| Entry |
|
|---|
| Name |
acetylenedicarboxylate decarboxylase;
acetylenedicarboxylate hydratase;
acetylenedicarboxylate hydrase;
acetylenedicarboxylate carboxy-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
|---|
| Sysname |
acetylenedicarboxylate carboxy-lyase (pyruvate-forming) |
|---|
| Reaction(IUBMB) |
acetylenedicarboxylate + H2O = pyruvate + CO2 [RN:R00218] |
|---|
| Reaction(KEGG) |
R00218;
(other) R04177
 |
|---|
| Substrate |
acetylenedicarboxylate [CPD:C03248];
H2O [CPD:C00001] |
|---|
| Product |
pyruvate [CPD:C00022];
CO2 [CPD:C00011] |
|---|
| Comment |
The mechanism appears to involve hydration of the acetylene and
decarboxylation of the oxaloacetic acid formed, although free
oxaloacetate is not an intermediate. It is thus analogous to EC
4.2.1.27 (acetylenecarboxylate hydratase) in its mechanism. |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13575441]
YAMADA EW, JAKOBY WB.
Enzymatic utilization of acetylenic compounds. I. An enzyme
converting acetylenedicarboxylic acid to pyruvate.
J. Biol. Chem. 233 (1958) 706-11.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.1.78
IUBMB Enzyme Nomenclature: 4.1.1.78
ExPASy - ENZYME nomenclature database: 4.1.1.78
BRENDA, the Enzyme Database: 4.1.1.78
CAS: 72561-10-5 |
|---|
