KEGG   ENZYME: 4.2.1.70Help
Entry
EC 4.2.1.70                 Enzyme                                 

Name
pseudouridylate synthase;
pseudouridylic acid synthetase;
pseudouridine monophosphate synthetase;
5-ribosyluracil 5-phosphate synthetase;
pseudouridylate synthetase;
upsilonUMP synthetase;
uracil hydro-lyase (adding D-ribose 5-phosphate);
YeiN;
pseudouridine-5'-phosphate glycosidase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
Reaction(IUBMB)
uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O [RN:R01055]
Reaction(KEGG)
Substrate
uracil [CPD:C00106];
D-ribose 5-phosphate [CPD:C00117]
Product
pseudouridine 5'-phosphate [CPD:C01168];
H2O [CPD:C00001]
Comment
The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5].
History
EC 4.2.1.70 created 1978
Pathway
ec00240  Pyrimidine metabolism
Orthology
K16329  pseudouridylate synthase
K16330  pseudouridylate synthase / pseudouridine kinase
Genes
OAA: 103167706
GGA: 418114
MGP: 100549193
CJO: 107315955
APLA: 101794949
ACYG: 106031003
TGU: 100222446
GFR: 102033289
FAB: 101805779
PHI: 102105751
PMAJ: 107204525
CCW: 104696187
FPG: 101920111
FCH: 102057389
CLV: 102089100
EGZ: 104135563
AAM: 106488877
AMJ: 102565606
CMY: 102943015
ACS: 100556121
PVT: 110082704
GJA: 107108785
XLA: 108710735
XTR: 100485794
NPR: 108798720
DRE: 678543(zgc:136858)
SANH: 107661485
SGH: 107590813
IPU: 108269048
AMEX: 103028575
TRU: 101068240
LCO: 104940690
NCC: 104946800
MZE: 101471709
OLA: 101173144
XMA: 102233731
PRET: 103465818
NFU: 107388477
CSEM: 103380561
LCF: 108888529
HCQ: 109530857
BPEC: 110169581
SASA: 106561644
ELS: 105021834
SFM: 108936440
LCM: 102365846
CMK: 103181812
CIN: 100183226
SPU: 577497
APLC: 110986192
SKO: 102809771
DSI: Dsimw501_GD23033(Dsim_GD23033)
AME: 412233
BIM: 100746573
BTER: 100642217
SOC: 105195411
AEC: 105151022
ACEP: 105619786
PBAR: 105424996
HST: 105180730
CFO: 105250807
LHU: 105674958
PGC: 109859906
NVI: 100678438
TCA: 663878
BMOR: 101743270
PMAC: 106712233
ZNE: 110828757
CEL: CELE_T24C12.3(T24C12.3)
CBR: CBG14065
CRG: 105318930
MYI: 110466192
OBI: 106880549
EPA: 110234321
ADF: 107351232
HMG: 100197220
AQU: 100636487
ATH: AT1G50510
CRB: 17899684
THJ: 104804468
CPAP: 110811880
CIT: 102608204
TCC: 18589933
GRA: 105794037
GHI: 107954308
DZI: 111285808
EGR: 104421484
GMX: 100795266
VRA: 106758795
VAR: 108321610
CCAJ: 109791429
CAM: 101502447
