KEGG   ENZYME: 4.2.1.75Help
Entry
EC 4.2.1.75                 Enzyme                                 
Name uroporphyrinogen-III synthase;
porphobilinogenase;
uroporphyrinogen isomerase;
uroporphyrinogen III cosynthase;
URO-synthase;
hydroxymethylbilane hydro-lyase (cyclizing)
Class Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname hydroxymethylbilane hydro-lyase (cyclizing;
uroporphyrinogen-III-forming)
Reaction(IUBMB) hydroxymethylbilane = uroporphyrinogen III + H2O [RN:R03165]
Reaction(KEGG) R03165
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Substrate hydroxymethylbilane [CPD:C01024]
Product uroporphyrinogen III [CPD:C01051];
H2O [CPD:C00001]
Comment In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the
enzyme forms uroporphyrinogen III from porphobilinogen.
Pathway PATH: ec00860  Porphyrin and chlorophyll metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01719  uroporphyrinogen-III synthase
Genes HSA: 7390(UROS)
PTR: 450813(UROS)
MCC: 696043(UROS)
MMU: 22276(Uros)
RNO: 309070(Uros)
CFA: 492116(UROS)
BTA: 613425(UROS)
SSC: 100153444
ECB: 100056401
MDO: 100010046
GGA: 426223(UROS)
TGU: 100222432
XLA: 447178
XTR: 100135131
DRE: 404731(uros)
BFO: BRAFLDRAFT_127880
CIN: 100179207
SPU: 586365
DME: Dmel_CG1885
DPO: Dpse_GA15099
DAN: Dana_GF19123
DER: Dere_GG19019
DPE: Dper_GL13032
DSE: Dsec_GM13694
DYA: Dyak_GE17428
DGR: Dgri_GH12072
DMO: Dmoj_GI15566
AGA: AgaP_AGAP008064
AAG: AaeL_AAEL001978
CQU: CpipJ_CPIJ002599
AME: 408847
NVI: 100114801
TCA: 655957
SMM: Smp_079840
NVE: NEMVE_v1g204353
POP: POPTR_917649
RCU: RCOM_1591750
VVI: 100250675
OSA: 4331869(Os03g0186100)
SBI: SORBI_01g044830(SORBIDRAFT_01g044830)
ZMA: 100192907
PPP: PHYPADRAFT_131588
CRE: CHLREDRAFT_195943(UROS)
OLU: OSTLU_5668
CME: CML040C
SCE: YOR278W(HEM4)
AGO: AGOS_AER351W
KLA: KLLA0C07150g
LTH: KLTH0D12606g
DHA: DEHA0E06424g
PIC: PICST_59732(HEM4)
PPA: PAS_chr2-1_0533
VPO: Kpol_1064p43
LEL: LELG_02491
ZRO: ZYRO0A06138g
CTP: CTRG_02033
CDU: CD36_24400
CGR: CAGL0L11000g
YLI: YALI0F09449g
SPO: SPAC31G5.08(ups)
NCR: NCU02395
PAN: PODANSg9251
MGR: MGG_09567
FGR: FG06387.1
AFM: AFUA_6G12800
AOR: AO090003000401
ANG: An08g10680
AFV: AFLA_034180
PCS: Pc22g01660
NFI: NFIA_058760
CIM: CIMG_01716
URE: UREG_05429
SSL: SS1G_11134
BFU: BC1G_08125
CNE: CNK02510
CNB: CNBK1040
LBC: LACBIDRAFT_318859
MGL: MGL_0319
PTI: PHATRDRAFT_44610(HemD)
