| Entry |
|
|---|
| Name |
threonine aldolase;
L-threonine acetaldehyde-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
 |
|---|
| Sysname |
L-threonine acetaldehyde-lyase (glycine-forming) |
|---|
| Reaction(IUBMB) |
L-threonine = glycine + acetaldehyde [RN:R00751] |
|---|
| Reaction(KEGG) |
R00751;
(other) R06171
 |
|---|
| Substrate |
L-threonine [CPD:C00188] |
|---|
| Product |
glycine [CPD:C00037];
acetaldehyde [CPD:C00084] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01620 threonine aldolase |
|---|
| Genes |
RNO: 688286
BTA: 507443
OAA: 100087020
XTR: 594999
DRE: 431723
BFO: BRAFLDRAFT_260210
CIN: 100186858
SPU: 579654
DME: Dmel_CG10184
DPO: Dpse_GA10138
DAN: Dana_GF18752
DER: Dere_GG12420
DPE: Dper_GL13839
DSE: Dsec_GM23553
DSI: Dsim_GD18368
DYA: Dyak_GE23939
DGR: Dgri_GH19068
DMO: Dmoj_GI10703
AGA: AgaP_AGAP003688
AAG: AaeL_AAEL005819
CQU: CpipJ_CPIJ012034
AME: 552565
NVI: 100123835
TCA: 659017
API: 100159142 100161178
ISC: IscW_ISCW008580
CEL: R102.4
CBR: CBG17652
NVE: NEMVE_v1g192932
HMG: 100197094
ATH: AT1G08630(THA1) AT3G04520(THA2)
POP: POPTR_729883 POPTR_826083
RCU: RCOM_0609060
VVI: 100265578
OSA: 4336402(Os04g0516600)
SBI: SORBI_06g022630(SORBIDRAFT_06g022630)
ZMA: 100272842 100282861
PPP: PHYPADRAFT_187197
OLU: OSTLU_33121
SCE: YEL046C(GLY1)
AGO: AGOS_AFR366W AGOS_AGR200W
KLA: KLLA0F16775g
LTH: KLTH0C03168g KLTH0E13090g
DHA: DEHA0B14894g DEHA0G23969g
PIC: PICST_71203(GLY2) PICST_74130(GLY1)
PPA: PAS_chr4_0112
VPO: Kpol_1059p12
LEL: LELG_00328 LELG_03248
ZRO: ZYRO0F05500g
CAL: CaO19.13682(GLY12)
CTP: CTRG_00533 CTRG_03338
CDU: CD36_09840 CD36_30270
CGR: CAGL0I01342g
YLI: YALI0A21417g
SPO: SPAC23H3.09c(gly1)
NCR: NCU00944
PAN: PODANSg09447
MGR: MGG_11389
FGR: FG05335.1 FG05623.1
ANI: AN7564.2
AFM: AFUA_2G14930 AFUA_7G06540
AOR: AO090005000497 AO090012000408
ANG: An03g01360 An07g00680 An15g03260
AFV: AFLA_016730 AFLA_077440
PCS: Pc12g01020
NFI: NFIA_027830 NFIA_060300 NFIA_090170
CIM: CIMG_01439 CIMG_04525
URE: UREG_01355 UREG_01734
SSL: SS1G_01438
BFU: BC1G_07981
CNE: CNC04680
CNB: CNBC2500
LBC: LACBIDRAFT_301794
MPR: MPER_09666
UMA: UM04787.1
MGL: MGL_1950
TET: TTHERM_00989450 TTHERM_01001240
LMA: LmjF01.0480
LIF: LinJ01.0490
TVA: TVAG_496760
PTI: PHATRDRAFT_49372
TPS: THAPSDRAFT_33203
ECO: b0870(ltaE)
ECJ: JW0854(ltaE)
ECD: ECDH10B_0940(ltaE)
EBW: BWG_0723(ltaE)
ECE: Z1104(ybjU)
ECS: ECs0956
