| Entry |
|
|---|
| Name |
CDP-glucose 4,6-dehydratase;
cytidine diphosphoglucose oxidoreductase;
CDP-glucose 4,6-hydro-lyase |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
|---|
| Sysname |
CDP-glucose 4,6-hydro-lyase
(CDP-4-dehydro-6-deoxy-D-glucose-forming) |
|---|
| Reaction(IUBMB) |
CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O [RN:R02426] |
|---|
| Reaction(KEGG) |
R02426
 |
|---|
| Substrate |
CDP-glucose [CPD:C00501] |
|---|
| Product |
CDP-4-dehydro-6-deoxy-D-glucose [CPD:C01219];
H2O [CPD:C00001] |
|---|
| Cofactor |
NAD+ [CPD:C00003] |
|---|
| Comment |
Requires bound NAD+. |
|---|
| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism |
|---|
| Orthology |
KO: K01709 CDP-glucose 4,6-dehydratase |
|---|
| Genes |
STY: STY2301(rfbG)
STT: t0781(rfbG)
SPT: SPA0775(rfbG)
SEK: SSPA0729
SPQ: SPAB_00939
SEH: SeHA_C2317(rfbG)
SEE: SNSL254_A2273(rfbG)
SEW: SeSA_A2324(rfbG)
SEA: SeAg_B2216(rfbG)
SED: SeD_A2431(rfbG)
SEG: SG2122(rfbG)
SET: SEN2087(rfbG)
STM: STM2091(rfbG)
YPE: YPO3114(ascB)
YPK: y1069
YPM: YP_0816(wcaG1)
YPA: YPA_2606
YPN: YPN_0975 YPN_0976
YPP: YPDSF_2750
YPS: YPTB1000(ddhB)
YPI: YpsIP31758_3050(ddhB)
YPY: YPK_3190
YPB: YPTS_1043
YEN: YE3086(ddhB)
ECA: ECA1423(rfbG)
VFI: VF_0183(ddhB)
PPF: Pput_1480
PPW: PputW619_3718
PSP: PSPPH_0958
PFL: PFL_5095(rfbG)
PFO: Pfl01_1511
AVN: Avin_27770(rfbG)
SDN: Sden_2656
PAT: Patl_3062
PIN: Ping_0774
TCX: Tcr_1689
AHA: AHA_4165(rfbG)
CVI: CV_3892(rfbG)
LHK: LHK_02715(rfbG)
RPI: Rpic_4735
RPF: Rpic12D_3658
REH: H16_A2896
CTI: RALTA_B2137
BPS: BPSS0420(rfbG)
BPM: BURPS1710b_A1962(rfbG)
BPL: BURPS1106A_A0569(rfbG)
BPD: BURPS668_A0663(rfbG)
BTE: BTH_II1983(rfbG)
BAC: BamMC406_2291
PNE: Pnec_0332
BAV: BAV1254(rfbG)
RFR: Rfer_1251
POL: Bpro_4010
VEI: Veis_4419
HAR: HEAR1134
DAR: Daro_1257
TBD: Tbd_1880
SUN: SUN_2138
GUR: Gura_3789
GLO: Glov_0783
GBM: Gbem_0856
GEO: Geob_2125
GEM: GM21_3401
PCA: Pcar_1131(ddhB)
PPD: Ppro_3349
DVU: DVU0073
DVL: Dvul_2888
DVM: DvMF_1909
DDE: Dde_3695
DDS: Ddes_0876
DBA: Dbac_1872
BBA: Bd1665(rfbG)
DOL: Dole_1960
SCL: sce4869
SAT: SYN_02648
PLA: Plav_3352
SME: SM_b21417(ddhB)
AVI: Avi_0627(rfbG)
RLE: RL0245
RLT: Rleg2_4218
RLG: Rleg_4510
RHI: NGR_c24350(ddhB)
BJA: bll5979
RPA: RPA4049(rfbG)
RPE: RPE_4254
AZC: AZC_3479
MEX: Mext_0847
MEA: Mex_1p0613(rfbG)
MDI: METDI0984(rfbG)
MRD: Mrad2831_1258
MET: M446_4030
MPO: Mpop_0771
MCH: Mchl_0806
MNO: Mnod_3176
CAK: Caul_2715
PZU: PHZ_c0495
HBA: Hbal_2140
ACR: Acry_0592
RCE: RC1_3779(rfbG)
BCE: BC3359 BC3517
BCA: BCE_3396
BCZ: BCZK3070(rfbG)
BCR: BCAH187_A3400(rfbG)
BCB: BCB4264_A3374(rfbG1) BCB4264_A3529(rfbG2)
BCG: BCG9842_B1702(rfbG_1)
BCQ: BCQ_3172(rfbG)
BCY: Bcer98_0777
BAY: RBAM_007530(yfnG)
BPU: BPUM_0677(yfnG)
BBE: BBR47_17460(ddhB)
PJD: Pjdr2_3843
CTH: Cthe_2561
CBK: CLL_A2337(rfbG)
MMI: MMAR_2336(galE6)
CCU: Ccur_10410
LIL: LA1632(rfbG)
LIC: LIC12151(rfbG)
ACA: ACP_0579(rfbG)
BTH: BT_1350
BFR: BF1536
BFS: BF2602
BVU: BVU_4030
DFE: Dfer_4602
COC: Coch_0709
SYN: slr0984(rfbG)
SYC: syc1441_d(rfbG)
SYF: Synpcc7942_0061
MAR: MAE_10890(rfbG)
CYP: PCC8801_3334
CYH: Cyan8802_2783
PMM: PMM1203(rfbG)
PMC: P9515_07611(rfbG)
PMF: P9303_01401(rfbG)
PMJ: P9211_12911(rfbG)
AMR: AM1_2189
CPC: Cpar_1449
SAF: SULAZ_1206(rfbG)
PMX: PERMA_1995(rfbG)
TYE: THEYE_A1516
MAE: Maeo_0387
MPL: Mpal_2191
 |
|---|
| Structures |
PDB: 1RKX 1WVG |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4380946]
Hey AE, Elbein AD.
Biosynthesis of tyvelose. The purification and properties of
cytidine diphosphate D-glucose oxidoreductase.
J. Biol. Chem. 241 (1966) 5473-8.
Salmonella typhi |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4288651]
Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL.
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3.
Cytidine diphosphate D-glucose oxidoreductase.
J. Biol. Chem. 241 (1966) 4283-7.
Pasteurella pseudotuberculosis |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4869560]
Melo A, Elliott WH, Glaser L.
The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen
transfer catalyzed by deoxythymidine diphosphate D-glucose
oxidoreductase.
J. Biol. Chem. 243 (1968) 1467-74.
Salmonella typhimurium LT2 [GN:stm] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.1.45
IUBMB Enzyme Nomenclature: 4.2.1.45
ExPASy - ENZYME nomenclature database: 4.2.1.45
BRENDA, the Enzyme Database: 4.2.1.45
CAS: 37259-55-5 |
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