KEGG   ENZYME: 4.1.2.11Help
Entry
EC 4.1.2.11                 Enzyme                                 

Name
hydroxymandelonitrile lyase;
hydroxynitrile lyase;
oxynitrilase;
Sorghum hydroxynitrile lyase;
(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde [RN:R02676]
Reaction(KEGG)
R02676;
(other) R01409 R02811
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Substrate
(S)-4-hydroxymandelonitrile [CPD:C03742]
Product
cyanide [CPD:C00177];
4-hydroxybenzaldehyde [CPD:C00633]
Comment
Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 (mandelonitrile lyase), EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)].
History
EC 4.1.2.11 created 1965, modified 1999
Pathway
Cyanoamino acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K08249  
hydroxymandelonitrile lyase
Reference
1
  Authors
Bove, C. and Conn, E.E.
  Title
Metabolism of aromatic compounds in higher plants. II. Purification and properties of the oxynitrilase of Sorghum vulgare.
  Journal
J. Biol. Chem. 236 (1961) 207-210.
Reference
2  [PMID:5922969]
  Authors
Seely MK, Criddle RS, Conn EE.
  Title
The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin.
  Journal
J. Biol. Chem. 241 (1966) 4457-62.
  Organism
Sorghum vulgare
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-38-1

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