KEGG   ENZYME: 4.1.1.33Help
Entry
EC 4.1.1.33                 Enzyme                                 
Name diphosphomevalonate decarboxylase;
pyrophosphomevalonate decarboxylase;
mevalonate-5-pyrophosphate decarboxylase;
pyrophosphomevalonic acid decarboxylase;
5-pyrophosphomevalonate decarboxylase;
mevalonate 5-diphosphate decarboxylase;
ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP;
isopentenyl-diphosphate-forming)
Reaction(IUBMB) ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl
diphosphate + CO2 [RN:R01121]
Reaction(KEGG) R01121
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Substrate ATP [CPD:C00002];
(R)-5-diphosphomevalonate [CPD:C01143]
Product ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl diphosphate [CPD:C00129];
CO2 [CPD:C00011]
Pathway PATH: ec00900  Terpenoid backbone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K01597  diphosphomevalonate decarboxylase
Genes HSA: 4597(MVD)
PTR: 468069(MVD)
MCC: 696865(MVD)
MMU: 192156(Mvd)
RNO: 81726(Mvd)
CFA: 489663(MVD)
BTA: 509958(MVD)
ECB: 100049914
MDO: 100026108
OAA: 100078306
GGA: 425359(MVD)
TGU: 100224697
DRE: 492781
BFO: BRAFLDRAFT_277163
CIN: 100178513
DME: Dmel_CG8239
DPO: Dpse_GA20922
DER: Dere_GG17907
DPE: Dper_GL14496
DSE: Dsec_GM22575
DYA: Dyak_GE17215
DGR: Dgri_GH20637
DMO: Dmoj_GI19000
AGA: AgaP_AGAP001611
AAG: AaeL_AAEL004050
CQU: CpipJ_CPIJ003140
AME: 725817
NVI: 100116409
TCA: 658650
API: 100158798
ISC: IscW_ISCW022273
CBR: CBG20661
BMY: Bm1_42945
SMM: Smp_172660
NVE: NEMVE_v1g118942
TAD: TRIADDRAFT_55561
ATH: AT2G38700(MVD1) AT3G54250
POP: POPTR_655777 POPTR_660167
RCU: RCOM_0888230
VVI: 100251686
OSA: 4328025(Os02g0107200) 4328034(Os02g0109100)
SBI: SORBI_04g035950(SORBIDRAFT_04g035950)
ZMA: 100282878
PPP: PHYPADRAFT_107531 PHYPADRAFT_107613
SCE: YNR043W(MVD1)
AGO: AGOS_AGL232C
LTH: KLTH0A07238g
DHA: DEHA0A13816g
PIC: PICST_90752
PPA: PAS_chr1-4_0003
VPO: Kpol_1028p24
LEL: LELG_01448
ZRO: ZYRO0D17270g
CTP: CTRG_04280
CDU: CD36_00080
CGR: CAGL0C03630g
YLI: YALI0F05632g
SPO: SPAC24C9.03(mvd1)
NCR: NCU11381
PAN: PODANSg1075
MGR: MGG_09750
FGR: FG10424.1
ANI: AN4414.2
AFM: AFUA_4G07130
AOR: AO090023000862
ANG: An04g01540
AFV: AFLA_112720
PCS: Pc22g18320
NFI: NFIA_109090
URE: UREG_05590
SSL: SS1G_03958
BFU: BC1G_14194
CNE: CNL04950
CNB: CNBI1880
LBC: LACBIDRAFT_190457 LACBIDRAFT_228351
MPR: MPER_05313
UMA: UM05179.1
MGL: MGL_1650
MBR: MONBRDRAFT_26828
DDI: DDBDRAFT_0218058
TET: TTHERM_00849200
PTM: GSPATT00008724001
TBR: Tb10.05.0010 Tb10.61.2745
TCR: 507993.330 511281.40
LMA: LmjF18.0020
LIF: LinJ18.0020
LBZ: LbrM18_V2.0030
GLA: GL50803_23420
TVA: TVAG_302660
PTI: PHATRDRAFT_bd1325(MPDC)
TPS: THAPSDRAFT_15226
TTU: TERTU_3245(mvaD)
CBU: CBU_0607(mvaD)
LPN: lpg2040
LPF: lpl2018
LPP: lpp2023
LPC: LPC_1526
TCX: Tcr_1734
DNO: DNO_0504(mvaD)
BBA: Bd1629
MXA: MXAN_5018(mvaD)
SCL: sce4206
HOH: Hoch_3408
LAS: CLIBASIA_04590(mvaD)
OIH: OB0226
SAU: SA0548(mvaD)
SAV: SAV0591(mvaD)
SAW: SAHV_0589(mvaD)
SAM: MW0546(mvaD)
SAR: SAR0597(mvaD)
SAS: SAS0550
