KEGG   ENZYME: 4.1.3.1Help
Entry
EC 4.1.3.1                  Enzyme                                 
Name isocitrate lyase;
isocitrase;
isocitritase;
isocitratase;
threo-Ds-isocitrate glyoxylate-lyase;
isocitrate glyoxylate-lyase
Class Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname isocitrate glyoxylate-lyase (succinate-forming)
Reaction(IUBMB) isocitrate = succinate + glyoxylate [RN:R00479]
Reaction(KEGG) R00479
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Substrate isocitrate [CPD:C00311]
Product succinate [CPD:C00042];
glyoxylate [CPD:C00048]
Comment The isomer of isocitrate involved is
(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3].
Pathway PATH: ec00630  Glyoxylate and dicarboxylate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01637  isocitrate lyase
Genes ATH: AT3G21720(ICL)
POP: POPTR_562291 POPTR_741351
RCU: RCOM_1362920
VVI: 100248231
OSA: 4343441(Os07g0529000)
SBI: SORBI_02g035150(SORBIDRAFT_02g035150)
PPP: PHYPADRAFT_137303 PHYPADRAFT_189731
SCE: YER065C(ICL1) YPR006C(ICL2)
AGO: AGOS_ADL066C AGOS_AGL057W
KLA: KLLA0C08107g KLLA0E13948g
LTH: KLTH0A04466g
DHA: DEHA0D14212g
PIC: PICST_62080(ICL1)
PPA: PAS_chr1-4_0338
VPO: Kpol_1036p1 Kpol_467p7
LEL: LELG_01826
ZRO: ZYRO0C08272g ZYRO0F04708g
CTP: CTRG_04702
CDU: CD36_04240
CGR: CAGL0J03058g CAGL0L09273g
YLI: YALI0C16885g YALI0F31999g
SPO: SPBC1683.11c
NCR: NCU04230 NCU11238
PAN: PODANSg9124
MGR: MGG_02616 MGG_04895
FGR: FG00176.1 FG09896.1
ANI: AN5634.2 AN8755.2
AFM: AFUA_4G13510 AFUA_6G02860
AOR: AO090009000219 AO090120000179
ANG: An01g09270 An12g07630
AFV: AFLA_052400 AFLA_091690
PCS: Pc22g03660 Pc22g23150
NFI: NFIA_049200 NFIA_102860
CIM: CIMG_01988 CIMG_10137
URE: UREG_03573 UREG_06912
SSL: SS1G_04900 SS1G_04975
BFU: BC1G_09152 BC1G_13616
CNE: CNH03280
CNB: CNBI3510
LBC: LACBIDRAFT_171643 LACBIDRAFT_229070
MPR: MPER_05906
UMA: UM01892.1
MGL: MGL_0642
DDI: DDB_0230179
TET: TTHERM_01141570
PTM: GSPATT00017260001 GSPATT00019454001
PTI: PHATRDRAFT_51088
TPS: THAPS_35523
ECO: b4015(aceA)
ECJ: JW3975(aceA)
ECD: ECDH10B_4204(aceA)
EBW: BWG_3671(aceA)
ECE: Z5601(aceA)
ECS: ECs4933
ECF: ECH74115_5485(aceA)
ETW: ECSP_5084(aceA)
