| Entry |
|
|---|
| Name |
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
N-acetylneuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
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| Sysname |
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming) |
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| Reaction(IUBMB) |
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate [RN:R01811] |
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| Reaction(KEGG) |
R01811
 |
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| Substrate |
N-acetylneuraminate [CPD:C00270] |
|---|
| Product |
N-acetyl-D-mannosamine [CPD:C00645];
pyruvate [CPD:C00022] |
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| Comment |
Also acts on N-glycoloylneuraminate, and on O-acetylated sialic
acids, other than 4-O-acetylated derivatives. |
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| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism |
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| Orthology |
KO: K01639 N-acetylneuraminate lyase |
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| Genes |
HSA: 80896(NPL)
PTR: 457567(NPL)
MCC: 715503
MMU: 74091(Npl)
RNO: 304860(Npl)
CFA: 490313(NPL)
BTA: 507597(NPL)
SSC: 397141(NPL)
ECB: 100051658
MDO: 100023776
OAA: 100085693
GGA: 429074(NPL)
TGU: 100219070
XLA: 495191(npl-b) 734827(MGC131246)
XTR: 496638(npl)
DRE: 100148292(npl)
SPU: 586574
DMO: Dmoj_GI15737
AGA: AgaP_AGAP007700
AAG: AaeL_AAEL009298
CQU: CpipJ_CPIJ000182
AME: 725646
NVI: 100115260 100124084
TCA: 100142385
ISC: IscW_ISCW019293
NVE: NEMVE_v1g128905 NEMVE_v1g63798
MBR: MONBRDRAFT_26275
TVA: TVAG_044970
ECO: b3225(nanA)
ECJ: JW3194(nanA)
ECD: ECDH10B_3402(nanA)
EBW: BWG_2926(nanA)
ECE: Z4583(nanA)
ECS: ECs4098
ECF: ECH74115_4542(nanA)
ETW: ECSP_4194(nanA)
ECG: E2348C_3497(nanA)
ECC: c3639 c3979(nanA)
ECI: UTI89_C3655(nanA)
ECP: ECP_3308
ECV: APECO1_3218(nanA)
ECW: EcE24377A_3707(nanA)
ECX: EcHS_A3413(nanA)
ECM: EcSMS35_3520(nanA)
ECY: ECSE_3504
ECL: EcolC_0481
ECK: EC55989_3638(nanA)
ECQ: ECED1_3876(nanA) ECED1_4911
ECR: ECIAI1_3367(nanA)
ECT: ECIAI39_3714(nanA)
ECZ: ECS88_3602(nanA)
EUM: ECUMN_3385 ECUMN_3699(nanA)
ELF: LF82_1446(nanA)
EBL: B21_03036(nanA)
EBD: ECBD_0522
EBR: ECB_03085(nanA)
EOH: ECO103_3966(nanA)
EOI: ECO111_4045(nanA)
EOJ: ECO26_4324(nanA)
EFE: EFER_3196(nanA)
STY: STY3520(nanA)
STT: t3256(nanA)
SPT: SPA3207(nanA)
SEK: SSPA2994
SPQ: SPAB_04163
SEI: SPC_3409(nanA)
SEC: SC3277(nanA)
SEH: SeHA_C3637(nanA)
SEE: SNSL254_A3602(nanA)
SEW: SeSA_A3532(nanA)
SEA: SeAg_B3530(nanA)
SED: SeD_A3699(nanA)
SEG: SG3229(nanA)
SET: SEN3172(nanA)
SES: SARI_04285
STM: STM3339(nanA)
YPE: YPO3024(nanA)
YPK: y1458
YPM: YP_2647(dapA1)
YPA: YPA_2212
YPN: YPN_1361
YPG: YpAngola_A2776
YPP: YPDSF_2129
YPS: YPTB2742(nanA)
YPI: YpsIP31758_1293
YPY: YPK_1400
YPB: YPTS_2843
YEN: YE1188(nanA)
SFL: SF3261(nanA)
SFX: S3478(nanA)
SFV: SFV_3250(nanA)
SSN: SSON_3366(nanA)
SBO: SBO_3164(nanA)
SBC: SbBS512_E3551(nanA)
SDY: SDY_3400(nanA)
ENT: Ent638_3661
ESA: ESA_03612
CKO: CKO_04629
