| Entry |
|
|---|
| Name |
methylisocitrate lyase;
2-methylisocitrate lyase;
MICL;
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
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| Sysname |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
(succinate-forming) |
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| Reaction(IUBMB) |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = succinate + pyruvate
[RN:R00409] |
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| Reaction(KEGG) |
R00409
 |
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| Substrate |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate [CPD:C04593] |
|---|
| Product |
succinate [CPD:C00042];
pyruvate [CPD:C00022] |
|---|
| Comment |
The enzyme acts on threo-Ds-2-methylisocitrate, but not on
threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate. |
|---|
| Pathway |
PATH: ec00640 Propanoate metabolism |
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| Orthology |
KO: K03417 methylisocitrate lyase |
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| Genes |
AFM: AFUA_2G00120 AFUA_2G00540 AFUA_2G03820 AFUA_4G02820
UMA: UM01112.1
ECO: b0331(prpB)
ECJ: JW0323(prpB)
ECE: Z0427(prpB)
ECS: ECs0385(prpB)
ECF: ECH74115_0403(prpB)
ECG: E2348C_0291(prpB)
ECC: c0451(prpB)
ECI: UTI89_C0363(prpB)
ECP: ECP_0407(prpB)
ECV: APECO1_1657(prpB)
ECW: EcE24377A_0356(prpB)
ECX: EcHS_A0397(prpB)
ECM: EcSMS35_0363(prpB)
ECY: ECSE_0356(prpB)
ECL: EcolC_3293(prpB)
ECK: EC55989_0338(prpB)
ECQ: ECED1_0364(prpB)
ECR: ECIAI1_0333(prpB)
ECT: ECIAI39_0348(prpB)
ECZ: ECS88_0343(prpB)
EUM: ECUMN_0375(prpB)
EBR: ECB_00286(prpB)
EFE: EFER_2660(prpB)
STY: STY0400(prpB)
STT: t2496(prpB)
SPT: SPA2355(prpB)
SEK: SSPA2197(prpB)
SPQ: SPAB_03229(prpB)
SEI: SPC_0378(prpB)
SEC: SC0409(prpB)
SEH: SeHA_C0462(prpB)
SEE: SNSL254_A0408(prpB)
SEW: SeSA_A0420(prpB)
SEA: SeAg_B0402(prpB)
SED: SeD_A0400(prpB)
SEG: SG0380(prpB)
SET: SEN0351(prpB)
SES: SARI_02557(prpB)
STM: STM0368(prpB)
PLU: plu3542(prpB)
PAY: PAU_01234(prpB)
CKO: CKO_02830(prpB)
XFA: XF1234(prpB)
XFT: PD0509(prpB)
XFM: Xfasm12_0571(prpB)
XFN: XfasM23_0506(prpB)
XCC: XCC1031(prpB)
XCB: XC_3215(prpB)
XCA: xccb100_3314(prpB)
XCV: XCV1156(prpB)
XAC: XAC1137(prpB)
XOO: XOO0892(prpB)
XOM: XOO_0816(prpB)
XOP: PXO_02718(prpB)
SML: Smlt3610(prpB)
SMT: Smal_3030(prpB)
VCH: VC1336(prpB)
VCO: VC0395_A0952(prpB)
VVU: VV1_2732(prpB)
VVY: VV1529(prpB)
VPA: VP1648(prpB)
VHA: VIBHAR_02397(prpB)
VEX: VEA_003388
PPR: PBPRB0235(prpB)
PAE: PA0796(prpB)
PAU: PA14_53940(prpB)
PAP: PSPA7_4722(prpB)
PAG: PLES_45461(prpB)
PPU: PP_2334(prpB)
PPF: Pput_3436
PPG: PputGB1_1935(prpB)
PPW: PputW619_1775(prpB)
PST: PSPTO_2287(prpB)
PSB: Psyr_2085(prpB)
PSP: PSPPH_2056(prpB)
PFL: PFL_1861(prpB)
PFO: Pfl01_1764(prpB)
PEN: PSEEN1902(prpB)
PMY: Pmen_2080(prpB)
PSA: PST_2034(prpB)
PAR: Psyc_1110(prpB)
PCR: Pcryo_1311(prpB)
PRW: PsycPRwf_1197(prpB)
ACI: ACIAD2758(prpB)
ACB: A1S_0073(prpB)
ABM: ABSDF0091(prpB)
ABY: ABAYE3793(prpB)
ABC: ACICU_00099(prpB)
ABN: AB57_0122(prpB)
ABB: ABBFA_003439(prpB)
SON: SO_0345(prpB)
SDN: Sden_1664(prpB)
SFR: Sfri_1857(prpB)
SAZ: Sama_3294(prpB)