ADU: 107470977
AIP: 107622952
LJA: Lj3g3v0461700.1(Lj3g3v0461700.1)
LANG: 109359143
FVE: 101309609
PPER: 18778206
PMUM: 103326776
PAVI: 110761605
MDM: 103413165
CSV: 101217190
CMO: 103492003
MCHA: 111021655
CMAX: 111485484
CMOS: 111461367
CPEP: 111779605
RCU: 8261161
JCU: 105628643
HBR: 110632302
POP: 7467984
JRE: 108994665
VVI: 100247897
SLY: 101255656
SPEN: 107003055
SOT: 102578459
CANN: 107853890
NSY: 104236012
NTO: 104102126
INI: 109172091
SIND: 105163652
OEU: 111369959
HAN: 110865845
LSV: 111875950
DCR: 108227465
BVG: 104890060
SOE: 110783298
NNU: 104586286
OSA: 4345970
DOSA: Os08t0504400-01(Os08g0504400)
OBR: 102712749
BDI: 100825346
ATS: 109783000
SBI: 8061374
ZMA: 100282483(cl13733_1)
SITA: 101755656
PDA: 103723746
EGU: 105035704
MUS: 103988795
DCT: 110111802
AOF: 109837389
ATR: 18447596
PPP: 112274537
MNG: MNEG_7971
APRO: F751_1735
CAUR: QG37_01347
NCR: NCU03020
NTE: NEUTE1DRAFT150742(NEUTE1DRAFT_150742)
MGR: MGG_14801
MAW: MAC_03789
MAJ: MAA_04222
CMT: CCM_06297
MBE: MBM_01329
ANI: AN7471.2
ANG: ANI_1_3344024(An02g14550)
ABE: ARB_05053
TVE: TRV_01446
PTE: PTT_08230
CNE: CNH02430
CNB: CNBL2450
ABP: AGABI1DRAFT110531(AGABI1DRAFT_110531)
ABV: AGABI2DRAFT189568(AGABI2DRAFT_189568)
MGL: MGL_0689
DFA: DFA_07675
EHI: EHI_149860(270.t00006)
SMIN: v1.2.003813.t1(symbB.v1.2.003813.t1)
ECO: b2165(psuG)
ECJ: JW2152(yeiN)
ECD: ECDH10B_2322(yeiN)
EBW: BWG_1947(yeiN)
ECOK: ECMDS42_1734(yeiN)
ECE: Z3422(yeiN)
ECS: ECs3057
ETW: ECSP_3043(yeiN)
EOJ: ECO26_3077(yeiN)
EOI: ECO111_2883(yeiN)
EOH: ECO103_2640(yeiN)
ECG: E2348C_2311(yeiN)
EOK: G2583_2708(yeiN)
ECP: ECP_2205
ECI: UTI89_C2439(yeiN)
ECV: APECO1_4389(yeiN)
ECY: ECSE_2433
ECR: ECIAI1_2245(yeiN)
ECQ: ECED1_2613(yeiN)
ECK: EC55989_2418(yeiN)
ECT: ECIAI39_2305(yeiN) ECIAI39_4228(yeiN)
EOC: CE10_2537(psuG) CE10_4264
EUM: ECUMN_2501(yeiN)
ECZ: ECS88_2313(yeiN)
ELH: ETEC_2300
ESE: ECSF_2046
ESO: O3O_17015
ESM: O3M_08570
ESL: O3K_08620
EBR: ECB_02094(yeiN)
EBD: ECBD_1493
EAB: ECABU_c24960(yeiN)
EDJ: ECDH1ME8569_2101(yeiN)
ELW: ECW_m2366(psuG)
ELL: WFL_11575
ELC: i14_2500(yeiN)
ELD: i02_2500(yeiN)
ELP: P12B_c2259(yeiN)
EBL: ECD_02094(psuG)
EBE: B21_02053(pscG)
ELF: LF82_3016(yeiN)
ECOI: ECOPMV1_02325(psuG)
ECOJ: P423_12170
ECOO: ECRM13514_2927(yeiN)
ECOH: ECRM13516_2867(yeiN)
ECOS: EC958_2501(yeiN)
EFE: EFER_2251(yeiN)
SFL: SF2250(yeiN)
SFX: S2379(yeiN)