ECG: E2348C_4318(aceA)
ECC: c4972(aceA)
ECI: UTI89_C4574(aceA)
ECP: ECP_4225
ECV: APECO1_2461(aceA)
ECW: EcE24377A_4557(aceA)
ECX: EcHS_A4249(aceA)
ECM: EcSMS35_4469(aceA)
ECY: ECSE_4300
ECL: EcolC_4015
ECK: EC55989_4500(aceA)
ECQ: ECED1_4722(aceA)
ECR: ECIAI1_4235(aceA)
ECT: ECIAI39_4401(aceA)
ECZ: ECS88_4480(aceA)
EUM: ECUMN_4541(aceA)
ELF: LF82_0012(aceA)
EBL: B21_03847(aceA)
EBD: ECBD_4022
EBR: ECB_03887(aceA)
EOH: ECO103_4759(aceA)
EOI: ECO111_4827(aceA)
EOJ: ECO26_5119(aceA)
EFE: EFER_4068(aceA)
STY: STY4402(aceA)
STT: t4112(aceA)
SPT: SPA4022(aceA)
SEK: SSPA3732
SPQ: SPAB_05177
SEI: SPC_4244(aceA)
SEC: SC4063(aceA)
SEH: SeHA_C4517(aceA)
SEE: SNSL254_A4520(aceA)
SEW: SeSA_A4395(aceA)
SEA: SeAg_B4430(aceA)
SED: SeD_A4593(aceA)
SEG: SG4044(aceA)
SET: SEN3966(aceA)
SES: SARI_03472
STM: STM4184(aceA)
YPE: YPO3725(aceA)
YPK: y0016(aceA)
YPM: YP_3087(aceA)
YPA: YPA_0018
YPN: YPN_0015
YPG: YpAngola_A0640(aceA)
YPP: YPDSF_0174
YPS: YPTB3656(aceA)
YPI: YpsIP31758_0295(aceA)
YPY: YPK_0365
YPB: YPTS_3842
YEN: YE3880(aceA)
SFL: SF4081(aceA)
SFX: S3649(aceA)
SFV: SFV_4086(aceA)
SSN: SSON_4187(aceA)
SBC: SbBS512_E4509(aceA)
SDY: SDY_4328(aceA)
ECA: ECA3990(aceA)
PCT: PC1_3778
PWA: Pecwa_3957
PLU: plu4395(aceA)
PAY: PAU_00417(aceA)
ENT: Ent638_0219
ESA: ESA_00054
CTU: Ctu_38030(aceA)
KPN: KPN_04396(aceA)
KPE: KPK_5278(aceA)
KPU: KP1_0254(aceA)
CKO: CKO_03905
SPE: Spro_4502
PMR: PMI2763(aceA)
EIC: NT01EI_1119
DDA: Dd703_0451
DDC: Dd586_3693
DZE: Dd1591_0366
XCC: XCC0238(aceA)
XCB: XC_0248
XCA: xccb100_0260(aceA)
XCV: XCV0265(aceA)
XAC: XAC0257(aceA)
SML: Smlt0232(aceA)
SMT: Smal_0189
VCH: VC0736
VCO: VC0395_A0267(aceA)
VCM: VCM66_0694(aceA)
VCJ: VCD_003589
VVU: VV1_0449
VVY: VV0742
VPA: VP0584
VHA: VIBHAR_01042
VSP: VS_II0264
VEX: VEA_004371
VFI: VF_1972(aceA)
VFM: VFMJ11_2106(aceA)
VSA: VSAL_I2438(aceA)
PPR: PBPRA0738
PAE: PA2634(aceA)
PAU: PA14_30050(aceA)
PAP: PSPA7_2573
PAG: PLES_24711(aceA)
PPU: PP_4116(aceA)
PPF: Pput_1748
PPG: PputGB1_3687
PPW: PputW619_3389
PST: PSPTO_3364(aceA)
PSB: Psyr_3196
PSP: PSPPH_3108(aceA)
PFL: PFL_3897(aceA)
PFO: Pfl01_3602
PFS: PFLU3817
PEN: PSEEN3481(aceA)
PMY: Pmen_2407
