| Entry |
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| Name |
scytalone dehydratase;
scytalone 7,8-hydro-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
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| Reaction(IUBMB) |
scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN: R02907]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.
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| Reference |
1 |
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| Authors |
Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A. |
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| Title |
Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi. |
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| Journal |
Exp. Mycol. 12 (1988) 367-376. |
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| Reference |
2 |
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| Authors |
Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J. |
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| Title |
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus. |
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| Journal |
Exp. Mycol. 13 (1989) 69. |
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| Reference |
3 |
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| Authors |
Wheeler, M.H. and Greenblatt, G.A. |
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| Title |
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. |
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| Journal |
Exp. Mycol. 12 (1988) 151-160. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 118901-79-4 |
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