| Entry |
|
|---|
| Name |
GDP-mannose 4,6-dehydratase;
guanosine 5'-diphosphate-D-mannose oxidoreductase;
guanosine diphosphomannose oxidoreductase;
guanosine diphosphomannose 4,6-dehydratase;
GDP-D-mannose dehydratase;
GDP-D-mannose 4,6-dehydratase;
Gmd;
GDP-mannose 4,6-hydro-lyase |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
|---|
| Sysname |
GDP-mannose 4,6-hydro-lyase
(GDP-4-dehydro-6-deoxy-D-mannose-forming) |
|---|
| Reaction(IUBMB) |
GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O [RN:R00888] |
|---|
| Reaction(KEGG) |
R00888
 |
|---|
| Substrate |
GDP-mannose [CPD:C00096] |
|---|
| Product |
GDP-4-dehydro-6-deoxy-D-mannose [CPD:C01222];
H2O [CPD:C00001] |
|---|
| Cofactor |
NAD+ [CPD:C00003] |
|---|
| Comment |
The bacterial enzyme requires bound NAD+. This enzyme forms the
first step in the biosynthesis of GDP-D-rhamnose and GDP-L-fucose.
In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a
bifunctional enzyme, catalysing the above reaction as well as the
reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose
reductase [5]. Belongs to the short-chain dehydrogenase/reductase
enzyme family, having homologous structures and a conserved
catalytic triad of Lys, Tyr and Ser/Thr residues [6]. |
|---|
| Pathway |
PATH: ec00051 Fructose and mannose metabolism
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01711 GDPmannose 4,6-dehydratase |
|---|
| Genes |
HSA: 2762(GMDS)
PTR: 462390(GMDS)
MCC: 707051(GMDS)
MMU: 218138(Gmds)
RNO: 291095(Gmds)
CFA: 488189(GMDS)
BTA: 617688(GMDS)
SSC: 100154846
ECB: 100057325(GMDS)
MDO: 100028966
OAA: 100079151
GGA: 420890(GMDS)
TGU: 100229558
XLA: 380044(gmds) 444039
XTR: 394693(gmds)
DRE: 393461(gmds)
BFO: BRAFLDRAFT_275563
CIN: 100182733
SPU: 588885
DME: Dmel_CG8890(Gmd)
DPO: Dpse_GA21394
DAN: Dana_GF21530
DER: Dere_GG24331
DPE: Dper_GL26488
DSE: Dsec_GM18052
DSI: Dsim_GD22672
DYA: Dyak_GE18711
DMO: Dmoj_GI17012
AGA: AgaP_AGAP006783
AAG: AaeL_AAEL014961
CQU: CpipJ_CPIJ012919
AME: 411696
NVI: 100121796
TCA: 662112
API: 100163729
CEL: C53B4.7(bre-1) F56H6.5(gmd-2)
CBR: CBG21737
BMY: Bm1_36340
SMM: Smp_153490
NVE: NEMVE_v1g248392
HMG: 100215889
TAD: TRIADDRAFT_50808
ATH: AT3G51160(MUR1) AT5G66280(GMD1)
POP: POPTR_1083784 POPTR_836590
RCU: RCOM_0292370
VVI: 100264358(GSVIVT00036807001)
OSA: 4340050(Os06g0137700)
SBI: SORBI_10g002560(SORBIDRAFT_10g002560)
ZMA: 100282677
PPP: PHYPADRAFT_141365 PHYPADRAFT_227754 PHYPADRAFT_232551
OLU: OSTLU_13420
AFM: AFUA_7G06990
CIM: CIMG_10130
LBC: LACBIDRAFT_183999
MBR: MONBRDRAFT_8488
PFA: PF08_0077
PFD: PFDG_03390
PFH: PFHG_04520