PSA: PST_2311
AVN: Avin_28420
PAR: Psyc_1627(aceA)
PCR: Pcryo_1860
PRW: PsycPRwf_1448
ACI: ACIAD1084(aceA)
ACB: A1S_1008
ABM: ABSDF2383(aceA)
ABY: ABAYE2783(aceA)
ABC: ACICU_00968
ABN: AB57_1087
ABB: ABBFA_002602
SON: SO_1484(aceA)
SDN: Sden_1246
SFR: Sfri_1102 Sfri_3139
SAZ: Sama_2380
SBL: Sbal_1317
SBM: Shew185_1308
SBN: Sbal195_1344
SBP: Sbal223_3042
SLO: Shew_1276
SPC: Sputcn32_1239
SSE: Ssed_1415 Ssed_2353
SPL: Spea_2041
SHE: Shewmr4_2766
SHM: Shewmr7_2844
SHN: Shewana3_2942
SHW: Sputw3181_2865
SHL: Shal_2253
SWD: Swoo_2234
SWP: swp_2629
ILO: IL0608(aceA)
CPS: CPS_1232(icl)
PHA: PSHAb0062(aceA)
PAT: Patl_1215
MAQ: Maqu_3465
AMC: MADE_01326
PIN: Ping_0304
TTU: TERTU_0340
AEH: Mlg_2682
HHA: Hhal_1402
TGR: Tgr7_2552
HCH: HCH_02323(aceA)
CSA: Csal_2449
ABO: ABO_2741(aceA)
MMW: Mmwyl1_1180
AHA: AHA_2817(aceA)
ASA: ASA_1514(aceA)
RMA: Rmag_0538
CVI: CV_1641(aceA)
LHK: LHK_02742
RSO: RSc1358(aceA)
RPI: Rpic_0542 Rpic_1232 Rpic_4801
RPF: Rpic12D_0529 Rpic12D_1295 Rpic12D_3724
REU: Reut_A0384 Reut_A1961
REH: H16_A2211(iclA) H16_A2227(iclB)
RME: Rmet_1385 Rmet_4737
CTI: RALTA_A1766(aceA1) RALTA_B0267(aceA2)
BMA: BMA1586(aceA)
BMV: BMASAVP1_A2088(aceA)
BML: BMA10229_A3224(aceA)
BMN: BMA10247_1361(aceA)
BPS: BPSL2188(aceA)
BPM: BURPS1710b_2613(aceA)
BPL: BURPS1106A_2524(aceA)
BPD: BURPS668_2470(aceA)
BPR: GBP346_A2594(aceA)
BTE: BTH_I1998(aceA)
BVI: Bcep1808_1954 Bcep1808_4997
BUR: Bcep18194_A5357 Bcep18194_B0610
BCN: Bcen_3921 Bcen_6029
BCH: Bcen2424_2048 Bcen2424_4447
BCM: Bcenmc03_2067 Bcenmc03_5860
BCJ: BCAL2118(aceA) BCAM1588
BAM: Bamb_2080 Bamb_3879
BAC: BamMC406_1950 BamMC406_4340
BMU: Bmul_1229
BMJ: BMULJ_02018(aceA)
BXE: Bxe_A1651
BPH: Bphy_1368
BPY: Bphyt_2486
BGL: bglu_1g12420
PNU: Pnuc_1506
BPE: BP2085(aceA)
BPA: BPP1769(aceA)
BBR: BB3339(aceA)
BPT: Bpet3251(aceA)
RFR: Rfer_1335
POL: Bpro_2101
PNA: Pnap_2855
AAV: Aave_2860
AJS: Ajs_2401
VEI: Veis_3088
DAC: Daci_4617
DIA: Dtpsy_1447
VAP: Vapar_1869
CTT: CtCNB1_3032
MPT: Mpe_A1889
HAR: HEAR1689(aceA)
MMS: mma_1943(aceA)
LCH: Lcho_1744
EBA: ebA4473(aceA)
AZO: azo1117(aceA)
DAR: Daro_3098
TMZ: Tmz1t_1247
APP: CAP2UW1_3854
DMA: DMR_26970
ADE: Adeh_2998
ACP: A2cp1_1726