ECF: ECH74115_1031(ltaE)
ETW: ECSP_0975(ltaE)
ECG: E2348C_0867(ltaE)
ECC: c1003(ybjU)
ECI: UTI89_C0873(ybjU)
ECP: ECP_0885
ECV: APECO1_1224(ybjU)
ECW: EcE24377A_0943(ltaE)
ECX: EcHS_A0974(ltaE)
ECM: EcSMS35_0899(ltaE)
ECY: ECSE_0928
ECL: EcolC_2726
ECK: EC55989_0915(ltaE)
ECQ: ECED1_0837(ltaE)
ECR: ECIAI1_0910(ltaE)
ECT: ECIAI39_0851(ltaE)
ECZ: ECS88_0891(ltaE)
EUM: ECUMN_1065(ltaE)
ELF: LF82_1236(ltaE)
EBL: B21_00881(ltaE)
EBD: ECBD_2724
EBR: ECB_00875(ltaE)
EOH: ECO103_0914(ltaE)
EOI: ECO111_0939(ltaE)
EOJ: ECO26_0997(ltaE)
EFE: EFER_1013(ltaE)
STY: STY0930(ybjU)
STT: t1999(ybjU)
SPT: SPA1865(ybjU)
SEK: SSPA1735
SPQ: SPAB_02590
SEI: SPC_0936(ybjU)
SEC: SC0889(ltaA)
SEH: SeHA_C1032(ltaE)
SEE: SNSL254_A0969(ltaE)
SEW: SeSA_A1051(ltaE)
SEA: SeAg_B0934(ltaE)
SED: SeD_A1001(ltaE)
SEG: SG0877(ltaA)
SET: SEN0842(ltaA)
SES: SARI_02028
STM: STM0934(ltaA)
YPE: YPO1357(ltaA)
YPK: y2823
YPM: YP_1239(ltaA)
YPA: YPA_0645
YPN: YPN_2625
YPG: YpAngola_A1588(ltaE)
YPP: YPDSF_2340
YPS: YPTB1383(ltaA)
YPI: YpsIP31758_2620(ltaE)
YPY: YPK_2705
YPB: YPTS_1482
YEN: YE1505(ltaA)
SFL: SF0825(ybjU)
SFX: S0866(ybjU)
SFV: SFV_0858(ybjU)
SSN: SSON_0856(ybjU)
SBO: SBO_0803(ybjU)
SBC: SbBS512_E2461(ltaE)
SDY: SDY_2393(ybjU)
PCT: PC1_1475
SGL: SG1098
ENT: Ent638_1386
ESA: ESA_02467
CTU: Ctu_14810(ltaE)
KPN: KPN_00903(ltaE)
KPE: KPK_3659(ltaE)
KPU: KP1_1868(ltaE)
CKO: CKO_02211
SPE: Spro_1663
PMR: PMI1269
EIC: NT01EI_2506
ETR: ETAE_2221(ltaA)
XCC: XCC0460
XCB: XC_0474
XCA: xccb100_0495(ltaE)
XCV: XCV0506
XAC: XAC0477
XOO: XOO4048
XOM: XOO_3823
XOP: PXO_04194
VCH: VCA0765
VCO: VC0395_0706(ybjU)
VCM: VCM66_A0724(ybjU)
VCJ: VCD_000555
VVU: VV2_0053
VVY: VVA0561
VPA: VPA1011
VHA: VIBHAR_05668
VSP: VS_II0638
VEX: VEA_000046
VFI: VF_A0497
VFM: VFMJ11_A0544
VSA: VSAL_II0582(gly)
PPR: PBPRB0795
PAE: PA0902 PA5413(ltaA)
PAU: PA14_52610 PA14_71440(ltaA)
PAP: PSPA7_4613 PSPA7_6201(ltaA)
PAG: PLES_44141 PLES_58081(ltaA)
PPU: PP_0321
PPF: Pput_0343
PPG: PputGB1_0344
PPW: PputW619_4886
PST: PSPTO_0410 PSPTO_1841
PSB: Psyr_3557 Psyr_4766
PSP: PSPPH_3513
PFL: PFL_4507 PFL_5731(ltaE)
PFO: Pfl01_4276 Pfl01_5210
PFS: PFLU4749 PFLU5654(ltaE)
PEN: PSEEN5163(ltaE)
PMY: Pmen_2904 Pmen_4134
PSA: PST_1368 PST_1799(ltaA)
PRW: PsycPRwf_0904
SON: SO_3338(ybjU)
SDN: Sden_1361
SFR: Sfri_2801
SAZ: Sama_2462
SBL: Sbal_3011
SBM: Shew185_3026
SBN: Sbal195_3169
SBP: Sbal223_1352
