KEGG   ENZYME: 4.1.2.14Help
Entry
EC 4.1.2.14                 Enzyme                                 
Name 2-dehydro-3-deoxy-phosphogluconate aldolase;
phospho-2-keto-3-deoxygluconate aldolase;
KDPG aldolase;
phospho-2-keto-3-deoxygluconic aldolase;
2-keto-3-deoxy-6-phosphogluconic aldolase;
2-keto-3-deoxy-6-phosphogluconate aldolase;
6-phospho-2-keto-3-deoxygluconate aldolase;
ODPG aldolase;
2-oxo-3-deoxy-6-phosphogluconate aldolase;
2-keto-3-deoxygluconate-6-P-aldolase;
2-keto-3-deoxygluconate-6-phosphate aldolase;
2-dehydro-3-deoxy-D-gluconate-6-phosphate
D-glyceraldehyde-3-phosphate-lyase
Class Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname 2-dehydro-3-deoxy-D-gluconate-6-phosphate
D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Reaction(IUBMB) 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate +
D-glyceraldehyde 3-phosphate [RN:R05605]
Reaction(KEGG) R05605;
(other) R00471
Show
Substrate 2-dehydro-3-deoxy-D-gluconate 6-phosphate [CPD:C04442]
Product pyruvate [CPD:C00022];
D-glyceraldehyde 3-phosphate [CPD:C00118]
Comment Also acts on 2-oxobutanoate.
Pathway PATH: ec00030  Pentose phosphate pathway
PATH: ec00040  Pentose and glucuronate interconversions
PATH: ec00330  Arginine and proline metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01625  2-dehydro-3-deoxyphosphogluconate aldolase /
            4-hydroxy-2-oxoglutarate aldolase
Genes CME: CMP292C
ECO: b1850(eda)
ECJ: JW1839(eda)
ECD: ECDH10B_1991(eda)
EBW: BWG_1664(eda)
ECE: Z2902(eda)
ECS: ECs2560
ECF: ECH74115_2585(eda)
ETW: ECSP_2424(eda)
ECG: E2348C_1975(eda)
ECC: c2263(eda)
ECI: UTI89_C2053(eda)
ECP: ECP_1794
ECV: APECO1_900(eda)
ECW: EcE24377A_2080(eda)
ECX: EcHS_A1942(eda)
ECM: EcSMS35_1337(eda)
ECY: ECSE_2025
ECL: EcolC_1782
ECK: EC55989_2028(eda)
ECQ: ECED1_2055(eda)
ECR: ECIAI1_1923(eda)
ECT: ECIAI39_1200(eda)
ECZ: ECS88_1906(eda)
EUM: ECUMN_2147(eda)
ELF: LF82_0546(eda)
EBL: B21_01809(eda)
EBD: ECBD_1789
EBR: ECB_01821(eda)
EOH: ECO103_2040(eda)
EOI: ECO111_2358(eda)
EOJ: ECO26_2688(eda)
EFE: EFER_1223(eda)
STT: t0993
SPT: SPA0985(eda)
SEK: SSPA0919
SPQ: SPAB_01285
SEI: SPC_1832(eda)
SEC: SC1889(eda)
SEH: SeHA_C2098(eda)
SEE: SNSL254_A2043(eda)
SEW: SeSA_A2038(eda)
SEA: SeAg_B1240(eda)
SED: SeD_A1365(eda)
SEG: SG1168(eda)
SET: SEN1119(eda)
SES: SARI_01062
STM: STM1884(eda)
YPE: YPO2067(eda)
YPK: y2243(eda)
YPM: YP_1910(eda)
YPA: YPA_1450
YPN: YPN_1544
YPG: YpAngola_A2411(eda)
YPP: YPDSF_1055
YPS: YPTB2050(eda)
YPI: YpsIP31758_2021(eda)
YPY: YPK_2132
YPB: YPTS_2111
YEN: YE2382(eda)
