| Entry |
|
|---|
| Name |
2-oxoglutarate decarboxylase;
oxoglutarate decarboxylase;
alpha-ketoglutarate decarboxylase;
alpha-ketoglutaric decarboxylase;
oxoglutarate decarboxylase;
pre-2-oxoglutarate decarboxylase;
2-oxoglutarate carboxy-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
|---|
| Sysname |
2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming) |
|---|
| Reaction(IUBMB) |
2-oxoglutarate = succinate semialdehyde + CO2 [RN:R00272] |
|---|
| Reaction(KEGG) |
R00272
 |
|---|
| Substrate |
2-oxoglutarate [CPD:C00026] |
|---|
| Product |
succinate semialdehyde [CPD:C00232];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Thiamin diphosphate [CPD:C00068] |
|---|
| Comment |
Requires thiamine diphosphate. Highly specific. |
|---|
| Orthology |
KO: K01616 2-oxoglutarate decarboxylase |
|---|
| Genes |
MTU: Rv1248c(kgd)
MTC: MT1286(kgd)
MRA: MRA_1256(kgd)
MTF: TBFG_11274(kgd)
MBO: Mb1280c(kgd)
MBB: BCG_1308c(kgd)
MLE: ML1095(kgd)
MPA: MAP2536(kgd)
MSM: MSMEG_5049(kgd)
MUL: MUL_4500(kgd)
MVA: Mvan_4477(kgd)
MGI: Mflv_2218(kgd)
MAB: MAB_1393c(kgd)
MMC: Mmcs_3973(kgd)
MKM: Mkms_4047(kgd)
MJL: Mjls_3987(kgd)
MMI: MMAR_4194(kgd)
NFA: nfa46950(kgd)
RHA: RHA1_ro06012(kgd)
SEN: SACE_6385(kgd)
 |
|---|
Reference
Authors
Title
Journal
|
1
Shigeoka, S., Onishi, T., Maeda, K., Nakano, Y. and Kitaoka, S.
Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate
decarboxylase in mitochondria of Euglena gracilis.
FEBS Lett. 195 (1986) 43-47. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.1.71
IUBMB Enzyme Nomenclature: 4.1.1.71
ExPASy - ENZYME nomenclature database: 4.1.1.71
BRENDA, the Enzyme Database: 4.1.1.71
CAS: 37205-42-8 |
|---|
