KEGG   ENZYME: 4.1.1.45Help
Entry
EC 4.1.1.45                 Enzyme                                 
Name aminocarboxymuconate-semialdehyde decarboxylase;
picolinic acid carboxylase;
picolinic acid decarboxylase;
alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase;
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde
beta-decarboxylase;
2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase;
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase
(2-aminomuconate-semialdehyde-forming)
Reaction(IUBMB) 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate
semialdehyde + CO2 [RN:R04323]
Reaction(KEGG) R04323
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Substrate 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate [CPD:C04409]
Product 2-aminomuconate semialdehyde [CPD:C03824];
CO2 [CPD:C00011]
Comment Product rearranges non-enzymically to picolinate.
Pathway PATH: ec00380  Tryptophan metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K03392  aminocarboxymuconate-semialdehyde decarboxylase
Genes HSA: 130013(ACMSD)
PTR: 459627(ACMSD)
MCC: 708917(ACMSD)
MMU: 266645(Acmsd)
RNO: 171385(Acmsd)
CFA: 476125(ACMSD)
BTA: 515030(ACMSD)
ECB: 100050432
MDO: 100015778
GGA: 424288(ACMSD)
TGU: 100226130
DRE: 557166(acmsd)
CIN: 100178473
SPU: 583197
CEL: Y71D11A.3
CBR: CBG11728
NVE: NEMVE_v1g126268
PAN: PODANSg09797
AFM: AFUA_2G17440
AOR: AO090102000067
NFI: NFIA_092840
MBR: MONBRDRAFT_13314
DDI: DDBDRAFT_0218836
SWD: Swoo_1407
PAT: Patl_0847
REU: Reut_B5503
REH: H16_B0330(acmD)
RME: Rmet_5212
BVI: Bcep1808_6383
BUR: Bcep18194_B2954 Bcep18194_C7640
BCH: Bcen2424_0158
BCJ: BCAM2129(nbaD)
BAM: Bamb_4307
BXE: Bxe_C0621 Bxe_C0650
BPY: Bphyt_1472
POL: Bpro_5140
AZO: azo2542(fldW)
MXA: MXAN_0918
SWI: Swit_1753 Swit_3524
BCA: BCE_2152
BCX: BCA_2150
BTL: BALH_1839
GTN: GTNG_3156(nbaD)
BBE: BBR47_29730
MVA: Mvan_0424
MJL: Mjls_4213
NFA: nfa32640
SCO: SCO6305(SCIF3.07c)
ACH: Achl_3548
STP: Strop_3521
SAQ: Sare_3896
RXY: Rxyl_2240
ABA: Acid345_0682
TRO: trd_1095
Taxonomy
Structures PDB: 2F6K  2HBV  2WM1  
Reference
  Authors

  Title


  Journal
  Organism
 1  [PMID:14275130]
ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O,
SENOH S.
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN
MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID
FROM 3-HYDROXYANTHRANILIC ACID.
J. Biol. Chem. 240 (1965) 740-9.
Felis catus
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.45
IUBMB Enzyme Nomenclature: 4.1.1.45
ExPASy - ENZYME nomenclature database: 4.1.1.45
BRENDA, the Enzyme Database: 4.1.1.45
CAS: 37289-47-7
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