AFW: Anae109_1587
ANK: AnaeK_1653
MXA: MXAN_6442(aceA)
SCL: sce8726(aceA)
HOH: Hoch_6438
PUB: SAR11_1240(aceA)
MLO: mll6527
MES: Meso_0311
PLA: Plav_0592
SME: SMc00768(aceA)
SMD: Smed_0308
ATU: Atu0607(aceA)
ATC: AGR_C_1079
ARA: Arad_8429(aceA)
AVI: Avi_0816(aceA)
RET: RHE_CH00712(aceA)
REC: RHECIAT_CH0000795(aceA)
RLE: RL0761
RLT: Rleg2_0373
RLG: Rleg_0405
RHI: NGR_c14310
BME: BMEI0409
BMF: BAB1_1631
BMB: BruAb1_1601(aceA)
BMC: BAbS19_I15240
BMS: BR1614(aceA)
BMT: BSUIS_A1670(aceA)
BOV: BOV_1558(aceA)
BCS: BCAN_A1651(aceA)
BMR: BMI_I1629(aceA)
OAN: Oant_3930
BJA: blr2455
BRA: BRADO3748(aceA)
BBT: BBta_4188(aceA)
RPA: RPA4394(aceA)
RPB: RPB_4199
RPC: RPC_1379
RPD: RPD_4053
RPE: RPE_1395
RPT: Rpal_4878
NWI: Nwi_2985
NHA: Nham_1097
OCA: OCAR_7022
BID: Bind_0047
MSL: Msil_3157
CCR: CC_1764
CCS: CCNA_01841
PZU: PHZ_c3210(aceA)
PDE: Pden_1363
MMR: Mmar10_1625
HNE: HNE_1239(aceA)
NAR: Saro_1029
SAL: Sala_0943
SWI: Swit_2926
ELI: ELI_05300
GBE: GbCGDNIH1_0486
ACR: Acry_1090 Acry_1501
GDI: GDI_2449(aceA)
GDJ: Gdia_0698
RCE: RC1_2686(aceA)
BHA: BH2677
BAN: BA1132(aceA)
BAR: GBAA1132(aceA)
BAT: BAS1052
BAH: BAMEG_3448(aceA)
BAI: BAA_1216(aceA)
BCE: BC1128
BCA: BCE_1229(aceA)
BCZ: BCZK1030(aceA)
BCR: BCAH187_A1287(aceA)
BCB: BCB4264_A1182(aceA)
BCU: BCAH820_1210(aceA)
BCG: BCG9842_B4157(aceA)
BCQ: BCQ_1192(aceA)
BCX: BCA_1173(aceA)
BCY: Bcer98_0854
BTK: BT9727_1027(aceA)
BTL: BALH_0996
BWE: BcerKBAB4_1033
BLI: BL02646
BLD: BLi04207
BCL: ABC2973
OIH: OB2404
GKA: GK0676
GTN: GTNG_0583
GWC: GWCH70_0665
GYC: GYMC61_1480
AFL: Aflv_2241
LSP: Bsph_0633
EAT: EAT1b_1896
BBE: BBR47_00200(aceA)
AAC: Aaci_0028
STH: STH590
MTU: Rv0467(icl) Rv1915(aceAa) Rv1916(aceAb)
MTC: MT0483(aceA-1) MT1966(aceA-2)
MRA: MRA_0473(icl) MRA_1926(aceAa) MRA_1927(aceAb)
MTF: TBFG_10474 TBFG_11944 TBFG_11945
MTB: TBMG_00469(TBMG_00469.1) TBMG_02076(TBMG_02076.1)
     TBMG_02077(TBMG_02077.1)
MBO: Mb0476(icl) Mb1950(aceA)
MBB: BCG_0507(icl) BCG_1954(aceA)
MBT: JTY_0477(icl) JTY_1938(aceA)
MLE: ML1985(aceA)
MLB: MLBr_01985(aceA)
MPA: MAP1643(aceAb) MAP3961(aceA)
MAV: MAV_2781(aceA) MAV_4682(aceA)
MSM: MSMEG_0911(aceA) MSMEG_3706(aceA)