SAC: SACOL0637(mvaD)
SAB: SAB0541(mvaD)
SAA: SAUSA300_0573(mvaD)
SAX: USA300HOU_0584(mvaD)
SAO: SAOUHSC_00578
SAJ: SaurJH9_0614
SAH: SaurJH1_0629
SAE: NWMN_0554(mvaD)
SAD: SAAV_0553(mvaD)
SEP: SE0362
SER: SERP0239(mvaD)
SHA: SH2401(mvaD)
SSP: SSP2121
SCA: Sca_0245(mvaD)
LMO: lmo0011
LMF: LMOf2365_0012(mvaD)
LMH: LMHCC_2652(mvaD)
LMC: Lm4b_00011
LIN: lin0011
LWE: lwe0012(mvaD)
LLA: L9089(yeaH)
LLK: LLKF_0457(mvaD)
LLC: LACR_0455
LLM: llmg_0426(mvaD)
SPY: SPy_0877(mvaD)
SPZ: M5005_Spy_0683(mvaD)
SPM: spyM18_0938(mvd)
SPG: SpyM3_0596(mvaD)
SPS: SPs1257
SPH: MGAS10270_Spy0741(mvaD)
SPI: MGAS10750_Spy0775(mvaD)
SPJ: MGAS2096_Spy0754(mvaD)
SPK: MGAS9429_Spy0738(mvaD)
SPF: SpyM51125(mvaD)
SPA: M6_Spy0700
SPB: M28_Spy0663(mvaD)
SOZ: Spy49_0691(mvaD)
SPN: SP_0382
SPD: SPD_0347(mvaD)
SPR: spr0339(mvd1)
SPW: SPCG_0377(mvd1)
SPX: SPG_0347(mvaD)
SNE: SPN23F_03540(mvaD)
SPV: SPH_0489(mvaD)
SNM: SP70585_0453(mvaD)
SJJ: SPJ_0369(mvaD)
SPP: SPP_0420(mvaD)
SNT: SPT_0427(mvaD)
SAG: SAG1325(mvaD)
SAN: gbs1395
SAK: SAK_1356(mvaD)
SMU: SMU.937
STC: str0560(mvaD)
STL: stu0560(mvaD)
STE: STER_0599
SSA: SSA_0334(mvaD)
SSU: SSU05_0290
SSV: SSU98_0286
SSB: SSUBM407_0261(mvaD)
SSI: SSU0270(mvaD)
SSS: SSUSC84_0259(mvaD)
SGO: SGO_0240(mvaD)
SEQ: SZO_08840
SEZ: Sez_1083
SEU: SEQ_1105
SUB: SUB0766(mvaD)
SDS: SDEG_0834(mvaD)
LPL: lp_1734(mvaD)
LPJ: JDM1_1457(mvaD)
LJO: LJ1206
LJF: FI9785_974(mvaD)
LAC: LBA1168(mvaD)
LSA: LSA0907(mvaD)
LSL: LSL_0684
LDB: Ldb0998(mvaD)
LBU: LBUL_0905
LBR: LVIS_0859
LCA: LSEI_1492
LCB: LCABL_17140(mvaD)
LGA: LGAS_1034
LRE: Lreu_0914
LRF: LAR_0861
LHE: lhv_1276
LFE: LAF_1193
LRH: LGG_01499(mvaD)
LRL: LC705_01514(mvaD)
PPE: PEPE_0926
EFA: EF0903(mvaD)
LME: LEUM_1386
LCI: LCK_00622(mvaD)
ACL: ACL_0799(mvaD)
MUL: MUL_3524
MMI: MMAR_3216
CKP: ckrop_0027(mvaD)
NFA: nfa22080
BBU: BB0686
BBZ: BbuZS7_0706(mvaD)
BGA: BG0709
BAF: BAPKO_0730
BTU: BT0686
BHR: BH0686
BDU: BDU_689(mvaD)
BRE: BRE_692(mvaD)
GFO: GFO_3632
FJO: Fjoh_1389
FPS: FP0310(mvaD)
FBA: FIC_01859
COC: Coch_0497
RBI: RB2501_08645
BBL: BLBBGE_357(mvaD)
BPI: BPLAN_283
LBA: Lebu_0141
SMF: Smon_1123
RRS: RoseRS_4285
RCA: Rcas_0936
CAU: Caur_0617
CAG: Cagg_3390
CHL: Chy400_0667
HAU: Haur_1612
HAL: VNG0593G(dmd)
HSL: OE1893F(mvd)
HMA: rrnAC1489(dmd)
HWA: HQ1525A(mvaD)
NPH: NP1580A(mvaD)
HLA: Hlac_1434
HUT: Huta_0691
HMU: Hmuk_2128
PTO: PTO0478 PTO1356
SSO: SSO2989
STO: ST0977
SAI: Saci_1245(mvd)
SIS: LS215_2535
SIA: M1425_2362
SIM: M1627_2440
SID: M164_2369
SIY: YG5714_2509
SIN: YN1551_0397
MSE: Msed_1576
Taxonomy
Structures PDB: 1FI4  2HK2  2HK3  2HKE  3D4J  3F0N  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13801508]
BLOCH K, CHAYKIN S, PHILLIPS AH, DE WAARD A.
Mevalonic acid pyrophosphate and isopentenylpyrophosphate.
J. Biol. Chem. 234 (1959) 2595-604.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.33
IUBMB Enzyme Nomenclature: 4.1.1.33
ExPASy - ENZYME nomenclature database: 4.1.1.33
BRENDA, the Enzyme Database: 4.1.1.33
CAS: 9024-66-2
DBGET integrated database retrieval system