KEGG   ENZYME: 4.1.3.4Help
Entry
EC 4.1.3.4                  Enzyme                                 
Name hydroxymethylglutaryl-CoA lyase;
hydroxymethylglutaryl coenzyme A-cleaving enzyme;
hydroxymethylglutaryl coenzyme A lyase;
3-hydroxy-3-methylglutaryl coenzyme A lyase;
3-hydroxy-3-methylglutaryl CoA cleaving enzyme;
3-hydroxy-3-methylglutaryl-CoA lyase;
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
Class Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
(acetyl-CoA-forming)
Reaction(IUBMB) (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate
[RN:R01360]
Reaction(KEGG) R01360
Show
Substrate (S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356]
Product acetyl-CoA [CPD:C00024];
acetoacetate [CPD:C00164]
Pathway PATH: ec00072  Synthesis and degradation of ketone bodies
PATH: ec00280  Valine, leucine and isoleucine degradation
PATH: ec00650  Butanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01640  hydroxymethylglutaryl-CoA lyase
Genes HSA: 3155(HMGCL)
PTR: 456624(HMGCL)
MCC: 710833(HMGCL) 714982
MMU: 15356(Hmgcl)
RNO: 79238(Hmgcl)
CFA: 478187(HMGCL)
BTA: 317658(HMGCL)
ECB: 100057686
MDO: 100010594
OAA: 100082402
GGA: 396316(HMGCL)
TGU: 100217934
XLA: 432233
DRE: 394190(hmgcl)
CIN: 100184013
SPU: 756856
DME: Dmel_CG10399
DPO: Dpse_GA10298
DAN: Dana_GF15438
DER: Dere_GG10447
DPE: Dper_GL26197
DSE: Dsec_GM16259
DYA: Dyak_GE14242
DGR: Dgri_GH13343
DMO: Dmoj_GI17729
AGA: AgaP_AGAP008717
AAG: AaeL_AAEL002065
CQU: CpipJ_CPIJ001976
AME: 726494
NVI: 100120133
TCA: 661818
API: 100160586
ISC: IscW_ISCW015386
CEL: Y71G12B.10
CBR: CBG22170
SMM: Smp_185140
NVE: NEMVE_v1g89324
TAD: TRIADDRAFT_61193
ATH: AT2G26800
POP: POPTR_833174
RCU: RCOM_1635180
VVI: 100243192(GSVIVT00023263001) 100264975(GSVIVT00017259001)
OSA: 4326266(Os01g0269000)
SBI: SORBI_05g002170(SORBIDRAFT_05g002170)
ZMA: 100193689
PPP: PHYPADRAFT_58979
CRE: CHLREDRAFT_195057
CME: CMA068C
YLI: YALI0B22550g
NCR: NCU05419
PAN: PODANSg6798
MGR: MGG_09181
FGR: FG00638.1
ANI: AN5273.2
AFM: AFUA_2G12450 AFUA_7G01720
AOR: AO090026000392 AO090038000541
ANG: An02g04640
AFV: AFLA_070820 AFLA_135360
PCS: Pc20g14670 Pc21g09480
NFI: NFIA_087590 NFIA_114450
CIM: CIMG_05209
URE: UREG_06412
SSL: SS1G_10681
BFU: BC1G_04231
CNE: CNC00210
CNB: CNBC7020
LBC: LACBIDRAFT_247997
UMA: UM02001.1
MBR: MONBRDRAFT_33622
DDI: DDB_0230167(hmgL)
TGO: TGME49_004460