PYO: PY06463
PCB: PC000770.03.0
PBE: PB000220.03.0
PKN: PKH_142460
PVX: PVX_123080
TGO: TGME49_038940
TBR: Tb10.61.0880
TCR: 510027.10
TPS: THAPSDRAFT_40586(GMD1)
ECO: b2053(gmd)
ECJ: JW2038(gmd)
ECD: ECDH10B_2203(gmd)
EBW: BWG_1843(gmd)
ECE: Z3198 Z3217(gmd)
ECS: ECs2839 ECs2858
ECF: ECH74115_2968(gmd) ECH74115_2988(gmd)
ETW: ECSP_2789(gmd1) ECSP_2808(gmd2)
ECG: E2348C_2195(gmd)
ECC: c2579(gmd)
ECI: UTI89_C2327(gmd)
ECP: ECP_2093
ECV: APECO1_1143(gmd)
ECW: EcE24377A_2346(gmd)
ECM: EcSMS35_1009(gmd)
ECY: ECSE_2327
ECL: EcolC_1588
ECK: EC55989_2309(gmd)
ECQ: ECED1_2399(gmd)
ECR: ECIAI1_2128(gmd)
ECT: ECIAI39_0962(gmd)
ECZ: ECS88_2150(gmd)
EUM: ECUMN_2389(gmd)
ELF: LF82_0900(gmd)
EBD: ECBD_1602
EBR: ECB_01959(gmd)
EOH: ECO103_2532(gmd)
EOI: ECO111_2765
EOJ: ECO26_2964(gmd)
EFE: EFER_2137(gmd)
STY: STY2321(gmd)
STT: t0763(gmd)
SPT: SPA0757(gmd)
SEK: SSPA0714
SPQ: SPAB_00921
SEI: SPC_1612(gmd)
SEC: SC2110(gmd)
SEH: SeHA_C2335(gmd)
SEE: SNSL254_A2291(gmd)
SEW: SeSA_A2342(gmd)
SEA: SeAg_B2234(gmd)
SED: SeD_A2449(gmd)
SEG: SG2141(gmd)
SET: SEN2105(gmd)
SES: SARI_00789
STM: STM2109(gmd)
YPA: YPA_2596
YPN: YPN_0986
YPP: YPDSF_2740
YPS: YPTB1009(gmd)
YPI: YpsIP31758_3041(gmd)
YPY: YPK_3183
YPB: YPTS_1054
YEN: YE3075(gmd)
SFL: SF2116(gmd)
SFX: S2239(gmd)
SFV: SFV_2110(gmd)
SSN: SSON_2106(gmd)
SBO: SBO_0880(gmd)
SBC: SbBS512_E1179(gmd)
PCT: PC1_1312
SGL: SG0331
ENT: Ent638_2667
ESA: ESA_01165
CTU: Ctu_27500(gmd)
KPU: KP1_3711(gmd)
CKO: CKO_00732
DDA: Dd703_3277
XFA: XF0609
XFT: PD1545(gmd)
XFM: Xfasm12_1701
XFN: XfasM23_1630
XCC: XCC0606
XCB: XC_3627
XCA: xccb100_3744(gmd)
XCV: XCV3718(gmd)
VCH: VC0243
VCO: VC0395_A2623(gmd)
VCM: VCM66_0231(rfbD)
VCJ: VCD_001374
VVY: VV0349
PAE: PA5453(gmd)
PAU: PA14_71990(gmd)
PAP: PSPA7_6243(gmd)
PPU: PP_1799(gmd)
PPW: PputW619_1408
PST: PSPTO_1005(gmd)
PSB: Psyr_0916
PSP: PSPPH_0953(gmd)
PFL: PFL_5491(gmd)
PFO: Pfl01_5682
PFS: PFLU3668
CPS: CPS_4199(gmd)
SDE: Sde_2117
PIN: Ping_0770
CBU: CBU_0689(gmd)
CBS: COXBURSA331_A0807(gmd)
CBD: CBUD_0703(gmd)
CBG: CbuG_1313(gmd)
CBC: CbuK_1565(gmd)
MCA: MCA1146(gmd)
FPH: Fphi_1247
TCX: Tcr_1680
NOC: Noc_1523
TGR: Tgr7_2093
HNA: Hneap_0492
AHA: AHA_2902(gmd)
TAU: Tola_2053
AFE: Lferr_2592 Lferr_2890
AFR: AFE_2977(gmd-1) AFE_3292(gmd-2)
RMA: Rmag_0903
RPI: Rpic_1158
REU: Reut_A0719
REH: H16_A2900
RME: Rmet_5860
CTI: RALTA_B0041(gmd)
BMA: BMA2297 BMAA1709(gmd)
BMV: BMASAVP1_1660(gmd) BMASAVP1_A0531
BML: BMA10229_1868(gmd) BMA10229_A1069
BMN: BMA10247_2175 BMA10247_A0540(gmd)
BPS: BPSL2797(wcbK) BPSS1688(gca)
BPM: BURPS1710b_3293(wcbK) BURPS1710b_A0758(gmd)