SFV: SFV_2240(yeiN)
SFE: SFxv_2483
SFN: SFy_3195
SFS: SFyv_3270
SFT: NCTC1_02473(psuG)
SSN: SSON_2221(yeiN)
SBO: SBO_2161(yeiN)
KOX: KOX_25800
KOE: A225_4059
CKO: CKO_00617
CRO: ROD_22921
CAMA: F384_11545
YFR: AW19_2166(psuG)
YIN: CH53_2806(psuG)
YKR: CH54_3620
SPE: Spro_1699
SRL: SOD_c18080(psuG2)
DDD: Dda3937_00974(indA)
DDQ: DDI_4391
XBO: XBJ1_2250
XBV: XBW1_2290(psuG)
XNE: XNC1_2070
XNM: XNC2_2003
XPO: XPG1_0719(psuG)
MMK: MU9_3155
HAP: HAPS_1217(idgA)
HPAZ: K756_00580
HPAS: JL26_11295
HPAK: JT17_09180
MVR: X781_70
MVE: X875_50
VNI: VIBNI_A0243(psuG)
SLO: Shew_2724
SSE: Ssed_1352
SPL: Spea_2950
SHL: Shal_3040
SWD: Swoo_1446
PNG: PNIG_a0229(psuG)
FBL: Fbal_0380
LPN: lpg1928(indA)
LPH: LPV_2203(indA)
LPO: LPO_2004(indA)
LPM: LP6_1910(indA)
LPF: lpl1892
LPP: lpp1903
LPC: LPC_1382
LPA: lpa_02787
LPE: lp12_1867
LLO: LLO_0449(indA)
LFA: LFA_2150(indA)
LHA: LHA_1038(indA)
LCD: clem_09795(psuG)
TMC: LMI_2182(indA)
GAI: IMCC3135_07080(psuG)
HCH: HCH_01392
AHA: AHA_3405
ASA: ASA_0901
AVR: B565_0809
AMED: B224_0731
ASR: WL1483_2409(psuG)
ACAV: VI35_04510
REH: H16_B2031(idgA)
CNC: CNE_2c19810(psuG)
BSTG: WT74_17105
BPH: Bphy_6602
POL: Bpro_0080
JAG: GJA_4418
ADE: Adeh_1601
MXA: MXAN_3335
CCX: COCOR_03079(psuG)
SCL: sce6742
HOH: Hoch_5964
MLO: mll0028
MES: Meso_1265
SME: SMc00472
SMER: DU99_09845
SMD: Smed_1524
SFD: USDA257_c40750(psuG)
EAD: OV14_2976
ATU: Atu1876
ARA: Arad_2620
ATF: Ach5_17970(psuG)
AVI: Avi_2560
REL: REMIM1_CH02336(psuG)
REI: IE4771_CH02454(psuG)
REP: IE4803_CH02367(psuG)
RLG: Rleg_2171
RGA: RGR602_CH02115(psuG)
RHN: AMJ98_CH02382(psuG)
RPHA: AMC79_CH02452(psuG)
RHT: NT26_1896(psuG)
RHX: AMK02_CH02397(psuG)
SHZ: shn_08545
MET: M446_1663
MNO: Mnod_1045
PHL: KKY_1068
MMED: Mame_03309(psuG)
HDI: HDIA_3920(psuG)
RBM: TEF_13620
SIL: SPO2061
RSP: RSP_2858
JAN: Jann_2308
RDE: RD1_2734
PDE: Pden_1813
DSH: Dshi_2110
KVU: EIO_1414
KVL: KVU_0904
KRO: BVG79_01162(psuG)
PSF: PSE_4072
PGD: Gal_01897
OTM: OSB_14850(psuG)
PTP: RCA23_c15940(psuG)
CID: P73_2549
MALG: MALG_01906
RHC: RGUI_0278
SPSE: SULPSESMR1_01606(psuG)
LVS: LOKVESSMR4R_01494(psuG)
AHT: ANTHELSMS3_03412(psuG)
GXY: GLX_03860
ASZ: ASN_1321(idgA)
RCE: RC1_0645
TXI: TH3_15165
BBEV: BBEV_1066(psuG)
GKA: GK1373
GTN: GTNG_1232
GGH: GHH_c12970(psuG)
GEA: GARCT_01384(psuG)
ANM: GFC28_386
LSP: Bsph_3909
BSE: Bsel_2512
SAU: SA0301
SAV: SAV0312