TPS: THAPSDRAFT_2950(UroS)
ECO: b3804(hemD)
ECJ: JW3776(hemD)
ECD: ECDH10B_3995(hemD)
EBW: BWG_3483(hemD)
ECE: Z5318(hemD)
ECS: ECs4734(hemD)
ECF: ECH74115_5242(hemD)
ETW: ECSP_4856(hemD)
ECG: E2348C_4102(hemD)
ECC: c4723(hemD)
ECI: UTI89_C4363(hemD)
ECP: ECP_3996(hemD)
ECV: APECO1_2674(hemD)
ECW: EcE24377A_4319(hemD)
ECX: EcHS_A4024(hemD)
ECM: EcSMS35_4169(hemD)
ECY: ECSE_4085(hemD)
ECL: EcolC_4203(hemD)
ECK: EC55989_4274(hemD)
ECQ: ECED1_4489(hemD)
ECR: ECIAI1_3990(hemD)
ECT: ECIAI39_2986(hemD)
ECZ: ECS88_4226(hemD)
EUM: ECUMN_4328(hemD)
ELF: LF82_0978(hemD)
EBL: B21_03628(hemD)
EBD: ECBD_4238
EBR: ECB_03679(hemD)
EOH: ECO103_4363(hemD)
EOI: ECO111_4627(hemD)
EOJ: ECO26_4785(hemD)
EFE: EFER_3701(hemD)
STY: STY3622(hemD)
STT: t3360(hemD)
SPT: SPA3778(hemD)
SEK: SSPA3517(hemD)
SPQ: SPAB_04885(hemD)
SEI: SPC_4047(hemD)
SEC: SC3838(hemD)
SEH: SeHA_C4267(hemD)
SEE: SNSL254_A4219(hemD)
SEW: SeSA_A4150(hemD)
SEA: SeAg_B4165(hemD)
SED: SeD_A4326(hemD)
SEG: SG3510(hemD)
SET: SEN3738(hemD)
SES: SARI_03715(hemD)
STM: STM3937(hemD)
YPE: YPO3850(hemD)
YPK: y0380(hemD)
YPM: YP_3196(hemD)
YPA: YPA_0171(hemD)
YPN: YPN_0113(hemD)
YPG: YpAngola_A0535(hemD)
YPP: YPDSF_3468(hemD)
YPS: YPTB0183(hemD)
YPI: YpsIP31758_0197(hemD)
YPY: YPK_4017(hemD)
YPB: YPTS_0195(hemD)
YEN: YE0186(hemD)
SFL: SF3876(hemD)
SFX: S3880(hemD)
SFV: SFV_3698(hemD)
SSN: SSON_3976(hemD)
SBO: SBO_3815(hemD)
SBC: SbBS512_E4263(hemD)
SDY: SDY_3942(hemD)
ECA: ECA4189(hemD)
PCT: PC1_3981
PWA: Pecwa_4172
ETA: ETA_02110(hemD)
PLU: plu4645(hemD)
PAY: PAU_04126(hemD)
WBR: WGLp241(hemD)
SGL: SG2367(hemD)
ENT: Ent638_3988(hemD)
ESA: ESA_03754(hemD)
CTU: Ctu_02360(hemD)
KPN: KPN_04303(hemD)
KPE: KPK_5375(hemD)
KPU: KP1_0162(hemD)
CKO: CKO_00146(hemD)
SPE: Spro_0177(hemD)
PMR: PMI3331(hemD)
EIC: NT01EI_0109
ETR: ETAE_0117(hemD)
BFL: Bfl581(hemD)
BPN: BPEN_602(hemD)
HDE: HDEF_0704(hemD)
DDA: Dd703_0227
DDC: Dd586_3877
DZE: Dd1591_0178
HDU: HD1742(hemD)
HAP: HAPS_1005(hemD)
HSO: HS_0045(hemD)
HSM: HSM_1938
PMU: PM1813(hemX)
MSU: MS0275(hemD)
APL: APL_1009(hemD)
APJ: APJL_1027(hemD)
APA: APP7_1066
ASU: Asuc_0355
AAP: NT05HA_1599
AAT: D11S_0696
XFA: XF1799
XFT: PD1068(hemD)
XFM: Xfasm12_1226
XFN: XfasM23_1133
XCC: XCC0198(hemD)
XCB: XC_0208
XCA: xccb100_0219(hemD)
XCV: XCV0201(hemD)
XAC: XAC0216(hemD)
XOO: XOO4088(hemD)
XOM: XOO_3862
XOP: PXO_04233(hemD)
SML: Smlt0167(hemD)
SMT: Smal_0131
