| Entry |
|
|---|
| Name |
aminodeoxychorismate lyase;
enzyme X;
4-amino-4-deoxychorismate lyase;
4-amino-4-deoxychorismate pyruvate-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
|---|
| Sysname |
4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
|---|
| Reaction(IUBMB) |
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate [RN:R05553] |
|---|
| Reaction(KEGG) |
R05553
 |
|---|
| Substrate |
4-amino-4-deoxychorismate [CPD:C11355] |
|---|
| Product |
4-aminobenzoate [CPD:C00568];
pyruvate [CPD:C00022] |
|---|
| Comment |
A pyridoxal-phosphate protein. Forms part of the folate biosynthesis
pathway. Acts on 4-amino-4-deoxychorismate, the product of EC
2.6.1.85, aminodeoxychorismate synthase, to form p-aminobenzoate. |
|---|
| Pathway |
PATH: ec00790 Folate biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids |
|---|
| Orthology |
KO: K02619 4-amino-4-deoxychorismate lyase |
|---|
| Genes |
ECO: b1096(pabC)
ECJ: JW1082(pabC)
ECD: ECDH10B_1168(pabC)
EBW: BWG_0944(pabC)
ECE: Z1735(pabC)
ECS: ECs1474
ECF: ECH74115_1475(pabC)
ETW: ECSP_1397(pabC)
ECG: E2348C_1188(pabC)
ECC: c1366(pabC)
ECI: UTI89_C1222(pabC)
ECP: ECP_1088
ECV: APECO1_177(pabC)
ECW: EcE24377A_1217(pabC)
ECX: EcHS_A1218(pabC)
ECM: EcSMS35_2031(pabC)
ECY: ECSE_1160
ECL: EcolC_2505
ECK: EC55989_1208(pabC)
ECQ: ECED1_1239(pabC)
ECR: ECIAI1_1131(pabC)
ECT: ECIAI39_2065(pabC)
ECZ: ECS88_1110(pabC)
EUM: ECUMN_1273(pabC)
ELF: LF82_1588(pabC)
EBL: B21_01100(pabC)
EBD: ECBD_2505
EBR: ECB_01092(pabC)
EOH: ECO103_1141(pabC)
EOI: ECO111_1373(pabC)
EOJ: ECO26_1429(pabC)
EFE: EFER_1831(pabC)
STY: STY1237(pabC)
STT: t1722(pabC)
SPT: SPA1653(pabC)
SEK: SSPA1537
SPQ: SPAB_02325
SEI: SPC_2548(pabC)
SEC: SC1148(pabC)
SEH: SeHA_C1312(pabC)
SEE: SNSL254_A1297(pabC)
SEW: SeSA_A1274(pabC)
SEA: SeAg_B1988(pabC)
SED: SeD_A2171
SEG: SG1924(pabC)
SET: SEN1851(pabC)
SES: SARI_01794
STM: STM1198(pabC)
YPE: YPO1603(pabC)
YPK: y1762(pabC)
YPM: YP_2251(pabC)
YPA: YPA_1922
YPN: YPN_2026
YPG: YpAngola_A3495(pabC)
YPP: YPDSF_1844
YPS: YPTB2468(pabC)
YPI: YpsIP31758_1581(pabC)
YPY: YPK_1689
YPB: YPTS_2556
YEN: YE1638(pabC)
SFL: SF1100(pabC)
SFX: S1180(pabC)
SFV: SFV_1116(pabC)
SSN: SSON_1116(pabC)
SBO: SBO_1967(pabC)
SBC: SbBS512_E2228(pabC)
SDY: SDY_2054(pabC)
ECA: ECA1800(pabC)
PCT: PC1_2500
PWA: Pecwa_2804
ETA: ETA_20190(pabC)
PLU: plu2830(pabC)
PAY: PAU_01707(pabC)
SGL: SG1063
ENT: Ent638_1611
