| Entry |
|
|---|
| Name |
tyrosine phenol-lyase;
beta-tyrosinase;
L-tyrosine phenol-lyase (deaminating) |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
 |
|---|
| Sysname |
L-tyrosine phenol-lyase (deaminating; pyruvate-forming) |
|---|
| Reaction(IUBMB) |
L-tyrosine + H2O = phenol + pyruvate + NH3 [RN:R00728] |
|---|
| Reaction(KEGG) |
R00728
 |
|---|
| Substrate |
L-tyrosine [CPD:C00082];
H2O [CPD:C00001] |
|---|
| Product |
phenol [CPD:C00146];
pyruvate [CPD:C00022];
NH3 [CPD:C00014] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. The enzyme also slowly catalyses
pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine,
L-serine and D-serine. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec00910 Nitrogen metabolism |
|---|
| Orthology |
KO: K01668 tyrosine phenol-lyase |
|---|
| Genes |
CKO: CKO_03467
PMU: PM0811
AAP: NT05HA_0124
AAT: D11S_1940
DNO: DNO_0442
CTC: CTC00818
STH: STH2842
DSY: DSY3653
DHD: Dhaf_1723
NTH: Nther_1802
TDE: TDE1118(tpl)
FNU: FN1988
NPU: Npun_R5724
RRS: RoseRS_0320
RCA: Rcas_0866
CAU: Caur_0573
CAG: Cagg_3438
CHL: Chy400_0619
 |
|---|
| Structures |
PDB: 1C7G 1TPL 2EZ1 2EZ2 2TPL 2VLF 2VLH |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4908868]
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
Tyrosine phenol lyase. I. Purification, crystallization, and
properties.
J. Biol. Chem. 245 (1970) 1767-72.
Escherichia infermedia |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4908869]
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
Tyrosine phenol lyase. II. Cofactor requrements.
J. Biol. Chem. 245 (1970) 1773-7.
Escherichia infermedia |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.99.2
IUBMB Enzyme Nomenclature: 4.1.99.2
ExPASy - ENZYME nomenclature database: 4.1.99.2
BRENDA, the Enzyme Database: 4.1.99.2
CAS: 9059-31-8 |
|---|