SFL: SF1860(eda)
SFX: S1926(eda)
SFV: SFV_1852(eda)
SSN: SSON_1298(eda)
SBO: SBO_1158(eda)
SBC: SbBS512_E2125(eda)
SDY: SDY_1136(eda)
ECA: ECA2478(eda)
PCT: PC1_1833
PWA: Pecwa_2117
ETA: ETA_12440(eda)
PLU: plu0178(eda)
PAY: PAU_00128(eda)
ENT: Ent638_2419
ESA: ESA_01391
CTU: Ctu_25320(eda)
KPN: KPN_02365(eda)
KPE: KPK_1924(eda)
KPU: KP1_3494(eda)
CKO: CKO_01116
SPE: Spro_2767 Spro_4500
PMR: PMI2147(eda) PMI2761(eda)
EIC: NT01EI_1610
ETR: ETAE_1452(eda)
DDA: Dd703_2135
DDC: Dd586_2186
DZE: Dd1591_2243
HIN: HI0047(eda)
HIT: NTHI0055(eda)
HIP: CGSHiEE_03065
HSO: HS_1603(eda)
HSM: HSM_0408
PMU: PM0947(eda)
MSU: MS0546(eda) MS0566(eda)
APL: APL_1018(eda)
APJ: APJL_1036(eda)
APA: APP7_1075
ASU: Asuc_0152 Asuc_0374 Asuc_1471
AAP: NT05HA_0021
XFA: XF1061
XFT: PD0342
XFM: Xfasm12_0370
XFN: XfasM23_0334
XCC: XCC2140(eda)
XCB: XC_1973
XCA: xccb100_2038(eda)
XCV: XCV2233(alkH)
XAC: XAC2067(eda)
XOO: XOO2319(eda)
XOM: XOO_2195
XOP: PXO_00612
SML: Smlt0073 Smlt1789(kgdA)
SMT: Smal_0029 Smal_1527
VCH: VC0285
VCO: VC0395_A2663(eda)
VCM: VCM66_0270(eda)
VCJ: VCD_001335
VVU: VV1_1102 VV2_0904 VV2_1072
VVY: VV0062 VV0555 VVA1387 VVA1596
VPA: VP0065 VPA0083 VPA1708
VHA: VIBHAR_00515
VSP: VS_1242 VS_II0040
VEX: VEA_000917 VEA_001957
VFI: VF_0090(eda) VF_A0987
VFM: VFMJ11_0088 VFMJ11_A1082 VFMJ11_A1106
VSA: VSAL_I2956(eda) VSAL_II0664
PPR: PBPRA1276 PBPRB0159 PBPRB1732 PBPRB1883
PAE: PA3131 PA3181
PAU: PA14_23090(edaA) PA14_23620(kdgA)
PAP: PSPA7_1949 PSPA7_2001
PAG: PLES_18871 PLES_19281
PPU: PP_1024(eda)
PPF: Pput_1062
PPG: PputGB1_1022
PPW: PputW619_4200
PST: PSPTO_1302(eda-1)
PSB: Psyr_1122
PSP: PSPPH_1190(eda1)
PFL: PFL_4608(eda)
PFO: Pfl01_4361
PFS: PFLU4836
PEN: PSEEN4403(eda)
PMY: Pmen_3141
PSA: PST_2327(eda) PST_3495(eda-1)
CJA: CJA_1352(kdgA)
AVN: Avin_15720(eda-2) Avin_27250(eda-1) Avin_34340
ACI: ACIAD0543(eda)
ACB: A1S_0484
ABM: ABSDF3020(eda)
ABY: ABAYE3280(eda)
ABC: ACICU_00495
ABN: AB57_0588
ABB: ABBFA_003049
SON: SO_2486(eda)
SDN: Sden_2076
SFR: Sfri_1895
SAZ: Sama_1809
SBL: Sbal_2238 Sbal_4524
SBM: Shew185_2133
SBN: Sbal195_2178
SBP: Sbal223_2251
SLO: Shew_2045
SPC: Sputcn32_1869
SSE: Ssed_2073
SPL: Spea_2332
SHE: Shewmr4_2043
SHM: Shewmr7_1932
SHN: Shewana3_2148
SHW: Sputw3181_2139
SHL: Shal_1952
SWD: Swoo_2536
SWP: swp_2393
CPS: CPS_2284(eda)
PHA: PSHAa1367(eda) PSHAa1744
PAT: Patl_0974 Patl_2643
SDE: Sde_1382
MAQ: Maqu_1832
AMC: MADE_01248 MADE_01491
PIN: Ping_0129 Ping_2930
TTU: TERTU_0896
CBU: CBU_1277(eda)
CBS: COXBURSA331_A1426(eda)
CBD: CBUD_1366(eda)
CBG: CbuG_0732(eda)
CBC: CbuK_1139(eda)
