KEGG   ENZYME: 4.1.1.5Help
Entry
EC 4.1.1.5                  Enzyme                                 
Name acetolactate decarboxylase;
alpha-acetolactate decarboxylase;
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase;
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase
[(R)-2-acetoin-forming];
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase
[(3R)-3-hydroxybutan-2-one-forming]
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname (2S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase
[(3R)-3-hydroxybutan-2-one-forming]
Reaction(IUBMB) (2S)-2-hydroxy-2-methyl-3-oxobutanoate = (3R)-3-hydroxybutan-2-one +
CO2 [RN:R02948]
Reaction(KEGG) R02948;
(other) R02947
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Substrate (2S)-2-hydroxy-2-methyl-3-oxobutanoate
Product (3R)-3-hydroxybutan-2-one;
CO2 [CPD:C00011]
Pathway PATH: ec00650  Butanoate metabolism
PATH: ec00660  C5-Branched dibasic acid metabolism
Orthology KO: K01575  acetolactate decarboxylase
Genes YEN: YE4016(budA)
ECA: ECA0740(budA)
PCT: PC1_0618
PWA: Pecwa_0835
ETA: ETA_00110(budA)
ENT: Ent638_2026
ESA: ESA_00860
CTU: Ctu_29880(budA)
KPN: KPN_02059
KPE: KPK_2271(budA)
KPU: KP1_3136
SPE: Spro_3433
PMR: PMI1059(budA)
DDA: Dd703_3318
DDC: Dd586_0624
DZE: Dd1591_3440
VCH: VC1589
VCO: VC0395_A1191(aldC)
VCM: VCM66_1529(aldC)
VEX: VEA_000393
PAT: Patl_3762
CBU: CBU_1097(aldC)
CBG: CbuG_0905(aldC)
MCA: MCA1838(budA)
AHA: AHA_1125(budA)
ASA: ASA_3211(aldC)
SUN: SUN_0870
GLO: Glov_0718
PCA: Pcar_2457(budA)
DMA: DMR_13550(aldS)
DSA: Desal_3418
DOL: Dole_2293
DAL: Dalk_4199
SCL: sce9323
SFU: Sfum_3912
APT: APA01_03800(aldC)
BSU: BSU36000(alsD)
BAN: BA0867(alsD)
BAR: GBAA0867(alsD)
BAA: BA_1448
BAT: BAS0824
BAH: BAMEG_3692(alsD)
BAI: BAA_0973(alsD)
BCE: BC0884
BCA: BCE_0957(alsD)
BCZ: BCZK0773(alsD)
BCR: BCAH187_A1047(alsD)
BCB: BCB4264_A0921(alsD)
BCU: BCAH820_0959(alsD)
BCG: BCG9842_B4409(alsD)
BCQ: BCQ_0957(alsD)
BCX: BCA_0924(alsD)
BTK: BT9727_0772(alsD)
BTL: BALH_0785
BWE: BcerKBAB4_0771
BLI: BL02479(alsD)
BLD: BLi03847(alsD)
BAY: RBAM_033160(alsD)
BPU: BPUM_3272(alsD)
SAU: SA2007 SA2394
SAV: SAV2206 SAV2601
SAW: SAHV_2190 SAHV_2585
SAM: MW2131 MW2520
SAR: SAR2296 SAR2679
SAS: SAS2105 SAS2486
SAC: SACOL2198(budA1) SACOL2617(budA2)
SAB: SAB2086c SAB2474c
SAA: SAUSA300_2165(budA) SAUSA300_2536(budA)
SAX: USA300HOU_2201(alsD)
SAO: SAOUHSC_02467 SAOUHSC_02921
SAJ: SaurJH9_2236 SaurJH9_2623
SAH: SaurJH1_2275 SaurJH1_2677
SAE: NWMN_2110(alsD) NWMN_2498(aldB)
SAD: SAAV_2267(budA1) SAAV_2667(budA2)
SEP: SE2143