VCH: VC0119(hemD)
VCO: VC0395_A2399(hemD)
VCM: VCM66_0119(hemD)
VCJ: VCD_001579
VVU: VV1_1121(hemD)
VVY: VV0080(hemD)
VPA: VP2989(hemD)
VHA: VIBHAR_00315(hemD)
VSP: VS_3053(hemD)
VEX: VEA_002105
VFI: VF_0065(hemD)
VFM: VFMJ11_0063(hemD)
VSA: VSAL_I0219(hemD)
PPR: PBPRA3529
PAE: PA5259(hemD)
PAU: PA14_69440(hemD)
PAP: PSPA7_6005(hemD)
PAG: PLES_56531(hemD)
PPU: PP_0187(hemD)
PPF: Pput_0209
PPG: PputGB1_0212
PPW: PputW619_0257
PST: PSPTO_0129(hemD)
PSB: Psyr_0061
PSP: PSPPH_0066(hemD)
PFL: PFL_6001(hemD)
PFO: Pfl01_5486
PFS: PFLU5933(hemD)
PEN: PSEEN5352(hemD)
PMY: Pmen_0281
PSA: PST_0525(hemD)
CJA: CJA_3385(hemD)
AVN: Avin_47590(hemD)
PAR: Psyc_0090(hemD)
PCR: Pcryo_0099
PRW: PsycPRwf_2262
ACI: ACIAD0287(hemD)
ACB: A1S_0263
ABM: ABSDF3263(hemD)
ABY: ABAYE3507(hemD)
ABC: ACICU_00285
ABN: AB57_0351(hemD)
ABB: ABBFA_003270
SON: SO_4314(hemD)
SDN: Sden_0387
SFR: Sfri_0439
SAZ: Sama_3255
SBL: Sbal_4001
SBM: Shew185_3979
SBN: Sbal195_4095
SBP: Sbal223_3902
SLO: Shew_0317
SPC: Sputcn32_3588
SSE: Ssed_4134
SPL: Spea_0372
SHE: Shewmr4_0387
SHM: Shewmr7_3639
SHN: Shewana3_0385
SHW: Sputw3181_3727
SHL: Shal_3918
SWD: Swoo_0482
SWP: swp_0400
ILO: IL2559(hemD)
CPS: CPS_0073(hemD)
PHA: PSHAa0099(hemDX)
PAT: Patl_0341
MAQ: Maqu_0486
AMC: MADE_00149
PIN: Ping_3641
TTU: TERTU_0198(hemD)
CBU: CBU_2077(hemD)
CBS: COXBURSA331_A0008(hemD)
CBD: CBUD_2173(hemD)
CBG: CbuG_2078(hemD)
CBC: CbuK_2122(hemD)
LPN: lpg2736
LPF: lpl2661(hemD)
LPP: lpp2792(hemD)
LPC: LPC_0394(hemD)
MCA: MCA3061(hemDX)
FTU: FTT_1408c(hemD)
FTF: FTF1408c(hemD)
FTW: FTW_0480
FTL: FTL_0654
FTH: FTH_0657(hemD)
FTA: FTA_0690
FTM: FTM_0613
FTN: FTN_1373(hemD)
FPH: Fphi_1313
TCX: Tcr_0113
NOC: Noc_0503
AEH: Mlg_2669
HHA: Hhal_1026
TGR: Tgr7_0028
HNA: Hneap_1109 Hneap_2162
HCH: HCH_00290
CSA: Csal_3108
ABO: ABO_2321(hemD)
MMW: Mmwyl1_3592
AHA: AHA_0468(hemD)
ASA: ASA_3876(hemD)
TAU: Tola_3128
DNO: DNO_0298(hemD)
AFE: Lferr_2897
AFR: AFE_3299(hemD)
BCI: BCI_0062(hemD)
RMA: Rmag_0853
VOK: COSY_0778(hemD)
KKO: Kkor_0167
NMA: NMA0988(hemD)
NME: NMB0777(hemD)
NMC: NMC0730(hemD)
NMN: NMCC_0741(hemD)
NMI: NMO_0666(hemD)
NGO: NGO0359(hemD)
NGK: NGK_0516(hemD)
CVI: CV_0052(hemD)
LHK: LHK_00071(hemD)
RSO: RSc2356
RPI: Rpic_2570
RPF: Rpic12D_2165
REU: Reut_A0701
REH: H16_A2919(hemXD)
RME: Rmet_2748
CTI: RALTA_A2401
BMA: BMA0731
BMV: BMASAVP1_A2283
BML: BMA10229_A3001
BMN: BMA10247_1596