ESA: ESA_02248
CTU: Ctu_16750(pabC)
KPN: KPN_01094(pabC)
KPE: KPK_3462(pabC)
KPU: KP1_2085(pabC)
CKO: CKO_01962
SPE: Spro_1909
PMR: PMI0864(pabC)
EIC: NT01EI_2366
ETR: ETAE_2096(pabC)
BFL: Bfl402(pabC)
BPN: BPEN_414(pabC)
DDA: Dd703_1590
DDC: Dd586_1589
DZE: Dd1591_1626
HIN: HI1169
HIT: NTHI1337
HIP: CGSHiEE_06195
HIQ: CGSHiGG_09545
HDU: HD0409
HAP: HAPS_1187
HSO: HS_0128
HSM: HSM_2013
PMU: PM1465
MSU: MS2192(ilvE)
APL: APL_1144
APJ: APJL_1164
APA: APP7_1203
AAP: NT05HA_0660
AAT: D11S_0979
VCH: VC2018
VCO: VC0395_A1604(pabC)
VCM: VCM66_1942(pabC)
VCJ: VCD_002349
VVU: VV1_3005
VVY: VV1278
VPA: VP2051
VHA: VIBHAR_02905
VSP: VS_1027
VEX: VEA_002999
VFI: VF_1737(pabC)
VFM: VFMJ11_1864(pabC)
VSA: VSAL_I2243
PPR: PBPRA1198
PAE: PA2964(pabC)
PAU: PA14_25710(pabC)
PAP: PSPA7_2197
PAG: PLES_20991(pabC)
PPU: PP_1917(pabC)
PPF: Pput_3797
PPG: PputGB1_1493
PPW: PputW619_1528
PST: PSPTO_3829(pabC)
PSB: Psyr_1650
PSP: PSPPH_1644
PFL: PFL_1799
PFO: Pfl01_4154
PFS: PFLU4702
PEN: PSEEN1622
PMY: Pmen_1631
PSA: PST_2619(pabC)
CJA: CJA_1679(pabC)
AVN: Avin_14950(pabC)
PAR: Psyc_0141
PCR: Pcryo_0152
PRW: PsycPRwf_0121
ACI: ACIAD2590(pabC)
ACB: A1S_2530
ABM: ABSDF0941(pabC)
ABY: ABAYE0931(pabC)
ABC: ACICU_02806
ABN: AB57_2971(pabC)
ABB: ABBFA_000915(pabC)
SON: SO_2615(pabC)
SDN: Sden_2053
SFR: Sfri_2242
SAZ: Sama_2045
SBL: Sbal_2461
SBM: Shew185_2454
SBN: Sbal195_2574
SBP: Sbal223_1890
SLO: Shew_1577
SPC: Sputcn32_2216
SSE: Ssed_2650
SPL: Spea_1921
SHE: Shewmr4_1659
SHM: Shewmr7_1734
SHN: Shewana3_1764
SHW: Sputw3181_1793
SHL: Shal_2378
SWD: Swoo_1980
SWP: swp_2835
ILO: IL1338(pabC)
CPS: CPS_2300(pabC)
PHA: PSHAa1805(pabC)
PAT: Patl_2119
SDE: Sde_1632
MAQ: Maqu_1864
AMC: MADE_02332
PIN: Ping_1092
TTU: TERTU_1723
LPN: lpg0595
LPF: lpl0629
LPP: lpp0645
MCA: MCA1998(pabC)
FTU: FTT_0945
FTF: FTF0945
FTW: FTW_0839
FTL: FTL_1262
FTH: FTH_1237(trpE1)
FTA: FTA_1335
FTM: FTM_1005
FTN: FTN_0822
FPH: Fphi_1792
TCX: Tcr_0716
NOC: Noc_1662
AEH: Mlg_1418
HHA: Hhal_0004
TGR: Tgr7_1831
HNA: Hneap_1920
HCH: HCH_02146(pabC)
CSA: Csal_1604 Csal_2692
ABO: ABO_1072(pabC)
MMW: Mmwyl1_2269
AHA: AHA_2254
ASA: ASA_2051(pabC)
TAU: Tola_2189
DNO: DNO_0646
AFE: Lferr_1586
AFR: AFE_1911
BCI: BCI_0432(pabC)
RMA: Rmag_0218
VOK: COSY_0213(pabC)
KKO: Kkor_1191
NMA: NMA0477
NME: NMB1970
NMC: NMC1944
NMN: NMCC_0243
NMI: NMO_0198
NGO: NGO2112
NGK: NGK_2583
CVI: CV_3410(pabC)
LHK: LHK_02554(pabC)
