KEGG   ENZYME: 4.2.1.109Help
Entry
EC 4.2.1.109                Enzyme                                 
Name methylthioribulose 1-phosphate dehydratase;
1-PMT-ribulose dehydratase;
S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase
Class Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase
[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]
Reaction(IUBMB) S-methyl-5-thio-D-ribulose 1-phosphate =
5-(methylthio)-2,3-dioxopentyl phosphate + H2O [RN:R07392]
Reaction(KEGG) R07392
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Substrate S-methyl-5-thio-D-ribulose 1-phosphate [CPD:C04582]
Product 5-(methylthio)-2,3-dioxopentyl phosphate [CPD:C15650];
H2O [CPD:C00001]
Comment This enzyme forms part of the methionine-salvage pathway.
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K08964  methylthioribulose-1-phosphate dehydratase
Genes HSA: 51074(APIP)
PTR: 451118(APIP)
RNO: 295961(Apip)
CFA: 475943(APIP)
BTA: 508345(APIP)
ECB: 100060978
MDO: 100031578
OAA: 100076505
GGA: 428860(APIP)
TGU: 100230519
XLA: 414636
XTR: 548429
DRE: 447941
CIN: 100179775
DME: Dmel_CG11134
DPO: Dpse_GA10783
DAN: Dana_GF22600
DER: Dere_GG17808
DPE: Dper_GL19864
DSE: Dsec_GM17635
DSI: Dsim_GD17142
DYA: Dyak_GE17104
DGR: Dgri_GH11851
DMO: Dmoj_GI14333
AGA: AgaP_AGAP000470
AAG: AaeL_AAEL011830
CQU: CpipJ_CPIJ011356
AME: 552014
NVI: 100169980(Apip)
TCA: 657217
API: 100166027
NVE: NEMVE_v1g197093
HMG: 100202452
TAD: TRIADDRAFT_64275
CME: CMM212C
SCE: YJR024C(MDE1)
AGO: AGOS_ACL126W
KLA: KLLA0E16489g
LTH: KLTH0B01386g
DHA: DEHA0G07513g
PIC: PICST_89976(MTN2)
PPA: PAS_chr4_0280
VPO: Kpol_1050p40
LEL: LELG_04130
ZRO: ZYRO0G11440g
CAL: CaO19.11782
CTP: CTRG_05546
CDU: CD36_52610
CGR: CAGL0M07876g
YLI: YALI0C20427g
SPO: SPAC20H4.05c
NCR: NCU09264
PAN: PODANSg10039
MGR: MGG_01608
FGR: FG00493.1
ANI: AN3593.2
AFM: AFUA_4G12840
AOR: AO090009000312
ANG: An01g08410
AFV: AFLA_051550
PCS: Pc22g02780
NFI: NFIA_103490
CIM: CIMG_00610
URE: UREG_00618
SSL: SS1G_04684
BFU: BC1G_00083
CNE: CNH02290
CNB: CNBL2300
LBC: LACBIDRAFT_312101
MBR: MONBRDRAFT_29994
DDI: DDB_0233078
LMA: LmjF28.1840
LIF: LinJ28.1900
LBZ: LbrM28_V2.2010
YPG: YpAngola_A3331(mtnB)
YPP: YPDSF_2882
YPS: YPTB0874
YPI: YpsIP31758_3182
YPY: YPK_3321
YPB: YPTS_0915
YEN: YE3233(mntB)
ECA: ECA3487
PCT: PC1_3303
PWA: Pecwa_3457
ETA: ETA_26090
SGL: SG0272
ENT: Ent638_1143
ESA: ESA_02724
CTU: Ctu_12380(mtnB)
KPN: KPN_00634
KPE: KPK_3941(mtnB)
KPU: KP1_1585(mtnB)
CKO: CKO_03971
SPE: Spro_0942
DDA: Dd703_0918
DDC: Dd586_3258
DZE: Dd1591_0885
XFA: XF2209
XFT: PD1258(fucA2)
XFM: Xfasm12_1410
XFN: XfasM23_1343
