| Entry |
|
|---|
| Name |
methylglutaconyl-CoA hydratase;
methylglutaconyl coenzyme A hydratase;
3-methylglutaconyl CoA hydratase;
methylglutaconase;
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
|---|
| Sysname |
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
(trans-3-methylglutaconyl-CoA-forming) |
|---|
| Reaction(IUBMB) |
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA +
H2O [RN:R02085] |
|---|
| Reaction(KEGG) |
R02085
 |
|---|
| Substrate |
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356] |
|---|
| Product |
trans-3-methylglutaconyl-CoA [CPD:C03231];
H2O [CPD:C00001] |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05607 methylglutaconyl-CoA hydratase |
|---|
| Genes |
HSA: 549(AUH)
PTR: 464587(AUH) 470410
MCC: 704542(AUH)
MMU: 11992(Auh)
RNO: 361215(Auh)
CFA: 476348(AUH)
ECB: 100064392
MDO: 100028211
TGU: 100231431
XLA: 734576
XTR: 548406(auh)
DRE: 445182(auh)
SPU: 577505
AFM: AFUA_3G11480
UMA: UM01935.1
 |
|---|
| Structures |
PDB: 2ZQQ 2ZQR |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:13535602]
HILZ H, KNAPPE J, RINGELMANN E, LYNEN F.
[Methylglutaconase, a new hydrase participating in the metabolism of
various carboxylic acids.]
Biochem. Z. 329 (1958) 476-89. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.1.18
IUBMB Enzyme Nomenclature: 4.2.1.18
ExPASy - ENZYME nomenclature database: 4.2.1.18
BRENDA, the Enzyme Database: 4.2.1.18
CAS: 9024-24-2 |
|---|
