| Entry |
|
|---|
| Name |
arogenate dehydratase;
carboxycyclohexadienyl dehydratase;
L-arogenate hydro-lyase (decarboxylating) |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
|---|
| Sysname |
L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming) |
|---|
| Reaction(IUBMB) |
L-arogenate = L-phenylalanine + H2O + CO2 [RN:R00691] |
|---|
| Reaction(KEGG) |
R00691;
(other) R01373
 |
|---|
| Substrate |
L-arogenate [CPD:C00826] |
|---|
| Product |
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
CO2 [CPD:C00011] |
|---|
| Comment |
Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51,
prephenate dehydratase. |
|---|
| Pathway |
PATH: ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05359 carboxycyclohexadienyl dehydratase |
|---|
| Genes |
CVI: CV_0224
BVI: Bcep1808_0119
MSM: MSMEG_3442
 |
|---|
| Structures |
PDB: 3KBR |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:3600377]
Fischer R, Jensen R.
Arogenate dehydratase.
Methods. Enzymol. 142 (1987) 495-502. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2972718]
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA.
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite
from Neurospora crassa.
J. Biol. Chem. 263 (1988) 17284-90.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3124763]
Siehl DL, Conn EE.
Kinetic and regulatory properties of arogenate dehydratase in
seedlings of Sorghum bicolor (L.) Moench.
Arch. Biochem. Biophys. 260 (1988) 822-9.
Sorghum bicolor [GN:sbi] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.1.91
IUBMB Enzyme Nomenclature: 4.2.1.91
ExPASy - ENZYME nomenclature database: 4.2.1.91
BRENDA, the Enzyme Database: 4.2.1.91
CAS: 76600-70-9 |
|---|
