KEGG   ENZYME: 4.2.1.100Help
Entry
EC 4.2.1.100                Enzyme                                 

Name
cyclohexa-1,5-dienecarbonyl-CoA hydratase;
cyclohexa-1,5-diene-1-carbonyl-CoA hydratase;
dienoyl-CoA hydratase;
cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect);
6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
Reaction(IUBMB)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O [RN:R05597]
Reaction(KEGG)
Substrate
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749]
Product
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
H2O [CPD:C00001]
Comment
Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).
History
EC 4.2.1.100 created 2000, modified 2001
Pathway
Benzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K07537  
cyclohexa-1,5-dienecarbonyl-CoA hydratase
Genes
EBA: 
ebA5296(dch)
TMZ: 
GME: 
Gmet_2150(bamR)
GBM: 
Gbem_1432(bamR)
GEO: 
GEM: 
DTO: 
SAT: 
DTI: 
RVA: 
MAG: 
ABA: 
CTM: 
 » show all
Taxonomy
Reference
1  [PMID:9738901]
  Authors
Laempe D, Eisenreich W, Bacher A, Fuchs G.
  Title
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica.
  Journal
Eur. J. Biochem. 255 (1998) 618-27.
  Sequence
[up:O87873]
Reference
2  [PMID:8990279]
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J. Bacteriol. 179 (1997) 301-9.
Reference
3  [PMID:8436125]
  Authors
Koch J, Eisenreich W, Bacher A, Fuchs G.
  Title
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism.
  Journal
Eur. J. Biochem. 211 (1993) 649-61.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
214355-79-0

DBGET integrated database retrieval system