LPN: lpg0420(eda)
LPF: lpl0463(eda)
LPP: lpp0487(eda)
LPC: LPC_2923(eda)
MCA: MCA0038(eda)
HCH: HCH_00349(eda)
CSA: Csal_2739
MMW: Mmwyl1_0212 Mmwyl1_1039
AHA: AHA_0289(eda)
ASA: ASA_4108(eda)
TAU: Tola_0776 Tola_1796 Tola_3047
NMA: NMA1611(eda)
NME: NMB1394(eda)
NMC: NMC1333(eda)
NMN: NMCC_1309(eda)
NMI: NMO_1236(eda)
NGO: NGO0713
NGK: NGK_1177
CVI: CV_0143(eda)
LHK: LHK_03117(alkD)
RSO: RSp1190(eda)
RPI: Rpic_4192
RPF: Rpic12D_4302
REU: Reut_B4024
REH: H16_B1213(eda)
RME: Rmet_4768
CTI: RALTA_B1124(eda)
BMA: BMA2445(eda)
BMV: BMASAVP1_A0362(eda)
BML: BMA10229_A1220(eda)
BMN: BMA10247_2631(eda)
BPS: BPSL2931(eda)
BPM: BURPS1710b_3441
BPL: BURPS1106A_3441(eda)
BPD: BURPS668_3406(eda)
BPR: GBP346_A3586
BTE: BTH_I1218
BVI: Bcep1808_0629
BUR: Bcep18194_A3747
BCN: Bcen_0178
BCH: Bcen2424_0661
BCM: Bcenmc03_0628
BCJ: BCAL3366(eda)
BAM: Bamb_0556
BAC: BamMC406_0582
BMU: Bmul_2722
BMJ: BMULJ_00515(eda)
BXE: Bxe_A0590
BPH: Bphy_2579
BPY: Bphyt_3369
BGL: bglu_1g05530
BPT: Bpet0875(kdgA)
RFR: Rfer_2061
POL: Bpro_3550
PNA: Pnap_2985
AAV: Aave_2792
AJS: Ajs_2048
VEI: Veis_2569
DAC: Daci_3766
DIA: Dtpsy_1871
VAP: Vapar_3707
CTT: CtCNB1_3429
HAR: HEAR1087(eda)
MMS: mma_2310(eda)
LCH: Lcho_2918
MFA: Mfla_0760
MMB: Mmol_1726
MEI: Msip34_1896
HPY: HP1099
HPJ: jhp1025(eda)
HPA: HPAG1_1037
HPS: HPSH_05645
HPG: HPG27_1040
HPP: HPP12_1064(eda)
HPB: HELPY_1068(eda)
HAC: Hac_0443(eda)
CJD: JJD26997_1272
SCL: sce1239(kdgA1) sce5154(kdgA2)
HOH: Hoch_4429
MLO: mlr2994
MES: Meso_2733
SME: SMc02043(eda1) SMc03153(eda2)
SMD: Smed_2464 Smed_2779
ATU: Atu4494(kdgA)
ATC: AGR_L_750
ARA: Arad_3917(eda)
AVI: Avi_3816
RET: RHE_CH03635(eda)
REC: RHECIAT_CH0003906(eda)
RLE: RL4162(eda)
RLT: Rleg2_3397
RLG: Rleg_3696
RHI: NGR_c29340
BME: BMEII0009
BMI: BMEA_B0088(eda)
BMF: BAB2_0083
BMB: BruAb2_0084
BMC: BAbS19_II00780
BMT: BSUIS_B0089(eda)
BOV: BOV_A0079(eda)
BCS: BCAN_B0087(eda)
BMR: BMI_II86
OAN: Oant_4257
BJA: blr3923(kdgA)
BRA: BRADO1806(eda)
BBT: BBta_2126(eda)
BHE: BH12770(eda)
BTR: Btr_1752(eda)
BGR: Bgr_15590(eda)
XAU: Xaut_1019
AZC: AZC_0561
MEX: Mext_2006
MEA: Mex_1p1985(eda)
MDI: METDI2773(eda)
MRD: Mrad2831_3429
MET: M446_3071
MPO: Mpop_1962
MCH: Mchl_2283
MNO: Mnod_4545
BID: Bind_0629 Bind_2869
MSL: Msil_1123
CCR: CC_1495
CCS: CCNA_01562
CAK: Caul_1760
PZU: PHZ_c3250
SIL: SPO3031(eda-1) SPOA0330(eda-2)
SIT: TM1040_0375
RSP: RSP_2645(eda)
RSH: Rsph17029_1302
RSQ: Rsph17025_1180
RSK: RSKD131_0956
JAN: Jann_1954
RDE: RD1_2878(eda)
PDE: Pden_1245
DSH: Dshi_1768(eda)
MMR: Mmar10_2671
HNE: HNE_1187(eda)
HBA: Hbal_1544
