KEGG   ENZYME: 4.1.1.41Help
Entry
EC 4.1.1.41                 Enzyme                                 

Name
methylmalonyl-CoA decarboxylase;
propionyl-CoA carboxylase;
propionyl coenzyme A carboxylase;
methylmalonyl-coenzyme A decarboxylase;
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase [incorrect];
(S)-methylmalonyl-CoA carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
Reaction(IUBMB)
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2 [RN:R00923]
Reaction(KEGG)
Substrate
(S)-methylmalonyl-CoA [CPD:C00683]
Product
propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011]
Comment
The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.
History
EC 4.1.1.41 created 1972, modified 1983, modified 1986
Pathway
Propanoate metabolism
Orthology
K11264  
methylmalonyl-CoA decarboxylase
K18426  
ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase
Genes
HSA: 
55862(ECHDC1)
PTR: 
745395(ECHDC1)
PPS: 
100992035(ECHDC1)
GGO: 
101134705(ECHDC1)
PON: 
100173900(ECHDC1)
NLE: 
100592701(ECHDC1)
MCC: 
712072(ECHDC1)
MCF: 
102132641(ECHDC1)
CJC: 
100400374(ECHDC1)
MMU: 
52665(Echdc1)
RNO: 
361465(Echdc1)
CGE: 
100764713(Echdc1)
NGI: 
103734575(Echdc1)
HGL: 
101721458(Echdc1)
OCU: 
100339488(ECHDC1)
TUP: 
CFA: 
609850(ECHDC1)
AML: 
UMR: 
103663427(ECHDC1)
FCA: 
101086310(ECHDC1)
PTG: 
102958239(ECHDC1)
BTA: 
536284(ECHDC1)
BOM: 
102265974(ECHDC1)
PHD: 
102336638(ECHDC1)
CHX: 
102178542(ECHDC1)
OAS: 
101116321(ECHDC1)
SSC: 
100512509(ECHDC1)
CFR: 
102518806(ECHDC1)
BACU: 
103017976(ECHDC1)
LVE: 
103078139(ECHDC1)
ECB: 
100073045(ECHDC1)
MYB: 
102258272(ECHDC1)
MYD: 
102751783(ECHDC1)
PALE: 
MDO: 
100030825(ECHDC1)
SHR: 
100919338(ECHDC1)
OAA: 
GGA: 
769021(ECHDC1)
MGP: 
APLA: 
101804132(ECHDC1)
TGU: 
100227322(ECHDC1)
FAB: 
101806230(ECHDC1)
PHI: 
102113663(ECHDC1)
FPG: 
101918396(ECHDC1)
FCH: 
102055851(ECHDC1)
CLV: 
102084911(ECHDC1)
ASN: 
102383062(ECHDC1)
AMJ: 
102560692(ECHDC1)
PSS: 
102451093(ECHDC1)
CMY: 
102945116(ECHDC1)
ACS: 
100552293(echdc1)
PBI: 
103055176(ECHDC1)
XLA: 
496330(echdc1)
XTR: 
496886(echdc1)
DRE: 
553585(echdc1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352882(ECHDC1)
CMK: 
103182298(echdc1)
BFO: 
SPU: 
TCA: 
API: 
PHU: 
ISC: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
PIF: 
ECO: 
b2919(scpB)
ECJ: 
Y75_p2850(ygfG)
ECD: 
EBW: 
BWG_2642(scpB)
ECOK: 
ECE: 
Z4256(ygfG)
ECS: 
ECF: 
ETW: 
ECSP_3885(ygfG)
ELX: 
EOJ: 
EOI: 
EOH: 
EOK: 
ELR: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECK: 
ECT: 
EOC: 
CE10_3355(scpB)
EUM: 
ELO: 
ELH: 
ESO: 
ESM: 
ESL: 
ECL: 
EBR: 
ECB_02750(ygfG)
EBD: 
EKO: 
EKF: 
EDH: 
EDJ: 
EUN: 
ELW: 
ECW_m3174(scpB)
ELL: 
WFL_15495(scpB)
ELP: 
EBL: 
ECD_02750(ygfG)
EBE: 
B21_02713(scpB)
ECOA: 
ECOL: 
ECOO: 
ECOH: 
SES: 
SBG: 
SBG_2660(scpB)
SBZ: 
SBV: 
YEN: 
YEP: 
YEY: 
YEL: 
SFL: 
SF2904(ygfG)
SFX: 
S3104(ygfG)
SFV: 
SFV_2965(ygfG)
SFE: 
SFxv_3183(scpB)
SFN: 
SFS: 
SSN: 
SSON_3070(ygfG)
SSJ: 
SBO: 
SBO_3075(ygfG)
SBC: 
ESC: 
ENR: 
KOX: 
KOE: 
KOY: 
KOK: 
KOM: 
CFD: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BCAL3068(mmcD)
BCEN: 
BCT: 
BCED: 
BXE: 
BXB: 
PNU: 
LCH: 
AZA: 
DSU: 
APP: 
GUR: 
GLO: 
GBM: 
GEM: 
GEB: 
DAO: 
DTI: 
RVA: 
MAG: 
PUF: 
CAP: 
 » show all
Taxonomy
Reference
1  [PMID:5646172]
  Authors
Galivan JH, Allen SH.
  Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
  Journal
J. Biol. Chem. 243 (1968) 1253-61.
Reference
2  [PMID:7070502]
  Authors
Hilpert W, Dimroth P.
  Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
  Journal
Nature. 296 (1982) 584-5.
Reference
3  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur. J. Biochem. 179 (1989) 645-50.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-44-4

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