SBL: Sbal_4047(prpB)
SBM: Shew185_4021(prpB)
SBN: Sbal195_4140(prpB)
SBP: Sbal223_3945(prpB)
SLO: Shew_1820(prpB)
SPC: Sputcn32_3644(prpB)
SSE: Ssed_2111(prpB)
SPL: Spea_2322(prpB)
SHE: Shewmr4_3629(prpB)
SHM: Shewmr7_0315(prpB)
SHN: Shewana3_3825(prpB)
SHW: Sputw3181_3784(prpB)
SHL: Shal_1961(prpB)
SWD: Swoo_2499(prpB)
SWP: swp_2428(prpB)
ILO: IL1427(prpB)
CPS: CPS_2822(prpB)
PHA: PSHAa1775(prpB)
PAT: Patl_1419(prpB)
MAQ: Maqu_1666(prpB)
AMC: MADE_03370(prpB)
PIN: Ping_1869(prpB)
CBU: CBU_0771(prpB)
CBS: COXBURSA331_A1177(prpB)
CBD: CBUD_0819(prpB)
CBG: CbuG_1230(prpB)
CBC: CbuK_0641(prpB)
LPN: lpg0052(prpB)
LPF: lpl0052(prpB)
LPP: lpp0054(prpB)
LPC: LPC_0057(prpB)
NOC: Noc_2209(prpB)
AEH: Mlg_2605(prpB)
HHA: Hhal_1072(prpB)
HCH: HCH_02710(prpB)
CSA: Csal_2421(prpB)
ABO: ABO_1433(prpB)
MMW: Mmwyl1_0925
AHA: AHA_2265(prpB)
ASA: ASA_2041(prpB)
NMA: NMA2055(prpB)
NME: NMB0430(prpB)
NMC: NMC1733(prpB)
NMN: NMCC_1715(prpB)
NGO: NGO1526(prpB)
CVI: CV_2057(prpB)
RSO: RSc2000(prpB) RSp0122(prpB)
RPI: Rpic_2155(prpB) Rpic_3861(prpB)
RPF: Rpic12D_1831 Rpic12D_3975
REU: Reut_A1808(prpB)
REH: H16_A1905(prpB)
RME: Rmet_1587(prpB)
CTI: RALTA_A1599(prpB)
BMA: BMAA1870(prpB)
BMV: BMASAVP1_0879(prpB)
BML: BMA10229_1166(prpB)
BMN: BMA10247_A2143(prpB)
BPS: BPSS0206(prpB)
BPM: BURPS1710b_A1735(prpB)
BPL: BURPS1106A_A0288(prpB)
BPD: BURPS668_A0382(prpB)
BTE: BTH_II2189(prpB)
BVI: Bcep1808_3680(prpB)
BUR: Bcep18194_B0141(prpB) Bcep18194_B0773 Bcep18194_B2560
BCN: Bcen_5344(prpB)
BCH: Bcen2424_5517(prpB)
BAM: Bamb_4842(prpB)
BPA: BPP3233(prpB)
BBR: BB3685(prpB)
BPT: Bpet1817(prpB)
BAV: BAV1179(prpB)
POL: Bpro_1029
NMU: Nmul_A0865(prpB)
HHE: HH0397(prpB)
GME: Gmet_1122(prpB)
GUR: Gura_0071(prpB)
BBA: Bd2502
PUB: SAR11_1155(prpB)
BRA: BRADO4322
BBT: BBta_1130 BBta_5017
BCZ: BCZK2113(prpB)
MPA: MAP0296c
MAV: MAV_0345(prpB)
MSM: MSMEG_6646(prpB)
MAB: MAB_4618
CGL: NCgl0629(cgl0658) NCgl0665(cgl0695)
CGB: cg0760(prpB2) cg0797(prpB1)
CGT: cgR_0778 cgR_0815
CEF: CE0717
LXX: Lxx01280(prpB)
CMI: CMM_2379(prpB)
ART: Arth_1524
AAU: AAur_1661(prpB) AAur_pTC20151(prpB)
RSA: RSal33209_0825
KRH: KRH_15310(prpB)
FRA: Francci3_2655
FAL: FRAAL5022(prpB)
ACE: Acel_1657
RXY: Rxyl_2400(prpB)
ANA: all1863
AVA: Ava_4757
TER: Tery_4268
 |
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| Structures |
PDB: 1MUM 1O5Q 1OQF 1UJQ 1XG3 1XG4 3EOO 3IH1 3KZ2 |
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Reference
Authors
Title
Journal
|
1
Tabuchi, T. and Satoh, T.
Distinction between isocitrate lyase and methylisocitrate lyase in
Candida lipolytica.
Agric. Biol. Chem. 40 (1976) 1863-1869. |
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Reference
Authors
Title
Journal
|
2
Tabuchi, T. and Satoh, T.
Purification and properties of methylisocitrate lyase, a key enzyme
in propionate metabolism, from Candida lipolytica.
Agric. Biol. Chem. 41 (1977) 169-174. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.3.30
IUBMB Enzyme Nomenclature: 4.1.3.30
ExPASy - ENZYME nomenclature database: 4.1.3.30
BRENDA, the Enzyme Database: 4.1.3.30
CAS: 57827-77-7 |
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