BPS: BPSL1016
BPM: BURPS1710b_1231(hemX)
BPL: BURPS1106A_1078
BPD: BURPS668_1072
BPR: GBP346_A1070
BTE: BTH_I0873
BVI: Bcep1808_2508
BUR: Bcep18194_A5751
BCN: Bcen_1812
BCH: Bcen2424_2424
BCM: Bcenmc03_2428
BCJ: BCAL2629
BAM: Bamb_2467
BAC: BamMC406_2333
BMU: Bmul_0870
BMJ: BMULJ_02388(hemX)
BXE: Bxe_A3410
BPH: Bphy_2178
BPY: Bphyt_1070
BGL: bglu_1g27920
PNU: Pnuc_0657
PNE: Pnec_1199
BPE: BP2536
BPA: BPP2643
BBR: BB2086
BPT: Bpet2066(hemD)
BAV: BAV2299(hemD)
PNA: Pnap_3089
AAV: Aave_1998
AJS: Ajs_2891
VEI: Veis_1039
DAC: Daci_2231
DIA: Dtpsy_2378
VAP: Vapar_1375
CTT: CtCNB1_3533
MPT: Mpe_A3001
HAR: HEAR1008(hemD)
MMS: mma_1143(hemD)
LCH: Lcho_0765
NEU: NE0591(hemD)
NET: Neut_1038
NMU: Nmul_A2689
EBA: ebA1165(hemD)
AZO: azo0994(hemD)
DAR: Daro_3673
TMZ: Tmz1t_1438
TBD: Tbd_2567
MFA: Mfla_0034
MMB: Mmol_0165
MEI: Msip34_0033
APP: CAP2UW1_0792
HPY: HP1224(hemD)
HPJ: jhp1145(hemD)
HPA: HPAG1_1166(hemD)
HPS: HPSH_06330(hemD)
HPG: HPG27_1168(hemD)
HPP: HPP12_1190(hemD)
HPB: HELPY_1199(hemD)
HHE: HH0104(hemD)
HAC: Hac_1600(hemD)
WSU: WS1602(hemD)
TDN: Suden_0423(hemD) Suden_1228(hemD)
CJE: Cj1080c(hemD)
CJR: CJE1223(hemD)
CJJ: CJJ81176_1098(hemD)
CJU: C8J_1021(hemD)
CJD: JJD26997_0644(hemD)
CFF: CFF8240_1262(hemD)
CCV: CCV52592_0948(hemD)
CHA: CHAB381_1483(hemD)
CCO: CCC13826_0493(hemD)
CLA: Cla_1121(hemD)
ABU: Abu_1177(hemD)
SDL: Sdel_0596
NIS: NIS_1338
SUN: SUN_1892
NAM: NAMH_0982(hemD)
GSU: GSU3286
GME: Gmet_3235
GUR: Gura_0358
GLO: Glov_0501
GBM: Gbem_0409
GEO: Geob_1298
GEM: GM21_0409
PCA: Pcar_3062(hemD)
PPD: Ppro_3374
DVU: DVU0734
DVL: Dvul_2236
DVM: DvMF_2767
DDE: Dde_2837
DDS: Ddes_2207
DMA: DMR_44070
DSA: Desal_0251
LIP: LI0117(cysG)
DBA: Dbac_2449
DRT: Dret_0252
DPS: DP1734
DOL: Dole_3062
DAL: Dalk_4009
DAT: HRM2_35960(hemD)
ADE: Adeh_2491
ACP: A2cp1_1461
AFW: Anae109_1376
ANK: AnaeK_1364
MXA: MXAN_2657(hemD)
SCL: sce0014(hemD) sce6449
HOH: Hoch_3452
SAT: SYN_02272
SFU: Sfum_3201
WOL: WD1000
WBM: Wbm0728
WRI: WRi_009490
WPI: WPa_1128
AMA: AM830
AMF: AMF_620(hemD)
ACN: ACIS_00505(hemD)
APH: APH_0354
ERU: Erum5380(hemD)
ERW: ERWE_CDS_05640
ERG: ERGA_CDS_05530
ECN: Ecaj_0546
ECH: ECH_0480(hemD)
NRI: NRI_0415
PUB: SAR11_0309(hemD)
MLO: mll4221
MES: Meso_3201
PLA: Plav_1350
SME: SMc03232(hemD)
SMD: Smed_2967
ATU: Atu2653(hem4)
ATC: AGR_C_4810
ARA: Arad_4357(hemD)
AVI: Avi_4146
RET: RHE_CH03905(hemD)
REC: RHECIAT_CH0004189(hemD)