SLO: Shew_1155
SPC: Sputcn32_2673
SSE: Ssed_1247
SPL: Spea_1142 Spea_2205
SHE: Shewmr4_1207
SHM: Shewmr7_1278
SHN: Shewana3_1208
SHW: Sputw3181_1338
SHL: Shal_1187
SWD: Swoo_1347 Swoo_2345
SWP: swp_1290
ILO: IL0217
PHA: PSHAb0295(ltaE)
PIN: Ping_2292
TTU: TERTU_3986(ltaE)
FPH: Fphi_0104
NOC: Noc_2606
HCH: HCH_00857
CSA: Csal_0880
MMW: Mmwyl1_1844
AHA: AHA_1795
ASA: ASA_1753(ltaA)
KKO: Kkor_1108
CVI: CV_4309
LHK: LHK_02154
RSO: RS05504(RSp1116) RSc0808(ltaA)
RPI: Rpic_0754
RPF: Rpic12D_0824
REU: Reut_A0859
REH: H16_A2762(ltaA)
RME: Rmet_0809
CTI: RALTA_A2254(ltaA)
BMA: BMAA1834(ltaE)
BMV: BMASAVP1_0834(ltaE)
BML: BMA10229_1125(ltaE)
BMN: BMA10247_A2098(ltaE)
BPS: BPSL1714 BPSS0236(ltaE)
BPM: BURPS1710b_2159 BURPS1710b_A1771(ltaE)
BPL: BURPS1106A_2023 BURPS1106A_A0337(ltaE)
BPD: BURPS668_2003 BURPS668_2111 BURPS668_A0430(ltaE)
BPR: GBP346_A2049(ltaE)
BTE: BTH_II2147
BVI: Bcep1808_3651
BUR: Bcep18194_B0178
BCN: Bcen_5386
BCH: Bcen2424_5475
BCM: Bcenmc03_4794
BCJ: BCAM2671(ltaE)
BAM: Bamb_4817
BAC: BamMC406_5364
BMU: Bmul_3310
BMJ: BMULJ_05215(ltaA)
BXE: Bxe_A1314 Bxe_B2204
BPH: Bphy_1610 Bphy_3793
BPY: Bphyt_2821 Bphyt_5968
BGL: bglu_2g08310 bglu_2g21450
BPE: BP2407(ltaE)
BPA: BPP3272(ltaE)
BBR: BB3723(ltaE)
BPT: Bpet1784(ltaE) Bpet2199
BAV: BAV1150(ltaE)
RFR: Rfer_3604
POL: Bpro_2069 Bpro_4454
PNA: Pnap_3651
AAV: Aave_0639
VEI: Veis_1686
DAC: Daci_5734
VAP: Vapar_0576 Vapar_5453
MPT: Mpe_A1430
LCH: Lcho_1555
APP: CAP2UW1_2048
GSU: GSU3162 GSU3408
GME: Gmet_0270 Gmet_3503
GUR: Gura_1870
GLO: Glov_3333
GBM: Gbem_1928 Gbem_3418
GEM: GM21_2289 GM21_3480
DVU: DVU1878(ltaE)
DVL: Dvul_1286
DVM: DvMF_0572
DDE: Dde_1657
DSA: Desal_1078
BBA: Bd1811(lta)
DPS: DP1003
DAT: HRM2_12450(ltaE)
ADE: Adeh_0942
ACP: A2cp1_1000
AFW: Anae109_0983 Anae109_3740
ANK: AnaeK_1003
MXA: MXAN_1432
SCL: sce2044(ltaA) sce8223
HOH: Hoch_3444
SFU: Sfum_0699
WOL: WD0617 WD0618
WRI: WRi_005790 WRi_005800 WRi_010450 WRi_010460
PUB: SAR11_0689
MLO: mlr3032 mlr6130
MES: Meso_2745
PLA: Plav_1966 Plav_2819
SME: SMc04029
SMD: Smed_2712
ATU: Atu3785(ald)
ATC: AGR_L_2098
ARA: Arad_3838
AVI: Avi_3736
RET: RHE_CH03568(ypch01258)
REC: RHECIAT_CH0003822(ltaE)
RLE: RL4086(ltaE)
RLT: Rleg2_3318
RLG: Rleg_3617
RHI: NGR_b06890 NGR_c28700
BME: BMEII0041
BMI: BMEA_B0056
BMF: BAB2_0051
BMB: BruAb2_0052
BMC: BAbS19_II00460
BMS: BRA0052
BCS: BCAN_B0055(ltaE)
BMR: BMI_II54