TET: TTHERM_00686100
PTM: GSPATT00029666001
TBR: Tb927.4.2700
TCR: 506635.80 508027.129 508029.10
PTI: PHATRDRAFT_13643(HCL1)
EIC: NT01EI_1368 NT01EI_2169
ETR: ETAE_2032
XCC: XCC1832(mvaB)
XCB: XC_2357
XCA: xccb100_2120
XCV: XCV1897(mvaB)
XAC: XAC1851(mvaB)
XOO: XOO2903(mvaB)
XOM: XOO_2753
XOP: PXO_00102
SML: Smlt2207(hmgcL)
SMT: Smal_1800
VVU: VV2_0499 VV2_0500
VVY: VVA1049
VPA: VPA0615 VPA1129
VHA: VIBHAR_05477
VEX: VEA_000381 VEA_001540
PPR: PBPRB1119
PAE: PA2011(liuE)
PAU: PA14_38490(gnyL)
PAP: PSPA7_3278
PAG: PLES_33121(liuE)
PPU: PP_3394 PP_3540(mvaB)
PPF: Pput_2234 Pput_5024
PPG: PputGB1_2384
PPW: PputW619_1943 PputW619_2559
PST: PSPTO_2742(mvaB)
PSB: Psyr_2471
PSP: PSPPH_2629(mvaB)
PFL: PFL_3934(mvaB)
PFO: Pfl01_1315 Pfl01_3654
PFS: PFLU1417 PFLU3887
PEN: PSEEN2983(mvaB)
PMY: Pmen_2029
PSA: PST_1716(mvaB) PST_3217
CJA: CJA_2967
AVN: Avin_25990 Avin_49510
PAR: Psyc_0312(mvaB)
PCR: Pcryo_0343
PRW: PsycPRwf_2063
ACI: ACIAD2820
ACB: A1S_1372
ABY: ABAYE2292 ABAYE2344
ABC: ACICU_01407
ABN: AB57_1547 AB57_1597
ABB: ABBFA_002122 ABBFA_002172
SON: SO_1893(mvaB)
SDN: Sden_2250
SFR: Sfri_2731
SAZ: Sama_1358
SBL: Sbal_2832
SBM: Shew185_2850
SBN: Sbal195_2977
SBP: Sbal223_1526
SLO: Shew_2574
SPC: Sputcn32_1715
SSE: Ssed_1454
SPL: Spea_2802
SHE: Shewmr4_2326
SHM: Shewmr7_2398
SHN: Shewana3_1668
SHW: Sputw3181_2310
SHL: Shal_2907
SWD: Swoo_3227
SWP: swp_3448
ILO: IL0878
CPS: CPS_1599(mvaB)
PHA: PSHAa1448(hmgcL)
PAT: Patl_2762 Patl_2929
MAQ: Maqu_2126
AMC: MADE_02416
CBU: CBU_0520(leuA)
CBS: COXBURSA331_A0633(leuA)
CBD: CBUD_1542(leuA)
CBG: CbuG_1475(leuA)
CBC: CbuK_1317(leuA)
LPN: lpg1830(mvaB)
LPF: lpl1794
LPP: lpp1793
LPC: LPC_1274(mvaB)
NOC: Noc_1888
HCH: HCH_03947
ABO: ABO_2665(mvaB)
MMW: Mmwyl1_1472
AHA: AHA_2074
ASA: ASA_1908
KKO: Kkor_1055
CVI: CV_1759(mvaB)
LHK: LHK_02058
RSO: RSc0261
RPI: Rpic_0114 Rpic_1378 Rpic_2061
RPF: Rpic12D_0121 Rpic12D_1442
REU: Reut_A0153 Reut_A1462 Reut_A2107 Reut_B4194 Reut_C6248
REH: H16_A0186 H16_A1235(mvaB) H16_A1547 H16_A2385(hmgL1) H16_B0615
     H16_B2494(hmgL2)
RME: Rmet_0607 Rmet_2124
CTI: RALTA_A0129 RALTA_A1930 RALTA_B2209
BPS: BPSL0333
BPM: BURPS1710b_0543
BPL: BURPS1106A_0367
BPD: BURPS668_0353
BPR: GBP346_A0272
BTE: BTH_I0313
BVI: Bcep1808_3048
BUR: Bcep18194_A4853 Bcep18194_A6309 Bcep18194_C6961
BCN: Bcen_1213 Bcen_2345 Bcen_5396
BCH: Bcen2424_1692 Bcen2424_2959 Bcen2424_5465