BPL: BURPS1106A_3279 BURPS1106A_A2295(gmd)
BPD: BURPS668_3244 BURPS668_A2434(gmd)
BPR: GBP346_A3422
BTE: BTH_I1331(gmd-1) BTH_II0690(gmd-2)
BVI: Bcep1808_4472 Bcep1808_6523
BUR: Bcep18194_B2115 Bcep18194_B2116
BCN: Bcen_0400 Bcen_4397
BCH: Bcen2424_0880 Bcen2424_3970
BCM: Bcenmc03_3559
BCJ: BCAM1004(gca)
BAM: Bamb_0759 Bamb_3358
BAC: BamMC406_0770 BamMC406_3863
BMU: Bmul_4612
BMJ: BMULJ_03899(gmd)
BXE: Bxe_A2234 Bxe_A3863 Bxe_C1085
BPH: Bphy_1069 Bphy_2471
BPY: Bphyt_0821 Bphyt_1965
BGL: bglu_1g06550 bglu_2g08510
PNU: Pnuc_0302
RFR: Rfer_1237
POL: Bpro_4012
PNA: Pnap_3190
DIA: Dtpsy_0561
VAP: Vapar_0757
MPT: Mpe_A2731
LCH: Lcho_0627 Lcho_2349
NET: Neut_0156
AZO: azo3587(gmd)
TBD: Tbd_1776
MFA: Mfla_1271
MMB: Mmol_1025
HPY: HP0044
HPJ: jhp0038(gmd)
HPA: HPAG1_0041
HPS: HPSH_00215
HPG: HPG27_39
HPP: HPP12_0039(gmd)
HPB: HELPY_0040(gmd)
HHE: HH0172(gmd)
HAC: Hac_0056(gmd)
TDN: Suden_1704
CJR: CJE1611(wcbK)
CJJ: CJJ81176_1426(wcbK)
CJD: JJD26997_1763
SDL: Sdel_1790
NIS: NIS_1386(gmd)
SUN: SUN_0342(gmd)
NAM: NAMH_1668(gmd)
GSU: GSU0626(gmd)
GME: Gmet_1311 Gmet_1488
GUR: Gura_3210 Gura_3801
GLO: Glov_0773 Glov_1491
GBM: Gbem_1136
GEO: Geob_2121
GEM: GM21_2591 GM21_2604 GM21_3149
PPD: Ppro_3405
DVU: DVU0448(gmd)
DVL: Dvul_2488
DVM: DvMF_2694
DDE: Dde_0432 Dde_2901
DDS: Ddes_0412
DMA: DMR_26790(gmd) DMR_26800(gmd)
LIP: LIC082(gmd)
DBA: Dbac_2561 Dbac_3251 Dbac_3269
DPS: DP0025
DOL: Dole_1281 Dole_1968
ADE: Adeh_4287
ACP: A2cp1_4448
AFW: Anae109_4441
ANK: AnaeK_4424
MXA: MXAN_5327(gmd)
SAT: SYN_00584
SFU: Sfum_3362
PUB: SAR11_0176(gmdA) SAR11_0570(gmd)
MLO: mll5922 mlr5849
PLA: Plav_1923
ATU: Atu4789(gmd)
ATC: AGR_L_187
RET: RHE_CH00762(noeL1) RHE_CH01350(noeL2)
REC: RHECIAT_CH0000849(noeLch) RHECIAT_PC0000279(noeLc)
RLE: RL0825(gmd) pRL90133
RLT: Rleg2_0425 Rleg2_6433
RLG: Rleg_0439 Rleg_6237
RHI: NGR_a00410(noeL)
BME: BMEI1413 BMEI1418 BMEII0848
BMI: BMEA_B0397(gmd)
BMF: BAB1_0540 BAB1_0545(gmd)
BMB: BruAb1_0545(gmd)
BMC: BAbS19_I05110
BMS: BR0522(gmd) BRA0419
BMT: BSUIS_A0553(gmd) BSUIS_B0422(gmd)
BOV: BOV_0526(gmd-2) BOV_A0362(gmd-1)
BCS: BCAN_A0534(gmd) BCAN_B0422(gmd)
BMR: BMI_I524(gmd) BMI_II416
OAN: Oant_3372
BJA: bll1631(noeL) bll5465(gmd)
BRA: BRADO2185(gmd) BRADO5260(gmd)
BBT: BBta_5712(gmd)
RPA: RPA3951(gmd)
RPB: RPB_1525
RPD: RPD_1647
RPE: RPE_4261
RPT: Rpal_4472
NWI: Nwi_2385
NHA: Nham_2780
AZC: AZC_0054
MRD: Mrad2831_0173
MET: M446_4019 M446_5189
MNO: Mnod_3187 Mnod_6329
MSL: Msil_0082
CCR: CC_1010
CCS: CCNA_00472 CCNA_01062
SIT: TM1040_1482
RSP: RSP_4109(gmd)
JAN: Jann_4280
PDE: Pden_1298
DSH: Dshi_4139
HNE: HNE_0793(gmd)
HBA: Hbal_1799