SER: SERP2154(budA)
SHA: SH0462
SSP: SSP0083
SCA: Sca_1958
LMO: lmo1992
LMF: LMOf2365_2015(budA)
LMH: LMHCC_0568(budA)
LMC: Lm4b_02004
LIN: lin2099
LWE: lwe2011(budA)
ESI: Exig_2262
MCL: MCCL_0011(alsD)
BBE: BBR47_58910(aldB)
LLA: L0321(aldB) L0322(aldC)
LLK: LLKF_1134(aldC) LLKF_1271(aldB)
LLC: LACR_1209 LACR_1307
LLM: llmg_1275(aldB) llmg_1464(aldC)
SPN: SP_1392
SPD: SPD_1224(budA)
SPR: spr1249(aldB)
SPW: SPCG_1381(aldB)
SPX: SPG_1332
SNE: SPN23F_13560(aldB)
SPV: SPH_1523(budA)
SNM: SP70585_1431(budA)
SJJ: SPJ_1291(budA)
SPP: SPP_1411(budA)
SNT: SPT_0882
SAG: SAG1191(budA)
SAN: gbs1264
SAK: SAK_1278(budA)
SMU: SMU.1451(aldB)
STC: str0924(aldB)
STL: stu0924(aldB)
STE: STER_0941
SSA: SSA_0901(aldB)
SSU: SSU05_1493
SSV: SSU98_1504
SSB: SSUBM407_1389(aldB)
SSI: SSU1312(aldB)
SSS: SSUSC84_1342(aldB)
SGO: SGO_0853(budA)
SUB: SUB1112(aldB)
LPL: lp_2030(aldB)
LPJ: JDM1_1694(aldB)
LJO: LJ1125
LJF: FI9785_1082(aldB)
LSA: LSA0981(aldB)
LSL: LSL_0187(alsD)
LBR: LVIS_0492
LCA: LSEI_1840
LCB: LCABL_20640(aldB)
LRE: Lreu_0133
LRF: LAR_0127
LFE: LAF_0416
LRH: LGG_01898(aldB)
LRL: LC705_01883(aldB)
EFA: EF1214(budA)
OOE: OEOE_1704
LME: LEUM_0549 LEUM_0954
LCI: LCK_00459(budA)
CAC: CAC2967
PTH: PTH_2358(alsD)
MPE: MYPE6240(aldB)
MMO: MMOB2010(alsD)
MUL: MUL_2434
MMI: MMAR_1507
CDI: DIP0990
CJK: jk0157(alsD)
CAR: cauri_0574(alsD)
CKP: ckrop_0254
BLN: Blon_2239
DFE: Dfer_1956
SYE: Syncc9902_1512
SYG: sync_0772(budA)
SYR: SynRCC307_1716(alsD)
CYN: Cyan7425_4157
NPU: Npun_R6050
CPB: Cphamn1_1357
PLT: Plut_1041
MMP: MMP0613
MMQ: MmarC5_0992
MMX: MmarC6_0278
MMZ: MmarC7_1636
MVN: Mevan_1486
MAC: MA3744(aldC)
MBA: Mbar_A2915 Mbar_A2916
MMA: MM_0639
MBU: Mbur_1014
MTP: Mthe_0909
MHU: Mhun_0155
MEM: Memar_0825
MBN: Mboo_0212
MPL: Mpal_1761
MPD: MCP_1230
RCI: RCIX2494(alsD)
Taxonomy
Structures PDB: 1XV2  
Reference
  Authors
  Title


  Journal
 1
Hill, R.K., Sawada, S. and Arfin, S.M.
Stereochemistry of valine and isoleucine biosynthesis. IV.
Synthesis, configuration, and enzymatic specificity of
alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate.
Bioorg. Chem. 8 (1979) 175-189.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:6024768]
Stormer FC.
Isolation of crystalline pH 6 acetolactate-forming enzyme from
Aerobacter aerogenes.
J. Biol. Chem. 242 (1967) 1756-9.
Aerobacter aerogenes
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.5
IUBMB Enzyme Nomenclature: 4.1.1.5
ExPASy - ENZYME nomenclature database: 4.1.1.5
BRENDA, the Enzyme Database: 4.1.1.5
CAS: 9025-02-9
DBGET integrated database retrieval system