KEGG   ENZYME: 4.1.3.16Help
Entry
EC 4.1.3.16                 Enzyme                                 

Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]
Reaction(KEGG)
Substrate
4-hydroxy-2-oxoglutarate [CPD:C01127]
Product
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, L-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
Arginine and proline metabolism
Glyoxylate and dicarboxylate metabolism
Metabolic pathways
Orthology
K18123  
4-hydroxy-2-oxoglutarate aldolase
Genes
HSA: 
112817(HOGA1)
PTR: 
742884(HOGA1)
PPS: 
103782784(HOGA1)
GGO: 
101154009(HOGA1)
PON: 
100171598(HOGA1)
NLE: 
100589206(HOGA1)
MCC: 
706661(HOGA1)
MCF: 
102126728(HOGA1)
CSAB: 
103216345(HOGA1)
RRO: 
104682808(HOGA1)
CJC: 
103796777(HOGA1)
SBQ: 
104650492(HOGA1)
MMU: 
67432(Hoga1)
RNO: 
293949(Hoga1)
CGE: 
100759109(Hoga1)
NGI: 
103733196(Hoga1)
HGL: 
101700602(Hoga1)
OCU: 
100344505(HOGA1)
TUP: 
102486364(HOGA1)
CFA: 
608755(HOGA1)
AML: 
100478059(HOGA1)
UMR: 
103674087(HOGA1)
FCA: 
101101417(HOGA1)
PTG: 
102965487(HOGA1)
BTA: 
506001(HOGA1)
BOM: 
102265621(HOGA1)
PHD: 
102342808(HOGA1)
CHX: 
102173994(HOGA1)
OAS: 
101114573(HOGA1)
SSC: 
100153961(HOGA1)
CFR: 
102512614(HOGA1)
BACU: 
103004258(HOGA1)
LVE: 
103077167 103089444(HOGA1)
ECB: 
100070689(HOGA1)
MYB: 
102246939(HOGA1)
MYD: 
102768587(HOGA1)
PALE: 
102884382(HOGA1)
LAV: 
100670230(HOGA1)
MDO: 
100021876(HOGA1)
SHR: 
100929176(HOGA1)
OAA: 
100088274(HOGA1)
GGA: 
770036(HOGA1)
MGP: 
100548398(HOGA1)
CJO: 
107316003(HOGA1)
TGU: 
100231472(HOGA1)
GFR: 
102042170(HOGA1)
FAB: 
101806953(HOGA1)
PHI: 
102112987(HOGA1)
CCW: 
104695887(HOGA1)
FPG: 
101920952(HOGA1)
FCH: 
102052298(HOGA1)
CLV: 
102097409(HOGA1)
ASN: 
102382587(HOGA1)
AMJ: 
102563093(HOGA1)
ACS: 
100566929(hoga1)
PBI: 
103053263(HOGA1)
GJA: 
107114457(HOGA1)
XLA: 
495193(hoga1)
XTR: 
496669(hoga1)
DRE: 
405806(hoga1)
TRU: 
101061435(hoga1)
TNG: 
GSTEN00009068G001
MZE: 
101479315(hoga1)
OLA: 
101161460(hoga1)
XMA: 
102230783(hoga1)
SASA: 
106564335 106591168(hoga1) 106591313
LCM: 
102362318(HOGA1)
CMK: 
103172525(hoga1)
BFO: 
BRAFLDRAFT_251336
CIN: 
100181036
SPU: 
579934
SKO: 
100372772
API: 
100570569
DPX: 
DAPPUDRAFT_52277
ISC: 
IscW_ISCW017928
HRO: 
HELRODRAFT_157064
LGI: 
LOTGIDRAFT_211287
CRG: 
105328725
OBI: 
106884306
NVE: 
NEMVE_v1g82674
ADF: 
107337820
HMG: 
100199549
LIR: 
LAW_00107(dapA_1)
DOR: 
Desor_3029
IBU: 
IB211_03323c
TWI: 
Thewi_1732
TTO: 
Thethe_02138
ABAC: 
LuPra_06084(dapA_3)
TLI: 
Tlie_1310
AMO: 
Anamo_0048
 » show all
Taxonomy
Reference
1  [PMID:14089442]
  Authors
KURATOMI K, FUKUNAGA K.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
  Journal
Biochim. Biophys. Acta. 78 (1963) 617-28.
Reference
2  [PMID:5780845]
  Authors
Kobes RD, Dekker EE
  Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
  Journal
J. Biol. Chem. 244 (1969) 1919-25.
Reference
3  [PMID:5580656]
  Authors
Lane RS, Shapley A, Dekker EE.
  Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
  Journal
Biochemistry. 10 (1971) 1353-64.
Reference
4  [PMID:3942759]
  Authors
Scholtz JM, Schuster SM
  Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
  Journal
Biochim. Biophys. Acta. 869 (1986) 192-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-81-3
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