ZMN: Za10_0100
ELI: ELI_13420
GOX: GOX1612
GBE: GbCGDNIH1_2354
ACR: Acry_0508
RRU: Rru_A0253 Rru_B0047
RCE: RC1_4029(gmd)
MAG: amb1077
MGM: Mmc1_1429
GYM: GYMC10_5338
BBE: BBR47_17540 BBR47_17580(gmd)
PJD: Pjdr2_0404 Pjdr2_3512 Pjdr2_3524
CAC: CAC2180
CCE: Ccel_3441
DRM: Dred_1394 Dred_3135
DAE: Dtox_2843
MTU: Rv0112(gca) Rv1511(gmdA)
MTC: MT0121 MT1561(gmd)
MRA: MRA_0118(gca) MRA_1523(gmdA)
MTF: TBFG_10113 TBFG_11545
MTB: TBMG_00113(TBMG_00113.1) TBMG_02465(TBMG_02465.1)
MBO: Mb0116(gca)
MBB: BCG_0145(gca)
MBT: JTY_0116(gca)
MPA: MAP1231(gmdA)
MGI: Mflv_4754
MMC: Mmcs_0945
MKM: Mkms_0963
RHA: RHA1_ro05444
RER: RER_13240(gmd)
SGR: SGR_1542
CMI: CMM_1600(gmdA)
CMS: CMS_1581(gmd)
AAU: AAur_4113(gmd)
RSA: RSal33209_1341
KRH: KRH_20460(gmd)
NCA: Noca_4181 Noca_4203
TCU: Tcur_2622
SRO: Sros_8229
FRA: Francci3_1053 Francci3_1307
FRE: Franean1_5498
FAL: FRAAL1776(gmd)
ACE: Acel_0449
KRA: Krad_1827
SVI: Svir_00720
RXY: Rxyl_0567
AFO: Afer_0331
LIL: LA3964
LIC: LIC13168(gmd)
LBJ: LBJ_0410(gmd)
LBL: LBL_2667(gmd)
LBI: LEPBI_I0164(gmd)
LBF: LBF_0161(gmd)
BHY: BHWA1_00145(gmd)
ABA: Acid345_3814
BTH: BT_1224
BFR: BF1823
BFS: BF1888
BVU: BVU_2652 BVU_3946
PGI: PG1288(gmd)
PGN: PGN_1078
PDI: BDI_0652 BDI_2203
CHU: CHU_0059(gmd)
DFE: Dfer_3954
CPI: Cpin_1090
PHE: Phep_4001
GFO: GFO_0553(gmd)
FJO: Fjoh_0330
FPS: FP1640(gmd)
RBI: RB2501_01146 RB2501_06715
OTE: Oter_3945 Oter_4243
AMU: Amuc_1249
GAU: GAU_1970(gmd)
RBA: RB2512 RB2518
TAI: Taci_0017
SYN: sll1212(rfbD) slr1072(yefA)
SYW: SYNW0422(gmd)
SYC: syc0211_c
SYF: Synpcc7942_1342
SYE: Syncc9902_0174
SYG: sync_0146(gmd)
SYR: SynRCC307_0217(gmd)
SYX: SynWH7803_0114(gmd)
SYP: SYNPCC7002_A2565(gmd)
CYA: CYA_1520(gmd)
CYB: CYB_1095(gmd)
TEL: tll0634
MAR: MAE_03160 MAE_29910
CYT: cce_3233(gmd) cce_3335
CYP: PCC8801_2106 PCC8801_2561
CYC: PCC7424_3251 PCC7424_3395
CYN: Cyan7425_0211 Cyan7425_1105
CYH: Cyan8802_2150 Cyan8802_3545
GVI: gll0763 gll0764
ANA: all4828 alr3424 asl4827
NPU: Npun_F0313 Npun_F3485
AVA: Ava_2097 Ava_3444
PMA: Pro0063(gmd)
PMM: PMM1208(gmd)
PMN: PMN2A_1221
PMI: PMT9312_1316
PMB: A9601_13991(gmd) A9601_14531(rfbB)
PMC: P9515_01521(rfbB) P9515_07621 P9515_13001 P9515_13681(gmd)
P9515_14221
PMF: P9303_01131 P9303_01181(rfbB)
PMG: P9301_14001 P9301_14111(rfbB) P9301_14441(gmd)
PMH: P9215_14141(gmd) P9215_14361
PME: NATL1_20961(gmd) NATL1_21061
TER: Tery_0490
AMR: AM1_5749(gmd)
CCH: Cag_0652
CPH: Cpha266_2608
CPB: Cphamn1_1932
PVI: Cvib_0615
PLT: Plut_1863
PPH: Ppha_0571 Ppha_0589
CTS: Ctha_2065
RRS: RoseRS_3655 RoseRS_3928
RCA: Rcas_0917 Rcas_3217
CAU: Caur_1119 Caur_1970
CAG: Cagg_2042 Cagg_2084