BCM: Bcenmc03_1664 Bcenmc03_2980 Bcenmc03_4804
BCJ: BCAL0631 BCAL1750 BCAM2661
BAM: Bamb_1600 Bamb_3007 Bamb_4807 Bamb_6280
BAC: BamMC406_1622 BamMC406_2870 BamMC406_5348 BamMC406_5984
BMU: Bmul_1554 Bmul_2955
BMJ: BMULJ_00279(hmgL) BMULJ_01690(hmgL)
BXE: Bxe_A2729 Bxe_A4270
BPH: Bphy_0165 Bphy_4250 Bphy_6613
BPY: Bphyt_0440 Bphyt_0806 Bphyt_6976
BGL: bglu_1g32590
PNU: Pnuc_0873
BPE: BP0556(hmgcL) BP3695
BPA: BPP0239(hmgcL) BPP0508 BPP2803(hmgL)
BBR: BB0243(hmgcL) BB0714(hmgL) BB3124(hmgL)
BPT: Bpet2783 Bpet4318 Bpet4729
BAV: BAV0197(hmgcL)
RFR: Rfer_3824 Rfer_4199
POL: Bpro_2353 Bpro_4037 Bpro_4155
PNA: Pnap_0477 Pnap_1123 Pnap_3506
AAV: Aave_1652 Aave_4349
AJS: Ajs_2871 Ajs_3143 Ajs_3757
VEI: Veis_0293 Veis_0514
DAC: Daci_2875 Daci_2967 Daci_3137 Daci_5964
DIA: Dtpsy_2358 Dtpsy_2490 Dtpsy_3038
VAP: Vapar_0455 Vapar_1756 Vapar_2773 Vapar_3267 Vapar_4710
CTT: CtCNB1_0509 CtCNB1_1672 CtCNB1_1781 CtCNB1_3122
MPT: Mpe_A3354
HAR: HEAR0103
MMS: mma_0124(hmgL)
LCH: Lcho_0036 Lcho_0438 Lcho_0445 Lcho_2115
EBA: ebA4662(hmgL)
AZO: azo3065(mvaB)
DAR: Daro_0086
TMZ: Tmz1t_0753
APP: CAP2UW1_4325
GME: Gmet_3293
BBA: Bd3576(mvaB)
DAL: Dalk_3796
DAT: HRM2_21340(mvaB)
ADE: Adeh_1644
ACP: A2cp1_2302
AFW: Anae109_2166
ANK: AnaeK_2214
MXA: MXAN_3753
SCL: sce4321(mvaB)
HOH: Hoch_3592
SME: SM_b21125(hmgL)
SMD: Smed_4536
ATU: Atu3480(hmgL)
ATC: AGR_L_2702
ARA: Arad_1377(pyc)
AVI: Avi_7692(hmgL)
RHI: NGR_b11640
BME: BMEI1926
BMF: BAB1_0017
BMB: BruAb1_0017(mvaB)
BMC: BAbS19_I00140
BMT: BSUIS_A0018
BOV: BOV_0014(mvaB)
BMR: BMI_I17(mvaB)
OAN: Oant_0040
BJA: bll6364 blr0698 blr4422(hmgL)
BRA: BRADO3681(hmgL)
BBT: BBta_4049(hmgL)
RPA: RPA2540(hmgL)
RPB: RPB_2932
RPC: RPC_2780
RPD: RPD_2536
RPE: RPE_2910
RPT: Rpal_2810
XAU: Xaut_1854
AZC: AZC_1996
MRD: Mrad2831_3870
MET: M446_1232 M446_1922 M446_5092
MNO: Mnod_2776 Mnod_4905
CCR: CC_0467
CCS: CCNA_00500
CAK: Caul_4523
PZU: PHZ_c0425(mvaB)
SIL: SPO2788(mvaB)
SIT: TM1040_0739
RSP: RSP_2510(hmgL)
RSH: Rsph17029_1172
RSQ: Rsph17025_2009
RSK: RSKD131_0825
JAN: Jann_1149 Jann_3783
RDE: RD1_3295(mvaB)
PDE: Pden_3641 Pden_4878
DSH: Dshi_1303(mvaB)
MMR: Mmar10_2390
HNE: HNE_1080 HNE_3374
HBA: Hbal_1509
NAR: Saro_0177
SWI: Swit_2317
ACR: Acry_2695
RRU: Rru_A1940
RCE: RC1_0377
MAG: amb0673
BSU: BSU18230(yngG)
BHA: BH1134
BAN: BA2550(mvaB)
BAR: GBAA2550(mvaB)
BAA: BA_3052
BAT: BAS2372
