KEGG   ENZYME: 4.1.99.2Help
Entry
EC 4.1.99.2                 Enzyme                                 

Name
tyrosine phenol-lyase;
beta-tyrosinase;
L-tyrosine phenol-lyase (deaminating)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
BRITE hierarchy
Sysname
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
L-tyrosine + H2O = phenol + pyruvate + NH3 [RN:R00728]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
H2O [CPD:C00001]
Product
phenol [CPD:C00146];
pyruvate [CPD:C00022];
NH3 [CPD:C00014]
Comment
A pyridoxal-phosphate protein. The enzyme also slowly catalyses pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
History
EC 4.1.99.2 created 1972
Pathway
Tyrosine metabolism
Orthology
K01668  
tyrosine phenol-lyase
Genes
CKO: 
PAM: 
HPR: 
PMU: 
AAP: 
AAT: 
DNO: 
CTC: 
STH: 
DSY: 
DHD: 
TEP: 
NTH: 
ICA: 
TDE: 
TDE1118(tpl)
FNU: 
NPU: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
OPR: 
 » show all
Taxonomy
Reference
1  [PMID:4908868]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
  Journal
J. Biol. Chem. 245 (1970) 1767-72.
Reference
2  [PMID:4908869]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. II. Cofactor requrements.
  Journal
J. Biol. Chem. 245 (1970) 1773-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-31-8

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