RLE: RL4496
RLT: Rleg2_3700
RLG: Rleg_4021
RHI: NGR_c32100
LAS: CLIBASIA_04685(hemD)
BME: BMEI0177
BMF: BAB1_1886(hemD)
BMB: BruAb1_1863(hemD)
BMC: BAbS19_I17680
BMS: BR1886(hemD)
BMT: BSUIS_A1726
BOV: BOV_1814(hemD)
BCS: BCAN_A1929
BMR: BMI_I1907(hemD)
OAN: Oant_0976
BJA: bll0566
BRA: BRADO0301 BRADO5258
BBT: BBta_0288 BBta_5710
RPA: RPA0256
RPB: RPB_0314
RPC: RPC_0047
RPD: RPD_0469
RPE: RPE_0064 RPE_4220
RPT: Rpal_0257 Rpal_4563
NWI: Nwi_0472
NHA: Nham_0563
OCA: OCAR_4326(hemD)
XAU: Xaut_1159
AZC: AZC_0260
MEX: Mext_0733
MEA: Mex_1p0559
MDI: METDI0835
MRD: Mrad2831_2070
MET: M446_4534
MPO: Mpop_0706
MCH: Mchl_0747
MNO: Mnod_4468
BID: Bind_0008
MSL: Msil_0006
CCS: CCNA_00071
CAK: Caul_0119
PZU: PHZ_c3404(hemD)
SIL: SPO3853
SIT: TM1040_2828
RSP: RSP_6208
RSH: Rsph17029_0160
RSQ: Rsph17025_2913
RSK: RSKD131_2901
JAN: Jann_4081
RDE: RD1_0471(hemD)
PDE: Pden_1997
DSH: Dshi_3416(hemD)
MMR: Mmar10_0041
HNE: HNE_3228(hemD)
HBA: Hbal_0072
ZMO: ZMO1902
ZMN: Za10_1241
NAR: Saro_2787
SWI: Swit_1937
GOX: GOX1884
GBE: GbCGDNIH1_2423
ACR: Acry_0127
GDI: GDI_2069
GDJ: Gdia_0290
APT: APA01_07980
RRU: Rru_A3567
RCE: RC1_2364(hemD)
MAG: amb4421
BSU: BSU12230(yjjA) BSU28140(hemD)
BHA: BH1495 BH2162(hemD) BH3045(hemD)
BAN: BA2144 BA4695(hemD)
BAR: GBAA2144 GBAA4695(hemD)
BAA: BA_2640 BA_5134
BAT: BAS1995 BAS4360(hemD)
BAH: BAMEG_2448 BAMEG_4730(hemD)
BAI: BAA_2209 BAA_4713(hemD)
BCE: BC2134 BC4470(hemD)
BCA: BCE_4554(hemD)
BCZ: BCZK1947 BCZK4207(hemD)
BCR: BCAH187_A2291 BCAH187_A4599(hemD)
BCB: BCB4264_A2150 BCB4264_A4581(hemD)
BCU: BCAH820_2175 BCAH820_4550(hemD)
BCG: BCG9842_B0653(hemD) BCG9842_B3164
BCQ: BCQ_2119 BCQ_4250(hemD)
BCX: BCA_2228 BCA_4575(hemD)
BCY: Bcer98_0206 Bcer98_3179(hemD)
BTK: BT9727_1968 BT9727_4196(hemD)
BTL: BALH_1905 BALH_4056(hemD)
BWE: BcerKBAB4_1988 BcerKBAB4_4308(hemD)
BLI: BL00626(hemD)
BLD: BLi02842(hemD) BLi02944(hemD)
BCL: ABC2629(hemD) ABC3411(hemD)
BAY: RBAM_012310(hemD) RBAM_025200(hemD)
BPU: BPUM_1801(hemD) BPUM_2455(hemD)
OIH: OB1658(hemD) OB2067
GKA: GK1829(hemD) GK2644
GTN: GTNG_1719(hemD) GTNG_2573(hemD)
GWC: GWCH70_1526 GWCH70_2579
GYM: GYMC10_1520 GYMC10_5980
GYC: GYMC61_0873 GYMC61_2640
AFL: Aflv_0608(hemD) Aflv_1473(hemD)
SAU: SA1493(hemD)
SAV: SAV1669(hemD)
SAW: SAHV_1656(hemD)
SAM: MW1613(hemD)
SAR: SAR1749(hemD)
SAS: SAS1598
SAC: SACOL1716(hemD)
SAB: SAB1529c(hemD)
SAA: SAUSA300_1616(hemD)