ZMO: ZMO0997
ZMN: Za10_0308
NAR: Saro_2568
SAL: Sala_0192
SWI: Swit_1626 Swit_1883
ELI: ELI_00530
GOX: GOX0430
GBE: GbCGDNIH1_2044
ACR: Acry_0467
BSU: BSU22100(kdgA)
BHA: BH3723(kdgA)
BCZ: pE33L466_0341(kdgA)
BLI: BL02470(kdgA) BL03850
BLD: BLi03826(kdgA) BLi04071
BCL: ABC0523 ABC3136
BAY: RBAM_017970(kdgA)
BPU: BPUM_3243(kdgA)
OIH: OB2214 OB2703
GKA: GK1956
GTN: GTNG_1488 GTNG_1767(kdgA) GTNG_1856
GYM: GYMC10_4826 GYMC10_5049 GYMC10_5576
GYC: GYMC61_2703
SHA: SH2651
SSP: SSP2183
LMO: lmo1969
PJD: Pjdr2_0764 Pjdr2_5139
AAC: Aaci_2290
LLA: L0022(kdgA)
LLK: LLKF_1705(kdgA) LLKF_1783(kdgA)
LLC: LACR_1740
LLM: llmg_0864(kdgA)
SPY: SPy_0639(kgdA)
SPZ: M5005_Spy_0527(kgdA)
SPM: spyM18_0702(alkH)
SPG: SpyM3_0451(kgdA)
SPS: SPs1405
SPH: MGAS10270_Spy0522(kgdA) MGAS10270_Spy1172
SPI: MGAS10750_Spy0546(kgdA)
SPJ: MGAS2096_Spy0539(kgdA)
SPK: MGAS9429_Spy0518(kgdA)
SPF: SpyM51336(kgdA)
SPA: M6_Spy0548
SPB: M28_Spy0506(kgdA)
SOZ: Spy49_0533(kdgA)
SPN: SP_0317
SPD: SPD_0289(eda)
SPR: spr0287(kdgA)
SPW: SPCG_0323(kdgA)
SPX: SPG_0287(eda)
SNE: SPN23F_02910(kgdA)
SPV: SPH_0428
SNM: SP70585_0381 SP70585_2239
SJJ: SPJ_0312
SPP: SPP_0352
SNT: SPT_0366
SAG: SAG0700(eda-1) SAG1907(eda-2)
SAN: gbs0673 gbs1894
SAK: SAK_0826(eda)
SSU: SSU05_1160 SSU05_1222
SSV: SSU98_1175 SSU98_1237
SSB: SSUBM407_0728(kgdA) SSUBM407_0782(dgoA)
SSI: SSU1004(dgoA) SSU1061(kgdA)
SSS: SSUSC84_1042(dgoA) SSUSC84_1094(kgdA)
SEQ: SZO_06670 SZO_13130
SEZ: Sez_0688(kdgA) Sez_1300(kdgA)
SEU: SEQ_0715 SEQ_1481
SUB: SUB1204(dgoA) SUB1601(kgdA)
SDS: SDEG_0653(kgdA) SDEG_1365
LPJ: JDM1_0578
LBR: LVIS_0324
LCA: LSEI_0051
LCB: LCABL_00520(eda-1) LCABL_28630(eda-1)
LRH: LGG_00052(eda-1)
LRL: LC705_00044(eda-1) LC705_00469(kdgA)
EFA: EF0423(eda-1) EF2266 EF3134(eda-2)
CAC: CAC0394(kdgA) CAC2973(kdgA)
CPE: CPE0150
CPF: CPF_0397
CPR: CPR_0393
CNO: NT01CX_1477
CDF: CD3626(kdgA)
CDC: CD196_3441(kdgA)
CDL: CDR20291_3487(kdgA)
CBO: CBO0292(kdgA)
CBA: CLB_0336(eda)
CBH: CLC_0351(eda)
CBY: CLM_0350(eda)
CBL: CLK_3485(eda)
CBB: CLD_0458(eda)
CBI: CLJ_B0346(eda)
CBF: CLI_0365(eda)
CBE: Cbei_0462 Cbei_1836 Cbei_2201
CPY: Cphy_0054
CCE: Ccel_3192
AMT: Amet_1261
ATE: Athe_2386
APR: Apre_1599
EEL: EUBELI_01254
TEX: Teth514_0129 Teth514_0137
TPD: Teth39_1971 Teth39_2065 Teth39_2073
MTA: Moth_0420
CSC: Csac_0354
PML: ATP_00116(eda)
MSM: MSMEG_0312(eda) MSMEG_3788(eda)
MVA: Mvan_4889
CGT: cgR_0207
RHA: RHA1_ro02367 RHA1_ro02464 RHA1_ro02786
ROP: ROP_20810(eda) ROP_21900 ROP_24030(kdgA)
SCO: SCO0852(SCM2.05c) SCO2298(kdgA) SCO3473(SCE65.09c)
     SCO3495(SCE65.31c)
