(oadA)
SMU: SMU.1017(oadB) SMU.1023(pycB)
SEQ: SZO_09720 SZO_09780
SEZ: Sez_0992(oadB)
SEU: SEQ_1197 SEQ_1203
SUB: SUB1584 SUB1591(gcdB)
SDS: SDEG_0982(oadA1) SDEG_0989(oadB) SDEG_0996 SDEG_0999(oadA2)
LSA: LSA1222(oadA) LSA1229(oadB)
LCA: LSEI_1855 LSEI_1862
LCB: LCABL_20790(oadA) LCABL_20860(oadB)
LRH: LGG_01912(oadA) LGG_01918(oadB)
LRL: LC705_01900(oadA) LC705_01906(oadB)
EFA: EF3317
CTH: Cthe_0509 Cthe_0701
CPY: Cphy_1925 Cphy_2433 Cphy_2434
CCE: Ccel_1736
AMT: Amet_2638 Amet_3216 Amet_3220
AOE: Clos_0443 Clos_1574
SWO: Swol_0558
VPR: Vpar_0396 Vpar_1240
ATE: Athe_1319
DSY: DSY2367
DHD: Dhaf_3508
DRM: Dred_1064
DAE: Dtox_2603
PTH: PTH_1174
DAU: Daud_1015
HMO: HM1_0282(oadA) HM1_0380(oadA)
EEL: EUBELI_00923 EUBELI_00924
ERE: EUBREC_1629 EUBREC_1630
TTE: TTE0252(oadB) TTE1208(pycA) TTE1336(pycA2)
TEX: Teth514_1582 Teth514_1850
TPD: Teth39_0907 Teth39_1145
CHY: CHY_1999(oadA)
MTA: Moth_1525
ADG: Adeg_1284
CSC: Csac_1883
CPO: COPRO5265_0907
NTH: Nther_0631 Nther_1492
CEF: CE0804
CDI: DIP0739(pycB)
CKP: ckrop_0042(oadA)
ROP: ROP_29690
PAC: PPA2008
NCA: Noca_1247
CCU: Ccur_05220
SHI: Shel_07970
ELE: Elen_2542
TPA: TP0056 TP0057
TPP: TPASS_0056(oadA) TPASS_0057(oadB)
BHY: BHWA1_00380 BHWA1_00381
ABA: Acid345_3026
SUS: Acid_6961
BTH: BT_1689 BT_1696
BFR: BF2936 BF3292
BFS: BF2819 BF3131(mmdB)
BVU: BVU_1974 BVU_1976 BVU_2488
PGN: PGN_0351 PGN_0504
PDI: BDI_0160 BDI_1670 BDI_2683 BDI_2684
APS: CFPG_533
FSU: Fisuc_0845 Fisuc_1599
FNU: FN1376
LBA: Lebu_2280
OTE: Oter_3311 Oter_3314 Oter_3316
AMU: Amuc_0204 Amuc_2034
TAI: Taci_0241 Taci_0294 Taci_1435
GVI: gll0879
CTE: CT0834(oadA)
CPC: Cpar_0858
CCH: Cag_0859
CPH: Cpha266_1192 Cpha266_1594
CPB: Cphamn1_1199 Cphamn1_1200 Cphamn1_1201
CLI: Clim_0808 Clim_0809 Clim_0886
PVI: Cvib_1017 Cvib_1018 Cvib_1251
PLT: Plut_1266 Plut_1267 Plut_1434
PPH: Ppha_0944 Ppha_1568
PAA: Paes_0916 Paes_0917
CTS: Ctha_0175
DET: DET0119(oadA)
DEH: cbdb_A139(oadA)
RRS: RoseRS_3692
RCA: Rcas_0953
CAU: Caur_3052 Caur_3432
CAG: Cagg_0382 Cagg_0996
CHL: Chy400_3298 Chy400_3694
TRO: trd_1683
AAE: aq_1614(oadA)
HYA: HY04AAS1_0631 HY04AAS1_1435
SUL: SYO3AOP1_0139
SAF: SULAZ_0887(oadA)
PMX: PERMA_0625(oadA)
TMA: TM0128 TM0880
TPT: Tpet_0047 Tpet_0796
TLE: Tlet_0266 Tlet_0920
TRQ: TRQ2_0047 TRQ2_0819
TNA: CTN_0561 CTN_1696
TNP: Tnap_0047 Tnap_0758
TME: Tmel_1864 Tmel_1898
TAF: THA_159 THA_192
FNO: Fnod_1275 Fnod_1310 Fnod_1755
PMO: Pmob_1439 Pmob_1666
KOL: Kole_1395 Kole_1742
TYE: THEYE_A1737(oadA)
AFU: AF2084(oadB) AF2085
PHO: PH0834
TKO: TK0990
TON: TON_0038 TON_0904
TGA: TGAM_1753(pycB) TGAM_2029(mmdB)
TSI: TSIB_0231 TSIB_1537
DKA: DKAM_0467
 |
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| Structures |
PDB: 2NX9 3B8I |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7016536]
Dimroth P.
Characterization of a membrane-bound biotin-containing enzyme:
oxaloacetate decarboxylase from Klebsiella aerogenes.
Eur. J. Biochem. 115 (1981) 353-8.
Klebsiella aerogenes |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7037395]
Dimroth P.
The role of biotin and sodium in the decarboxylation of oxaloacetate
by the membrane-bound oxaloacetate decarboxylase from Klebsiella
aerogenes.
Eur. J. Biochem. 121 (1982) 435-41.
Klebsiella aerogenes |
|---|
Reference
Authors
Title
Journal
|
3
Herbert, D.
Oxalacetic carboxylase of Micrococcus lysodeikticus.
Methods Enzymol. 1 (1955) 753-757. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14205502]
HORTON AA, KORNBERG HL.
OXALOACETATE 4-CARBOXY-LYASE FROM PSEUDOMONAS OVALIS CHESTER.
Biochim. Biophys. Acta. 89 (1964) 381-3.
Micrococcus lysodeikticus, Pseudomonas ovalis, Azotobacter
vinelandii [GN:avn] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:5972993]
Schmitt A, Bottke I, Siebert G.
[Properties of oxaloacetate decarboxylase from codfish muscles]
Hoppe. Seylers. Z. Physiol. Chem. 347 (1966) 18-34.
Gadus macrocephalus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.1.3
IUBMB Enzyme Nomenclature: 4.1.1.3
ExPASy - ENZYME nomenclature database: 4.1.1.3
BRENDA, the Enzyme Database: 4.1.1.3
CAS: 9024-98-0 |
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