SAX: USA300HOU_1661(hemD)
SAO: SAOUHSC_01773
SAJ: SaurJH9_1727
SAH: SaurJH1_1761
SAE: NWMN_1563(hemD)
SAD: SAAV_1656(hemD)
SEP: SE1344
SER: SERP1233(hemD)
SHA: SH1258(hemD)
SSP: SSP1095
SCA: Sca_1275(hemD)
LMO: lmo1201 lmo1555(hemD)
LMF: LMOf2365_1210 LMOf2365_1576(hemD)
LMH: LMHCC_1014(hemD) LMHCC_1450
LMC: Lm4b_01205 Lm4b_01566
LIN: lin1164 lin1590(hemD)
LWE: lwe1158(hemD) lwe1568(hemD)
LSP: Bsph_3969
ESI: Exig_2136
EAT: EAT1b_2644
MCL: MCCL_1303 MCCL_1338
BBE: BBR47_42680
PJD: Pjdr2_4436
AAC: Aaci_1837 Aaci_2422
SSA: SSA_0474 SSA_0486(hemD)
LRE: Lreu_1712
LRF: LAR_1600
CAC: CAC0098(hemD)
CPE: CPE1434(hemX)
CPF: CPF_1687(hemD)
CPR: CPR_1421(hemD)
CTC: CTC00728
CNO: NT01CX_0261
CTH: Cthe_2528
CDF: CD3420(hemD)
CDC: CD196_3196(hemD)
CDL: CDR20291_3242(hemD)
CBO: CBO0921(hemD)
CBA: CLB_0962(cobA)
CBH: CLC_0976(cobA)
CBY: CLM_1069
CBL: CLK_0359
CBK: CLL_A2906
CBB: CLD_3638
CBI: CLJ_B0972
CBT: CLH_2648
CBF: CLI_1008(cobA)
CBE: Cbei_1286
CKL: CKL_0719(hemD)
CKR: CKR_0641
CPY: Cphy_1371 Cphy_1787
CCE: Ccel_1278
AMT: Amet_0061
AOE: Clos_1328
SWO: Swol_0687
VPR: Vpar_1424
ATE: Athe_1199
DSY: DSY2224
DHD: Dhaf_3353
DRM: Dred_2162
DAE: Dtox_1252
PTH: PTH_0973
DAU: Daud_1346
HMO: HM1_1966(cobA)
EEL: EUBELI_00749
ERE: EUBREC_0904
TEX: Teth514_0319
TPD: Teth39_1890
CHY: CHY_1209(hemD) CHY_2407
MTA: Moth_1248
ADG: Adeg_1258
CSC: Csac_1652
NTH: Nther_1125
MTU: Rv0260c Rv0511(hemD)
MTC: MT0273 MT0532
MRA: MRA_0268 MRA_0518(hemD)
MTF: TBFG_10264 TBFG_10522
MTB: TBMG_00262(TBMG_00262.1) TBMG_00518(TBMG_00518.1)
MBO: Mb0266c Mb0524(hemD)
MBB: BCG_0298c BCG_0554(hemD)
MBT: JTY_0267 JTY_0524(hemD)
MLE: ML2420(hemD)
MLB: MLBr_02420(hemD)
MPA: MAP3706c MAP4004(cysG)
MAV: MAV_4638(hemD) MAV_4900
MSM: MSMEG_0954(hemD)
MUL: MUL_4600(hemD)
MVA: Mvan_0301 Mvan_0846
MGI: Mflv_0065 Mflv_0380
MAB: MAB_3520c MAB_3991c
MMC: Mmcs_0263 Mmcs_0678
MKM: Mkms_0273 Mkms_0691
MJL: Mjls_0253 Mjls_0671
MMI: MMAR_0520 MMAR_0844(hemD)
CGL: NCgl0414(cgl0429)
CGB: cg0510(hemD)
CGT: cgR_0499
CEF: CE0450
CDI: DIP0402
CJK: jk1900(hemD)
CUR: cur_0226
CAR: cauri_0300(hemD)
CKP: ckrop_1910
NFA: nfa45590 nfa51680(hemDX)
RHA: RHA1_ro02051 RHA1_ro05940 RHA1_ro06368
RER: RER_16430(cysGA) RER_22090 RER_41870
ROP: ROP_17230 ROP_60010 ROP_64290
GBR: Gbro_1015 Gbro_3505
SCO: SCO2958(SCE59.17c) SCO3317(SCE68.15c)
SMA: SAV_4741(hemD) SAV_5120
SGR: SGR_4157 SGR_4576
TWH: TWT731