SMA: SAV_5878(kdgA)
SGR: SGR_5216
ART: Arth_1807 Arth_1866
AAU: AAur_4060
ACH: Achl_1007 Achl_3696
RSA: RSal33209_0834
BCV: Bcav_1627
BFA: Bfae_01450
JDE: Jden_2209
XCE: Xcel_0907
PAC: PPA0371 PPA2133
TFU: Tfu_0188
TCU: Tcur_1744
SRO: Sros_3371
FRE: Franean1_7020 Franean1_7066
ACE: Acel_1213
NML: Namu_1527 Namu_2429 Namu_4292
KRA: Krad_0201 Krad_2133
SEN: SACE_1739(kdgA) SACE_4936 SACE_5973
SVI: Svir_27790
AMI: Amir_1422
SAQ: Sare_3005
CAI: Caci_0719 Caci_5015
RXY: Rxyl_0079
APV: Apar_0664 Apar_1280
TPA: TP0568
TPP: TPASS_0568(eda)
BHY: BHWA1_02238(eda)
ACA: ACP_1125(eda)
SUS: Acid_5289
BTH: BT_0489
BFR: BF2699
BFS: BF2718
BVU: BVU_3056
PDI: BDI_3185
APS: CFPG_647
RMR: Rmar_1159 Rmar_2276
DFE: Dfer_1016 Dfer_4126
CPI: Cpin_6830
PHE: Phep_2265
GFO: GFO_1162(kdgA) GFO_1707(eda)
FJO: Fjoh_0670 Fjoh_4260
FBA: FIC_01886
RBI: RB2501_13624
FSU: Fisuc_1588
STR: Sterm_0219 Sterm_0946 Sterm_3193 Sterm_4059
SMF: Smon_0116
OTE: Oter_4262
RSD: TGRD_071
SYN: sll0107(eda)
SYW: SYNW0306
SYC: syc1480_d(eda)
SYF: Synpcc7942_0017
SYD: Syncc9605_0302
SYE: Syncc9902_2042
SYG: sync_0356(eda)
SYR: SynRCC307_2192(kdgA)
SYX: SynWH7803_0356(kdgA)
SYP: SYNPCC7002_A0130(eda)
CYA: CYA_1625(eda)
CYB: CYB_1899(eda)
TEL: tlr1928
CYT: cce_0591
CYP: PCC8801_4339
CYC: PCC7424_1658
CYN: Cyan7425_4279
CYH: Cyan8802_4401
GVI: gll4271
ANA: all4771
NPU: Npun_F2718
AVA: Ava_2448
PMA: Pro0254(eda)
PMM: PMM0225
PMT: PMT1797
PMN: PMN2A_1594
PMI: PMT9312_0227
PMB: A9601_02461(eda)
PMC: P9515_02571(eda)
PMG: P9301_02471(eda)
PMH: P9215_02471(eda)
PME: NATL1_03051(eda)
TER: Tery_4949
AMR: AM1_4889(eda)
TRO: trd_0197
STI: Sthe_0952
DGE: Dgeo_2812 Dgeo_2816
DDR: Deide_1p01640 Deide_1p01670
TTH: TT_P0030
TTJ: TTHB072
TMA: TM0066
TPT: Tpet_0858
TLE: Tlet_0636
TRQ: TRQ2_0881
TNA: CTN_0627
TNP: Tnap_0696
DTH: DICTH_0483
DTU: Dtur_0647
TTR: Tter_2730
HMA: rrnAC3121(eda)
HWA: HQ1495A(eda)
HLA: Hlac_0151 Hlac_2860
HUT: Huta_1331
HMU: Hmuk_1228
Taxonomy
Structures PDB: 1EUA  1EUN  1FQ0  1FWR  1KGA  1MXS  1WA3  1WAU  1WBH  2C0A  
     2NUW  2NUX  2NUY  2YW3  2YW4  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:14245411]
MELOCHE HP, WOOD WA.
CRYSTALLIZATION AND CHARACTERISTICS OF
2-KETO-3-DEOXY-6-PHOSPHOGLUCONIC ALDOLASE.
J. Biol. Chem. 239 (1964) 3515-8.
Pseudomonas fluorescens, Pseudomonas saccharophila
Other DBs ExplorEnz - The Enzyme Database: 4.1.2.14
IUBMB Enzyme Nomenclature: 4.1.2.14
ExPASy - ENZYME nomenclature database: 4.1.2.14
BRENDA, the Enzyme Database: 4.1.2.14
CAS: 9024-53-7
DBGET integrated database retrieval system