KEGG   ENZYME: 4.1.1.45Help
Entry
EC 4.1.1.45                 Enzyme                                 
Name
aminocarboxymuconate-semialdehyde decarboxylase;
picolinic acid carboxylase;
picolinic acid decarboxylase;
alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase;
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase;
2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase;
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)
Reaction(IUBMB)
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2 [RN:R04323]
Reaction(KEGG)
Substrate
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate [CPD:C04409]
Product
2-aminomuconate semialdehyde [CPD:C03824];
CO2 [CPD:C00011]
Comment
Product rearranges non-enzymically to picolinate.
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K03392  
aminocarboxymuconate-semialdehyde decarboxylase
Genes
HSA: 
130013(ACMSD)
PTR: 
459627(ACMSD)
PPS: 
100990305(ACMSD)
GGO: 
101131539(ACMSD)
PON: 
100446661(ACMSD)
MCC: 
708917(ACMSD)
MMU: 
266645(Acmsd)
RNO: 
171385(Acmsd)
CFA: 
476125(ACMSD)
AML: 
100483355(ACMSD)
FCA: 
101090201(ACMSD)
BTA: 
515030(ACMSD)
SSC: 
100154768
ECB: 
100050432
MDO: 
100015778
SHR: 
100930254(ACMSD)
OAA: 
100079942
GGA: 
424288(ACMSD)
TGU: 
100226130(ACMSD)
ACS: 
100551851
XTR: 
100488272
DRE: 
557166(acmsd)
TRU: 
101069812
OLA: 
101167833
CIN: 
100178473
ISC: 
IscW_ISCW003735
CEL: 
CELE_Y71D11A.3(Y71D11A.3)
CBR: 
CBG11728
NVE: 
NEMVE_v1g126268
HMG: 
100210097
AQU: 
100636154
PAN: 
PODANSg09797
TTT: 
THITE_122630
MTM: 
MYCTH_2295409
NFI: 
NFIA_092840
AFM: 
AFUA_2G17440
AOR: 
AOR_1_112134(AO090102000067)
AFV: 
AFLA_001970 AFLA_079300
ACT: 
ACLA_076340
PCS: 
Pc20g02360
MBR: 
MONBRDRAFT_13314
NGR: 
NAEGRDRAFT_81621
DDI: 
DDB_G0286525(acmsd)
DPP: 
DICPUDRAFT_92803
SMW: 
SMWW4_v1c26930
RHD: 
R2APBS1_1218
PFE: 
PSF113_3366(ditL) PSF113_3402(ditL2)
SWD: 
Swoo_1407
PAT: 
Patl_0847
MAD: 
HP15_46
CYQ: 
Q91_1898
KKO: 
Kkor_0379
REU: 
Reut_B5503
REH: 
H16_B0330(acmD)
RME: 
Rmet_5212
CNC: 
CNE_2c02880 CNE_2c03490(acmD)
BVI: 
Bcep1808_6383
BUR: 
Bcep18194_B2954 Bcep18194_C7640
BCH: 
Bcen2424_0158
BCJ: 
BCAM2129(nbaD)
BAM: 
Bamb_4307
BXE: 
Bxe_C0621 Bxe_C0650
BPY: 
Bphyt_1472
BUG: 
BC1001_3828
BRH: 
RBRH_03006
BGD: 
bgla_2g09200
BUK: 
MYA_5777
BPX: 
BUPH_00403
AXY: 
AXYL_05543
PUT: 
PT7_3610
POL: 
Bpro_5140
VAP: 
Vapar_0614
RTA: 
Rta_02710
MXA: 
MXAN_0918
MFU: 
LILAB_04120
MSD: 
MYSTI_00936
CCX: 
COCOR_00868
SUR: 
STAUR_2726
SNO: 
Snov_0217
CAK: 
Caul_1931
NPP: 
PP1Y_AT33092
SWI: 
Swit_1753 Swit_3524
SSY: 
SLG_28570 SLG_28840
PGV: 
SL003B_1055
BCA: 
BCE_2152
BCX: 
BCA_2150
BCF: 
bcf_10190
BCER: 
BCK_24245
BTL: 
BALH_1839
BPF: 
BpOF4_12585
BMQ: 
BMQ_3592
BMD: 
BMD_3577
GTN: 
GTNG_3156(nbaD)
GYC: 
GYMC61_2293
GYA: 
GYMC52_1421
GCT: 
GC56T3_2060
GGH: 
GHH_c14790
SWA: 
A284_00370
BBE: 
BBR47_29730
AAC: 
Aaci_1616
AAD: 
TC41_1512
SDS: 
SDEG_2047
SDG: 
SDE12394_10350
SDA: 
GGS_1882
SDC: 
SDSE_2143(nbaD)
STB: 
SGPB_0737
TMR: 
Tmar_1786
MIT: 
OCO_14740
MIA: 
OCU_15180
MJL: 
Mjls_4213
MMI: 
MMAR_0083
MRH: 
MycrhN_2475
NFA: 
nfa32640
RER: 
RER_04740 RER_59370
ROP: 
ROP_46400(cmtD)
REQ: 
REQ_05080
SCO: 
SCO6305(SCIF3.07c)
SCB: 
SCAB_15151 SCAB_90581
SSX: 
SACTE_4110
SBH: 
SBI_07370
SHY: 
SHJG_8578
SHO: 
SHJGH_8338
SDV: 
BN159_0882
MTS: 
MTES_1747
ACH: 
Achl_3548
APN: 
Asphe3_01920
ARR: 
ARUE_c17900
CFI: 
Celf_2999
KFL: 
Kfla_3148 Kfla_5490
SRO: 
Sros_4717 Sros_9109
FRI: 
FraEuI1c_1242
FSY: 
FsymDg_2030
NML: 
Namu_4102
MMAR: 
MODMU_2920
PDX: 
Psed_1482 Psed_4983 Psed_5052
STP: 
Strop_3521
SAQ: 
Sare_3896
MAU: 
Micau_4934
MIL: 
ML5_3361
VMA: 
VAB18032_28726
CAI: 
Caci_7137
RXY: 
Rxyl_2240
CWO: 
Cwoe_3899
AYM: 
YM304_35950
ABA: 
Acid345_0682
SUS: 
Acid_7161
CTM: 
Cabther_A0087
FLI: 
Fleli_0540
MTT: 
Ftrac_2833
CAT: 
CA2559_07440
KDI: 
Krodi_1913
LAN: 
Lacal_1460
ASL: 
Aeqsu_0475
PTQ: 
P700755_002936
NDO: 
DDD_2058
POM: 
MED152_12789
FTE: 
Fluta_2702
OHO: 
Oweho_2635
TRO: 
trd_1095 trd_1402
STI: 
Sthe_0108
DPT: 
Deipr_2536
 » show all
Taxonomy
Reference
1  [PMID:14275130]
  Authors
ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O, SENOH S.
  Title
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID.
  Journal
J. Biol. Chem. 240 (1965) 740-9.
  Organism
Felis catus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-47-7
DBGET integrated database retrieval system