KEGG   ENZYME: 4.1.1.4Help
Entry
EC 4.1.1.4                  Enzyme                                 
Name acetoacetate decarboxylase;
acetoacetic acid decarboxylase;
acetoacetate carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname acetoacetate carboxy-lyase (acetone-forming)
Reaction(IUBMB) acetoacetate + H+ = acetone + CO2 [RN:R01366]
Reaction(KEGG) R01366
Show
Substrate acetoacetate [CPD:C00164];
H+ [CPD:C00080]
Product acetone [CPD:C00207];
CO2 [CPD:C00011]
Pathway PATH: ec00072  Synthesis and degradation of ketone bodies
PATH: ec00640  Propanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01574  acetoacetate decarboxylase
Genes TET: TTHERM_00035180
PAP: PSPA7_3628
ABY: ABAYE1742
LPN: lpg0672
LPF: lpl0708
LPP: lpp0728
LPC: LPC_2621(adc)
FTL: FTL_1279
FTH: FTH_1252(adc)
FTN: FTN_0808
CVI: CV_3520
RSO: RSp1058(adc)
RPI: Rpic_4271
RPF: Rpic12D_4381
BMA: BMAA0018(adc)
BMV: BMASAVP1_1168(adc)
BML: BMA10229_1448(adc)
BMN: BMA10247_A0022(adc)
BPS: BPSS0018(adc)
BPM: BURPS1710b_A1525
BPL: BURPS1106A_A0022
BPD: BURPS668_A0024
BTE: BTH_II0020
BVI: Bcep1808_3777 Bcep1808_4583
BUR: Bcep18194_B1397 Bcep18194_B3166
BCN: Bcen_5145
BCH: Bcen2424_5714
BCM: Bcenmc03_4525
BCJ: BCAM0023(adc)
BAM: Bamb_4983
BAC: BamMC406_3126
BMU: Bmul_5311
BMJ: BMULJ_03210(adc)
BXE: Bxe_A2916
BPY: Bphyt_1567
MLO: mll5917 mlr2399 mlr3634
RLE: pRL90174(adc)
BJA: bll7763 blr3945 blr7028
BBT: BBta_1411(adc)
BID: Bind_2695
ACR: Acry_0495
BAY: RBAM_030030
LSL: LSL_0135
LCA: LSEI_0716
CAC: CA_P0165(adc)
CBK: CLL_A2135
CBE: Cbei_3835
MAV: MAV_3542
RHA: RHA1_ro08625
SMA: SAV_1349(adc)
RSA: RSal33209_0180
NCA: Noca_1734
SEN: SACE_5407(adc)
RXY: Rxyl_1034
CPH: Cpha266_0763
Taxonomy
Structures PDB: 3BGT  3BH2  3BH3  3C8W  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:16747621]
Davies R.
Studies on the acetone-butanol fermentation: 4. Acetoacetic acid
decarboxylase of Cl. acetobutylicum (BY).
Biochem. J. 37 (1943) 230-8.
Clostridium acetobutylicum [GN:cac]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:5911291]
Zerner B, Coutts SM, Lederer F, Waters HH, Westheimer FH.
Acetoacetate decarboxylase. Preparation of the enzyme.
Biochemistry. 5 (1966) 813-6.
Clostridium acetobutylicum [GN:cac]
Reference
  Authors
  Title

  Journal
  Organism

 3  [PMID:19458715]
Ho MC, Menetret JF, Tsuruta H, Allen KN
The origin of the electrostatic perturbation in acetoacetate
decarboxylase.
Nature. 459 (2009) 393-7.
Chromobacterium violaceum [GN:cvi], Clostridium acetobutylicum
[GN:cac]
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.4
IUBMB Enzyme Nomenclature: 4.1.1.4
ExPASy - ENZYME nomenclature database: 4.1.1.4
BRENDA, the Enzyme Database: 4.1.1.4
CAS: 9025-03-0
DBGET integrated database retrieval system