OAN: Oant_4278
BJA: bll4016 blr5707
BRA: BRADO2796
BBT: BBta_5390
RPA: RPA1588 RPA2365
RPB: RPB_3700 RPB_4433
RPC: RPC_1602
RPD: RPD_1764
RPE: RPE_1630
RPT: Rpal_1776 Rpal_2609
AZC: AZC_1923 AZC_2018
MEX: Mext_3121 Mext_4651
MEA: Mex_1p3334(ltaE) Mex_1p5100
MDI: METDI3905(ltaE) METDI5701
MRD: Mrad2831_0009 Mrad2831_5537
MET: M446_1813
MPO: Mpop_3318 Mpop_5192
MCH: Mchl_3442 Mchl_5114
MNO: Mnod_1169
BID: Bind_3029
MSL: Msil_3876
CCR: CC_3093
CCS: CCNA_03190
CAK: Caul_0742 Caul_3880
PZU: PHZ_c0751
SIL: SPO3156
SIT: TM1040_0162
RSP: RSP_1448 RSP_2302
RSH: Rsph17029_0097 Rsph17029_0977
RSQ: Rsph17025_2198
RSK: RSKD131_0624 RSKD131_2832
JAN: Jann_2851
RDE: RD1_3525(ltaE)
PDE: Pden_3664
DSH: Dshi_2144
MMR: Mmar10_2153
HNE: HNE_0475(ltaE)
ZMO: ZMO1347
ZMN: Za10_0009
NAR: Saro_3267
SAL: Sala_0496
SWI: Swit_1176
ELI: ELI_13610
GOX: GOX0793
ACR: Acry_2826
GDI: GDI_1304 GDI_2428(ltaE)
GDJ: Gdia_0678 Gdia_2014
APT: APA01_03700
RRU: Rru_A2249
RCE: RC1_1727(ltaE)
BHA: BH3283
GKA: GK2764
AFL: Aflv_1024
SAU: SA1154
SAV: SAV1315
SAW: SAHV_1304
SAM: MW1203
SAR: SAR1326
SAS: SAS1256
SAC: SACOL1349
SAB: SAB1178c
SAA: SAUSA300_1214
SAX: USA300HOU_1260
SAO: SAOUHSC_01307
SAJ: SaurJH9_1377
SAH: SaurJH1_1404
SAE: NWMN_1228
SAD: SAAV_1295
SEP: SE0995
SER: SERP0883
SHA: SH1592
SCA: Sca_1514(ltaE)
LSP: Bsph_2514
BBE: BBR47_33020 BBR47_51890
SAG: SAG1756
SAN: gbs1799
SAK: SAK_1778(ltaE)
SSU: SSU05_0774
SSV: SSU98_0772
SSB: SSUBM407_1112
SSI: SSU0722
SSS: SSUSC84_0686
CAC: CAC3420
CTC: CTC01037
CDF: CD2591(ltaE)
CDC: CD196_2431(ltaE)
CDL: CDR20291_2478(ltaE)
CBO: CBO2233
CBA: CLB_2173
CBH: CLC_2156
CBY: CLM_2439
CBL: CLK_1673
CBB: CLD_2342
CBI: CLJ_B2444
CBF: CLI_2282
CBE: Cbei_4155
CKL: CKL_2734(ltaA)
CKR: CKR_2428
CPY: Cphy_2181
CCE: Ccel_0635
AMT: Amet_2445 Amet_3510
AOE: Clos_2339
STH: STH2403
DSY: DSY4242
DHD: Dhaf_1081
DRM: Dred_0105
FMA: FMG_1252
APR: Apre_0300
ERE: EUBREC_2364
TTE: TTE0267(gly1)
TEX: Teth514_0206
TPD: Teth39_2007
CHY: CHY_0904(ltaE)
CPO: COPRO5265_0160(glyA1)
NTH: Nther_0544
HOR: Hore_19940
MSM: MSMEG_4454(ltaE)
MVA: Mvan_1179
MGI: Mflv_5153
MMC: Mmcs_5263
MKM: Mkms_5352
MJL: Mjls_5642
CAR: cauri_0487
RER: RER_56170
SCO: SCO1087(2SCG4.03c)
SMA: SAV_1488(ltaA)
SGR: SGR_6518
CMI: CMM_0385(ltaE)
CMS: CMS_1932
ART: Arth_1658
AAU: AAur_1799 AAur_1914
ACH: Achl_1651
RSA: RSal33209_2381
MLU: Mlut_01000
BCV: Bcav_0329
XCE: Xcel_0112
