KEGG   ENZYME: 4.2.1.77Help
Entry
EC 4.2.1.77                 Enzyme                                 

Name
trans-L-3-hydroxyproline dehydratase;
trans-L-3-hydroxyproline hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O [RN:R04374]
Reaction(KEGG)
Substrate
trans-3-hydroxy-L-proline [CPD:C05147]
Product
1-pyrroline 2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
Comment
Highly specific.
History
EC 4.2.1.77 created 1984
Pathway
Arginine and proline metabolism
Orthology
K18384  
trans-L-3-hydroxyproline dehydratase
Genes
HSA: 
112849(L3HYPDH)
PTR: 
452942(L3HYPDH)
PPS: 
100973980(L3HYPDH)
GGO: 
101151045(L3HYPDH)
PON: 
100172276(L3HYPDH)
NLE: 
100585615(L3HYPDH)
MCC: 
MCF: 
102115940(L3HYPDH)
CJC: 
100402030(L3HYPDH)
MMU: 
67217(L3hypdh)
RNO: 
314214(L3hypdh)
CGE: 
100764709(L3hypdh)
NGI: 
103739192(L3hypdh)
HGL: 
101725460(L3hypdh)
OCU: 
TUP: 
102490555(L3HYPDH)
CFA: 
490715(L3HYPDH)
AML: 
UMR: 
103672703(L3HYPDH)
FCA: 
101098960(L3HYPDH)
PTG: 
102955955(L3HYPDH)
BTA: 
510525(L3HYPDH)
BOM: 
102267712(L3HYPDH)
PHD: 
102331969(L3HYPDH)
CHX: 
102170980(L3HYPDH)
OAS: 
101102239(L3HYPDH)
CFR: 
102510698(L3HYPDH)
BACU: 
103001798(L3HYPDH)
LVE: 
103089729(L3HYPDH)
ECB: 
100059502(L3HYPDH)
MYB: 
102251331(L3HYPDH)
MYD: 
102751344(L3HYPDH)
PALE: 
102892379(L3HYPDH)
MDO: 
100026616(L3HYPDH)
SHR: 
100916958(C2H14orf149)
OAA: 
100086994(L3HYPDH)
GGA: 
423531(C14ORF149)
APLA: 
101790625(L3HYPDH)
TGU: 
100232596(L3HYPDH)
FAB: 
101810740(L3HYPDH)
PHI: 
102107944(L3HYPDH)
FPG: 
101918943(L3HYPDH)
FCH: 
102059456(L3HYPDH)
CLV: 
102096316(L3HYPDH)
ASN: 
102369998(L3HYPDH)
AMJ: 
102565530(L3HYPDH)
PSS: 
102462476(L3HYPDH)
CMY: 
102947990(L3HYPDH)
ACS: 
100559609(l3hypdh)
PBI: 
XTR: 
493490(l3hypdh)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352794(L3HYPDH)
CMK: 
103178517(l3hypdh)
BFO: 
CIN: 
SPU: 
HRO: 
LGI: 
NVE: 
HMG: 
AQU: 
MTM: 
NHE: 
ANI: 
PFJ: 
NPA: 
DSQ: 
PSQ: 
MRR: 
SPIU: 
MCI: 
MAM: 
PSF: 
SSY: 
 » show all
Taxonomy
Reference
1
  Authors
Ramaswamy, S.G.
  Title
Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides.
  Journal
Fed. Proc. 42 (1983) 2232.
Reference
2  [PMID:22528483]
  Authors
Visser WF, Verhoeven-Duif NM, de Koning TJ
  Title
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.
  Journal
J. Biol. Chem. 287 (2012) 21654-62.
  Sequence
[hsa:112849]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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