SAW: SAHV_0309
SAM: MW0289
SAS: SAS0289
SAR: SAR0309
SAC: SACOL0309
SAE: NWMN_0254
SAD: SAAV_0279
SUE: SAOV_0265
SUC: ECTR2_272
SUZ: MS7_0302
SUG: SAPIG0325
SAUA: SAAG_00800
SAUE: RSAU_000258(psuG)
SAUS: SA40_0270
SAUU: SA957_0285
SAUG: SA268_0282
SAUT: SAI1T1_2002380(psuG)
SAUJ: SAI2T2_1002380(psuG)
SAUK: SAI3T3_1002380(psuG)
SAUQ: SAI4T8_1002380(psuG)
SAUV: SAI7S6_1002380(psuG)
SAUW: SAI5S5_1002370(psuG)
SAUX: SAI6T6_1002380(psuG)
SAUY: SAI8T7_1002380(psuG)
SAUF: X998_0298
SAB: SAB0249
SAUB: C248_0301
SAUM: BN843_3180
SAUC: CA347_325
SAUR: SABB_01536(psuG)
SAUI: AZ30_01605
SAUD: CH52_04165
SAMS: NI36_01470
SXO: SXYL_00262(psuG)
SHU: SHYC_01320(psuG)
SAGQ: EP23_08825
MCAK: MCCS_05480(psuG)
LMO: lmo2340
LMS: LMLG_0939
LMQ: LMM7_2378(yeiN)
LMP: MUO_11675
LMOG: BN389_23070(psuG)
LMOE: BN418_2765
LMOD: LMON_2352
LMOW: AX10_05675
LMOX: AX24_09490
LMOQ: LM6179_3057(yeiN)
LMR: LMR479A_2459(psuG)
LMOK: CQ02_11800
LMOM: IJ09_13200
LIN: lin2434
LWE: lwe2292
LSG: lse_2256
LIV: LIV_2262
SIV: SSIL_0623
KUR: ASO14_776
CBO: CBO1169
CBA: CLB_1200
CBH: CLC_1212
CBY: CLM_1320
CBL: CLK_0604
CBB: CLD_3400
CBI: CLJ_B1210
CBF: CLI_1251
CBM: CBF_1224
CSQ: CSCA_5163
CLD: CLSPO_c11690(psuG)
AMT: Amet_0703
AOE: Clos_0652
CPRO: CPRO_14290(psuG)
STH: STH1947
OVA: OBV_10260
TMR: Tmar_1525
SAY: TPY_0793
TTE: TTE0327(IndA)
THX: Thet_0301
TIT: Thit_0290
TKI: TKV_c02780(psuG)
CHY: CHY_0077
TTM: Tthe_1698
PMIC: NW74_01520
MAA: MAG0250
MAL: MAGa0260
MBH: MMB_0025
MBI: Mbov_0025
ACL: ACL_0802(indA)
ABRA: BN85310740(psuG)
AOC: Aocu_09130(psuG)
MBJ: KQ51_01157(psuG)
CGV: CGLAU_10005(psuG)
SCO: SCO1971(SC3C9.06)
SMA: SAVERM_6267(indA)
SGR: SGR_5552
SHY: SHJG_3431
SVE: SVEN_1606
SDV: BN159_6507(psuG)
SALB: XNR_5636
SALS: SLNWT_5931
SLV: SLIV_27860(psuG)
SGU: SGLAU_08885(psuG)
STRM: M444_10025
SAMB: SAM23877_2049(psuG)
SPRI: SPRI_5558
SRW: TUE45_02472(psuG)
SLE: sle_51690(sle_51690)
SRN: A4G23_01174(psuG_1) A4G23_04735(psuG_2)
STRD: NI25_29310
SMAL: SMALA_7248
SALF: SMD44_02132(psuG)
SLX: SLAV_27710(psuG1) SLAV_40130(psuG2)
LMOI: VV02_16070
NCA: Noca_4621
PSIM: KR76_07665
NAL: B005_4295
TCU: Tcur_2391
SRO: Sros_6401
FAL: FRAAL6645
NML: Namu_3777
GOB: Gobs_3557
MMAR: MODMU_3939
SEN: SACE_1229(indA)
AMD: AMED_2574
AMN: RAM_13080
AMM: AMES_2546
AMZ: B737_2547
AOI: AORI_2555
AJA: AJAP_26050(psuG)
AMQ: AMETH_4798(indA)
PDX: Psed_2987
PSEA: WY02_28040
