KEGG   ENZYME: 4.2.1.70Help
Entry
EC 4.2.1.70                 Enzyme                                 
Name
pseudouridylate synthase;
pseudouridylic acid synthetase;
pseudouridine monophosphate synthetase;
5-ribosyluracil 5-phosphate synthetase;
pseudouridylate synthetase;
upsilonUMP synthetase;
uracil hydro-lyase (adding D-ribose 5-phosphate)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
Reaction(IUBMB)
uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O [RN:R01055]
Reaction(KEGG)
Substrate
uracil [CPD:C00106];
D-ribose 5-phosphate [CPD:C00117]
Product
pseudouridine 5'-phosphate [CPD:C01168];
H2O [CPD:C00001]
Pathway
Pyrimidine metabolism
Orthology
K01718  
pseudouridylate synthase
Genes
DPO: 
OLU: 
CME: 
PIC: 
DDI: 
PFA: 
PKN: 
TAN: 
TBR: 
LMA: 
Taxonomy
Reference
1  [PMID:14165924]
  Authors
HEINRIKSON RL, GOLDWASSER E.
  Title
STUDIES ON THE BIOSYNTHESIS OF 5-RIBOSYLURACIL  5'-MONOPHOSPHATE IN TETRAHYMENA PYRIFORMIS.
  Journal
J. Biol. Chem. 239 (1964) 1177-87.
  Organism
Tetrahymena pyriformis
Reference
2  [PMID:4936431]
  Authors
Matsushita T, Davis FF.
  Title
Studies on pseudouridylic acid synthetase from various sources.
  Journal
Biochim. Biophys. Acta. 238 (1971) 165-73.
  Organism
Agrobacterium tumefaciens
Reference
3  [PMID:4569284]
  Authors
Remsen JF, Matsushita T, Chirikjian JG, Davis FF.
  Title
Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties.
  Journal
Biochim. Biophys. Acta. 281 (1972) 481-7.
  Organism
Tetrahymena pyriformis, Escherichia coli [GN:eco]
Reference
4  [PMID:5942965]
  Authors
Suzuki T, Hochster RM.
  Title
On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens.
  Journal
Can. J. Biochem. 44 (1966) 259-72.
  Organism
Agrobacterium tumefaciens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-35-2
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