PMR: PMI2973
EIC: NT01EI_1007
ETR: ETAE_0928 ETAE_1381(nanA)
HIN: HI0142(nanA)
HIT: NTHI0228(nanA)
HIP: CGSHiEE_02575
HIQ: CGSHiGG_03300
HDU: HD1850(nanA)
HAP: HAPS_0406(nanA)
HSO: HS_0695(nanA)
HSM: HSM_1106
PMU: PM1715(nanA)
APL: APL_1754(nanA)
APJ: APJL_1789(nanA)
APA: APP7_1839
AAP: NT05HA_0548
AAT: D11S_1580
VCH: VC1776
VCO: VC0395_A1374
VCM: VCM66_1714
VCJ: VCD_002594
VVU: VV2_0730
VVY: VVA1199
VFI: VF_0663(nanA)
VFM: VFMJ11_0681
VSA: VSAL_I0899
PPR: PBPRA2287
SPL: Spea_1522
PHA: PSHAb0156(nanA)
SME: SM_b20299(nanA)
SMD: Smed_3832
SAU: SA0304(nanA)
SAV: SAV0315(nanA)
SAW: SAHV_0312(nanA)
SAM: MW0292(nanA)
SAR: SAR0312
SAS: SAS0292
SAC: SACOL0312(nanA)
SAB: SAB0252c
SAA: SAUSA300_0315(nanA)
SAX: USA300HOU_0335(nanA)
SAO: SAOUHSC_00295
SAJ: SaurJH9_0298
SAH: SaurJH1_0305
SAE: NWMN_0257(nanA)
SAD: SAAV_0282(nanA)
SHA: SH0282(nanA)
SSP: SSP0375
SCA: Sca_2389(nanA)
PJD: Pjdr2_6208
SPY: SPy_0257(nanH)
SPZ: M5005_Spy_0217(nanH)
SPM: spyM18_0240
SPG: SpyM3_0185(nanH)
SPS: SPs0190
SPH: MGAS10270_Spy0217(nanH)
SPI: MGAS10750_Spy0212(nanH)
SPJ: MGAS2096_Spy0235(nanH)
SPK: MGAS9429_Spy0218(nanH)
SPF: SpyM50196(nanH)
SPA: M6_Spy0249
SPB: M28_Spy0211(nanH)
SOZ: Spy49_0216(nanH)
SPN: SP_1329 SP_1676
SPD: SPD_1163 SPD_1489
SPR: spr1186(npl-truncation) spr1520(npl-truncation)
SPW: SPCG_0850 SPCG_1648
SPX: SPG_1222 SPG_1585
SNE: SPN23F_12210(nanA) SPN23F_16770(nanH)
SPV: SPH_1471 SPH_1784
SNM: SP70585_1716
SJJ: SPJ_1245 SPJ_1571
SPP: SPP_1694
SNT: SPT_1615
SAG: SAG0039
SAN: gbs0038
SAK: SAK_0072
SSA: SSA_0078
SGO: SGO_0124
SEQ: SZO_17060
SEZ: Sez_0251(nanA)
SEU: SEQ_0326
SUB: SUB1653(nanH)
SDS: SDEG_1953(nanH)
LPL: lp_3568(nanA)
LPJ: JDM1_2852(nanA)
LSA: LSA1640(nanA)
LSL: LSL_1938(nanA)
CPE: CPE0185(nanA)
CPF: CPF_0178(nanA)
CPR: CPR_0175(nanA)
CDF: CD2240(nanA)
CDC: CD196_2096(nanA)
CDL: CDR20291_2139(nanA)
CSC: Csac_2743
MMY: MSC_0559(nal)
MSY: MS53_0198(nanA)
MCP: MCAP_0415(nanA)
CGB: cg2931(nanA)
RHA: RHA1_ro05285
BHY: BHWA1_01223
BFR: BF1706 BF3940
BFS: BF1712
BVU: BVU_4117
PDI: BDI_2941
DFE: Dfer_3023
PHE: Phep_2213 Phep_3256
COC: Coch_2063
FNU: FN1475
STR: Sterm_3485
SMF: Smon_1047
AMU: Amuc_1946
RBA: RB3352(nanA)
 |
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| Structures |
PDB: 1F5Z 1F6K 1F6P 1F73 1F74 1F7B 1FDY 1FDZ 1HL2 1NAL
2WKJ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13811398]
COMB DG, ROSEMAN S.
The sialic acids. I. The structure and enzymatic synthesis of
N-acetylneuraminic acid.
J. Biol. Chem. 235 (1960) 2529-37.
Bos taurus [GN:bta], Sus scofa [GN:ssc], Equus caballus [GN:ecb],
Ovis aries, Escherichia coli [GN:eco], Clostridium perfringens |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:6762816]
Schauer R.
Chemistry, metabolism, and biological functions of sialic acids.
Adv. Carbohydr. Chem. Biochem. 40 (1982) 131-234. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.3.3
IUBMB Enzyme Nomenclature: 4.1.3.3
ExPASy - ENZYME nomenclature database: 4.1.3.3
BRENDA, the Enzyme Database: 4.1.3.3
CAS: 9027-60-5 |
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