PSEE: FRP1_14690
AMI: Amir_1499
SESP: BN6_17830(psuG)
KAL: KALB_6857
ACTI: UA75_08355
ACAD: UA74_08380
AHG: AHOG_07855(psuG)
ALL: CRK55817
SAQ: Sare_1436
MIL: ML5_1846
ASE: ACPL_7120(indA)
ACTN: L083_6704(indA)
AFS: AFR_35350
ACTS: ACWT_6989
CAI: Caci_1754
TBI: Tbis_2147
RXY: Rxyl_0490
APV: Apar_0138
OLS: Olsu_0187
RCA: Rcas_3582
CAU: Caur_2036
CAG: Cagg_2613
HAU: Haur_3009
ATM: ANT_22550
ABAT: CFX1CAM_2262(psuG)
DRA: DR_2311
DGE: Dgeo_0357
TRA: Trad_1987
TTH: TT_C0813
TTJ: TTHA1177
TAQ: TO73_1302
MRB: Mrub_1065
GES: VT84_37870(psuG)
IPA: Isop_0436
SACI: Sinac_0553
BHY: BHWA1_00903(indA)
BRM: Bmur_0662
BPO: BP951000_2113(indA)
BPW: WESB_1013
BIP: Bint_0958(indA)
SUS: Acid_6660
SMF: Smon_0554
GAU: GAU_2610
GBA: J421_6334
RMR: Rmar_0999
CACI: CLOAM0999(indA)
TMA: TM1464
TMW: THMA_1495
TMQ: THMB_1495
TMX: THMC_1495
TPT: Tpet_1329
TRQ: TRQ2_1357
TNA: CTN_1029
TNP: Tnap_1346
TLE: Tlet_1964
TME: Tmel_1239
TAF: THA_1468
THER: Y592_07100
FNO: Fnod_1187
PMO: Pmob_0900
MARN: LN42_10930
DTN: DTL3_0711(psuG)
KOL: Kole_1400
CEX: CSE_08280
 » show all
Taxonomy
Reference
1  [PMID:14165924]
  Authors
HEINRIKSON RL, GOLDWASSER E.
  Title
STUDIES ON THE BIOSYNTHESIS OF 5-RIBOSYLURACIL  5'-MONOPHOSPHATE IN TETRAHYMENA PYRIFORMIS.
  Journal
J. Biol. Chem. 239 (1964) 1177-87.
Reference
2  [PMID:4936431]
  Authors
Matsushita T, Davis FF.
  Title
Studies on pseudouridylic acid synthetase from various sources.
  Journal
Biochim. Biophys. Acta. 238 (1971) 165-73.
Reference
3  [PMID:4569284]
  Authors
Remsen JF, Matsushita T, Chirikjian JG, Davis FF.
  Title
Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties.
  Journal
Biochim. Biophys. Acta. 281 (1972) 481-7.
Reference
4  [PMID:5942965]
  Authors
Suzuki T, Hochster RM.
  Title
On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens.
  Journal
Can. J. Biochem. 44 (1966) 259-72.
Reference
5  [PMID:18591240]
  Authors
Preumont A, Snoussi K, Stroobant V, Collet JF, Van Schaftingen E.
  Title
Molecular identification of pseudouridine-metabolizing enzymes.
  Journal
J. Biol. Chem. 283 (2008) 25238-46.
  Sequence
[eco:b2165]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.70
IUBMB Enzyme Nomenclature: 4.2.1.70
ExPASy - ENZYME nomenclature database: 4.2.1.70
BRENDA, the Enzyme Database: 4.2.1.70
CAS: 9023-35-2

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