XCC: XCC1820
XCB: XC_2369
XCA: xccb100_2107
XCV: XCV1886
XAC: XAC1840
XOO: XOO2139
XOM: XOO_2008
XOP: PXO_00848 PXO_06079
SML: Smlt2189
SMT: Smal_1782
PAE: PA1683
PAU: PA14_42740
PAP: PSPA7_3589(mtnB)
PAG: PLES_36441
PST: PSPTO_2045
PSB: Psyr_1855
PSP: PSPPH_1814
PFO: Pfl01_1724
AVN: Avin_23780
PHA: PSHAa2922
MAQ: Maqu_0907
MCA: MCA0799
TGR: Tgr7_2623
HCH: HCH_01844
ABO: ABO_1445
AFE: Lferr_0598
AFR: AFE_0436
SCL: sce1549
HOH: Hoch_4248
PLA: Plav_1852
BBT: BBta_2510
GOX: GOX1242
GBE: GbCGDNIH1_2265
ACR: Acry_0017
GDI: GDI_0585(mtnB)
GDJ: Gdia_1415
APT: APA01_07340
BSU: BSU13610(ykrY)
BAN: BA4257(mtnB)
BAR: GBAA4257(mtnB)
BAA: BA_4716
BAT: BAS3948(mtnB)
BAH: BAMEG_4298
BAI: BAA_4280
BCE: BC4038(mtnB)
BCA: BCE_4105(mtnB)
BCZ: BCZK3795(mtnB)
BCR: BCAH187_A4169(mtnB)
BCB: BCB4264_A4147(mtnB)
BCU: BCAH820_4059(mtnB)
BCG: BCG9842_B1091(mtnB)
BCQ: BCQ_3828
BCX: BCA_4151
BCY: Bcer98_2737(mtnB)
BTK: BT9727_3780(mtnB)
BTL: BALH_3655(mtnB)
BWE: BcerKBAB4_3867(mtnB)
BLI: BL03541(mtnB)
BLD: BLi01516(ykrY)
BAY: RBAM_013390(mtnB)
BPU: BPUM_1254(mtnB)
GKA: GK0955(mtnB)
GTN: GTNG_0843(mtnB)
GWC: GWCH70_0852
GYM: GYMC10_2265
GYC: GYMC61_1747
AFL: Aflv_1995(mtnB)
ESI: Exig_0428(mtnB)
EAT: EAT1b_1438
BBE: BBR47_48920(mtnB)
PJD: Pjdr2_2463
AAC: Aaci_0098
MLB: MLBr_00837
NFA: nfa14450
SMA: SAV_6659(fucA3)
FAL: FRAAL1412
SEN: SACE_3606
AMI: Amir_0986
LIL: LB292
LIC: LIC20226
LBJ: LBJ_4218
LBL: LBL_4232
LBI: LEPBI_II0200
LBF: LBF_4193
SYW: SYNW1963
SYC: syc2103_c
SYF: Synpcc7942_1993
SYD: Syncc9605_0490
SYE: Syncc9902_1845
SYR: SynRCC307_0449
SYX: SynWH7803_0538
SYP: SYNPCC7002_A0554
MAR: MAE_48300
CYP: PCC8801_1578
CYC: PCC7424_0307
CYH: Cyan8802_1603
PMT: PMT0185
PMF: P9303_21771
AAE: aq_1979(fucA2)
HYA: HY04AAS1_1514
SUL: SYO3AOP1_1268(mtnB)
SAF: SULAZ_1233(mtnB)
PMX: PERMA_1872(mtnB)
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:2838472]
Furfine ES, Abeles RH.
Intermediates in the conversion of 5'-S-methylthioadenosine to
methionine in Klebsiella pneumoniae.
J. Biol. Chem. 263 (1988) 9598-606.
Klebsiella pneumoniae [GN:kpn]
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:7852397]
Wray JW, Abeles RH.
The methionine salvage pathway in Klebsiella pneumoniae and rat
liver. Identification and characterization of two novel
dioxygenases.
J. Biol. Chem. 270 (1995) 3147-53.
Klebsiella pneumoniae [GN:kpn]
Other DBs ExplorEnz - The Enzyme Database: 4.2.1.109
IUBMB Enzyme Nomenclature: 4.2.1.109
ExPASy - ENZYME nomenclature database: 4.2.1.109
BRENDA, the Enzyme Database: 4.2.1.109
CAS: 1114239-22-3
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