TWS: TW745
LXX: Lxx01110(hemD)
CMI: CMM_0597(hemD)
CMS: CMS_2840
ART: Arth_1256 Arth_2766
AAU: AAur_1396
ACH: Achl_1303 Achl_2488
RSA: RSal33209_1224
KRH: KRH_17070
MLU: Mlut_15180
BCV: Bcav_2796
BFA: Bfae_26800
JDE: Jden_2199 Jden_2493
KSE: Ksed_24390
XCE: Xcel_1813
PAC: PPA0303 PPA0323
NCA: Noca_0354 Noca_0496
TFU: Tfu_2731
TCU: Tcur_2410 Tcur_4438
SRO: Sros_0550 Sros_5922
FRA: Francci3_0487 Francci3_0528 Francci3_0793
FRE: Franean1_1494 Franean1_6102 Franean1_6129
FAL: FRAAL0985(hemD) FRAAL1020(corA) FRAAL1354
ACE: Acel_0236 Acel_1742
NML: Namu_0920 Namu_2282
KRA: Krad_0619 Krad_1325
SEN: SACE_1074 SACE_3804 SACE_6944(hemD)
SVI: Svir_02870
AMI: Amir_0840 Amir_6728
STP: Strop_0358 Strop_3871
SAQ: Sare_0428 Sare_4262
CAI: Caci_6178 Caci_8324
RXY: Rxyl_1977
AFO: Afer_0251
CCU: Ccur_12360
SHI: Shel_11620
ELE: Elen_2069
CTR: CT433(hemD)
CTA: CTA_0473(hemD)
CTB: CTL0692(hemD)
CTL: CTLon_0688(hemD)
CTJ: JALI_4341
CMU: TC0717(hemD)
CPN: CPn0522(hemD)
CPA: CP0231(hemD)
CPJ: CPj0522(hemD)
CPT: CpB0543(hemD)
CCA: CCA00223(hemD)
CAB: CAB219(hemD)
CFE: CF0783(hemD)
PCU: pc0271(hemD)
ABA: Acid345_2562
ACA: ACP_0710(hemD)
SUS: Acid_3181
BVU: BVU_1187
PGN: PGN_0310
PDI: BDI_3054
APS: CFPG_188
SRU: SRU_1553(hemD)
RMR: Rmar_1890
CHU: CHU_0169(hemD)
DFE: Dfer_2913
CPI: Cpin_0486 Cpin_6501
PHE: Phep_0382
GFO: GFO_0106(hemD) GFO_3225(hemD)
FJO: Fjoh_0945
FPS: FP0042(hemD)
FBA: FIC_00013 FIC_02425
COC: Coch_0607 Coch_1477
RBI: RB2501_06010 RB2501_08350
BBL: BLBBGE_290(hemD) BLBBGE_576(hemD)
BPI: BPLAN_350
FSU: Fisuc_3036
FNU: FN0644
LBA: Lebu_0028
STR: Sterm_1023
MIN: Minf_2186(cysG)
AMU: Amuc_0896
GAU: GAU_2595(hemD)
RBA: RB7020(hemD) RB7803(uroD)
TAI: Taci_0043
SYN: sll0166(hemD)
SYW: SYNW2210(hemD)
SYC: syc1241_c(hemD)
SYF: Synpcc7942_0272
SYD: Syncc9605_2353
SYE: Syncc9902_0338
SYG: sync_2565(hemD)
SYR: SynRCC307_0278(hemD)
SYX: SynWH7803_2221(hemD)
SYP: SYNPCC7002_A1192(cysG)
CYA: CYA_0529(cobA)
CYB: CYB_0566(cobA)
TEL: tlr2155(hemD)
MAR: MAE_55370(hemD)
CYT: cce_2117(hemD)
CYP: PCC8801_1028
CYC: PCC7424_2558
CYN: Cyan7425_4844
CYH: Cyan8802_1057
GVI: gvip169(hemD)
ANA: alr3450
NPU: Npun_R1866
AVA: Ava_3075 Ava_3474
PMA: Pro0134(hemD)
PMM: PMM0113(hemD)
PMT: PMT1966(hemD)
PMN: PMN2A_1482
PMI: PMT9312_0116
PMB: A9601_01311(hemD)
PMC: P9515_01271(hemD)
PMF: P9303_26181(hemD)
PMG: P9301_01301(hemD)
PMH: P9215_01311(hemD)
PMJ: P9211_01291(hemD)
