KEGG   ENZYME: 4.2.1.8Help
Entry
EC 4.2.1.8                  Enzyme                                 
Name mannonate dehydratase;
mannonic hydrolase;
mannonate hydrolyase;
altronic hydro-lyase;
altronate hydrolase;
D-mannonate hydrolyase;
D-mannonate hydro-lyase
Class Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
Reaction(IUBMB) D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O [RN:R05606]
Reaction(KEGG) R05606
Show
Substrate D-mannonate [CPD:C00514]
Product 2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
H2O [CPD:C00001]
Pathway PATH: ec00040  Pentose and glucuronate interconversions
PATH: ec01100  Metabolic pathways
Orthology KO: K01686  mannonate dehydratase
Genes ECO: b4322(uxuA)
ECJ: JW4285(uxuA)
EBW: BWG_4020(uxuA)
ECE: Z5920(uxuA)
ECS: ECs5281
ECF: ECH74115_5828(uxuA)
ETW: ECSP_5406(uxuA)
ECG: E2348C_4628(uxuA)
ECC: c5402(uxuA)
ECI: UTI89_C5018(uxuA)
ECP: ECP_4658
ECV: APECO1_2109(uxuA)
ECW: EcE24377A_4920(uxuA)
ECX: EcHS_A4548(uxuA)
ECM: EcSMS35_4849(uxuA)
ECY: ECSE_4595
ECL: EcolC_3742
ECK: EC55989_4987(uxuA)
ECQ: ECED1_5204(uxuA)
ECR: ECIAI1_4538(uxuA)
ECT: ECIAI39_4795(uxuA)
ECZ: ECS88_4940(uxuA)
EUM: ECUMN_4930(uxuA)
ELF: LF82_2403(uxuA)
EBL: B21_04153(uxuA)
EBD: ECBD_3713
EBR: ECB_04191(uxuA)
EOH: ECO103_5103(uxuA)
EOI: ECO111_5178(uxuA)
EOJ: ECO26_5518(uxuA)
EFE: EFER_3030(uxuA)
STY: STY3306(uxuA)
STT: t3056(uxuA)
SPT: SPA3003(uxuA)
SEK: SSPA2801
SPQ: SPAB_03915
SEI: SPC_3203(uxuA)
SEC: SC3076(uxuA)
SEH: SeHA_C3381(uxuA)
SEE: SNSL254_A3387(uxuA)
SEW: SeSA_A3317(uxuA)
SEA: SeAg_B3307(uxuA)
SED: SeD_A3480(uxuA)
SEG: SG3029
SET: SEN2978
SES: SARI_04491
STM: STM3135
YPE: YPO1283(uxuA)
YPK: y2902(uxuA)
YPM: YP_1308(uxuA)
YPA: YPA_0999
YPN: YPN_2695
YPG: YpAngola_A1509(uxuA)
YPP: YPDSF_2413
YPS: YPTB1315(uxuA)
YPI: YpsIP31758_2699(uxuA)
YPY: YPK_2778
YPB: YPTS_1407
YEN: YE1440(uxuA)
SFL: SF4198(uxuA)
SFX: S4454(uxuA)
SFV: SFV_4204(uxuA)
SSN: SSON_4477(uxuA)
SBO: SBO_4373(uxuA)
SBC: SbBS512_E4792(uxuA)
ECA: ECA1093(uxuA)
PCT: PC1_0987
PWA: Pecwa_3323
PLU: plu0170(uxuA)
PAY: PAU_00120(uxuA)
SGL: SG1838
ENT: Ent638_2767
ESA: ESA_01068
CTU: Ctu_28370(uxuA)
KPN: KPN_02604 KPN_03620
KPE: KPK_0501 KPK_1558(uxuA)
KPU: KP1_3833 KP1_4932
CKO: CKO_00609 CKO_03736
SPE: Spro_3238
EIC: NT01EI_2579
ETR: ETAE_2289(uxuA)
DDA: Dd703_0975
DDC: Dd586_4087
DZE: Dd1591_4112
HIN: HI0055(uxuA)
HIT: NTHI0065(uxuA)
HIP: CGSHiEE_03030
HIQ: CGSHiGG_02775
HSO: HS_1596(uxuA)
HSM: HSM_0415
MSU: MS0537(uxuA)
ASU: Asuc_0151 Asuc_0370
AAT: D11S_1516
VVU: VV2_1064
VVY: VVA1588
VPA: VPA1700
PPR: PBPRB1874
CJA: CJA_1109(uxuA)
PAT: Patl_3648
SDE: Sde_1273 Sde_1891
PIN: Ping_0136
TTU: TERTU_0111(uxuA)
CSA: Csal_2980
MMW: Mmwyl1_2778
TAU: Tola_2884
CTI: RALTA_A1563(uxuA)
BUR: Bcep18194_B1358
BCN: Bcen_3876
BCH: Bcen2424_4493
BCM: Bcenmc03_5811
BCJ: BCAM1672(uxuA)
BMU: Bmul_4154
BMJ: BMULJ_04351(uxuA)
BPY: Bphyt_5748
RFR: Rfer_0947
AZO: azo0149(uxuA)
SCL: sce4078(uxuA)
MLO: mlr6866
MES: Meso_4498 Meso_4519
SME: SM_b20446(uxuA)
SMD: Smed_3684
ATU: Atu3257(uxuA) Atu3529(uxuA) Atu4625(uxuA)
