| Entry |
|
|---|
| Name |
hydroxymandelonitrile lyase;
hydroxynitrile lyase;
oxynitrilase;
Sorghum hydroxynitrile lyase;
(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
 |
|---|
| Sysname |
(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase
(cyanide-forming) |
|---|
| Reaction(IUBMB) |
(S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde
[RN:R02676] |
|---|
| Reaction(KEGG) |
R02676;
(other) R01409 R02811
 |
|---|
| Substrate |
(S)-4-hydroxymandelonitrile [CPD:C03742] |
|---|
| Product |
cyanide [CPD:C00177];
4-hydroxybenzaldehyde [CPD:C00633] |
|---|
| Comment |
Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10
(mandelonitrile lyase) and EC 4.1.2.37 (hydroxynitrilase). |
|---|
| Pathway |
PATH: ec00460 Cyanoamino acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K08249 hydroxymandelonitrile lyase |
|---|
| Genes |
ATH: AT3G07990(SCPL27)
OSA: 4327407(Os01g0833500)
 |
|---|
| Structures |
PDB: 1GXS |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:16495254]
Hong Y, Shaw PJ, Nath CE, Yadav SP, Stephen KR, Earl JW, McLachlan
AJ.
Population pharmacokinetics of liposomal amphotericin B in pediatric
patients with malignant diseases.
Antimicrob. Agents. Chemother. 50 (2006) 935-42. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5922969]
Seely MK, Criddle RS, Conn EE.
The metabolism of aromatic compounds in higher plants. 8. On the
requirement of hydroxynitrile lyase for flavin.
J. Biol. Chem. 241 (1966) 4457-62.
Sorghum vulgare |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.2.11
IUBMB Enzyme Nomenclature: 4.1.2.11
ExPASy - ENZYME nomenclature database: 4.1.2.11
BRENDA, the Enzyme Database: 4.1.2.11
CAS: 9075-38-1 |
|---|
