KEGG   ENZYME: 4.1.1.41Help
Entry
EC 4.1.1.41                 Enzyme                                 
Name methylmalonyl-CoA decarboxylase;
propionyl-CoA carboxylase;
propionyl coenzyme A carboxylase;
methylmalonyl-coenzyme A decarboxylase;
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase [incorrect];
(S)-methylmalonyl-CoA carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
Reaction(IUBMB) (S)-methylmalonyl-CoA = propanoyl-CoA + CO2 [RN:R00923]
Reaction(KEGG) R00923
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Substrate (S)-methylmalonyl-CoA [CPD:C00683]
Product propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011]
Comment The enzyme from Veillonella alcalescens is a biotinyl-protein,
requires Na+ and acts as a sodium pump.
Pathway PATH: ec00640  Propanoate metabolism
Orthology KO: K01603  methylmalonyl-CoA decarboxylase
KO: K01604  methylmalonyl-CoA decarboxylase alpha chain
KO: K01605  methylmalonyl-CoA decarboxylase beta chain
KO: K01606  methylmalonyl-CoA decarboxylase gamma chain
KO: K11264  methylmalonyl-CoA decarboxylase
Genes AFM: AFUA_5G07580
ECO: b2919(scpB)
ECJ: JW2886(ygfG)
ECD: ECDH10B_3094(ygfG)
EBW: BWG_2642(scpB)
ECE: Z4256(ygfG)
ECS: ECs3789
ECF: ECH74115_4215
ETW: ECSP_3885(ygfG)
ECW: EcE24377A_3246
ECX: EcHS_A3077
ECM: EcSMS35_3055
ECY: ECSE_3181
ECL: EcolC_0791
ECK: EC55989_3207(ygfG)
ECR: ECIAI1_3039(ygfG)
ECT: ECIAI39_3333(ygfG)
EUM: ECUMN_3263(ygfG)
EBL: B21_02713(ygfG)
EBD: ECBD_0819
EBR: ECB_02750(ygfG)
EOH: ECO103_3493(scpB)
EOI: ECO111_3655(scpB)
EOJ: ECO26_4006(scpB)
SES: SARI_04583
YEN: YE1894
SFL: SF2904(ygfG)
SFX: S3104(ygfG)
SFV: SFV_2965(ygfG)
SSN: SSON_3070(ygfG)
SBO: SBO_3075(ygfG)
SBC: SbBS512_E3341
CVI: CV_1805(mmdA)
BUR: Bcep18194_A4040
BCN: Bcen_0459
BCH: Bcen2424_0938
BCM: Bcenmc03_0900
BCJ: BCAL3068(mmcD)
BXE: Bxe_B2996
PNU: Pnuc_1611
LCH: Lcho_2461
APP: CAP2UW1_2101
GUR: Gura_3534
GLO: Glov_1378
GBM: Gbem_0684
GEM: GM21_0696
SAT: SYN_01398
RPC: RPC_1055
MAG: amb2242
GKA: GK2135
SPY: SPy_1176 SPy_1177 SPy_1184
SPZ: M5005_Spy_0896 M5005_Spy_0897
SPM: spyM18_1128 spyM18_1129 spyM18_1135
SPG: SpyM3_0824 SpyM3_0825 SpyM3_0831
SPS: SPs1025 SPs1031
SPH: MGAS10270_Spy1010 MGAS10270_Spy1011
SPI: MGAS10750_Spy1045 MGAS10750_Spy1046
SPF: SpyM50894 SpyM50901
SPA: M6_Spy0885 M6_Spy0886 M6_Spy0892
SPB: M28_Spy0869
SDS: SDEG_0997
EFA: EF3324
CTH: Cthe_0700
PTH: PTH_1366(mmcJ)
TTE: TTE1215(oadB2) TTE1798(oadB3)
CSC: Csac_1882
CEF: CE0807
CDI: DIP0740(mmdA) DIP0742
PAC: PPA2005
BTH: BT_1686 BT_1688
BFR: BF1137 BF3289 BF3291
BFS: BF1050(mmdB) BF3128(mmdA) BF3130(bcc)
PGI: PG1608(mmdB) PG1609(mmdC)
CCH: Cag_1521
PVI: Cvib_1248 Cvib_1250
PLT: Plut_1431
TMA: TM0717
TPT: Tpet_0212
AFU: AF2216(mmdC) AF2217(mmdA)
HAL: VNG1529G(mmdA)
PHO: PH1283 PH1284 PH1287
PAB: PAB1769(mmdA) PAB1771 PAB1772
PFU: PF0671 PF0673 PF0674
TKO: TK1622 TK1624 TK1625
SMR: Smar_1426
SSO: SSO2463(ppcB)
STO: ST0591
SAI: Saci_0262(pccB)
SIS: LS215_0283
SIA: M1425_0252
SIM: M1627_0252
SID: M164_0270
SIY: YG5714_0255
SIN: YN1551_2860
MSE: Msed_1375
Taxonomy
Structures PDB: 1EF8  1EF9  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5646172]
Galivan JH, Allen SH.
Methylmalonyl coenzyme A decarboxylase. Its role in succinate
decarboxylation by Micrococcus lactilyticus.
J. Biol. Chem. 243 (1968) 1253-61.
Micrococcus lactilyticus
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:7070502]
Hilpert W, Dimroth P.
Conversion of the chemical energy of methylmalonyl-CoA
decarboxylation into a Na+ gradient.
Nature. 296 (1982) 584-5.
Veillonella alcalescens
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:2920730]
Hoffmann A, Hilpert W, Dimroth P.
The carboxyltransferase activity of the sodium-ion-translocating
methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
Eur. J. Biochem. 179 (1989) 645-50.
Veillonella alcalescens
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.41
IUBMB Enzyme Nomenclature: 4.1.1.41
ExPASy - ENZYME nomenclature database: 4.1.1.41
BRENDA, the Enzyme Database: 4.1.1.41
CAS: 37289-44-4
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