KEGG   ENZYME: 4.1.1.72Help
Entry
EC 4.1.1.72                 Enzyme                                 

Name
branched-chain-2-oxoacid decarboxylase;
branched-chain oxo acid decarboxylase;
branched-chain alpha-keto acid decarboxylase;
branched-chain keto acid decarboxylase;
BCKA;
(3S)-3-methyl-2-oxopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
Reaction(IUBMB)
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2 [RN:R03894]
Reaction(KEGG)
Substrate
(3S)-3-methyl-2-oxopentanoate [CPD:C00671]
Product
2-methylbutanal [CPD:C02223];
CO2 [CPD:C00011]
Comment
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.
History
EC 4.1.1.72 created 1990
Reference
1  [PMID:3142877]
  Authors
Oku H, Kaneda T.
  Title
Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase.
  Journal
J. Biol. Chem. 263 (1988) 18386-96.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
63653-19-0

DBGET integrated database retrieval system