RSO: RSc2633(pabB)
RPI: Rpic_2868
RPF: Rpic12D_2462
REU: Reut_A2783
REH: H16_A3087
RME: Rmet_2920
CTI: RALTA_A2562(pabB)
BMA: BMA2324
BMV: BMASAVP1_A0503
BML: BMA10229_A1096
BMN: BMA10247_2203(pabB)
BPS: BPSL2825
BPM: BURPS1710b_3318(pabB)
BPL: BURPS1106A_3308(pabB)
BPD: BURPS668_3275(pabB)
BPR: GBP346_A3453
BTE: BTH_I1310
BVI: Bcep1808_0714
BUR: Bcep18194_A3841
BCN: Bcen_0270
BCH: Bcen2424_0754
BCM: Bcenmc03_0723
BCJ: BCAL3268
BAM: Bamb_0648
BAC: BamMC406_0671
BMU: Bmul_2631
BMJ: BMULJ_00607(pabB)
BXE: Bxe_A3959
BPH: Bphy_2495
BPY: Bphyt_0739
BGL: bglu_1g06360
PNU: Pnuc_0745
PNE: Pnec_1074
BPE: BP3242
BPA: BPP3599
BBR: BB4034
BPT: Bpet0871
BAV: BAV2809(pabB) BAV2810
RFR: Rfer_3314
POL: Bpro_0904
PNA: Pnap_0939
AAV: Aave_3849
AJS: Ajs_3496
VEI: Veis_2835
DIA: Dtpsy_2819
VAP: Vapar_3062
CTT: CtCNB1_3872
MPT: Mpe_A2628
HAR: HEAR2983
MMS: mma_3230(pabB)
LCH: Lcho_0651
EBA: ebA6309(pabB)
AZO: azo0198(pabB)
DAR: Daro_3087
TBD: Tbd_1545
MFA: Mfla_1502
MMB: Mmol_1140
MEI: Msip34_1383
APP: CAP2UW1_4131
HPY: HP0293
HPJ: jhp0278(pabB)
HPA: HPAG1_0295
HPS: HPSH_01520
HPG: HPG27_272
HPP: HPP12_0292(pabB)
HPB: HELPY_0299(pabB)
HHE: HH0304(trpE_1)
HAC: Hac_0553(pabB)
WSU: WS0690
TDN: Suden_0434
CJE: Cj0862c(pabB)
CJR: CJE0949(pabB)
CJJ: CJJ81176_0878(pabB)
CJU: C8J_0809(pabB)
CJD: JJD26997_1011(pabB)
CFF: CFF8240_1099
CCV: CCV52592_1310
CHA: CHAB381_1087
CLA: Cla_0984(pabB)
ABU: Abu_0265
SDL: Sdel_1637
NIS: NIS_1470
SUN: SUN_0387
NAM: NAMH_0500
GSU: GSU0523(pabB)
GME: Gmet_3010
GUR: Gura_0607
GLO: Glov_0163
GEO: Geob_1294
GEM: GM21_0332
PPD: Ppro_2808
DVU: DVU0362
DVL: Dvul_2622
DVM: DvMF_2314
DDE: Dde_3619
DMA: DMR_03810(pabB)
DSA: Desal_1100
DBA: Dbac_0380
DPS: DP0875
ACP: A2cp1_4032
AFW: Anae109_1629
ANK: AnaeK_3993
MLO: mlr3007
SME: SMc04014
SMD: Smed_2686
ATU: Atu3766
ATC: AGR_L_2139
ARA: Arad_3809
AVI: Avi_3704
RET: RHE_CH03551(ypch01254)
REC: RHECIAT_CH0003804
RLT: Rleg2_3298
RLG: Rleg_3599
RHI: NGR_c28440
BME: BMEII0014
BMI: BMEA_B0083
BMF: BAB2_0078
BMB: BruAb2_0079
BMC: BAbS19_II00730
BMS: BRA0079
BMT: BSUIS_B0084
BOV: BOV_A0074
BCS: BCAN_B0082
BMR: BMI_II81
OAN: Oant_4262
BID: Bind_1139
CCR: CC_2952
CCS: CCNA_03047
CAK: Caul_4200
PZU: PHZ_c2391(pabB)
SIL: SPO0925
SIT: TM1040_0634
RSP: RSP_0816
RSH: Rsph17029_2473
RSQ: Rsph17025_0363
RSK: RSKD131_2179
PDE: Pden_4434
ZMN: Za10_0895
NAR: Saro_0445
SAL: Sala_0171
ELI: ELI_11940
