KEGG   ENZYME: 4.2.1.94Help
Entry
EC 4.2.1.94                 Enzyme                                 

Name
scytalone dehydratase;
scytalone 7,8-hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
Reaction(IUBMB)
scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN:R02907]
Reaction(KEGG)
Substrate
scytalone [CPD:C00779]
Product
1,3,8-trihydroxynaphthalene [CPD:C01173];
H2O [CPD:C00001]
Comment
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.
History
EC 4.2.1.94 created 1992
Orthology
K17740  
scytalone dehydratase
Genes
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
VAL: 
SSL: 
BFU: 
AFM: 
ACT: 
NFI: 
PCS: 
PNO: 
PTE: 
ZTR: 
 » show all
Taxonomy
Reference
1
  Authors
Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A.
  Title
Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi.
  Journal
Exp. Mycol. 12 (1988) 367-376.
Reference
2
  Authors
Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J.
  Title
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.
  Journal
Exp. Mycol. 13 (1989) 69.
Reference
3
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp. Mycol. 12 (1988) 151-160.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
118901-79-4

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