| Entry |
|
|---|
| Name |
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
|---|
| Sysname |
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase |
|---|
| Reaction(IUBMB) |
(3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O [RN:R02685] |
|---|
| Reaction(KEGG) |
R02685 > R04170 R04738 R04740 R04744 R04746 R04749 R07889 R07893
R07897
 |
|---|
| Substrate |
(3S)-3-hydroxyacyl-CoA [CPD:C00640] |
|---|
| Product |
trans-2-enoyl-CoA [CPD:C00658];
H2O [CPD:C00001] |
|---|
| Comment |
Acts in the reverse direction. The best substrate is
oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not
act on crotonoyl-CoA. |
|---|
| Pathway |
PATH: ec00062 Fatty acid elongation in mitochondria
PATH: ec00071 Fatty acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:833142]
Fong JC, Schulz H.
Purification and properties of pig heart crotonase and the presence
of short chain and long chain enoyl coenzyme A hydratases in pig and
guinea pig tissues.
J. Biol. Chem. 252 (1977) 542-7.
Sus scofa [GN:ssc], Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4828315]
Schulz H.
Long chain enoyl coenzyme A hydratase from pig heart.
J. Biol. Chem. 249 (1974) 2704-9.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.1.74
IUBMB Enzyme Nomenclature: 4.2.1.74
ExPASy - ENZYME nomenclature database: 4.2.1.74
BRENDA, the Enzyme Database: 4.2.1.74
CAS: 62009-81-8 |
|---|
