KEGG   ENZYME: 4.1.1.41Help
Entry
EC 4.1.1.41                 Enzyme                                 
Name
methylmalonyl-CoA decarboxylase;
propionyl-CoA carboxylase;
propionyl coenzyme A carboxylase;
methylmalonyl-coenzyme A decarboxylase;
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase [incorrect];
(S)-methylmalonyl-CoA carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
Reaction(IUBMB)
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2 [RN:R00923]
Reaction(KEGG)
Substrate
(S)-methylmalonyl-CoA [CPD:C00683]
Product
propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011]
Comment
The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.
Pathway
Propanoate metabolism
Orthology
K11264  
methylmalonyl-CoA decarboxylase
Genes
ECO: 
b2919(scpB)
ECJ: 
Y75_p2850(ygfG)
ECD: 
EBW: 
BWG_2642(scpB)
ECOK: 
ECE: 
Z4256(ygfG)
ECS: 
ECF: 
ETW: 
ECSP_3885(ygfG)
ELX: 
EOJ: 
ECO26_4006(scpB)
EOI: 
ECO111_3655(scpB)
EOH: 
ECO103_3493(scpB)
EOK: 
G2583_3573(scpB)
ELR: 
ECO55CA74_17025
ECX: 
EcHS_A3077
ECW: 
EcE24377A_3246
ECM: 
EcSMS35_3055
ECY: 
ECSE_3181
ECR: 
ECIAI1_3039(ygfG)
ECK: 
EC55989_3207(ygfG)
ECT: 
ECIAI39_3333(ygfG)
EOC: 
CE10_3355(scpB)
EUM: 
ECUMN_3263(ygfG)
ELO: 
EC042_3128(mmcD)
ELH: 
ETEC_3111
ESO: 
O3O_20775
ESM: 
O3M_04920
ESL: 
O3K_04875
ECL: 
EcolC_0791
EBR: 
ECB_02750(ygfG)
EBD: 
ECBD_0819
EKO: 
EKO11_0813
EKF: 
KO11_08175(scpB)
EDH: 
EcDH1_0774
EDJ: 
ECDH1ME8569_2820(scpB)
EUN: 
UMNK88_3614
ELW: 
ECW_m3174(scpB)
ELL: 
WFL_15495(scpB)
ELP: 
P12B_c3011
EBL: 
ECD_02750(ygfG)
EBE: 
B21_02713(scpB)
ECOA: 
APECO78_18305
SES: 
SARI_04583
SBG: 
SBG_2660(scpB)
YEN: 
YE1894
YEP: 
YE105_C1974
YEY: 
Y11_07661
SFL: 
SF2904(ygfG)
SFX: 
S3104(ygfG)
SFV: 
SFV_2965(ygfG)
SFE: 
SFxv_3183(scpB)
SSN: 
SSON_3070(ygfG)
SSJ: 
SSON53_17885
SBO: 
SBO_3075(ygfG)
SBC: 
SbBS512_E3341
ESC: 
Entcl_0835
KOX: 
KOX_02550
BUR: 
Bcep18194_A4040
BCN: 
Bcen_0459
BCH: 
Bcen2424_0938
BCM: 
Bcenmc03_0900
BCJ: 
BCAL3068(mmcD)
BCT: 
GEM_2591
BXE: 
Bxe_B2996
PNU: 
Pnuc_1611
LCH: 
Lcho_2461
AZA: 
AZKH_2453
DSU: 
Dsui_3389
APP: 
CAP2UW1_2101
GUR: 
Gura_3534
GLO: 
Glov_1378
GBM: 
Gbem_0684
GEM: 
GM21_0696
GEB: 
GM18_3668
DAO: 
Desac_2400
DTI: 
Desti_3674
RVA: 
Rvan_2264
MAG: 
amb2242
CAP: 
CLDAP_04890
 » show all
Taxonomy
Reference
1  [PMID:5646172]
  Authors
Galivan JH, Allen SH.
  Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
  Journal
J. Biol. Chem. 243 (1968) 1253-61.
  Organism
Micrococcus lactilyticus
Reference
2  [PMID:7070502]
  Authors
Hilpert W, Dimroth P.
  Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
  Journal
Nature. 296 (1982) 584-5.
  Organism
Veillonella alcalescens
Reference
3  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur. J. Biochem. 179 (1989) 645-50.
  Organism
Veillonella alcalescens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-44-4
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