CHL: Chy400_1225 Chy400_2124
HAU: Haur_3742 Haur_4567
TRO: trd_A0915(gmd)
AAE: aq_1082(rfbD)
SUL: SYO3AOP1_1407
SAF: SULAZ_1202(gmd)
PMX: PERMA_2002(gmd)
TYE: THEYE_A0469(gmd)
TTR: Tter_1711
MMZ: MmarC7_0340
MAE: Maeo_0397
MAC: MA1173(gmd) MA1174(gmd)
MBA: Mbar_A0034
MMA: MM_0659
MHU: Mhun_2132 Mhun_2858
MBN: Mboo_1762
MPL: Mpal_2129 Mpal_2184
MPD: MCP_2715(gmd)
MTH: MTH333
MST: Msp_0990
AFU: AF0044m(gmd-1)
RCI: RCIX204(gmd)
SIS: LS215_0629
PIS: Pisl_1490
TNE: Tneu_0491
NMR: Nmar_0150
 |
|---|
| Structures |
PDB: 1DB3 1N7G 1N7H 1RPN 1T2A 2Z1M 2Z95 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14299611]
ELBEIN AD, HEATH EC.
THE BIOSYNTHESIS OF CELL WALL LIPOPOLYSACCHARIDE IN ESCHERICHIA
COLI. II. GUANOSINE DIPHOSPHATE 4-KETO-6-DEOXY-D-MANNOSE, AN
INTERMEDIATE IN THE BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE COLITOSE.
J. Biol. Chem. 240 (1965) 1926-31.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5047712]
Liao TH, Barber GA.
Purification of guanosine 5'-diphosphate D-mannose oxidoreductase
from Phaseolus vulgaris.
Biochim. Biophys. Acta. 276 (1972) 85-93.
Phaseolus vulgaris |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:4869560]
Melo A, Elliott WH, Glaser L.
The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen
transfer catalyzed by deoxythymidine diphosphate D-glucose
oxidoreductase.
J. Biol. Chem. 243 (1968) 1467-74. |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
4 [PMID:9525924]
Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ,
Boodhoo A, Potvin B, Cumming DA.
Molecular cloning of human GDP-mannose 4,6-dehydratase and
reconstitution of GDP-fucose biosynthesis in vitro.
J. Biol. Chem. 273 (1998) 8193-202.
Homo sapiens [GN:hsa]
HSA: 2762 |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
5 [PMID:11096116]
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S,
Messner P.
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases
synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus
L420-91T.
J. Biol. Chem. 276 (2001) 5577-83.
Aneurinibacillus thermoaerophilus
NCBI-GI: 45249998 |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:12501186]
Mulichak AM, Bonin CP, Reiter WD, Garavito RM.
Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis
thaliana: implications for ligand binding and specificity.
Biochemistry. 41 (2002) 15578-89.
Arabidopsis thaliana [GN:ath] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.1.47
IUBMB Enzyme Nomenclature: 4.2.1.47
ExPASy - ENZYME nomenclature database: 4.2.1.47
BRENDA, the Enzyme Database: 4.2.1.47
CAS: 37211-59-9 |
|---|