GBE: GbCGDNIH1_0761
MGM: Mmc1_0427
BSU: BSU00760(pabC)
BHA: BH0092(pabC)
BAN: BA0070(pabC)
BAR: GBAA0070(pabC)
BAA: BA_0660
BAT: BAS0070
BAH: BAMEG_0083(pabC)
BAI: BAA_0083(pabC)
BCE: BC0078
BCA: BCE_0069(pabC)
BCZ: BCZK0066(pabC)
BCR: BCAH187_A0082(pabC)
BCB: BCB4264_A0078(pabC)
BCU: BCAH820_0079(pabC)
BCG: BCG9842_B5238(pabC)
BCQ: BCQ_0080(pabC)
BCX: BCA_0083(pabC)
BCY: Bcer98_0066
BTK: BT9727_0066(pabC)
BTL: BALH_0069(pabC)
BWE: BcerKBAB4_0066
BLI: BL00860(pabC)
BLD: BLi00092(pabC)
BCL: ABC0112(pabC)
BAY: RBAM_000870(pabC)
BPU: BPUM_0060(pabC)
OIH: OB0702
GKA: GK0068
GTN: GTNG_0068
GWC: GWCH70_0071
GYM: GYMC10_0065
GYC: GYMC61_0068
AFL: Aflv_0068(pabC)
SAU: SA0670
SAV: SAV0715
SAW: SAHV_0712
SAM: MW0677
SAR: SAR0768
SAS: SAS0680
SAB: SAB0664
SAA: SAUSA300_0700
SAX: USA300HOU_0738(pabC)
SAO: SAOUHSC_00724
SAJ: SaurJH9_0739
SAH: SaurJH1_0755
SAE: NWMN_0684(pabC)
SAD: SAAV_0677
SEP: SE0490
SHA: SH2183
SSP: SSP2005
SCA: Sca_0363
LMO: lmo2750
LMF: LMOf2365_2737(pabB)
LMH: LMHCC_2782
LMC: Lm4b_02724
LIN: lin2893
LWE: lwe2698(pabB)
LSP: Bsph_0096
ESI: Exig_0059
EAT: EAT1b_1670
MCL: MCCL_0467
BBE: BBR47_01750(pabC)
PJD: Pjdr2_0077
AAC: Aaci_1357
SPY: SPy_1990(pabB)
SPZ: M5005_Spy_1697
SPM: spyM18_2056
SPG: SpyM3_1712(pabP)
SPS: SPs1712
SPH: MGAS10270_Spy1765
SPI: MGAS10750_Spy1789
SPJ: MGAS2096_Spy1724
SPK: MGAS9429_Spy1702
SPF: SpyM51667
SPA: M6_Spy1703
SPB: M28_Spy1682
SOZ: Spy49_1653(papB)
SPN: SP_0665
SPD: SPD_0578(pabB)
SPR: spr0582(pabB)
SPW: SPCG_0621
SPX: SPG_0606
SNE: SPN23F_06000(pabB)
SPV: SPH_0760
SNM: SP70585_0724
SJJ: SPJ_0615
SPP: SPP_0685
SNT: SPT_0689
SAG: SAG1528
SAN: gbs1584
SAK: SAK_1551(pabB)
STC: str0771(pabB)
STL: stu0771(pabB)
STE: STER_0809
SSA: SSA_0413(pabB)
SGO: SGO_0307(pabB)
SEQ: SZO_18060
SEZ: Sez_1794(pabA)
SEU: SEQ_2030
SDS: SDEG_0217
CPE: CPE1018
CNO: NT01CX_0378
CDC: CD196_1319(pabC)
CDL: CDR20291_1296(pabC)
CBE: Cbei_4118
DSY: DSY3274
DHD: Dhaf_4442
CHY: CHY_2669(pabC)
MTU: Rv0812
MTC: MT0833(dat)
MRA: MRA_0822
MTF: TBFG_10827
MTB: TBMG_00826(TBMG_00826.1)
MBO: Mb0835
MBB: BCG_0864
MBT: JTY_0834
MPA: MAP0642(pabC)
MAV: MAV_0751
MSM: MSMEG_5795
MUL: MUL_0426(pabC)
MVA: Mvan_5108
MGI: Mflv_1639
MAB: MAB_0731
MMC: Mmcs_4535
MKM: Mkms_4622
MJL: Mjls_4918
MMI: MMAR_4873(pabC)
CGL: NCgl2491(cgl2580)
CGB: cg2851
CGT: cgR_2483
CEF: CE2472
CDI: DIP1916
CJK: jk0373
CUR: cur_1612
CAR: cauri_2159(pabC)
CKP: ckrop_0388(pabC)
