KEGG   ENZYME: 4.1.1.64Help
Entry
EC 4.1.1.64                 Enzyme                                 

Name
2,2-dialkylglycine decarboxylase (pyruvate);
dialkyl amino acid (pyruvate) decarboxylase;
alpha-dialkyl amino acid transaminase;
2,2-dialkyl-2-amino acid-pyruvate aminotransferase;
L-alanine-alpha-ketobutyrate aminotransferase;
dialkylamino-acid decarboxylase (pyruvate);
2,2-dialkylglycine carboxy-lyase (amino-transferring)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)
Reaction(IUBMB)
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine [RN:R03854]
Reaction(KEGG)
Substrate
2,2-dialkylglycine [CPD:C02623];
pyruvate [CPD:C00022]
Product
dialkyl ketone [CPD:C02146];
CO2 [CPD:C00011];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate.
History
EC 4.1.1.64 created 1972
Orthology
K00596  
2,2-dialkylglycine decarboxylase (pyruvate)
Genes
BVI: 
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TMO: 
TMO_1799(dgdA)
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GPO: 
TPR: 
SCO: 
SCO7537(SC8G12.13c)
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Taxonomy
Reference
1
  Authors
Bailey, G.B. and Dempsey, W.B.
  Title
Purification and properties of an alpha-dialkyl amino acid transaminase.
  Journal
Biochemistry 6 (1967) 1526-1533.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-17-1

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