BAH: BAMEG_2050(mvaB)
BAI: BAA_2609(mvaB)
BCE: BC2486
BCA: BCE_2551(mvaB)
BCZ: BCZK2288(mvaB)
BCR: BCAH187_A2606(mvaB)
BCB: BCB4264_A2514(mvaB)
BCU: BCAH820_2563(mvaB)
BCG: BCG9842_B2809(mvaB)
BCQ: BCQ_2428(mvaB)
BCX: BCA_2634(mvaB)
BCY: Bcer98_1805
BTK: BT9727_2330(mvaB)
BTL: BALH_2291
BWE: BcerKBAB4_2358
BLI: BL01990(yngG)
BLD: BLi02141(yngG)
BCL: ABC0547
BAY: RBAM_018350(yngG)
BPU: BPUM_1782(yngG)
OIH: OB1343 OB3230
GKA: GK1601
GTN: GTNG_1450
GWC: GWCH70_1838
GYC: GYMC61_2443 GYMC61_3564
AFL: Aflv_0183
LSP: Bsph_0901
BBE: BBR47_38570(yngG)
AAC: Aaci_2053
CDF: CD0797
CDC: CD196_0747
CDL: CDR20291_0728
AOE: Clos_0815
MPA: MAP3194
MAV: MAV_4025
MSM: MSMEG_2024 MSMEG_2072
MUL: MUL_2447
MVA: Mvan_1894
MGI: Mflv_4466
MAB: MAB_4650c
MMC: Mmcs_1588
MKM: Mkms_1612
MJL: Mjls_1558
MMI: MMAR_1493
NFA: nfa46700
RHA: RHA1_ro04924 RHA1_ro05078
RER: RER_04250 RER_34990(hmgL)
ROP: ROP_45850(hmgL) ROP_49950 ROP_51390
GBR: Gbro_2863
SCO: SCO2778(hmgL)
SMA: SAV_5276(hmgL)
SGR: SGR_4757
AAU: AAur_4148
ACH: Achl_0192
KSE: Ksed_21580
NCA: Noca_0149
TCU: Tcur_0961 Tcur_1975
SRO: Sros_6411 Sros_6617
FRE: Franean1_3719 Franean1_4049
ACE: Acel_0401
NML: Namu_0348 Namu_4266
SEN: SACE_3041 SACE_4360 SACE_6499(hmgL)
SVI: Svir_05920
AMI: Amir_6387
STP: Strop_0026
SAQ: Sare_0032
CAI: Caci_0816
RXY: Rxyl_1697
AFO: Afer_1146
LIL: LA0845
LIC: LIC12782
LBL: LBL_2733(leuA-4)
LBI: LEPBI_I1932(mvaB)
LBF: LBF_1877
ABA: Acid345_1427
ACA: ACP_1662
SRU: SRU_1246
RMR: Rmar_2658
CHU: CHU_1436(leuA)
DFE: Dfer_4398
CPI: Cpin_2930
PHE: Phep_1418
GFO: GFO_2517(mvaB)
FJO: Fjoh_2213
FPS: FP1821(mvaB)
FBA: FIC_00098
RBI: RB2501_11347
RRS: RoseRS_0049 RoseRS_4162
RCA: Rcas_0594 Rcas_3494 Rcas_3515
CAU: Caur_0371 Caur_2265
CAG: Cagg_1303 Cagg_3092
CHL: Chy400_0397 Chy400_2438
HAU: Haur_0762
TRO: trd_A0543
STI: Sthe_0007
TTH: TTC1162
TTJ: TTHA1526
HLA: Hlac_1101
Taxonomy
Structures PDB: 1YDN  2CW6  2FTP  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13271348]
BACHHAWAT BK, ROBINSON WG, COON MJ.
The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme
A to acetoacetate and acetyl coenzyme A.
J. Biol. Chem. 216 (1955) 727-36.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 4.1.3.4
IUBMB Enzyme Nomenclature: 4.1.3.4
ExPASy - ENZYME nomenclature database: 4.1.3.4
BRENDA, the Enzyme Database: 4.1.3.4
CAS: 9030-83-5
DBGET integrated database retrieval system