KEGG   ENZYME: 4.1.1.47Help
Entry
EC 4.1.1.47                 Enzyme                                 
Name tartronate-semialdehyde synthase;
tartronate semialdehyde carboxylase;
glyoxylate carbo-ligase;
glyoxylic carbo-ligase;
hydroxymalonic semialdehyde carboxylase;
tartronic semialdehyde carboxylase;
glyoxalate carboligase;
glyoxylate carboxy-lyase (dimerizing)
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname glyoxylate carboxy-lyase (dimerizing;
tartronate-semialdehyde-forming)
Reaction(IUBMB) 2 glyoxylate = tartronate semialdehyde + CO2 [RN:R00013]
Reaction(KEGG) R00013
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Substrate glyoxylate [CPD:C00048]
Product tartronate semialdehyde [CPD:C01146];
CO2 [CPD:C00011]
Cofactor FAD [CPD:C00016];
Thiamin diphosphate [CPD:C00068]
Comment A flavoprotein.
Pathway PATH: ec00630  Glyoxylate and dicarboxylate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01608  tartronate-semialdehyde synthase
Genes ECO: b0507(gcl)
ECJ: JW0495(gcl)
ECD: ECDH10B_0463(gcl)
EBW: BWG_0384(gcl)
ECE: Z0661(gcl)
ECS: ECs0568
ECF: ECH74115_0608(gcl)
ETW: ECSP_0582(gcl)
ECG: E2348C_0441(gcl)
ECC: c0622(gcl)
ECI: UTI89_C0536(gcl) UTI89_C5032(gclA)
ECP: ECP_0568
ECV: APECO1_1507(gcl) APECO1_2095(gclA)
ECW: EcE24377A_0544(gcl)
ECX: EcHS_A0581(gcl)
ECM: EcSMS35_0550(gcl) EcSMS35_4866(gcxC)
ECY: ECSE_0533
ECL: EcolC_3115
ECK: EC55989_0522(gcl)
ECQ: ECED1_0528(gcl)
ECR: ECIAI1_0510(gcl)
ECZ: ECS88_0506(gcl)
EUM: ECUMN_0548(gcl)
ELF: LF82_0816(gcl) LF82_p732
EBL: B21_00462(gcl)
EBD: ECBD_3150
EBR: ECB_00457(gcl)
EOH: ECO103_0480(gcl)
EOI: ECO111_0540(gcl)
EOJ: ECO26_0540(gcl)
STY: STY0565(gcl)
STT: t2343(gcl)
SPT: SPA2205(gcl)
SEK: SSPA2049
SPQ: SPAB_03046
SEI: SPC_0532(gcl)
SEH: SeHA_C0625(gcl)
SEE: SNSL254_A0571(gcl)
SEA: SeAg_B0564(gcl)
SED: SeD_A0566(gcl)
SEG: SG0529(gcl)
SET: SEN0498(gcl)
STM: STM0517(gcl)
SFL: SF0446(gcl)
SFX: S0453(gcl)
SFV: SFV_0474(gcl)
SBO: SBO_0411(gcl)
SBC: SbBS512_E0441(gcl)
SDY: SDY_0395(gcl)
KPU: KP1_1361(gcl)
PPR: PBPRA2275
PAE: PA1502(gcl)
PAU: PA14_45000(gcl)
PAP: PSPA7_3829(gcl)
PAG: PLES_39101(gcl)
PPU: PP_4297(gcl)
PPF: Pput_1572
PPG: PputGB1_3862
PPW: PputW619_2312 PputW619_3622
PFL: PFL_1701(gcl)
PFO: Pfl01_1598
PFS: PFLU1803(gcl)
PEN: PSEEN1672(gcl)
PMY: Pmen_2769
PSA: PST_3114(gcl)
AVN: Avin_43400(gcl)
RSO: RSc3281(gcl)
RPI: Rpic_3478
RPF: Rpic12D_3151
REU: Reut_A3291
REH: H16_A3598
RME: Rmet_3448
CTI: RALTA_A3052(gcl)
BPS: BPSL1452(gcl)
BPM: BURPS1710b_2424(gcl)
BPL: BURPS1106A_2299(gcl)
BPD: BURPS668_2259(gcl)
BPR: GBP346_A2370(gcl)
BTE: BTH_I2173(gcl)
BVI: Bcep1808_1802
BUR: Bcep18194_A5178
BCN: Bcen_6201
BCH: Bcen2424_1878
BCM: Bcenmc03_1901
BCJ: BCAL1949(gcl)
BAM: Bamb_1815
BAC: BamMC406_1787
BMU: Bmul_1396
BMJ: BMULJ_01847(gcl)
BXE: Bxe_A2460
BPH: Bphy_1620
BPY: Bphyt_1782
BGL: bglu_1g13920
POL: Bpro_4561
DAC: Daci_2117
VAP: Vapar_3954
CTT: CtCNB1_3710
HAR: HEAR0332(gcl)
MMS: mma_0379(gcl)
LCH: Lcho_1135
TMZ: Tmz1t_1299
MLO: mlr0251
SME: SM_b20681(gcl)
SMD: Smed_4308
RHI: NGR_b20420(gcl)
OAN: Oant_0458
BJA: blr3166(gcl)
BRA: BRADO4946(gcl)
OCA: OCAR_6562(gcl)
XAU: Xaut_2367
AZC: AZC_3488
MNO: Mnod_3087
ACR: Acry_1157
MSM: MSMEG_5476(gcl)
RHA: RHA1_ro02574 RHA1_ro03223
ROP: ROP_22990(gcl)
SCO: SCO6201(SC2G5.22)
SMA: SAV_2028(gcl)
SGR: SGR_1329
ART: Arth_3691
AAU: AAur_3508(gcl)
ACH: Achl_3438
BFA: Bfae_08150
NML: Namu_0244
SEN: SACE_1935(gcl) SACE_6729(gcl)
CAI: Caci_4728
RXY: Rxyl_2853
CAG: Cagg_3455
DGE: Dgeo_2612
Taxonomy
Structures PDB: 2PAN  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:14257608]
GUPTA NK, VENNESLAND B.
GLYOXYLATE CARBOLIGASE OF ESCHERICHIA COLI: A FLAVOPROTEIN.
J. Biol. Chem. 239 (1964) 3787-9.
Escherichia coli [GN:eco]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13363977]
BARKULIS SS, KRAKOW G.
Conversion of glyoxylate to hydroxypyruvate by extracts of
Escherichia coli.
Biochim. Biophys. Acta. 21 (1956) 593-4.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.47
IUBMB Enzyme Nomenclature: 4.1.1.47
ExPASy - ENZYME nomenclature database: 4.1.1.47
BRENDA, the Enzyme Database: 4.1.1.47
CAS: 9027-24-1
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