NCA: Noca_3094
TCU: Tcur_1982
SRO: Sros_2555 Sros_9381
FRA: Francci3_0183
FRE: Franean1_4076
FAL: FRAAL0384(itaE)
ACE: Acel_0686
NML: Namu_4532
KRA: Krad_1277
SEN: SACE_7162(ltaE)
SVI: Svir_38080
AMI: Amir_4499 Amir_6894
STP: Strop_3255
SAQ: Sare_3482
CAI: Caci_5175 Caci_6047
BLO: BL1103
BLJ: BLD_0857(gly1)
BLN: Blon_1935
BAD: BAD_0527(tal)
BLA: BLA_1144(tal)
BLC: Balac_0614
BLT: Balat_0614
RXY: Rxyl_0796
AFO: Afer_0679
SHI: Shel_08120
ELE: Elen_2927
TDE: TDE0005(ltaE)
BHY: BHWA1_00425
ABA: Acid345_2367
ACA: ACP_0847(ltaE)
SUS: Acid_4804 Acid_5925
BTH: BT_1815
BFR: BF3384
BFS: BF3212
BVU: BVU_1700
PGI: PG0474
PGN: PGN_1495
PDI: BDI_1505
SRU: SRU_1423(ybjU)
RMR: Rmar_1115
DFE: Dfer_4745
CPI: Cpin_6238 Cpin_7125
PHE: Phep_3290
GFO: GFO_1799
FJO: Fjoh_2554
FPS: FP0874(ltaE)
FBA: FIC_02394
COC: Coch_0102
RBI: RB2501_15569
FNU: FN0810
LBA: Lebu_2061
OTE: Oter_4021
AMU: Amuc_1162
GAU: GAU_1110
RBA: RB10307(gly1)
TAI: Taci_1535
CYB: CYB_0540
GVI: glr2478
ANA: alr3296
NPU: Npun_F1429
AVA: Ava_4955
TER: Tery_1646
DEH: cbdb_A181(gly1)
DEB: DehaBAV1_0218
DEV: DhcVS_161(gly1)
RCA: Rcas_0734
CAU: Caur_2587
CAG: Cagg_1282
CHL: Chy400_2796
HAU: Haur_1036
TRO: trd_1884
STI: Sthe_2344
DRA: DR_1313
DGE: Dgeo_1451
DDR: Deide_09290
TTH: TTC0397
TTJ: TTHA0753
TMA: TM1744
TPT: Tpet_1039
TLE: Tlet_1942
TRQ: TRQ2_1081
TNA: CTN_0942
TNP: Tnap_1063
TAF: THA_244
PMO: Pmob_0162
DTH: DICTH_0344
DTU: Dtur_0449
TTR: Tter_0228
HAL: VNG2447G(lta)
HSL: OE4436R(lta)
HLA: Hlac_1281
HMU: Hmuk_2053
 |
|---|
| Structures |
PDB: 1JG8 1LW4 1LW5 1M6S 1SVV |
|---|
Reference
Authors
Title
Journal
|
1
Bell, S.C. and Turner, J.M.
Bacterial threonine aldolase and serine hydroxymethyltransferase
enzyme.
Biochem. Soc. Trans. 1 (1973) 678-681. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13449064]
KARASEK MA, GREENBERG DM.
Studies on the properties of threonine aldolases.
J. Biol. Chem. 227 (1957) 191-205.
Ovis aries, Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5017702]
Kumagai H, Nagate T, Yoshida H, Yamada H.
Threonine aldolase from Candida humicola. II. Purification,
crystallization and properties.
Biochim. Biophys. Acta. 258 (1972) 779-90.
Candida humicola |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.2.5
IUBMB Enzyme Nomenclature: 4.1.2.5
ExPASy - ENZYME nomenclature database: 4.1.2.5
BRENDA, the Enzyme Database: 4.1.2.5
CAS: 62213-23-4 |
|---|