NFA: nfa5840
RHA: RHA1_ro01826 RHA1_ro04846
RER: RER_48190
ROP: ROP_15030 ROP_49290
GBR: Gbro_0953
TWH: TWT533
TWS: TW227
LXX: Lxx17640(pabC)
ART: Arth_3850
AAU: AAur_3654
ACH: Achl_3637
RSA: RSal33209_1022
KRH: KRH_03910 KRH_23130
MLU: Mlut_18900
BFA: Bfae_03810 Bfae_31460
PAC: PPA2261
NML: Namu_5028
KRA: Krad_3389 Krad_4082
SEN: SACE_7111(pabC)
SVI: Svir_37740
AMI: Amir_6835
STP: Strop_0311
SAQ: Sare_0374
BLN: Blon_0384
BAD: BAD_0076(pabC)
PCU: pc1325(pabC)
LIL: LA0110
LIC: LIC10098(pabB)
LBJ: LBJ_0090
LBL: LBL_0046
LBI: LEPBI_I2353
LBF: LBF_2283
BTH: BT_0768
BFR: BF2240
BFS: BF2336
BVU: BVU_2234
PGN: PGN_1333
PDI: BDI_1173
SRU: SRU_1685
RMR: Rmar_2114
CHU: CHU_1302(pabC)
DFE: Dfer_3376
FBA: FIC_02486
FSU: Fisuc_1532
FNU: FN1729
MIN: Minf_0724(ilvE-like)
AMU: Amuc_1948
SYN: slr0887
SYX: SynWH7803_2471
SYP: SYNPCC7002_A0380
MAR: MAE_39050
CYT: cce_3751
CYP: PCC8801_4306
CYC: PCC7424_3756
CYH: Cyan8802_4367
ANA: alr1260
AVA: Ava_0576
PMC: P9515_18841
PMF: P9303_29691(pabC)
PME: NATL1_21671(pabC)
CTE: CT1712
CPC: Cpar_0480
CCH: Cag_0422
CPH: Cpha266_0499
CPB: Cphamn1_0490
CLI: Clim_1992
PVI: Cvib_1468
PLT: Plut_1683
PPH: Ppha_0502
PAA: Paes_0455
CTS: Ctha_2549
HAU: Haur_2989
AAE: aq_1606(pabC)
HYA: HY04AAS1_1339
SUL: SYO3AOP1_0610 SYO3AOP1_1235
SAF: SULAZ_0571
PMX: PERMA_1633
TYE: THEYE_A1969
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2251281]
Ye QZ, Liu J, Walsh CT.
p-Aminobenzoate synthesis in Escherichia coli: purification and
characterization of PabB as aminodeoxychorismate synthase and enzyme
X as aminodeoxychorismate lyase.
Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 9391-5.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1644759]
Green JM, Merkel WK, Nichols BP.
Characterization and sequence of Escherichia coli pabC, the gene
encoding aminodeoxychorismate lyase, a pyridoxal
phosphate-containing enzyme.
J. Bacteriol. 174 (1992) 5317-23.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10876155]
Nakai T, Mizutani H, Miyahara I, Hirotsu K, Takeda S, Jhee KH,
Yoshimura T, Esaki N.
Three-dimensional structure of 4-amino-4-deoxychorismate lyase from
Escherichia coli.
J. Biochem. (Tokyo). 128 (2000) 29-38.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.3.38
IUBMB Enzyme Nomenclature: 4.1.3.38
ExPASy - ENZYME nomenclature database: 4.1.3.38
BRENDA, the Enzyme Database: 4.1.3.38
CAS: 132264-33-6 |
|---|