PME: NATL1_01871(hemD)
TER: Tery_3325
AMR: AM1_4654
CTE: CT1428(hemD)
CPC: Cpar_0039 Cpar_0736
CCH: Cag_1514
CPH: Cpha266_1797
CPB: Cphamn1_0932 Cphamn1_1843
CLI: Clim_0709 Clim_0892
PVI: Cvib_1246
PLT: Plut_1428
PPH: Ppha_0949
PAA: Paes_0043 Paes_1540
CTS: Ctha_2291
RRS: RoseRS_1751
RCA: Rcas_2031
CAU: Caur_2595
CAG: Cagg_1290
CHL: Chy400_2804
HAU: Haur_1744 Haur_2335 Haur_3549
STI: Sthe_1803
DRA: DR_0786 DR_A0011
DGE: Dgeo_2131
DDR: Deide_18180 Deide_19180(hemD)
TTH: TTC0312(hemD) TTC1143(hemD)
TTJ: TTHA0671(hemD) TTHA1507
AAE: aq_1771(hemD)
HYA: HY04AAS1_0640
SUL: SYO3AOP1_0052 SYO3AOP1_0185(hemD)
SAF: SULAZ_0252(hemD)
PMX: PERMA_1098(hemD)
TME: Tmel_0708
TAF: THA_1078
TYE: THEYE_A0718
TTR: Tter_0581
MJA: MJ0994
MFE: Mefer_1494
MVU: Metvu_0380
MMP: MMP0394(hemD)
MMQ: MmarC5_1244
MMX: MmarC6_0516
MMZ: MmarC7_1392
MAE: Maeo_0075
MVN: Mevan_1381
MAC: MA3034(hemD)
MBA: Mbar_A1792(hemD)
MMA: MM_0308(hemD)
MBU: Mbur_1106(hemD)
MLA: Mlab_0359
MEM: Memar_0539
MBN: Mboo_0514
MPL: Mpal_2749
MPD: MCP_2923(hemD)
MTH: MTH166
MST: Msp_1191(hemD)
MSI: Msm_1504
MKA: MK1550(hemD)
AFU: AF0116(hemD)
HAL: VNG2332G(hemD)
HSL: OE4281F(hemD)
HMA: rrnAC3088(hemD)
HWA: HQ3452A(hemD)
NPH: NP1330A(hemD)
HLA: Hlac_2254
HUT: Huta_0928
HMU: Hmuk_1103
TAC: Ta0573(hemD)
TVO: TVN0633(hemD)
PTO: PTO0250(hemD)
RCI: RCIX916(hemD)
APE: APE_1493(hemD)
IHO: Igni_0090
SSO: SSO0184
STO: ST0218
SAI: Saci_0781
SIS: LS215_2114
SIA: M1425_1951
SIM: M1627_2029
SID: M164_1959
SIY: YG5714_2073
SIN: YN1551_0845
MSE: Msed_0218
PAI: PAE0589
PIS: Pisl_0116
PCL: Pcal_1712
PAS: Pars_2250
CMA: Cmaq_1901
TNE: Tneu_0287 Tneu_1898
NMR: Nmar_0493
Taxonomy
Structures PDB: 1JR2  1WCW  1WCX  1WD7  3D8N  3D8R  3D8S  3D8T  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:6769048]
Battersby AR, Fookes CJ, Matcham GW, McDonald E.
Biosynthesis of the pigments of life: formation of the macrocycle.
Nature. 285 (1980) 17-21.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:3805019]
Tsai SF, Bishop DF, Desnick RJ.
Purification and properties of uroporphyrinogen III synthase from
human erythrocytes.
J. Biol. Chem. 262 (1987) 1268-73.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 4.2.1.75
IUBMB Enzyme Nomenclature: 4.2.1.75
ExPASy - ENZYME nomenclature database: 4.2.1.75
BRENDA, the Enzyme Database: 4.2.1.75
CAS: 37340-55-9
DBGET integrated database retrieval system