KEGG ENZYME: 4.1.3.16

ENZYME: 4.1.3.16

Entry

EC 4.1.3.16 Enzyme

Name

4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA

Class

Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases

Sysname

4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Reaction(IUBMB)

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]

Reaction(KEGG)

R00470 > R00471 R10283

Substrate

4-hydroxy-2-oxoglutarate [CPD:C01127]

Product

pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]

Comment

The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.

History

EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)

Pathway

ec00330

Arginine and proline metabolism

ec00630

Glyoxylate and dicarboxylate metabolism

ec01100

Metabolic pathways

Orthology

K18123

4-hydroxy-2-oxoglutarate aldolase

Genes

HSA:	112817(HOGA1)

PTR:	742884(HOGA1)

PPS:	103782784(HOGA1)

GGO:	101154009(HOGA1)

PON:	100171598(HOGA1)

NLE:	100589206(HOGA1)

MCC:	706661(HOGA1)

MCF:	102126728(HOGA1)

CSAB:

103216345(HOGA1)

RRO:	104682808(HOGA1)

RBB:	108534698(HOGA1)

CJC:	103796777(HOGA1)

SBQ:	104650492(HOGA1)

MMU:	67432(Hoga1)

RNO:	293949(Hoga1)

CGE:	100759109(Hoga1)

NGI:	103733196(Hoga1)

HGL:	101700602(Hoga1)

CCAN:

109695304(Hoga1)

OCU:	100344505(HOGA1)

TUP:	102486364(HOGA1)

CFA:	608755(HOGA1)

AML:	100478059(HOGA1)

UMR:	103674087(HOGA1)

ORO:	101385318(HOGA1)

FCA:	101101417(HOGA1)

PTG:	102965487(HOGA1)

AJU:	106966929(HOGA1)

BTA:	506001(HOGA1)

BOM:	102265621(HOGA1)

BIU:	109552999(HOGA1)

PHD:	102342808(HOGA1)

CHX:	102173994(HOGA1)

OAS:	101114573(HOGA1)

SSC:	100153961(HOGA1)

CFR:	102512614(HOGA1)

CDK:	105084288(HOGA1)

BACU:

103004258(HOGA1)

LVE:	103077167 103089444(HOGA1)

OOR:	101271753(HOGA1)

ECB:	100070689(HOGA1)

EPZ:	103558701(HOGA1)

EAI:	106844960(HOGA1)

MYB:	102246939(HOGA1)

MYD:	102768587(HOGA1)

HAI:	109379716(HOGA1)

RSS:	109443910(HOGA1)

PALE:

102884382(HOGA1)

LAV:	100670230(HOGA1)

TMU:

101355404

MDO:	100021876(HOGA1)

SHR:	100929176(HOGA1)

OAA:	100088274(HOGA1)

GGA:	770036(HOGA1)

MGP:	100548398(HOGA1)

CJO:	107316003(HOGA1)

ACYG:

106036839(HOGA1)

TGU:	100231472(HOGA1)

GFR:	102042170(HOGA1)

FAB:	101806953(HOGA1)

PHI:	102112987(HOGA1)

PMAJ:

107206698(HOGA1)

CCW:	104695887(HOGA1)

FPG:	101920952(HOGA1)

FCH:	102052298(HOGA1)

CLV:	102097409(HOGA1)

EGZ:	104132255(HOGA1)

ASN:	102382587(HOGA1)

AMJ:	102563093(HOGA1)

CPIC:

103307603(HOGA1)

ACS:	100566929(hoga1)

PVT:	110089167(HOGA1)

PBI:	103053263(HOGA1)

GJA:	107114457(HOGA1)

XLA:	495193(hoga1.L)

XTR:	496669(hoga1)

NPR:	108792933(HOGA1)

DRE:	405806(hoga1)

SRX:

107706114

SANH:

107663482(hoga1)

SGH:	107551368 107588470(hoga1)

CCAR:

109069442

IPU:	108259603(hoga1)

AMEX:

103023796(hoga1)

TRU:	101061435(hoga1)

TNG:	GSTEN00009068G001

LCO:	104930035(hoga1)

NCC:	104953008(hoga1)

MZE:	101479315(hoga1)

OLA:	101161460(hoga1)

XMA:	102230783(hoga1)

PRET:

103470116(hoga1)

NFU:	107382406(hoga1)

CSEM:

103383203(hoga1)

LCF:	108880833(hoga1)

HCQ:	109511381(hoga1)

BPEC:

110155940(hoga1)

SASA:

106564335 106591168(hoga1) 106591313

ELS:	105006876(hoga1)

SFM:	108924852(hoga1)

LCM:	102362318(HOGA1)

CMK:	103172525(hoga1)

BFO:	BRAFLDRAFT_251336

CIN:

SPU:

APLC:

SKO:

API:

DNX:

ZNE:

FCD:

DPX:	DAPPUDRAFT_52277

ISC:	IscW_ISCW017928

HRO:	HELRODRAFT_157064

LGI:	LOTGIDRAFT_211287

CRG:

MYI:

OBI:

LAK:

NVE:	NEMVE_v1g82674

EPA:

ADF:

HMG:

NCR:

NTE:	NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)

SMP:	SMAC_03823 SMAC_07903

PAN:	PODANSg09878 PODANSg3113 PODANSg3131

TTT:	THITE_2041371 THITE_2110019 THITE_2122366

MTM:	MYCTH_82456

CTHR:

CTHT_0040680 CTHT_0055950

MGR:	MGG_05159 MGG_07933

TMN:	UCRPA7_1105 UCRPA7_1858 UCRPA7_4535 UCRPA7_6686 UCRPA7_7278 UCRPA7_729 UCRPA7_7973

FGR:	FGSG_01813 FGSG_02063 FGSG_03069 FGSG_03647 FGSG_05048 FGSG_09521

FPU:	FPSE_01888 FPSE_02157 FPSE_03347 FPSE_04939 FPSE_05154 FPSE_11340

FVR:	FVEG_04070 FVEG_06008 FVEG_07522 FVEG_07725 FVEG_08807 FVEG_10721

FOX:	FOXG_04402 FOXG_04587 FOXG_06217 FOXG_08665 FOXG_09663 FOXG_12147

NHE:	NECHADRAFT_103547 NECHADRAFT_41228 NECHADRAFT_51004 NECHADRAFT_53351 NECHADRAFT_55688 NECHADRAFT_73269 NECHADRAFT_75207 NECHADRAFT_82289 NECHADRAFT_99111

TRE:	TRIREDRAFT_122582 TRIREDRAFT_2036 TRIREDRAFT_3717 TRIREDRAFT_53123

MAW:	MAC_01236 MAC_04491 MAC_09455

MAJ:	MAA_00627 MAA_07813 MAA_09251

CMT:	CCM_05289 CCM_07759 CCM_07861

PLJ:	VFPFJ_01790 VFPFJ_02536 VFPFJ_03142 VFPFJ_07463 VFPFJ_09031

VAL:	VDBG_01853 VDBG_03325 VDBG_05072 VDBG_08158 VDBG_09109 VDBG_09557

VDA:	VDAG_01702 VDAG_02228 VDAG_04788 VDAG_07257 VDAG_10050 VDAG_10512

CFJ:	CFIO01_04102 CFIO01_04988 CFIO01_05142 CFIO01_05423 CFIO01_08392 CFIO01_08695 CFIO01_12712 CFIO01_13735

ELA:	UCREL1_1 UCREL1_10034 UCREL1_3023 UCREL1_4493 UCREL1_7875 UCREL1_8344 UCREL1_9767

PFY:	PFICI_02155 PFICI_06710 PFICI_10660 PFICI_11183 PFICI_13580 PFICI_14195

SSL:	SS1G_02917

BFU:	BC1G_02281

MBE:

MBM_05778

PSCO:

LY89DRAFT_58302 LY89DRAFT_587194 LY89DRAFT_685858 LY89DRAFT_694995 LY89DRAFT_705574

GLZ:	GLAREA_07669

ANI:

AN1503.2

AFM:	AFUA_2G01230 AFUA_8G05040

AOR:	AO090005000638 AO090701000399

ANG:	ANI_1_1986144(An16g07700) ANI_1_26174(An10g00330)

AFV:	AFLA_058590 AFLA_078890

ACT:	ACLA_048040 ACLA_058440 ACLA_072950 ACLA_094540

NFI:	NFIA_033530 NFIA_089760 NFIA_097850 NFIA_107490

PCS:	Pc20g10350(dap) Pc22g00220

PDP:	PDIP_02670 PDIP_46650

CIM:	CIMG_00151 CIMG_06885

CPW:	CPC735_032800 CPC735_059910

PBL:	PAAG_03143 PAAG_03793

PBN:	PADG_03024 PADG_03296

URE:	UREG_00255 UREG_03604

ABE:	ARB_01658 ARB_05761

TVE:	TRV_00049 TRV_04481

AJE:	HCAG_01713 HCAG_07219 HCAG_09247

PNO:	SNOG_03839 SNOG_04544 SNOG_15818

PTE:	PTT_08311 PTT_12228 PTT_17993

BZE:	COCCADRAFT_109610 COCCADRAFT_9535

BSC:	COCSADRAFT_271752 COCSADRAFT_33387 COCSADRAFT_335849

BOR:	COCMIDRAFT_23190 COCMIDRAFT_26603 COCMIDRAFT_8673

AALT:

CC77DRAFT_1017551 CC77DRAFT_1040104 CC77DRAFT_840448

ZTR:	MYCGRDRAFT_66153

PFJ:	MYCFIDRAFT_29231

BCOM:

BAUCODRAFT_150164 BAUCODRAFT_558779 BAUCODRAFT_573577 BAUCODRAFT_68239

NPA:	UCRNP2_1393 UCRNP2_68 UCRNP2_7892 UCRNP2_894

TML:	GSTUM_00008462001

CNE:

CNC03990

CNB:

CNBC3190

CGI:	CGB_C6100W

TMS:	TREMEDRAFT_70222

TVS:	TRAVEDRAFT_145691 TRAVEDRAFT_29711 TRAVEDRAFT_62801

DSQ:	DICSQDRAFT_129292 DICSQDRAFT_152921

PCO:	PHACADRAFT_166860 PHACADRAFT_201197 PHACADRAFT_252672 PHACADRAFT_255535 PHACADRAFT_257602

SHS:	STEHIDRAFT_119341 STEHIDRAFT_49383

HIR:	HETIRDRAFT_157267 HETIRDRAFT_412119 HETIRDRAFT_448998

PSQ:	PUNSTDRAFT_52021 PUNSTDRAFT_70957

ADL:	AURDEDRAFT_110014 AURDEDRAFT_148009

FME:	FOMMEDRAFT_131642

GTR:	GLOTRDRAFT_116882 GLOTRDRAFT_57228

LBC:	LACBIDRAFT_189233

MRR:	Moror_14079 Moror_4689 Moror_8005

CCI:	CC1G_04219 CC1G_06285

SCM:	SCHCODRAFT_84616

ABP:	AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)

ABV:	AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)

CPUT:

CONPUDRAFT_129595 CONPUDRAFT_51541

SLA:	SERLADRAFT_361556 SERLADRAFT_454235

WSE:	WALSEDRAFT_29927 WALSEDRAFT_61673

WIC:	J056_003032

LIR:	LAW_00107(dapA_1)

DOR:	Desor_3029

IBU:	IB211_03323c

TWI:	Thewi_1732

TTO:	Thethe_02138

ABA:	Acid345_2666

TRS:	Terro_1985 Terro_2351

SUS:

Acid_1067

ABAC:

LuPra_06084(dapA_3)

TLI:

Tlie_1310

AMO:	Anamo_0048

» show all

Reference

1 [PMID:14089442]

Authors

KURATOMI K, FUKUNAGA K.

Title

THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.

Journal

Biochim. Biophys. Acta. 78 (1963) 617-28.

Reference

2 [PMID:5780845]

Authors

Kobes RD, Dekker EE

Title

2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.

Journal

J. Biol. Chem. 244 (1969) 1919-25.

Reference

3 [PMID:5580656]

Authors

Lane RS, Shapley A, Dekker EE.

Title

2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.

Journal

Biochemistry. 10 (1971) 1353-64.

Reference

4 [PMID:3942759]

Authors

Scholtz JM, Schuster SM

Title

Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.

Journal

Biochim. Biophys. Acta. 869 (1986) 192-6.

Other DBs

ExplorEnz - The Enzyme Database:

4.1.3.16

IUBMB Enzyme Nomenclature:

4.1.3.16

ExPASy - ENZYME nomenclature database:

4.1.3.16

BRENDA, the Enzyme Database:

4.1.3.16

CAS:

9030-81-3

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (2385)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (365)   
   KEGG MGENES (357)   
   RefGene (1661)   
Protein sequence (8264)   
   UniProt (3569)   
   SWISS-PROT (18)   
   RefSeq(pep) (4630)   
   PDBSTR (47)   
DNA sequence (17322)   
   RefSeq(nuc) (13292)   
   GenBank (2043)   
   EMBL (1987)   
3D Structure (8)   
   PDB (8)   
Protein domain (2)   
   InterPro (1)   
   PROSITE(DOC) (1)   
All databases (27997)   

Download RDF

DBGET integrated database retrieval system