ATC: AGR_L_2605 AGR_L_3119 AGR_L_515
ARA: Arad_8485(uxuA) Arad_8885(uxuA) Arad_9703(uxuAch)
AVI: Avi_3897(uxuA) Avi_5616(uxuA)
RET: RHE_CH02058(uxuAch) RHE_PB00006(uxuAb)
REC: RHECIAT_CH0002105(uxuAch) RHECIAT_PC0000344(uxuAc)
RLE: RL2336(uxuA) pRL90057(uxuA)
RLT: Rleg2_1690 Rleg2_6490
RLG: Rleg_1876 Rleg_6000
RHI: NGR_b15780 NGR_b19260(uxuA)
BME: BMEII0474
BMI: BMEA_B0793(uxuA)
BMF: BAB2_0422(uxuA)
BMB: BruAb2_0418(uxuA)
BMC: BAbS19_II03970
BMS: BRA0814(uxuA)
BMT: BSUIS_B0806(uxuA)
BOV: BOV_A0764(uxuA)
BCS: BCAN_B0829(uxuA)
BMR: BMI_II808(uxuA)
OAN: Oant_4095
BJA: bll6830(uxuA)
BRA: BRADO1803(uxuA)
BBT: BBta_2123(uxuA)
AZC: AZC_2768
MNO: Mnod_0977
SIL: SPO1723(uxuA)
SIT: TM1040_3873
RSP: RSP_0773
RSH: Rsph17029_2429
RSQ: Rsph17025_0406
RSK: RSKD131_2133
RDE: RD1_0665(uxuA)
PDE: Pden_5061
ACR: Acry_1858
BSU: BSU12340(uxuA)
BHA: BH0706 BH1063
BLI: BL00281 BL03802(uxuA)
BLD: BLi01356(uxuA) BLi02116
BCL: ABC0631(uxuA)
BAY: RBAM_017980(uxuA)
OIH: OB3411
GTN: GTNG_1764(uxuA)
GYM: GYMC10_6104
GYC: GYMC61_2699
SHA: SH2647(uxuA)
PJD: Pjdr2_0333 Pjdr2_4217
AAC: Aaci_2289
LLA: L0020(uxuA)
LLK: LLKF_1788(uxuA)
LLC: LACR_1745
LLM: llmg_0859(uxuA)
SPH: MGAS10270_Spy1170
SNM: SP70585_2237(uxuA)
SAG: SAG0702(uxuA)
SAN: gbs0675
SAK: SAK_0828(uxuA)
SSU: SSU05_1157
SSV: SSU98_1173
SSB: SSUBM407_0784(uxuA)
SSI: SSU1002(uxuA)
SSS: SSUSC84_1040(uxuA)
SEQ: SZO_13110
SEZ: Sez_0690
SEU: SEQ_0717
SUB: SUB1202(uxuA)
SDS: SDEG_1362
LBR: LVIS_0146
LRH: LGG_00056(uxuA)
LRL: LC705_00047(uxuA)
EFA: EF3135
CAC: CAC1332(uxuA)
CPE: CPE0151(uxuA)
CBE: Cbei_2200 Cbei_4084 Cbei_4659
CPY: Cphy_1061
CCE: Ccel_0140 Ccel_1674
AMT: Amet_1292 Amet_3784
ATE: Athe_0856
APR: Apre_1601
EEL: EUBELI_20595
MTA: Moth_0430
CSC: Csac_2687
BCV: Bcav_3719
XCE: Xcel_2667
PAC: PPA2327
BHY: BHWA1_02240(uxuA)
SUS: Acid_3346 Acid_5062 Acid_5529
BTH: BT_0129 BT_1432
BFR: BF0177
BFS: BF0142(uxuA)
BVU: BVU_1262 BVU_3035
PDI: BDI_0376
APS: CFPG_171
DFE: Dfer_0595 Dfer_1408 Dfer_4123
CPI: Cpin_1501
PHE: Phep_1314 Phep_2262
FJO: Fjoh_1995 Fjoh_4191
FBA: FIC_01740
RBI: RB2501_04520
STR: Sterm_4047
SMF: Smon_1306
OTE: Oter_4342
RSD: TGRD_069
TRO: trd_0912
DDR: Deide_1p01660(uxuA)
TMA: TM0069
TPT: Tpet_0855
TRQ: TRQ2_0878
TNA: CTN_0624
TNP: Tnap_0699
HLA: Hlac_2239
HUT: Huta_0869
TAC: Ta0753
TVO: TVN0074
PTO: PTO0148
CMA: Cmaq_1160
Taxonomy
Structures PDB: 1TZ9  3BAN  3BDK  3DBN  3FVM  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13584413]
ASHWELL A, WAHBA AJ, HICKMAN J.
A new pathway of uronic acid metabolism.
Biochim. Biophys. Acta. 30 (1958) 186-7.
Escherichia coli [GN:eco]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4581499]
Robert-Baudouy JM, Stoeber FR.
[Purification and properties of D-mannonate hydrolyase from
Escherichia coli K12]
Biochim. Biophys. Acta. 309 (1973) 473-85.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 4.2.1.8
IUBMB Enzyme Nomenclature: 4.2.1.8
ExPASy - ENZYME nomenclature database: 4.2.1.8
BRENDA, the Enzyme Database: 4.2.1.8
CAS: 9024-31-1
DBGET integrated database retrieval system