MUL: MUL_2943(aceAb) MUL_4536(icl)
MVA: Mvan_0801 Mvan_2977
MGI: Mflv_0107 Mflv_3260
MAB: MAB_4095c
MMC: Mmcs_0187 Mmcs_0636
MKM: Mkms_0196 Mkms_0649
MJL: Mjls_0176 Mjls_0629
MMI: MMAR_0792(icl) MMAR_2821(aceAb)
CGL: NCgl0096(cgl0097) NCgl2248(cgl2331)
CGB: cg2560(aceA)
CGT: cgR_2212
CEF: CE2232(aceA)
CJK: jk1933(aceA)
CUR: cur_0191
CKP: ckrop_1958(aceA)
NFA: nfa52300(aceA)
RHA: RHA1_ro02122
RER: RER_15740(aceA)
ROP: ROP_18410
GBR: Gbro_0763
SCO: SCO0982(aceA)
SMA: SAV_2043(aceA)
SGR: SGR_1643
ART: Arth_0583
AAU: AAur_0722(aceA)
ACH: Achl_0711
RSA: RSal33209_0173
KRH: KRH_02220(aceA)
MLU: Mlut_02080
XCE: Xcel_0923
TFU: Tfu_1377
TCU: Tcur_2490
SRO: Sros_3449
FAL: FRAAL2355(aceA)
NML: Namu_0999
SEN: SACE_1449(aceA)
SVI: Svir_28360
AMI: Amir_2006
RXY: Rxyl_2063
ABA: Acid345_4706
SUS: Acid_5701
RMR: Rmar_2249
FJO: Fjoh_1739
FBA: FIC_00669
MIN: Minf_0891(aceA)
CYC: PCC7424_4054
RRS: RoseRS_4164
RCA: Rcas_4375
CAU: Caur_3889
CAG: Cagg_0040
CHL: Chy400_4203
HAU: Haur_1017
TRO: trd_0496
DRA: DR_0828
DGE: Dgeo_1287
DDR: Deide_11980
TTH: TTC1485
TTJ: TTHA1836
HWA: HQ3094A(aceA)
SSO: SSO1333(aceA)
SAI: Saci_2191(aceA)
SIS: LS215_1004
SIA: M1425_0657
SIM: M1627_0663
SID: M164_0683
SIY: YG5714_0575
SIN: YN1551_2349
PAI: PAE1872
Taxonomy
Structures PDB: 1DQU  1F61  1F8I  1F8M  1IGW  3EOL  3I4E  
Reference
  Authors
  Title

  Journal
 1
McFadden, B.A. and Howes, W.V.
Crystallisation and some properties of isocitrate lyase from
Pseudomonas indigofera.
J. Biol. Chem. 238 (1963) 1737-1742.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:14285253]
SHIIO I, SHIIO T, MCFADDEN BA.
ISOCITRATE LYASE FROM PSEUDOMONAS INDIGOFERA. I. PREPARATION, AMINO
ACID COMPOSITION AND MOLECULAR WEIGHT.
Biochim. Biophys. Acta. 96 (1965) 114-22.
Pseudomonas indigofera
Reference
  Authors
  Title
  Journal
 3  [PMID:13925783]
VICKERY HB.
A suggested new nomenclature for the isomers of isocitric acid.
J. Biol. Chem. 237 (1962) 1739-41.
Other DBs ExplorEnz - The Enzyme Database: 4.1.3.1
IUBMB Enzyme Nomenclature: 4.1.3.1
ExPASy - ENZYME nomenclature database: 4.1.3.1
BRENDA, the Enzyme Database: 4.1.3.1
CAS: 9045-78-7
DBGET integrated database retrieval system