Entry |
|
Name |
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
|
Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
Sysname |
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
|
Reaction(IUBMB) |
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN: R00470]
|
Reaction(KEGG) |
|
Substrate |
4-hydroxy-2-oxoglutarate [CPD: C01127]
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Product |
|
Comment |
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.
|
History |
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
|
Pathway |
ec00330 | Arginine and proline metabolism |
ec00630 | Glyoxylate and dicarboxylate metabolism |
|
Orthology |
K18123 | 4-hydroxy-2-oxoglutarate aldolase |
|
Genes |
» show all
 |
Reference |
|
Authors |
KURATOMI K, FUKUNAGA K. |
Title |
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE. |
Journal |
Biochim. Biophys. Acta. 78 (1963) 617-28. |
Reference |
|
Authors |
Kobes RD, Dekker EE |
Title |
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties. |
Journal |
J. Biol. Chem. 244 (1969) 1919-25. |
Reference |
|
Authors |
Lane RS, Shapley A, Dekker EE. |
Title |
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine. |
Journal |
Biochemistry. 10 (1971) 1353-64. |
Reference |
|
Authors |
Scholtz JM, Schuster SM |
Title |
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase. |
Journal |
Biochim. Biophys. Acta. 869 (1986) 192-6. |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.3.16 |
ExPASy - ENZYME nomenclature database: | 4.1.3.16 |
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